{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:26:22Z","timestamp":1771467982247,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060181"],"award-info":[{"award-number":["82060181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.gene.2024.149049","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T11:26:24Z","timestamp":1730114784000},"page":"149049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Integrated miRNA sequencing and experimental validation Unveil that low-level laser enhances vascular endothelial cell proliferation, migration, and lumen formation via miR-90\/VEGFA"],"prefix":"10.1016","volume":"935","author":[{"given":"Lili","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiancheng","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.149049_b0005","unstructured":"Avci P, G.A., Sadasivam M, Vecchio D, Pam Z, Pam N, Hamblin MR. , 2013 Mar. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. . Semin Cutan Med Surg 32, 41-52."},{"key":"10.1016\/j.gene.2024.149049_b0010","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-021-02493-5","article-title":"Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis","volume":"12","author":"Bai","year":"2021","journal-title":"Stem. Cell. Res. Ther."},{"key":"10.1016\/j.gene.2024.149049_b0015","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.msec.2016.08.003","article-title":"Orbital implants: State-of-the-art review with emphasis on biomaterials and recent advances","volume":"69","author":"Baino","year":"2016","journal-title":"Mater. Sci. Eng. C, Mater. Biological App."},{"key":"10.1016\/j.gene.2024.149049_b0020","doi-asserted-by":"crossref","unstructured":"Bilska A, S.A., Pyzlak M, Wojdasiewicz P, Szukiewicz D., 2020 Dec 2. Skin surface infrared thermography in pressure ulcer outcome prognosis. . J Wound Care 29, 707-718. doi: 10.12968\/jowc.2020.29.12.707.","DOI":"10.12968\/jowc.2020.29.12.707"},{"key":"10.1016\/j.gene.2024.149049_b0025","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2024.149049_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00438-017-1370-9","article-title":"Gene regulation of mammalian long non-coding RNA","volume":"293","author":"Bunch","year":"2017","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.gene.2024.149049_b0035","doi-asserted-by":"crossref","first-page":"9589","DOI":"10.1073\/pnas.1017945108","article-title":"Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells","volume":"108","author":"Chen","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2024.149049_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246249","article-title":"Deciphering miRNAs\u2019 Action through miRNA Editing","volume":"20","author":"Correia de Sousa","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2024.149049_b0045","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nature04479","article-title":"Endothelial cells and VEGF in vascular development","volume":"438","author":"Coultas","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.gene.2024.149049_b0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/14764172.2017.1314507","article-title":"The efficacy and safety of the fractional radiofrequency technique for the treatment of atrophic acne scar in Asians: a meta-analysis","volume":"19","author":"Dai","year":"2017","journal-title":"J. Cosmet. Laser Ther."},{"key":"10.1016\/j.gene.2024.149049_b0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10103-016-2080-y","article-title":"Effect of low-level laser therapy on angiogenesis and matrix metalloproteinase-2 immunoexpression in wound repair","volume":"32","author":"de Medeiros","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.gene.2024.149049_b0060","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.amjcard.2010.06.017","article-title":"Usefulness of intravascular low-power laser illumination in preventing restenosis after percutaneous coronary intervention","volume":"106","author":"Derkacz","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.gene.2024.149049_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101793","article-title":"Effect of 532nm photodynamic therapy with hemoporfin on the expression of vascular endothelial growth factor in cultured human vascular endothelial cells","volume":"30","author":"Dong","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.gene.2024.149049_b0070","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/jbio.201600176","article-title":"Photobiomodulation in human muscle tissue: an advantage in sports performance?","volume":"9","author":"Ferraresi","year":"2016","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.gene.2024.149049_b0075","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10103-014-1650-0","article-title":"Effect of LLLT on endothelial cells culture","volume":"30","author":"G\u00f3ralczyk","year":"2014","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.gene.2024.149049_b0080","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1152\/physiolgenomics.00144.2007","article-title":"Altered microRNA expression in human heart disease","volume":"31","author":"Ikeda","year":"2007","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.gene.2024.149049_b0085","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ajo.2004.04.062","article-title":"Porous polyethylene orbital implant in the pediatric population","volume":"138","author":"Iordanidou","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.gene.2024.149049_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17159\/2078-516X\/2019\/v31i1a6058","article-title":"Exploring the efficacy of low-level laser therapy and exercise for knee osteoarthritis","volume":"31","author":"Kholvadia","year":"2019","journal-title":"South African J. Sports Med."},{"key":"10.1016\/j.gene.2024.149049_b0095","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s10103-017-2269-8","article-title":"Laser irradiation promotes the proliferation of mouse pre-osteoblast cell line MC3T3-E1 through hedgehog signaling pathway","volume":"32","author":"Li","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.gene.2024.149049_b0100","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10103-018-2636-0","article-title":"The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503\/Wnt3a pathway","volume":"34","author":"Li","year":"2018","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.gene.2024.149049_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2019.103959","article-title":"Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K\/Akt signaling pathway","volume":"129","author":"Li","year":"2020","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.gene.2024.149049_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/life13020320","article-title":"Low-level laser therapy induces melanoma tumor growth by promoting angiogenesis","volume":"13","author":"Lin","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.gene.2024.149049_b0115","first-page":"766","article-title":"Laser therapy for treatment of peri-implant mucositis and peri-implantitis: an American Academy of Periodontology best evidence review","volume":"89","author":"Lin","year":"2018","journal-title":"J. Periodontol."},{"key":"10.1016\/j.gene.2024.149049_b0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ad.2020.03.010","article-title":"L\u00e1ser de baja potencia para tratar la alopecia androg\u00e9nica","volume":"112","author":"Mart\u00ednez-Pizarro","year":"2021","journal-title":"Actas Dermo-Sifiliogr\u00e1ficas"},{"key":"10.1016\/j.gene.2024.149049_b0125","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/dvdy.23795","article-title":"Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway","volume":"241","author":"Moran","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.gene.2024.149049_b0130","doi-asserted-by":"crossref","first-page":"1333D","DOI":"10.1136\/bjo.84.11.1333d","article-title":"Enucleation, evisceration and exenteration of the Eye","volume":"84","author":"Pitts","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.gene.2024.149049_b0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11061-y","article-title":"The impact of wavelengths of LED light-therapy on endothelial cells","volume":"7","author":"Rohringer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2024.149049_b0140","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/jbm.a.37076","article-title":"Bone marrow coagulated and low-level laser therapy accelerate bone healing by enhancing angiogenesis, cell proliferation, osteoblast differentiation, and mineralization","volume":"109","author":"Santinoni","year":"2020","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.gene.2024.149049_b0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/IOP.0000000000000207","article-title":"Hydroxyapatite orbital implant in children following enucleation: analysis of 531 sockets","volume":"31","author":"Shah","year":"2015","journal-title":"Ophthal. Plast. Reconstr. Surg."},{"key":"10.1016\/j.gene.2024.149049_b0150","doi-asserted-by":"crossref","first-page":"112388-","DOI":"10.1016\/j.jphotobiol.2022.112388","article-title":"Red and near infrared light-stimulated angiogenesis mediated via Ca2+ influx, VEGF production and NO synthesis in endothelial cells in macrophage or malignant environments","volume":"227","author":"Stepanov","year":"2022","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.gene.2024.149049_b0155","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3892\/ijo.2016.3608","article-title":"MicroRNA-195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K\/Akt and Raf\/MEK\/ERK signaling pathways","volume":"49","author":"Sun","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.gene.2024.149049_b0160","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/IOP.0b013e3181cff9fd","article-title":"Orbital augmentation with injectable calcium hydroxylapatite for correction of postenucleation\/evisceration socket syndrome","volume":"27","author":"Vagefi","year":"2011","journal-title":"Ophthal. Plast. Reconstr. Surg."},{"key":"10.1016\/j.gene.2024.149049_b0165","doi-asserted-by":"crossref","first-page":"9845","DOI":"10.1073\/pnas.1305472110","article-title":"A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis","volume":"110","author":"Vecchione","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2024.149049_b0170","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1089\/scd.2011.0695","article-title":"MicroRNA-193 pro-proliferation effects for bone mesenchymal stem cells after low-level laser irradiation treatment through inhibitor of growth family, member 5","volume":"21","author":"Wang","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.gene.2024.149049_b0175","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2021.9745","article-title":"Biological role of postoperative low level laser therapy in preventing hydroxyapatite orbital implantation exposure: a case report","volume":"21","author":"Xu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.gene.2024.149049_b0180","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-017-0166-2","article-title":"The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells","volume":"7","author":"Yuan","year":"2017","journal-title":"Cell Biosci."},{"key":"10.1016\/j.gene.2024.149049_b0185","first-page":"1024","article-title":"Removal of the eye in a tertiary care center of China: a retrospective study on 573 cases in 20 years","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Ophthalmol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924009302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924009302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T13:22:37Z","timestamp":1732195357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924009302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":37,"alternative-id":["S0378111924009302"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149049","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated miRNA sequencing and experimental validation Unveil that low-level laser enhances vascular endothelial cell proliferation, migration, and lumen formation via miR-90\/VEGFA","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149049"}}