{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:41:13Z","timestamp":1784662873409,"version":"3.55.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.gene.2024.149141","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T17:45:36Z","timestamp":1733334336000},"page":"149141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The significance of exosomal non-coding RNAs (ncRNAs) in the metastasis of colorectal cancer and development of therapy resistance"],"prefix":"10.1016","volume":"937","author":[{"given":"Omid Rahbar","family":"Farzam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6200-1728","authenticated-orcid":false,"given":"Sahand","family":"Eslami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-1923","authenticated-orcid":false,"given":"Ali","family":"Jafarizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sania Ghobadi","family":"Alamdari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dabbaghipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima Alizadeh","family":"Nobari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8642-6795","authenticated-orcid":false,"given":"Behzad","family":"Baradaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.149141_b0005","first-page":"24","article-title":"Regulation of cancer metastasis by cell-free miRNAs, Biochimica et Biophysica Acta (BBA)-Reviews on","volume":"1855","author":"Ale\u010dkovi\u0107","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0010","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.gene.2024.149141_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118369","article-title":"Targeted doxorubicin-loaded mesenchymal stem cells-derived exosomes as a versatile platform for fighting against colorectal cancer","volume":"261","author":"Bagheri","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2024.149141_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.568738","article-title":"Exosomal miR-128-3p promotes epithelial-to-mesenchymal transition in colorectal cancer cells by targeting FOXO4 via TGF-\u03b2\/SMAD and JAK\/STAT3 signaling","volume":"9","author":"Bai","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2024.149141_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117305","article-title":"LncRNAs in colorectal cancer: Biomarkers to therapeutic targets","volume":"543","author":"Chen","year":"2023","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.gene.2024.149141_b0030","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24688","article-title":"CircPTPRM accelerates malignancy of papillary thyroid cancer via miR\u2010885\u20105p\/DNMT3A axis","volume":"36","author":"Chen","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.gene.2024.149141_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.582723","article-title":"Exosomal long non-coding RNA HOTTIP increases resistance of colorectal cancer cells to mitomycin via impairing MiR-214-mediated degradation of KPNA3","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2024.149141_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-023-02619-y","article-title":"Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway","volume":"42","author":"Chen","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.gene.2024.149141_b0045","doi-asserted-by":"crossref","first-page":"495","DOI":"10.59249\/TDBJ7410","article-title":"Focus: cell fate: H19: an oncogenic long non-coding RNA in colorectal cancer","volume":"96","author":"Chowdhury","year":"2023","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.gene.2024.149141_b0050","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.3390\/ijms20246249","article-title":"Deciphering miRNAs\u2019 action through miRNA editing","volume":"20","author":"Correia de Sousa","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2024.149141_b0055","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/ijc.32608","article-title":"Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells","volume":"146","author":"Deng","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0060","first-page":"1","article-title":"lncRNA BANCR promotes the colorectal cancer metastasis through accelerating exosomes-mediated M2 macrophage polarization via regulating RhoA\/ROCK signaling","author":"Ding","year":"2023","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.gene.2024.149141_b0065","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3390\/diagnostics12061413","article-title":"Diagnostic potential of exosomal microRNAs in colorectal cancer","volume":"12","author":"Dohmen","year":"2022","journal-title":"Diagnostics"},{"key":"10.1016\/j.gene.2024.149141_b0070","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1002\/jcp.31076","article-title":"Decoding hepatocarcinogenesis from a noncoding RNAs perspective","volume":"238","author":"El-Aziz","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.gene.2024.149141_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-016-0440-5","article-title":"Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C","volume":"16","author":"El-Derany","year":"2016","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.gene.2024.149141_b0080","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12935-022-02736-2","article-title":"Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer","volume":"22","author":"Emam","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.gene.2024.149141_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03545-4","article-title":"Exosomes: cell-created drug delivery systems","volume":"459","author":"Familtseva","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.gene.2024.149141_b0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/bioengineering9030099","article-title":"Exosomes in the pathogenesis, progression, and treatment of osteoarthritis","volume":"9","author":"Fan","year":"2022","journal-title":"Bioengineering"},{"key":"10.1016\/j.gene.2024.149141_b0095","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9916228","article-title":"Exosomal lncRNA PCAT1 promotes tumor circulating cell-mediated colorectal cancer liver metastasis by regulating the activity of the miR-329-3p\/Netrin-1-CD146 complex","author":"Fang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.gene.2024.149141_b0100","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9916228","article-title":"Exosomal lncRNA PCAT1 promotes tumor circulating cell\u2010mediated colorectal cancer liver metastasis by regulating the activity of the miR\u2010329\u20103p\/Netrin\u20101\u2010CD146 Complex","author":"Fang","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.gene.2024.149141_b0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41420-021-00680-0","article-title":"Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305\/TGF-\u03b22\/SMAD3 pathway","volume":"7","author":"Gao","year":"2021","journal-title":"Cell Death Discovery"},{"key":"10.1016\/j.gene.2024.149141_b0110","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fonc.2020.00472","article-title":"The role of exosomal microRNA in cancer drug resistance","volume":"10","author":"Guo","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdiacomp.2007.10.006","article-title":"Influence of vitamin E supplementation on endothelial complications in type 2 diabetes mellitus patients who underwent coronary artery bypass graft","volume":"23","author":"Hamdy","year":"2009","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.gene.2024.149141_b0120","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.2147\/IJN.S386037","article-title":"Insights on the dynamic innovative tumor targeted-nanoparticles-based drug delivery systems activation techniques","volume":"17","author":"Hamdy","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.gene.2024.149141_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-020-01184-8","article-title":"CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17","volume":"19","author":"Han","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0130","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/s41419-021-04430-z","article-title":"Current landscape of tumor-derived exosomal ncRNAs in glioma progression, detection, and drug resistance","volume":"12","author":"He","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2024.149141_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-019-1019-x","article-title":"CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer","volume":"18","author":"Hu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ncrna.2023.09.001","article-title":"Exosomal non-coding RNAs: blueprint in colorectal cancer metastasis and therapeutic targets","author":"Hussen","year":"2023","journal-title":"Non-coding RNA Res."},{"key":"10.1016\/j.gene.2024.149141_b0145","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.cmet.2021.08.006","article-title":"Exosomes as mediators of intercellular crosstalk in metabolism","volume":"33","author":"Isaac","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.gene.2024.149141_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122214","article-title":"MSC-Derived exosomes suppress colorectal cancer cell proliferation and metastasis via miR-100\/mTOR\/miR-143 pathway","volume":"627","author":"Jahangiri","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.gene.2024.149141_b0155","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13581","article-title":"Exosomal circEPB41L2 serves as a sponge for miR\u201021\u20105p and miR\u2010942\u20105p to suppress colorectal cancer progression by regulating the PTEN\/AKT signalling pathway","volume":"51","author":"Jiang","year":"2021","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.gene.2024.149141_b0160","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1016\/S0021-9258(18)48095-7","article-title":"Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)","volume":"262","author":"Johnstone","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2024.149141_b0165","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","author":"Kalluri","year":"2020","journal-title":"Science 367"},{"key":"10.1016\/j.gene.2024.149141_b0170","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.omto.2018.12.011","article-title":"A systematic review of miR-29 in cancer","volume":"12","author":"Kwon","year":"2019","journal-title":"Molecular Therapy-Oncolytics"},{"key":"10.1016\/j.gene.2024.149141_b0175","article-title":"Exosomal lncRNA PVT1\/VEGFA axis promotes colon cancer metastasis and stemness by downregulation of tumor suppressor miR-152-3p","author":"Lai","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.gene.2024.149141_b0180","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1002\/ijc.31931","article-title":"Circulating exosomal noncoding RNAs as prognostic biomarkers in human hepatocellular carcinoma","volume":"144","author":"Lee","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0185","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41420-022-01124-z","article-title":"Exosomal circPABPC1 promotes colorectal cancer liver metastases by regulating HMGA2 in the nucleus and BMP4\/ADAM19 in the cytoplasm","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discovery"},{"key":"10.1016\/j.gene.2024.149141_b0190","article-title":"Exosome-derived Circ_0094343 promotes chemosensitivity of colorectal cancer cells by regulating glycolysis via the miR-766-5p\/TRIM67 Axis","author":"Li","year":"2022","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.gene.2024.149141_b0195","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1007\/s10620-020-06458-1","article-title":"Mesenchymal stem cell-derived exosomal microRNA-3940-5p inhibits colorectal cancer metastasis by targeting integrin \u03b16","volume":"66","author":"Li","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.gene.2024.149141_b0200","article-title":"A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.gene.2024.149141_b0205","doi-asserted-by":"crossref","first-page":"22513","DOI":"10.18632\/oncotarget.4154","article-title":"The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer","volume":"6","author":"Liang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2024.149141_b0210","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41419-019-2077-0","article-title":"LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization","volume":"10","author":"Liang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2024.149141_b0215","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/cas.13833","article-title":"Nuclear factor I\/B promotes colorectal cancer cell proliferation, epithelial\u2010mesenchymal transition and 5\u2010fluorouracil resistance","volume":"110","author":"Liu","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.gene.2024.149141_b0220","doi-asserted-by":"crossref","DOI":"10.1093\/carcin\/bgad013","article-title":"Exosome-transmitted miR-29a induces colorectal cancer metastasis by destroying the vascular endothelial barrier","author":"Liu","year":"2023","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.gene.2024.149141_b0225","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/CS20191087","article-title":"Colorectal cancer-derived exosomal miR-106b-3p promotes metastasis by down-regulating DLC-1 expression","volume":"134","author":"Liu","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.gene.2024.149141_b0230","doi-asserted-by":"crossref","first-page":"13048","DOI":"10.18632\/oncotarget.14369","article-title":"Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2024.149141_b0235","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.omtn.2019.12.009","article-title":"Circulating lncRNA UCA1 promotes malignancy of colorectal cancer via the miR-143\/MYO6 axis","volume":"19","author":"Luan","year":"2020","journal-title":"Molecular Therapy-Nucleic Acids"},{"key":"10.1016\/j.gene.2024.149141_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.749753","article-title":"Competitive endogenous role of the LINC00511\/miR-185-3p axis and miR-301a-3p from liquid biopsy as molecular markers for breast cancer diagnosis","volume":"11","author":"Mahmoud","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175722","article-title":"Exosomal circCOL1A2 from cancer cells accelerates colorectal cancer progression via regulating miR-665\/LASP1 signal axis","author":"Miao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.gene.2024.149141_b0250","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.ymthe.2021.04.028","article-title":"Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer","volume":"29","author":"Ning","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2024.149141_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijo.2022.5304","article-title":"N6\u2011methyladenosine upregulates miR\u2011181d\u20115p in exosomes derived from cancer\u2011associated fibroblasts to inhibit 5\u2011FU sensitivity by targeting NCALD in colorectal cancer","volume":"60","author":"Pan","year":"2022","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0260","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.gene.2024.149141_b0265","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202204513","article-title":"A novel protein encoded by exosomal CircATG4B induces oxaliplatin resistance in colorectal cancer by promoting autophagy","volume":"9","author":"Pan","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.gene.2024.149141_b0270","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.2147\/IJGM.S353380","article-title":"Comprehensive analysis of prognostic value and immune infiltration of NLRC4 and CASP1 in colorectal cancer","author":"Peng","year":"2022","journal-title":"International Journal of General Medicine"},{"key":"10.1016\/j.gene.2024.149141_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113266","article-title":"CAFs-secreted exosomal cricN4BP2L2 promoted colorectal cancer stemness and chemoresistance by interacting with EIF4A3","volume":"418","author":"Qu","year":"2022","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.gene.2024.149141_b0280","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.3390\/molecules27217289","article-title":"Exosomes as new generation vehicles for drug delivery: biomedical applications and future perspectives","volume":"27","author":"Rajput","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.gene.2024.149141_b0285","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.7150\/thno.25541","article-title":"Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19","volume":"8","author":"Ren","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.gene.2024.149141_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119035","article-title":"Exosome-mediated delivery of functionally active miRNA-375-3p mimic regulate epithelial mesenchymal transition (EMT) of colon cancer cells","volume":"269","author":"Rezaei","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2024.149141_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122850","article-title":"Revealing the role of serum exosomal novel long non-coding RNA NAMPT-AS as a promising diagnostic\/prognostic biomarker in colorectal cancer patients","volume":"352","author":"Rizk","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2024.149141_b0300","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.molonc.2016.10.003","article-title":"Exosomal proteins as prognostic biomarkers in non-small cell lung cancer","volume":"10","author":"Sandfeld-Paulsen","year":"2016","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-12-505","article-title":"Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer","volume":"12","author":"Schee","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-020-01235-0","article-title":"Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p\/miR-506-3p-TGF-\u03b21 axis","volume":"19","author":"Shang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0315","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/jcm5040042","article-title":"Considering exosomal miR-21 as a biomarker for cancer","volume":"5","author":"Shi","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.gene.2024.149141_b0320","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4149\/neo_2020_200924N1018","article-title":"miR-1246 shuttling from fibroblasts promotes colorectal cancer cell migration","volume":"68","author":"Si","year":"2020","journal-title":"Neoplasma"},{"key":"10.1016\/j.gene.2024.149141_b0325","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2024.149141_b0330","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.omtn.2021.02.022","article-title":"Exosome-transmitted miRNA-335-5p promotes colorectal cancer invasion and metastasis by facilitating EMT via targeting RASA1","volume":"24","author":"Sun","year":"2021","journal-title":"Molecular Therapy-Nucleic Acids"},{"key":"10.1016\/j.gene.2024.149141_b0335","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1038\/s41598-020-65207-6","article-title":"Exosomal miR-21 promotes proliferation, invasion and therapy resistance of colon adenocarcinoma cells through its target PDCD4","volume":"10","author":"Sun","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2024.149141_b0340","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10571-019-00771-8","article-title":"Glioblastoma stem cell-derived exosomes enhance stemness and tumorigenicity of glioma cells by transferring Notch1 protein","volume":"40","author":"Sun","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.gene.2024.149141_b0345","doi-asserted-by":"crossref","first-page":"78598","DOI":"10.18632\/oncotarget.20009","article-title":"Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer","volume":"8","author":"Takano","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2024.149141_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147413","article-title":"Tumor cells-derived exosomal circVCP promoted the progression of colorectal cancer by regulating macrophage M1\/M2 polarization","author":"Tang","year":"2023","journal-title":"Gene"},{"key":"10.1016\/j.gene.2024.149141_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147413","article-title":"Tumor cells-derived exosomal circVCP promoted the progression of colorectal cancer by regulating macrophage M1\/M2 polarization","volume":"870","author":"Tang","year":"2023","journal-title":"Gene"},{"key":"10.1016\/j.gene.2024.149141_b0360","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1111\/cas.15028","article-title":"Exosome\u2010delivered miR\u2010221\/222 exacerbates tumor liver metastasis by targeting SPINT1 in colorectal cancer","volume":"112","author":"Tian","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.gene.2024.149141_b0365","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000463387","article-title":"Circulating exosomal microRNA-21 as a biomarker in each tumor stage of colorectal cancer","volume":"92","author":"Tsukamoto","year":"2017","journal-title":"Oncology"},{"key":"10.1016\/j.gene.2024.149141_b0370","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.12998\/wjcc.v9.i18.4467","article-title":"Roles of exosomes in diagnosis and treatment of colorectal cancer","volume":"9","author":"Umwali","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.gene.2024.149141_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101730","article-title":"Unlocking the potential of non-coding RNAs in cancer research and therapy","volume":"35","author":"Uppaluri","year":"2023","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0380","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.3748\/wjg.v24.i34.3834","article-title":"Drug resistance and new therapies in colorectal cancer","volume":"24","author":"Van der Jeught","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.gene.2024.149141_b0385","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/s41419-018-1187-4","article-title":"Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2024.149141_b0390","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1111\/jcmm.15274","article-title":"Lung CSC\u2010derived exosomal miR\u2010210\u20103p contributes to a pro\u2010metastatic phenotype in lung cancer by targeting FGFRL1","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.gene.2024.149141_b0395","article-title":"Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma","author":"Wang","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.gene.2024.149141_b0400","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41419-022-04825-6","article-title":"Exosomal miR-146a-5p and miR-155-5p promote CXCL12\/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2024.149141_b0405","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/1878-0261.12629","article-title":"Exosome\u2010delivered circRNA promotes glycolysis to induce chemoresistance through the miR\u2010122\u2010PKM2 axis in colorectal cancer","volume":"14","author":"Wang","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0410","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2022.897583","article-title":"Expression of miR-4739 in gastric cancer and its relationship with clinical pathological features of patients","volume":"9","author":"Wei","year":"2022","journal-title":"Front. Surg."},{"key":"10.1016\/j.gene.2024.149141_b0415","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00280-021-04348-5","article-title":"EVs delivery of miR-1915-3p improves the chemotherapeutic efficacy of oxaliplatin in colorectal cancer","volume":"88","author":"Xiao","year":"2021","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.gene.2024.149141_b0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-020-01562-6","article-title":"Exosomal MALAT1 sponges miR-26a\/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K\/Akt pathway","volume":"39","author":"Xu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.gene.2024.149141_b0425","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s12094-019-02237-1","article-title":"Novel exosomal miR-46146 transfer oxaliplatin chemoresistance in colorectal cancer","volume":"22","author":"Xu","year":"2020","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0430","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4149\/neo_2020_200417N414","article-title":"Exosomal transfer of circular RNA FBXW7 ameliorates the chemoresistance to oxaliplatin in colorectal cancer by sponging miR-18b-5p","volume":"68","author":"Xu","year":"2020","journal-title":"Neoplasma"},{"key":"10.1016\/j.gene.2024.149141_b0435","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.ymthe.2021.02.006","article-title":"Tumor-derived exosomal microRNA-106b-5p activates EMT-cancer cell and M2-subtype TAM interaction to facilitate CRC metastasis","volume":"29","author":"Yang","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.gene.2024.149141_b0440","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-018-0660-6","article-title":"Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer","volume":"18","author":"Yang","year":"2018","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.gene.2024.149141_b0445","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.738945","article-title":"Tumor-derived exosomal non-coding RNAs: the emerging mechanisms and potential clinical applications in breast cancer","volume":"11","author":"Yi","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0450","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00109-018-1716-8","article-title":"Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer","volume":"97","author":"Yuan","year":"2019","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.gene.2024.149141_b0455","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fphar.2013.00028","article-title":"Mechanisms and insights into drug resistance in cancer","volume":"4","author":"Zahreddine","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.gene.2024.149141_b0460","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1002\/1878-0261.12796","article-title":"CircFNDC3B sequestrates miR\u2010937\u20105p to derepress TIMP3 and inhibit colorectal cancer progression","volume":"14","author":"Zeng","year":"2020","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0465","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1111\/jcmm.15765","article-title":"Cancer\u2010associated fibroblast\u2010derived exosomal microRNA\u201024\u20103p enhances colon cancer cell resistance to MTX by down\u2010regulating CDX2\/HEPH axis","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.gene.2024.149141_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106534","article-title":"Exosomal miR-625-3p secreted by cancer-associated fibroblasts in colorectal cancer promotes EMT and chemotherapeutic resistance by blocking the CELF2\/WWOX pathway","volume":"186","author":"Zhang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.gene.2024.149141_b0475","first-page":"1","article-title":"Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205\/CCND2 axis","author":"Zhang","year":"2022","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.gene.2024.149141_b0480","doi-asserted-by":"crossref","first-page":"e00517","DOI":"10.1128\/MCB.00517-20","article-title":"Exosome-mediated transfer of circ_0000338 enhances 5-fluorouracil resistance in colorectal cancer through regulating microRNA 217 (miR-217) and miR-485-3p","volume":"41","author":"Zhao","year":"2021","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.gene.2024.149141_b0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102315","article-title":"Fecal microbiota transplantation plus tislelizumab and fruquintinib in refractory microsatellite stable metastatic colorectal cancer: an open-label, single-arm, phase II trial (RENMIN-215)","volume":"66","author":"Zhao","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.gene.2024.149141_b0490","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-020-00991-2","article-title":"Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer","volume":"13","author":"Zhao","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.gene.2024.149141_b0495","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-018-0817-x","article-title":"Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.gene.2024.149141_b0500","first-page":"3174","article-title":"High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer","volume":"7","author":"Zheng","year":"2014","journal-title":"Int. J. Clin. Exp. Path."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924010229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924010229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T13:29:15Z","timestamp":1739194155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924010229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":100,"alternative-id":["S0378111924010229"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149141","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The significance of exosomal non-coding RNAs (ncRNAs) in the metastasis of colorectal cancer and development of therapy resistance","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149141"}}