{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:48Z","timestamp":1791495168539,"version":"4.3.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.gene.2024.149156","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T16:17:51Z","timestamp":1733588271000},"page":"149156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Autocrine small extracellular vesicles induce tubular phenotypic transformation in diabetic nephropathy via miR-21-5p"],"prefix":"10.1016","volume":"938","author":[{"given":"Mengting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.gene.2024.149156_b0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00467-017-3816-z","article-title":"Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases","volume":"34","author":"Al","year":"2019","journal-title":"Pediatr. Nephrol."},{"issue":"2","key":"10.1016\/j.gene.2024.149156_b0010","first-page":"429","article-title":"Inhibition of miR\u2011155\u20115p attenuates the valvular damage induced by rheumatic heart disease","volume":"45","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.gene.2024.149156_b0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.apsb.2016.02.001","article-title":"Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges","volume":"6","author":"Ha","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.gene.2024.149156_b0020","article-title":"Advances in Biological Function and Clinical Application of Small Extracellular Vesicle Membrane Proteins","volume":"11","author":"Huang","year":"2021","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.gene.2024.149156_b0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1210\/en.2018-01010","article-title":"Shedding Perspective on Extracellular Vesicle Biology in Diabetes and Associated Metabolic Syndromes","volume":"160","author":"Javeed","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2024.149156_b0030","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.2147\/OTT.S163771","article-title":"MicroRNA-21-5p promotes proliferation of gastric cancer cells through targeting SMAD7","volume":"11","author":"Jiang","year":"2018","journal-title":"Onco Targets Ther."},{"issue":"2","key":"10.1016\/j.gene.2024.149156_b0035","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000514550","article-title":"Global Epidemiology of End-Stage Kidney Disease and Disparities in Kidney Replacement Therapy","volume":"52","author":"Js","year":"2021","journal-title":"Am. J. Nephrol."},{"issue":"2","key":"10.1016\/j.gene.2024.149156_b0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.imlet.2006.09.005","article-title":"Exosomes: from biogenesis and secretion to biological function","volume":"107","author":"Keller","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.gene.2024.149156_b0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-9-9","article-title":"Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages","volume":"9","author":"L\u00e4sser","year":"2011","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.gene.2024.149156_b0050","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/ckj\/sfac218","article-title":"Temporal trends in prevalence and mortality for chronic kidney disease in China from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019","volume":"16","author":"Li","year":"2023","journal-title":"Clin. Kidney J."},{"issue":"1652","key":"10.1016\/j.gene.2024.149156_b0055","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0502","article-title":"Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers","volume":"369","author":"Li","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"9","key":"10.1016\/j.gene.2024.149156_b0060","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.apsb.2021.01.001","article-title":"The biology, function, and applications of exosomes in cancer","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"8","key":"10.1016\/j.gene.2024.149156_b0065","doi-asserted-by":"crossref","first-page":"R435","DOI":"10.1016\/j.cub.2018.01.059","article-title":"Exosomes and Ectosomes in Intercellular Communication","volume":"28","author":"Meldolesi","year":"2018","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.gene.2024.149156_b0070","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2337\/db20-0199","article-title":"CD31(+) Extracellular Vesicles From Patients With Type 2 Diabetes Shuttle a miRNA Signature Associated With Cardiovascular Complications","volume":"70","author":"Prattichizzo","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2024.149156_b0075","doi-asserted-by":"crossref","unstructured":"Ho Ptb, Clark Im, Ltt. L. MicroRNA-Based Diagnosis and Therapy. Int J Mol Sci. 2022;23(13):7167.","DOI":"10.3390\/ijms23137167"},{"key":"10.1016\/j.gene.2024.149156_b0080","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-3-031-08356-3_3","article-title":"Regulation of Immune Cells by microRNAs and microRNA-Based Cancer Immunotherapy","volume":"1385","author":"Rn","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.gene.2024.149156_b0085","article-title":"Crosstalk between tubular epithelial cells and glomerular endothelial cells in diabetic kidney disease","volume":"53","author":"Sj","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.gene.2024.149156_b0090","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.2147\/DMSO.S336791","article-title":"The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus","volume":"14","author":"Ss","year":"2021","journal-title":"Diabetes Metab Syndr Obes."},{"key":"10.1016\/j.gene.2024.149156_b0095","doi-asserted-by":"crossref","unstructured":"Th\u00e9ry C, Witwer Kw, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750.","DOI":"10.1080\/20013078.2018.1461450"},{"issue":"2","key":"10.1016\/j.gene.2024.149156_b0100","doi-asserted-by":"crossref","first-page":"178","DOI":"10.7150\/ijbs.24074","article-title":"MicroRNA-21-5p mediates TGF-\u03b2-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury","volume":"14","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.gene.2024.149156_b0105","first-page":"1897","article-title":"MicroRNA\u201121\u20115p promotes epithelial to mesenchymal transition by targeting SRY\u2011box 17 in endometrial cancer","volume":"43","author":"Wang","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.gene.2024.149156_b0110","doi-asserted-by":"crossref","unstructured":"Xiong M, Wang P, Pan B, et al. The diagnostic and prognostic values of microRNA-196a in cancer. Biosci Rep. 2021;41(1):BSR20203559.","DOI":"10.1042\/BSR20203559"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924010370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924010370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T17:37:00Z","timestamp":1735234620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924010370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":22,"alternative-id":["S0378111924010370"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149156","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autocrine small extracellular vesicles induce tubular phenotypic transformation in diabetic nephropathy via miR-21-5p","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149156"}}