{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:10:51Z","timestamp":1788221451180,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.gene.2024.149181","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T08:11:13Z","timestamp":1734595873000},"page":"149181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Genes encoding antibiotic modifying enzymes conferring resistance against aminoglycosides in bacteria: Their identification and detection from wastewater"],"prefix":"10.1016","volume":"939","author":[{"given":"Abhinandan","family":"Patnaik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad","family":"Kumar Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Kumar Dhaked","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.149181_b0005","unstructured":"Adedeji, W.A., 2016. The treasure called antibiotics. Annals of Ibadan postgraduate medicine. 14(2):56.PMID: 28337088; PMCID: PMC5354621."},{"issue":"2","key":"10.1016\/j.gene.2024.149181_b0010","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/1084822316659285","article-title":"Superbugs: antibiotic resistance is becoming a major public health concern","volume":"29","author":"Alpert","year":"2017","journal-title":"Home Health Care Manag. Pract."},{"issue":"2","key":"10.1016\/j.gene.2024.149181_b0015","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/sj.jim.7000260","article-title":"The detection of diverse aminoglycoside phosphotransferases within natural populations of actinomycetes","volume":"29","author":"Anderson","year":"2002","journal-title":"J. Ind. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.gene.2024.149181_b0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1128\/MMBR.00023-12","article-title":"Enterococci in the environment","volume":"76","author":"Byappanahalli","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"106","key":"10.1016\/j.gene.2024.149181_b0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biortech.2011.11.093","article-title":"Reactor performance and bacterial pathogen removal in response to sludge retention time in a mesophilic anaerobic digester treating sewage sludge","volume":"1","author":"Chen","year":"2012","journal-title":"Bioresour. Technol."},{"issue":"216","key":"10.1016\/j.gene.2024.149181_b0030","article-title":"Distinct effects of typical sludge pretreatment approaches on the antibiotic resistance genes variations, associated bacterial community dynamics and metabolic activities during anaerobic fermentation process","volume":"1","author":"Cheng","year":"2023","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.gene.2024.149181_b0035","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/w9060409","article-title":"Characteristics and biodegradability of wastewater organic matter in municipal wastewater treatment plants collecting domestic wastewater and industrial discharge","volume":"9","author":"Choi","year":"2017","journal-title":"Water."},{"issue":"2","key":"10.1016\/j.gene.2024.149181_b0040","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1086\/313949","article-title":"Aminoglycoside resistance in enterococci","volume":"31","author":"Chow","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.gene.2024.149181_b0045","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00239-019-09914-3","article-title":"Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence","volume":"88","author":"Christaki","year":"2020","journal-title":"J. Mol. Evol."},{"issue":"8","key":"10.1016\/j.gene.2024.149181_b0050","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1073\/pnas.69.8.2110","article-title":"Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA","volume":"69","author":"Cohen","year":"1972","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7365","key":"10.1016\/j.gene.2024.149181_b0055","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10388","article-title":"Antibiotic resistance is ancient","volume":"477","author":"D\u2019Costa","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.gene.2024.149181_b0060","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.exppara.2013.03.003","article-title":"Optimization of single-tube nested PCR for the diagnosis of visceral leishmaniasis","volume":"134","author":"da Silva","year":"2013","journal-title":"Exp. Parasitol."},{"issue":"17","key":"10.1016\/j.gene.2024.149181_b0065","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1073\/pnas.1402789111","article-title":"Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA","volume":"111","author":"Dunkle","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"307","key":"10.1016\/j.gene.2024.149181_b0070","article-title":"A review of emerging organic contaminants (EOCs), antibiotic resistant bacteria (ARB), and antibiotic resistance genes (ARGs) in the environment: Increasing removal with wetlands and reducing environmental impacts","volume":"1","author":"Garc\u00eda","year":"2020","journal-title":"Bioresour. Technol."},{"issue":"212","key":"10.1016\/j.gene.2024.149181_b0075","article-title":"A systematic review of enteric pathogens and antibiotic resistance genes in outdoor urban aerosols","volume":"1","author":"Ginn","year":"2022","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.gene.2024.149181_b0080","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3390\/antibiotics11040466","article-title":"A new variant of the aadE-sat4-aphA-3 gene cluster found in a conjugative plasmid from a MDR Campylobacter jejuni isolate","volume":"11","author":"Guirado","year":"2022","journal-title":"Antibiotics"},{"issue":"123","key":"10.1016\/j.gene.2024.149181_b0085","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.watres.2017.07.002","article-title":"Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements","volume":"15","author":"Guo","year":"2017","journal-title":"Water Res."},{"issue":"9","key":"10.1016\/j.gene.2024.149181_b0090","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/j.envpol.2010.05.023","article-title":"Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China","volume":"158","author":"Hu","year":"2010","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.gene.2024.149181_b0095","first-page":"223","article-title":"High-level aminoglycoside resistance in Enterococcus faecalis and Enterococcus faecium; as a serious threat in hospitals","volume":"20","author":"Khodabandeh","year":"2020","journal-title":"Infectious Disorders-Drug Targets (formerly Current Drug Targets-Infectious Disorders)"},{"issue":"4","key":"10.1016\/j.gene.2024.149181_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2021.106324","article-title":"Increased antimicrobial resistance during the COVID-19 pandemic","volume":"57","author":"Lai","year":"2021","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"17","key":"10.1016\/j.gene.2024.149181_b0105","doi-asserted-by":"crossref","first-page":"10492","DOI":"10.1021\/acs.est.5b02345","article-title":"Profile and fate of bacterial pathogens in sewage treatment plants revealed by high-throughput metagenomic approach","volume":"49","author":"Li","year":"2015","journal-title":"Environ. Sci. Tech."},{"issue":"838","key":"10.1016\/j.gene.2024.149181_b0110","article-title":"Antibiotic resistant bacteria and genes in wastewater treatment plants: From occurrence to treatment strategies","volume":"10","author":"Li","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"7","key":"10.1016\/j.gene.2024.149181_b0115","first-page":"263","article-title":"Survival of antibiotic resistant bacteria and horizontal gene transfer control antibiotic resistance gene content in anaerobic digesters","volume":"8","author":"Miller","year":"2016","journal-title":"Front. Microbiol."},{"issue":"215","key":"10.1016\/j.gene.2024.149181_b0120","article-title":"Antibiotic resistant genes in the environment-exploring surveillance methods and sustainable remediation strategies of antibiotics and ARGs","volume":"1","author":"Nava","year":"2022","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.gene.2024.149181_b0125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/w11010071","article-title":"Monitoring antimicrobial resistance dissemination in aquatic systems","volume":"11","author":"Ng","year":"2019","journal-title":"Water."},{"key":"10.1016\/j.gene.2024.149181_b0130","doi-asserted-by":"crossref","unstructured":"Perry J, Waglechner N, Wright G. The prehistory of antibiotic resistance. Cold Spring Harbor perspectives in medicine. 2016 Jun;6(6). 10.1101%2Fcshperspect.a025197.","DOI":"10.1101\/cshperspect.a025197"},{"issue":"530","key":"10.1016\/j.gene.2024.149181_b0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.scitotenv.2015.05.091","article-title":"Diversity of enterococcal species and characterization of high-level aminoglycoside resistant enterococci of samples of wastewater and surface water in Tunisia","volume":"15","author":"Said","year":"2015","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.gene.2024.149181_b0140","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3390\/pathogens12091164","article-title":"One Health Spread of 16S Ribosomal RNA Methyltransferase-Harboring Gram-Negative Bacterial Genomes: An Overview of the Americas","volume":"12","author":"Sellera","year":"2023","journal-title":"Pathogens."},{"key":"10.1016\/j.gene.2024.149181_b0145","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-3-319-46718-4_14","article-title":"Aminoglycosides: Mechanisms of action and resistance","volume":"1","author":"Serio","year":"2017","journal-title":"Antimicrobial Drug Resistance: Mechanisms of Drug Resistance"},{"issue":"8","key":"10.1016\/j.gene.2024.149181_b0150","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1080\/07388551.2018.1471038","article-title":"Research progress on distribution, migration, transformation of antibiotics and antibiotic resistance genes (ARGs) in aquatic environment","volume":"38","author":"Shao","year":"2018","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.gene.2024.149181_b0155","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-57488-8_9","article-title":"Water resources of madhya pradesh: contemporary issues and challenges","volume":"109\u201325","author":"Sharma","year":"2021","journal-title":"Water Science and Sustainability."},{"key":"10.1016\/j.gene.2024.149181_b0160","doi-asserted-by":"crossref","unstructured":"Tietze E, Brevet J. Nucleotide sequence of the bacterial streptothricin resistance gene sat3. Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression. 1995 Aug 22;1263(2):176-8. 10.1016\/0167-4781(95)00103-N.","DOI":"10.1016\/0167-4781(95)00103-N"},{"issue":"3","key":"10.1016\/j.gene.2024.149181_b0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.drup.2012.05.001","article-title":"Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update","volume":"15","author":"Wachino","year":"2012","journal-title":"Drug Resist. Updat."},{"issue":"12","key":"10.1016\/j.gene.2024.149181_b0170","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1128\/AAC.00926-07","article-title":"Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides","volume":"51","author":"Wachino","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"issue":"796","key":"10.1016\/j.gene.2024.149181_b0175","article-title":"Occurrence of antibiotics and antibiotic resistance genes in WWTP effluent-receiving water bodies and reclaimed wastewater treatment plants","volume":"20","author":"Wang","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.gene.2024.149181_b0180","doi-asserted-by":"crossref","first-page":"D9","DOI":"10.2741\/A408","article-title":"Aminoglycoside phosphotransferases: proteins, structure, and mechanism","volume":"1","author":"Wright","year":"1999","journal-title":"Front Biosci."},{"key":"10.1016\/j.gene.2024.149181_b0185","article-title":"Effect of antibiotics, antibiotic-resistant bacteria, and extracellular antibiotic resistance genes on the fate of ARGs in marine sediments","volume":"27","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192401062X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192401062X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T02:19:15Z","timestamp":1736216355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811192401062X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":37,"alternative-id":["S037811192401062X"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149181","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genes encoding antibiotic modifying enzymes conferring resistance against aminoglycosides in bacteria: Their identification and detection from wastewater","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149181"}}