{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:59:28Z","timestamp":1792159168281,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.gene.2024.149210","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T17:15:23Z","timestamp":1735838123000},"page":"149210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Bisphenol A alters JUN promoter methylation, impairing steroid metabolism in placental cells and linking to sub-representative phenotypes"],"prefix":"10.1016","volume":"941","author":[{"given":"Sufen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-1820","authenticated-orcid":false,"given":"Wanhong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-7966","authenticated-orcid":false,"given":"Daru","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2024.149210_b0005","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/biolre\/ioac001","article-title":"The impact of bisphenol A on the placenta","volume":"106","author":"Adu-Gyamfi","year":"2022","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.gene.2024.149210_b0010","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.gene.2024.149210_b0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.reprotox.2010.04.004","article-title":"Bisphenol A exposure leads to specific microRNA alterations in placental cells","volume":"29","author":"Avissar-Whiting","year":"2010","journal-title":"Reprod. Toxicol."},{"issue":"10","key":"10.1016\/j.gene.2024.149210_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046078","article-title":"3D Models of MBP, a Biologically Active Metabolite of Bisphenol A, in Human Estrogen Receptor \u03b1 and Estrogen Receptor \u03b2","volume":"7","author":"Baker","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.gene.2024.149210_b0025","doi-asserted-by":"crossref","first-page":"393.e1-7","DOI":"10.1016\/j.ajog.2010.01.025","article-title":"Transfer of bisphenol A across the human placenta","volume":"202","author":"Balakrishnan","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.gene.2024.149210_b0030","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.reprotox.2018.10.009","article-title":"Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells","volume":"82","author":"Basak","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.gene.2024.149210_b0035","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1210\/jc.2007-1394","article-title":"The mechanism for protein kinase C inhibition of androgen production and 17\u03b1-hydroxylase expression in a theca cell tumor model","volume":"92","author":"Beshay","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.gene.2024.149210_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132244","article-title":"Maternal exposure to bisphenol A induces fetal growth restriction via upregulating the expression of estrogen receptors","volume":"287","author":"Cao","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.gene.2024.149210_b0045","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3389\/fphar.2018.01027","article-title":"Physiology and Pathophysiology of Steroid Biosynthesis, Transport and Metabolism in the Human Placenta","volume":"9","author":"Chatuphonprasert","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.gene.2024.149210_b0050","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity\u2014A review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.gene.2024.149210_b0055","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/biolre\/iox162","article-title":"Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells","volume":"98","author":"Chu","year":"2018","journal-title":"Biol. Reprod."},{"issue":"405","key":"10.1016\/j.gene.2024.149210_b0060","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3390\/jcm9020405","article-title":"Involvement of the endocrine-disrupting chemical bisphenol A (BPA) in human placentation","volume":"9","author":"de Aguiar Greca","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.gene.2024.149210_b0065","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12920-015-0131-z","article-title":"Genome-wide microRNA expression profiling in placentas from pregnant women exposed to BPA","volume":"8","author":"De Felice","year":"2015","journal-title":"BMC Genom."},{"key":"10.1016\/j.gene.2024.149210_b0070","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nprot.2010.190","article-title":"Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling","volume":"6","author":"Gu","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2024.149210_b0075","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.cdd.4401946","article-title":"c-Jun promotes cellular survival by suppression of PTEN","volume":"14","author":"Hettinger","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2024.149210_b0080","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jsbmb.2010.05.007","article-title":"Steroid metabolome in fetal and maternal body fluids in human late pregnancy","volume":"122","author":"Hill","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2024.149210_b0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.toxlet.2009.06.853","article-title":"Bisphenol A downregulates CYP19 transcription in JEG-3 cells","volume":"189","author":"Huang","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.gene.2024.149210_b0090","article-title":"Bisphenol A exposure disrupts genomic imprinting in the mouse","volume":"9","author":"Kelsey","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.gene.2024.149210_b0095","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envres.2018.01.031","article-title":"Exposure to bisphenols and parabens during pregnancy and relations to steroid changes","volume":"163","author":"Kolatorova","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.gene.2024.149210_b0100","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.bbi.2011.02.005","article-title":"Epigenetic perspective on the developmental effects of bisphenol A. Brain","volume":"25","author":"Kundakovic","year":"2011","journal-title":"Behav Immun."},{"key":"10.1016\/j.gene.2024.149210_b0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/toxsci\/kfv162","article-title":"Low-dose bisphenol A activates Cyp11a1 gene expression and corticosterone secretion in adrenal gland via the JNK signaling pathway","volume":"148","author":"Lan","year":"2015","journal-title":"Toxicol Sci."},{"key":"10.1016\/j.gene.2024.149210_b0110","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chemosphere.2017.07.004","article-title":"Bisphenol A disrupts steroidogenesis and induces a sex hormone imbalance through c-Jun phosphorylation in Leydig cells","volume":"185","author":"Lan","year":"2017","journal-title":"Chemosphere."},{"key":"10.1016\/j.gene.2024.149210_b0115","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.scitotenv.2017.10.042","article-title":"Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs","volume":"626","author":"Lee","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.gene.2024.149210_b0120","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/humrep\/dev327","article-title":"Associations between maternal phenolic exposure and cord sex hormones in male newborns","volume":"31","author":"Liu","year":"2016","journal-title":"Hum Reprod."},{"key":"10.1016\/j.gene.2024.149210_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2021.101662","article-title":"Impact of bisphenol A (BPA) on cells and tissues at the human materno-fetal interface","volume":"73","author":"Manzan-Martins","year":"2021","journal-title":"Tissue. Cell"},{"key":"10.1016\/j.gene.2024.149210_b0130","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.placenta.2010.08.001","article-title":"Activating protein-1 family of transcription factors in the human placenta complicated by preeclampsia with and without fetal growth restriction","volume":"31","author":"Marzioni","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.gene.2024.149210_b0135","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.reprotox.2011.03.002","article-title":"In utero exposure to bisphenol-A and its effect on birth weight of offspring","volume":"32","author":"Miao","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.gene.2024.149210_b0140","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.reprotox.2010.02.007","article-title":"Placental transport and in vitro effects of Bisphenol A","volume":"30","author":"Morck","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.gene.2024.149210_b0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.reprotox.2011.05.003","article-title":"Antiproliferative and proapoptotic effects of bisphenol A on human trophoblastic JEG-3 cells","volume":"32","author":"Morice","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.gene.2024.149210_b0150","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1210\/en.2013-1370","article-title":"Bisphenol a: a model endocrine disrupting chemical with a new potential mechanism of action","volume":"154","author":"Nagel","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2024.149210_b0155","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.toxlet.2010.02.002","article-title":"Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol","volume":"194","author":"Nakamura","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.gene.2024.149210_b0160","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.yhbeh.2017.12.001","article-title":"Opening the black box of endocrine disruption of brain development: Lessons from the characterization of Bisphenol A","volume":"101","author":"Nesan","year":"2018","journal-title":"Horm. Behav."},{"key":"10.1016\/j.gene.2024.149210_b0165","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1080\/14767058.2017.1368076","article-title":"Bisphenol A and adverse pregnancy outcomes: a systematic review of the literature","volume":"31","author":"Pergialiotis","year":"2017","journal-title":"J. Matern.-Fetal Neonatal Med."},{"issue":"31","key":"10.1016\/j.gene.2024.149210_b0170","doi-asserted-by":"crossref","first-page":"18301","DOI":"10.1074\/jbc.270.31.18301","article-title":"Epidermal growth factor and c-Jun Act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage (CYP11A1) promoter","volume":"270","author":"Pestell","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2024.149210_b0175","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/biolre\/ioab139","article-title":"Comparing effects and action mechanisms of BPA and BPS on HTR-8\/SVneo placental cellsdagger","volume":"105","author":"Profita","year":"2021","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.gene.2024.149210_b0180","doi-asserted-by":"crossref","first-page":"21205","DOI":"10.1007\/s11356-018-2299-1","article-title":"Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats","volume":"25","author":"Saadeldin","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.gene.2024.149210_b0185","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jsbmb.2009.05.009","article-title":"Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line","volume":"116","author":"Samson","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.gene.2024.149210_b0190","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mce.2010.12.017","article-title":"Regulation of steroid production: analysis of Cyp11a1 promoter","volume":"336","author":"Shih","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.gene.2024.149210_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125301","article-title":"Developmental programming: Prenatal bisphenol A treatment disrupts mediators of placental function in sheep","volume":"243","author":"Song","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.gene.2024.149210_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111389","article-title":"Differential methylation of genes in the human placenta associated with bisphenol A exposure","volume":"200","author":"Song","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.gene.2024.149210_b0205","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.envint.2018.08.055","article-title":"Maternal exposure to bisphenol A and anogenital distance throughout infancy: A longitudinal study from Shanghai","volume":"121","author":"Sun","year":"2018","journal-title":"China. Environ. Int."},{"key":"10.1016\/j.gene.2024.149210_b0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/jat.3480","article-title":"Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies","volume":"38","author":"Tomza-Marciniak","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.gene.2024.149210_b0215","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/molehr\/gau036","article-title":"Dehydroascorbic acid taken up by glucose transporters stimulates estradiol production through inhibition of JNK\/c-Jun\/AP1 signaling in JAR cells","volume":"20","author":"Wang","year":"2014","journal-title":"Mol. Human Reprod."},{"key":"10.1016\/j.gene.2024.149210_b0220","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1210\/en.2005-1159","article-title":"Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure","volume":"147","author":"Welshons","year":"2006","journal-title":"Endocrinology."},{"key":"10.1016\/j.gene.2024.149210_b0225","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1210\/en.2007-0262","article-title":"Ascorbic acid transported by sodium-dependent vitamin c transporter 2 stimulates steroidogenesis in human choriocarcinoma cells","volume":"149","author":"Wu","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2024.149210_b0230","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.reprotox.2010.12.002","article-title":"Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice","volume":"31","author":"Xi","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.gene.2024.149210_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104615","article-title":"Bisphenol A affects estradiol metabolism by targeting CYP1A1 and CYP19A1 in human placental JEG-3 cells","volume":"61","author":"Xu","year":"2019","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.gene.2024.149210_b0240","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1096\/fj.201800934RRR","article-title":"Bisphenol A exposure alters placentation and causes preeclampsia\u2010like features in pregnant mice involved in reprogramming of DNA methylation of WNT2","volume":"33","author":"Ye","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2024.149210_b0245","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1210\/jcem-63-3-751","article-title":"Competitive studies with dehydroepiandrosterone sulfate and 16 alpha-hydroxydehydroepiandrosterone sulfate in cultured human choriocarcinoma JEG-3 cells: effect on estrone, 17 beta-estradiol, and estriol secretion","volume":"63","author":"Zbella","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.gene.2024.149210_b0250","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00109-016-1396-1","article-title":"IGF-I stimulates ERbeta and aromatase expression via IGF1R\/PI3K\/AKT-mediated transcriptional activation in endometriosis","volume":"94","author":"Zhou","year":"2016","journal-title":"J. Mol. Med."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924010916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111924010916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T11:49:33Z","timestamp":1740743373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111924010916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":50,"alternative-id":["S0378111924010916"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2024.149210","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bisphenol A alters JUN promoter methylation, impairing steroid metabolism in placental cells and linking to sub-representative phenotypes","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2024.149210","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"149210"}}