{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:58:46Z","timestamp":1777327126412,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.gene.2025.149287","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T16:15:21Z","timestamp":1737994521000},"page":"149287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Identification of novel hub gene and biological pathways associated with ferroptosis in In-Stent restenosis"],"prefix":"10.1016","volume":"945","author":[{"given":"Shan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenping","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunmiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3091-0323","authenticated-orcid":false,"given":"Lijuan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.gene.2025.149287_b0005","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.4244\/EIJ-D-21-01034","article-title":"Management of in-stent restenosis","volume":"18","author":"Alfonso","year":"2022","journal-title":"EuroIntervention"},{"issue":"3","key":"10.1016\/j.gene.2025.149287_b0010","doi-asserted-by":"crossref","first-page":"H659","DOI":"10.1152\/ajpheart.00452.2017","article-title":"Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes","volume":"314","author":"Baba","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5\u20136","key":"10.1016\/j.gene.2025.149287_b0015","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s10495-020-01609-1","article-title":"Upregulation of microRNA-532 enhances cardiomyocyte apoptosis in the diabetic heart","volume":"25","author":"Chandrasekera","year":"2020","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.gene.2025.149287_b0020","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030591","article-title":"Targeting iron metabolism and ferroptosis as novel therapeutic approaches in cardiovascular diseases","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.gene.2025.149287_b0025","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jacc.2022.05.017","article-title":"Coronary in-stent restenosis: JACC state-of-the-art review","volume":"80","author":"Giustino","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.gene.2025.149287_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.109007","article-title":"SP1-mediated transcriptional activation of PTTG1 regulates the migration and phenotypic switching of aortic vascular smooth muscle cells in aortic dissection through MAPK signaling","volume":"711","author":"Hu","year":"2021","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"10.1016\/j.gene.2025.149287_b0035","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014103","article-title":"Drug-eluting stent targeting Sp-1-attenuated restenosis by engaging YAP-mediated vascular smooth muscle cell phenotypic modulation","volume":"9","author":"Huang","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"10.1016\/j.gene.2025.149287_b0040","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.123.013302","article-title":"Drug-coated balloons in the management of coronary artery disease","volume":"17","author":"Korjian","year":"2024","journal-title":"Circ Cardiovasc Interv"},{"issue":"11","key":"10.1016\/j.gene.2025.149287_b0045","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","article-title":"Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ"},{"issue":"3","key":"10.1016\/j.gene.2025.149287_b0050","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/00015385.2023.2209448","article-title":"LncRNA PVT1 inhibits endothelial cells apoptosis in coronary heart disease through regulating MAPK1 expression via miR-532-3p","volume":"79","author":"Liu","year":"2024","journal-title":"Acta Cardiol"},{"issue":"11","key":"10.1016\/j.gene.2025.149287_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/biom12111702","article-title":"The role of macrophage iron overload and ferroptosis in atherosclerosis","volume":"12","author":"Ma","year":"2022","journal-title":"Biomolecules"},{"issue":"21","key":"10.1016\/j.gene.2025.149287_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192113934","article-title":"Carotid plaque features and inflammatory biomarkers as predictors of restenosis and mortality following carotid endarterectomy","volume":"19","author":"Niculescu","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"10.1016\/j.gene.2025.149287_b0065","first-page":"187","article-title":"Classification and current treatment options of in-stent restenosis","volume":"29","author":"Ong","year":"2004","journal-title":"Present Status and Future Perspectives. Herz"},{"issue":"25","key":"10.1016\/j.gene.2025.149287_b0070","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.jacc.2008.01.071","article-title":"Telomerase-positive neutrophils: plaque \u201csurvivors\u201d and restenosis","volume":"51","author":"Sane","year":"2008","journal-title":"J Am Coll Cardiol."},{"issue":"9","key":"10.1016\/j.gene.2025.149287_b0075","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.7150\/ijbs.80735","article-title":"Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death","volume":"19","author":"Sanguigno","year":"2023","journal-title":"Int J Biol Sci"},{"issue":"5","key":"10.1016\/j.gene.2025.149287_b0080","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1039\/D3NA00751K","article-title":"Nanogold-coated stent facilitated non-invasive photothermal ablation of stent thrombosis and restoration of blood flow","volume":"6","author":"Singh","year":"2024","journal-title":"Nanoscale Adv"},{"issue":"6","key":"10.1016\/j.gene.2025.149287_b0085","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.gene.2025.149287_b0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S392036","article-title":"Biomarkers associated with immune checkpoint, N6-methyladenosine, and ferroptosis in patients with restenosis","volume":"16","author":"Tong","year":"2023","journal-title":"J Inflamm Res"},{"issue":"26","key":"10.1016\/j.gene.2025.149287_b0095","doi-asserted-by":"crossref","first-page":"18097","DOI":"10.1074\/jbc.M113.532093","article-title":"Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils","volume":"289","author":"Ueno-Shuto","year":"2014","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.gene.2025.149287_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/cells11172726","article-title":"Molecular mechanisms of ferroptosis and relevance to cardiovascular disease","volume":"11","author":"Xie","year":"2022","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.gene.2025.149287_b0105","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/cbin.11873","article-title":"LncRNA KCNQ1OT1 contributes to hydrogen peroxide-induced apoptosis, inflammation, and oxidative stress of cardiomyocytes via miR-130a-3p\/ZNF791 axis","volume":"46","author":"Xin","year":"2022","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.gene.2025.149287_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110406","article-title":"Knockdown of versican 1 in lung fibroblasts aggravates Lipopolysaccharide-induced acute inflammation through up-regulation of the SP1-Toll-like Receptor 2-NF-kappaB Axis: a potential barrier to promising Versican-targeted therapy","volume":"121","author":"Xu","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.gene.2025.149287_b0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.omtn.2020.01.032","article-title":"lncRNA KCNQ1OT1 suppresses the inflammation and proliferation of vascular smooth muscle cells through IkappaBa in intimal hyperplasia","volume":"20","author":"Ye","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"issue":"7","key":"10.1016\/j.gene.2025.149287_b0120","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41419-022-05027-w","article-title":"TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.gene.2025.149287_b0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijcard.2021.07.009","article-title":"Targeting KCNQ1OT1 in cardiovascular disease","volume":"339","author":"Zhang","year":"2021","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.gene.2025.149287_b0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s10020-022-00549-7","article-title":"Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice","volume":"28","author":"Zhang","year":"2022","journal-title":"Mol Med"},{"issue":"3","key":"10.1016\/j.gene.2025.149287_b0135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10557-021-07220-z","article-title":"SLC7A11\/xCT prevents cardiac hypertrophy by inhibiting ferroptosis","volume":"36","author":"Zhang","year":"2022","journal-title":"Cardiovasc Drugs Ther"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925000757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925000757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T21:07:35Z","timestamp":1740690455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925000757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":27,"alternative-id":["S0378111925000757"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149287","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel hub gene and biological pathways associated with ferroptosis in In-Stent restenosis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149287","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149287"}}