{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:58:29Z","timestamp":1776859109686,"version":"3.51.2"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.gene.2025.149385","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T06:38:39Z","timestamp":1740897519000},"page":"149385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["miRNA-1229-5p promotes migration and invasion and suppresses apoptosis of endometrial cells via the STMN1\/p38 MAPK axis in endometriosis"],"prefix":"10.1016","volume":"950","author":[{"given":"Lusha","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiyi","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149385_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bpobgyn.2018.06.001","article-title":"Risk for and consequences of endometriosis: A critical epidemiologic review","volume":"51","author":"Shafrir","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.gene.2025.149385_b0010","doi-asserted-by":"crossref","unstructured":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril, 1997, 67(5): 817-821. Doi: 10.1016\/s0015-0282(97)81391-x.","DOI":"10.1016\/S0015-0282(97)81391-X"},{"key":"10.1016\/j.gene.2025.149385_b0015","article-title":"Pathophysiology, diagnosis, and management of endometriosis","volume":"379","author":"Horne","year":"2022","journal-title":"BMJ"},{"issue":"12","key":"10.1016\/j.gene.2025.149385_b0020","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1093\/humrep\/dead216","article-title":"The role of small extracellular vesicle-miRNAs in endometriosis","volume":"38","author":"Nazri","year":"2023","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.gene.2025.149385_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1223828","article-title":"The landscape of non-coding RNAs in the immunopathogenesis of Endometriosis","volume":"14","author":"Abbaszadeh","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41420-023-01309-0","article-title":"Gut microbiota and microbiota-derived metabolites promotes endometriosis","volume":"9","author":"Chadchan","year":"2023","journal-title":"Cell Death Discov"},{"issue":"7","key":"10.1016\/j.gene.2025.149385_b0035","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1007\/s43032-021-00734-9","article-title":"MicroRNA-92a-3p Inhibits Cell Proliferation and Invasion by Regulating the Transcription Factor 21\/Steroidogenic Factor 1 Axis in Endometriosis","volume":"30","author":"Zhu","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.gene.2025.149385_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinsp.2022.100112","article-title":"miRNA-223 expression in patient-derived eutopic and ectopic endometrial stromal cells and its effect on epithelial-to-mesenchymal transition in endometriosis","volume":"77","author":"Xue","year":"2022","journal-title":"Clinics (Sao Paulo)"},{"issue":"14","key":"10.1016\/j.gene.2025.149385_b0045","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.7150\/ijbs.47203","article-title":"miRNA-based biomarkers, therapies, and resistance in Cancer","volume":"16","author":"He","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"14","key":"10.1016\/j.gene.2025.149385_b0050","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.3390\/ijms23147785","article-title":"MicroRNAs in Dystrophinopathy","volume":"23","author":"He","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.gene.2025.149385_b0055","first-page":"1135","article-title":"MicroRNAs in endometriosis: biological function and emerging biomarker candidates\u2020","volume":"100","author":"Bjorkman","year":"2019","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12958-022-00928-z","article-title":"miR-218-5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1","volume":"20","author":"Zhang","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"19","key":"10.1016\/j.gene.2025.149385_b0065","doi-asserted-by":"crossref","first-page":"15001","DOI":"10.3390\/ijms241915001","article-title":"MicroRNAs in Endometriosis: Insights into Inflammation and Progesterone Resistance","volume":"24","author":"Hon","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.gene.2025.149385_b0070","doi-asserted-by":"crossref","first-page":"e6426","DOI":"10.1590\/1414-431x20176426","article-title":"Analysis of serum microRNA expression in male workers with occupational noise-induced hearing loss","volume":"51","author":"Li","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"5","key":"10.1016\/j.gene.2025.149385_b0075","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/jcm9051402","article-title":"Association of Circulating microRNAs with Coronary Artery Disease and Usefulness for Reclassification of Healthy Individuals: The REGICOR Study","volume":"9","author":"D\u00e9gano","year":"2020","journal-title":"J. Clin. Med."},{"issue":"12","key":"10.1016\/j.gene.2025.149385_b0080","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.2174\/1389450121666200615145552","article-title":"MicroRNAs in Noise-Induced Hearing Loss and their Regulation by Oxidative Stress and Inflammation","volume":"21","author":"Forouzanfar","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.gene.2025.149385_b0085","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.847168","article-title":"MicroRNA Profiling of the Tears of Children With Vernal Keratoconjunctivitis","volume":"13","author":"Syed","year":"2022","journal-title":"Front. Genet."},{"issue":"19","key":"10.1016\/j.gene.2025.149385_b0090","doi-asserted-by":"crossref","first-page":"16146","DOI":"10.1074\/jbc.M010637200","article-title":"Stathmin family proteins display specific molecular and tubulin binding properties","volume":"276","author":"Charbaut","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2025.149385_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110775","article-title":"STNM1 in human cancers: role, function and potential therapy sensitizer","volume":"109","author":"Liu","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.gene.2025.149385_b0100","doi-asserted-by":"crossref","first-page":"28833","DOI":"10.1038\/srep28833","article-title":"Downregulation of stathmin 1 in human gallbladder carcinoma inhibits tumor growth in vitro and in vivo","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.gene.2025.149385_b0105","doi-asserted-by":"crossref","first-page":"26000","DOI":"10.18632\/oncotarget.11006","article-title":"Stathmin overexpression is associated with growth, invasion and metastasis of lung adenocarcinoma","volume":"8","author":"Yurong","year":"2017","journal-title":"Oncotarget"},{"issue":"20","key":"10.1016\/j.gene.2025.149385_b0110","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1158\/0008-5472.CAN-12-1158","article-title":"Inhibition of stathmin1 accelerates the metastatic process","volume":"72","author":"Williams","year":"2012","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.gene.2025.149385_b0115","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/jog.14710","article-title":"The role of mitogen-activated protein kinase signaling pathway in endometriosis","volume":"47","author":"Bora","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"16","key":"10.1016\/j.gene.2025.149385_b0120","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1111\/jcmm.17464","article-title":"ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38\/ATF-2 signalling pathway","volume":"26","author":"Liu","year":"2022","journal-title":"J. Cell Mol. Med."},{"issue":"11","key":"10.1016\/j.gene.2025.149385_b0125","doi-asserted-by":"crossref","first-page":"19384","DOI":"10.1002\/jcp.28666","article-title":"The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression","volume":"234","author":"Samimi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"12","key":"10.1016\/j.gene.2025.149385_b0130","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1093\/humrep\/deq287","article-title":"SB203580, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis by down-regulating proinflammatory cytokines and proteolytic factors in a mouse model","volume":"25","author":"Zhou","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.gene.2025.149385_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110870","article-title":"LncRNA MEG3-210 regulates endometrial stromal cells migration, invasion and apoptosis through p38 MAPK and PKA\/SERCA2 signalling via interaction with Galectin-1 in endometriosis","volume":"513","author":"Liu","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.gene.2025.149385_b0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2016.05.020","article-title":"Aromatase inhibitor regulates let-7 expression and let-7f-induced cell migration in endometrial cells from women with endometriosis","volume":"106","author":"Cho","year":"2016","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.gene.2025.149385_b0145","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/1933719117725828","article-title":"p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival","volume":"25","author":"Cakmak","year":"2018","journal-title":"Reproductive Sciences (thousand Oaks, Calif.),"},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0150","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41420-024-01914-7","article-title":"miR-218-5p and doxorubicin combination enhances anticancer activity in breast cancer cells through Parkin-dependent mitophagy inhibition","volume":"10","author":"Naso","year":"2024","journal-title":"Cell Death Discov"},{"issue":"6","key":"10.1016\/j.gene.2025.149385_b0155","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/jdi.14180","article-title":"High glucose promotes atherosclerosis by regulating miRNA let7d-5p level","volume":"15","author":"Wang","year":"2024","journal-title":"J Diabetes Investig"},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s42003-024-05986-0","article-title":"MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A\/STAT3 signaling pathway to promote wound healing in diabetes","volume":"7","author":"Hu","year":"2024","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.gene.2025.149385_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100759","article-title":"Corrigendum to \u201cMiR-143-3p facilitates motility and invasiveness of endometriotic stromal cells by targeting VASH1\/TGF-\u03b2 signaling\u201d","volume":"23","author":"Li","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.gene.2025.149385_b0170","article-title":"MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2","volume":"2021","author":"Sun","year":"2021","journal-title":"Anal. Cell. Pathol. (Amst.)"},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0175","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12958-020-00590-3","article-title":"hsa-miR-100-5p, an overexpressed miRNA in human ovarian endometriotic stromal cells, promotes invasion through attenuation of SMARCD1 expression","volume":"18","author":"Takebayashi","year":"2020","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"8","key":"10.1016\/j.gene.2025.149385_b0180","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1177\/1933719118808923","article-title":"Alteration of Myeloid-Derived Suppressor Cells, Chronic Inflammatory Cytokines, and Exosomal miRNA Contribute to the Peritoneal Immune Disorder of Patients With Endometriosis","volume":"26","author":"Chen","year":"2019","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0185","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12964-024-01570-5","article-title":"Tumor-derived miR-6794-5p enhances cancer growth by promoting M2 macrophage polarization","volume":"22","author":"Choi","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.gene.2025.149385_b0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0195","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1620\/tjem.2022.J048","article-title":"Serum Extracellular Vesicles Attenuate Cardiomyocyte Injury Induced by Hypoxic\/Reoxygenation by Regulating miR-1229-5p","volume":"258","author":"Jin","year":"2022","journal-title":"Tohoku J. Exp. Med."},{"issue":"2","key":"10.1016\/j.gene.2025.149385_b0200","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jsb.2006.07.018","article-title":"Structure and thermodynamics of the tubulin-stathmin interaction","volume":"158","author":"Steinmetz","year":"2007","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.gene.2025.149385_b0205","doi-asserted-by":"crossref","unstructured":"Trovik J., Wik E., Stefansson IM., Marcickiewicz J., Tingulstad S., Staff AC., Njolstad TS., MoMaTec Study Group, Vandenput, I., Amant, F., et al. Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. Clin Cancer Res, 2011, 17(10): 3368-3377. Doi: 10.1158\/1078-0432.CCR-10-2412.","DOI":"10.1158\/1078-0432.CCR-10-2412"},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10238-015-0403-0","article-title":"High expression of stathmin 1 is a strong prognostic marker in oral squamous cell carcinoma patients treated by docetaxel-containing regimens","volume":"17","author":"Harada","year":"2017","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.gene.2025.149385_b0215","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12894-015-0028-3","article-title":"miR-221 facilitates the TGFbeta1-induced epithelial-mesenchymal transition in human bladder cancer cells by targeting STMN1","volume":"15","author":"Liu","year":"2015","journal-title":"BMC Urol."},{"issue":"2","key":"10.1016\/j.gene.2025.149385_b0220","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41419-021-03459-4","article-title":"circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1\/EMT axis","volume":"12","author":"Tan","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2025.149385_b0225","doi-asserted-by":"crossref","unstructured":"Veillat V., Carli C., Metz CN., Al-Abed Y., Naccache PH., & Akoum A.. Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathways. The Journal of clinical endocrinology and metabolism, 2010, 95(12), E403\u2013E412. Doi: 10.1210\/jc.2010-0417.","DOI":"10.1210\/jc.2010-0417"},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0230","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.fertnstert.2014.03.029","article-title":"Lipoxin A4 regulates expression of the estrogen receptor and inhibits 17\u03b2-estradiol induced p38 mitogen-activated protein kinase phosphorylation in human endometriotic stromal cells","volume":"102","author":"Chen","year":"2014","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0235","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1038\/s41467-020-16230-8","article-title":"The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation","volume":"11","author":"Fischer","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.gene.2025.149385_b0240","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.gene.2015.03.010","article-title":"Interleukin 18 augments growth ability via NF-\u03baB and p38\/ATF2 pathways by targeting cyclin B1, cyclin B2, cyclin A2, and Bcl-2 in BRL-3A rat liver cells","volume":"563","author":"Zhang","year":"2015","journal-title":"Gene"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925001738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925001738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:15:00Z","timestamp":1741684500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925001738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":48,"alternative-id":["S0378111925001738"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149385","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miRNA-1229-5p promotes migration and invasion and suppresses apoptosis of endometrial cells via the STMN1\/p38 MAPK axis in endometriosis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149385","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"149385"}}