{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:30:06Z","timestamp":1759883406095,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830098"],"award-info":[{"award-number":["81830098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["TD2019H001"],"award-info":[{"award-number":["TD2019H001"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.gene.2025.149659","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:19:19Z","timestamp":1751663959000},"page":"149659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transcriptomic analysis reveals potential novel circRNA in goiters progression"],"prefix":"10.1016","volume":"965","author":[{"given":"Guanying","family":"Nie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixuan","family":"Ru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiashuang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149659_b0005","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.beem.2014.01.001","article-title":"Epidemiology of nodular goitre, Influence of iodine intake","volume":"28","author":"Carl\u00e9","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.gene.2025.149659_b0010","article-title":"Elevated serum thyroglobulin and low iodine intake are associated with nontoxic nodular goiter among adults living near the Eastern Mediterranean Coast","volume":"913672","author":"Ovadia","year":"2014","journal-title":"J. Thyroid Res."},{"key":"10.1016\/j.gene.2025.149659_b0015","doi-asserted-by":"crossref","first-page":"19731","DOI":"10.3402\/fnr.v56i0.19731","article-title":"Iodine Intake in Human Nutrition: a Systematic Literature Review","volume":"56","author":"Gunnarsdottir","year":"2012","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.gene.2025.149659_b0020","first-page":"131","article-title":"A Review of the Pathology, Diagnosis and Management of Colloid Goitre","volume":"16","author":"Trinh","year":"2020","journal-title":"Eur Endocrinol."},{"key":"10.1016\/j.gene.2025.149659_b0025","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s00104-020-01218-3","article-title":"Bartsch, D, Nodular Goiter, Der","volume":"91","author":"Holzer","year":"2020","journal-title":"Chirurg"},{"key":"10.1016\/j.gene.2025.149659_b0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.32895\/UMP.MPR.4.1.3","article-title":"Tracheomalacia due to trachea compression related to benign goiter","volume":"4","author":"Tieu","year":"2020","journal-title":"MedPharmRes"},{"key":"10.1016\/j.gene.2025.149659_b0035","doi-asserted-by":"crossref","first-page":"569","DOI":"10.4103\/bbrj.bbrj_99_22","article-title":"Comparison of Clinical Efficacy of Antithyroid Drugs, Radioactive Iodine, and Thyroidectomy for Treatment of patients with Graves\u2019 Disease, toxic Thyroid Adenoma, and toxic Multinodular Goiter","volume":"6","author":"Bawand","year":"2022","journal-title":"Biomedical and Biotechnology Research Journal"},{"issue":"3","key":"10.1016\/j.gene.2025.149659_b0040","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI84424","article-title":"Targeting noncoding RNAs in disease","volume":"127","author":"Adams","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.gene.2025.149659_b0045","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41576-023-00662-1","article-title":"Non-coding RNAs in disease: from mechanisms to therapeutics","volume":"25","author":"Nemeth","year":"2024","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.gene.2025.149659_b0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.canlet.2017.12.029","article-title":"Statistical analysis of non-coding RNA data","volume":"417","author":"He","year":"2018","journal-title":"Cancer Lett."},{"issue":"8","key":"10.1016\/j.gene.2025.149659_b0055","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/gb-2005-6-8-r71","article-title":"MicroRNA profiling of the murine hematopoietic system","volume":"6","author":"Monticelli","year":"2005","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.gene.2025.149659_b0060","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1515\/hsz-2018-0343","article-title":"MiR-23a-3p-regulated abnormal acetylation of FOXP3 induces regulatory T cell function defect in Graves' disease","volume":"400","author":"Zhang","year":"2019","journal-title":"Biol. Chem."},{"issue":"1","key":"10.1016\/j.gene.2025.149659_b0065","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12020-017-1465-4","article-title":"MicroRNA-326 contributes to autoimmune thyroiditis by targeting the Ets-1 protein","volume":"59","author":"Zhao","year":"2018","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.gene.2025.149659_b0070","first-page":"2465","article-title":"miRNA-125a modulates autophagy of thyroiditis through PI3K\/Akt\/mTOR signaling pathway","volume":"17","author":"Chen","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.gene.2025.149659_b0075","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","article-title":"Regulation of circRNA Biogenesis","volume":"12","author":"Chen","year":"2015","journal-title":"RNA Biol."},{"key":"10.1016\/j.gene.2025.149659_b0080","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.7150\/thno.42174","article-title":"Circular RNA-Protein Interactions: Functions, Mechanisms, and Identification","volume":"10","author":"Huang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.gene.2025.149659_b0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molcel.2017.02.021","article-title":"Translation of CircRNAs","volume":"66","author":"Pamudurti","year":"2017","journal-title":"Mol. Cell"},{"issue":"7441","key":"10.1016\/j.gene.2025.149659_b0090","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.gene.2025.149659_b0095","article-title":"Emerging Roles for Noncoding RNAs in Autoimmune Thyroid Disease","volume":"161(8):bqaa053","author":"Yin","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2025.149659_b0100","doi-asserted-by":"crossref","unstructured":"Guo JU, Agarwal V, Guo H, Bartel DP. Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 2014;15(7):409. Published 2014 Jul 29. doi:10.1186\/s13059-014-0409-z.","DOI":"10.1186\/PREACCEPT-1176565312639289"},{"key":"10.1016\/j.gene.2025.149659_b0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2990.1986.tb00139.x","article-title":"The Effects on Fetal Brain Development in the Rat of a Severely Iodine Deficient Diet Derived from an Endemic Area: Observations on the first Generation","volume":"12","author":"Li","year":"1986","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.gene.2025.149659_b0110","unstructured":"WS\/T 572-2017 Determination of Iodine in Serum\u2014As3+\u4e00Ce4+ Catalytic Spectrophotometry. 2017."},{"key":"10.1016\/j.gene.2025.149659_b0115","unstructured":"GB5009.267\u20142020 \u201cNational Food Safety Standard for Determination of Iodine in Food\u201d. 2020."},{"key":"10.1016\/j.gene.2025.149659_b0120","doi-asserted-by":"crossref","unstructured":"Sun, D. Endemic Disease in China; Springer, 2019; Vol. 2; ISBN 9811325294.","DOI":"10.1007\/978-981-13-2529-8"},{"key":"10.1016\/j.gene.2025.149659_b0125","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12011-013-9873-7","article-title":"A Comparative Study on the Effects of Excess Iodine and Herbs with Excess Iodine on Thyroid Oxidative stress in Iodine-Deficient Rats","volume":"157","author":"Gao","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.gene.2025.149659_b0130","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac107","article-title":"Murine Thyroid IL-4 Expression Worsens Hypothyroidism on Iodine Restriction and Mitigates Graves Disease Development","volume":"163","author":"Merakchi","year":"2022","journal-title":"Endocrinology"},{"key":"10.1016\/j.gene.2025.149659_b0135","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s12020-021-02679-0","article-title":"MicroRNA Expression Profiles of the Thyroid after Goiter Formation and Involution in Rats under Different Iodine Regimens","volume":"73","author":"Zhao","year":"2021","journal-title":"Endocrine"},{"key":"10.1016\/j.gene.2025.149659_b0140","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1210\/jc.2016-1315","article-title":"TSH\/IGF-1 Receptor Cross talk in Graves\u2019 Ophthalmopathy Pathogenesis","volume":"101","author":"Krieger","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.gene.2025.149659_b0145","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.bbamcr.2007.03.011","article-title":"Deficiency Activates Antioxidant Genes and Causes DNA damage in the Thyroid Gland of Rats and mice","volume":"1773","author":"Maier","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2025.149659_b0150","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3892\/ijo.2014.2668","article-title":"Pharmacological suppression of the Ras\/MAPK Pathway in Thyroid Carcinoma Cells can Provoke Opposite Effects on Cell Migration and Proliferation: the Appearance of Yin-Yang Effects and the need of Combinatorial Treatments","volume":"45","author":"Glassmann","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.gene.2025.149659_b0155","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molonc.2009.06.004","article-title":"Ras\/MAPK Signaling from Endomembranes","volume":"3","author":"Fehrenbacher","year":"2009","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.gene.2025.149659_b0160","first-page":"484","article-title":"Effects of Different Levels of Iodine Concentration on Insulin-like Growth Factors \u2160mRNA Expression of Thyroid and Breast in Lactating Rats","volume":"6","author":"Xin","year":"2009","journal-title":"Chin J Endemiol."},{"key":"10.1016\/j.gene.2025.149659_b0165","doi-asserted-by":"crossref","first-page":"T29","DOI":"10.1530\/JME-17-0276","article-title":"IGF-I Receptor and Thyroid-Associated Ophthalmopathy","volume":"61","author":"Mohyi","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.gene.2025.149659_b0170","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00423-011-0788-5","article-title":"Molecular Pathogenesis of Nodular Goiter","volume":"396","author":"Paschke","year":"2011","journal-title":"Langenbecks Arch. Surg."},{"key":"10.1016\/j.gene.2025.149659_b0175","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1210\/er.2018-00066","article-title":"Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy","volume":"40","author":"Smith","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.gene.2025.149659_b0180","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000363160","article-title":"Iodine Deficiency in Children","volume":"26","author":"Pearce","year":"2014","journal-title":"Paediatric Thyroidology"},{"key":"10.1016\/j.gene.2025.149659_b0185","first-page":"215","article-title":"The Level of IGF-1 and TGF-Beta-1 in the Blood Serum and the Thyroid size in Children with Normal Ioduria","volume":"11","author":"Brzozowska","year":"2015","journal-title":"Endokrynol. Diabetol. Chor. Przemiany Materii Wieku Rozw."},{"key":"10.1016\/j.gene.2025.149659_b0190","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s12020-012-9864-z","article-title":"Expression and significance of IGF-1 and IGF-1R in Thyroid Nodules","volume":"44","author":"Liu","year":"2013","journal-title":"Endocrine"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925004482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925004482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:16:33Z","timestamp":1759857393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925004482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":38,"alternative-id":["S0378111925004482"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149659","relation":{},"ISSN":["0378-1119"],"issn-type":[{"type":"print","value":"0378-1119"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic analysis reveals potential novel circRNA in goiters progression","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"149659"}}