{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:30:21Z","timestamp":1778509821681,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Commission","doi-asserted-by":"publisher","award":["PWZxq2022-02"],"award-info":[{"award-number":["PWZxq2022-02"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004204","name":"Tongji University","doi-asserted-by":"publisher","award":["NO.TJTJ00621401"],"award-info":[{"award-number":["NO.TJTJ00621401"]}],"id":[{"id":"10.13039\/501100004204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.gene.2025.149660","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T21:19:08Z","timestamp":1751663948000},"page":"149660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transcriptomic and single-cell insights into mitochondrial genes NDUFA8, ECI2, and ACADM in acute myocardial infarction"],"prefix":"10.1016","volume":"965","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4604-1572","authenticated-orcid":false,"given":"Ying","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChengHui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RuiLin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YunLi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149660_b0005","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/s41590-022-01185-3","article-title":"Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation","volume":"23","author":"Billingham","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.gene.2025.149660_b0010","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s42003-023-04817-y","article-title":"Differential binding of NLRP3 to non-oxidized and ox-mtDNA mediates NLRP3 inflammasome activation","volume":"6","author":"Cabral","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.gene.2025.149660_b0015","doi-asserted-by":"crossref","first-page":"7184","DOI":"10.1038\/s41467-024-51489-1","article-title":"The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2025.149660_b0020","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1160\/TH14-06-0497","article-title":"Peroxisomes in cardiomyocytes and the peroxisome \/ peroxisome proliferator-activated receptor-loop","volume":"113","author":"Colasante","year":"2015","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.gene.2025.149660_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158745","article-title":"Human Cardiac Mesenchymal Stromal Cells with CD105+CD34- Phenotype Enhance the Function of Post-Infarction Heart in mice","volume":"11","author":"Czapla","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2025.149660_b0030","article-title":"Mfn2-mediated mitochondrial fusion alleviates doxorubicin-induced cardiotoxicity with enhancing its anticancer activity through metabolic switch","volume":"52","author":"Ding","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.gene.2025.149660_b0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41586-022-04421-w","article-title":"The cGAS\u2013STING pathway drives type I IFN immunopathology in COVID-19","volume":"603","author":"Domizio","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.gene.2025.149660_b0040","first-page":"255","article-title":"The inflammatory response in myocardial injury, repair, and remodelling. Nat. Rev","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Cardiol"},{"key":"10.1016\/j.gene.2025.149660_b0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.gene.2025.149660_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111340","article-title":"Ndufa8 promotes white fat Browning by improving mitochondrial respiratory chain complex I function to ameliorate obesity by in vitro and in vivo","volume":"122","author":"Fu","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.gene.2025.149660_b0055","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/SHK.0b013e31824bc9ab","article-title":"The role of cyclosporine in the treatment of myocardial reperfusion injury","volume":"37","author":"Gill","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.gene.2025.149660_b0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2025.149660_b0065","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.gene.2025.149660_b0070","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-023-05720-6","article-title":"Macrophage fumarate hydratase restrains mtRNA-mediated interferon production","volume":"615","author":"Hooftman","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.gene.2025.149660_b0075","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/CIRCULATIONAHA.111.059253","article-title":"Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection","volume":"124","author":"Horstkotte","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.gene.2025.149660_b0080","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/humu.10315","article-title":"Molecular basis of Refsum disease: sequence variations in phytanoyl-CoA hydroxylase (PHYH) and the PTS2 receptor (PEX7)","volume":"23","author":"Jansen","year":"2004","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.gene.2025.149660_b0085","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/CIRCRESAHA.111.300484","article-title":"Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts","volume":"112","author":"Jung","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2025.149660_b0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000085107","article-title":"Epithelial defence by gamma delta T cells","volume":"137","author":"Kabelitz","year":"2005","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.gene.2025.149660_b0095","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1089\/ars.2007.1636","article-title":"Role of oxygen in postischemic myocardial injury","volume":"9","author":"Kutala","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.gene.2025.149660_b0100","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.gene.2025.149660_b0105","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2025.149660_b0110","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s11033-023-09154-1","article-title":"Rhein alleviates myocardial ischemic injury by inhibiting mitochondrial division, activating mitochondrial autophagy and suppressing myocardial cell apoptosis through the Drp1\/Pink1\/Parkin pathway","volume":"51","author":"Li","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.gene.2025.149660_b0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.gene.2025.149660_b0120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4161\/cam.5.2.13796","article-title":"Extracellular matrix-derived peptides and myocardial repair","volume":"5","author":"Mihardja","year":"2011","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.gene.2025.149660_b0125","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.gene.2025.149660_b0130","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the powerhouses of immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.gene.2025.149660_b0135","doi-asserted-by":"crossref","first-page":"12268","DOI":"10.1038\/s41598-017-12166-0","article-title":"A whole blood molecular signature for acute myocardial infarction","volume":"7","author":"Muse","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2025.149660_b0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.gene.2025.149660_b0145","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Alternatively Activated Macrophages. Front Immunol"},{"key":"10.1016\/j.gene.2025.149660_b0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.carpath.2015.09.004","article-title":"Death from undetected acute myocardial infarction secondary to coronary artery dissection after blunt thoracic trauma","volume":"25","author":"Puanglumyai","year":"2016","journal-title":"Cardiovasc Pathol"},{"key":"10.1016\/j.gene.2025.149660_b0155","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2025.149660_b0160","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.gene.2025.149660_b0165","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.mad.2008.09.020","article-title":"Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey","volume":"129","author":"Starr","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.gene.2025.149660_b0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2014.04.017","article-title":"Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction","volume":"74","author":"Suresh","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.gene.2025.149660_b0175","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7149408","article-title":"S100A9 increases IL-6 and RANKL Expressions through MAPKs and STAT3 Signaling Pathways in Osteocyte-like Cells","volume":"2020","author":"Takagi","year":"2020","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.gene.2025.149660_b0180","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.immuni.2009.03.015","article-title":"Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow","volume":"30","author":"Tokoyoda","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.gene.2025.149660_b0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1750-1172-8-43","article-title":"In vitro and in vivo consequences of variant medium-chain acyl-CoA dehydrogenase genotypes","volume":"8","author":"Touw","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.gene.2025.149660_b0190","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.gene.2025.149660_b0195","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.celrep.2016.09.008","article-title":"Mitochondrial dysfunction prevents repolarization of inflammatory macrophages","volume":"17","author":"Van den Bossche","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2025.149660_b0200","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1096\/fj.12-206326","article-title":"Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids","volume":"26","author":"van Weeghel","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2025.149660_b0205","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00395-012-0250-z","article-title":"S100A8\/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-\u03baB signaling","volume":"107","author":"Volz","year":"2012","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.gene.2025.149660_b0210","first-page":"3190","article-title":"Neutrophil extracellular trap mitochondrial DNA and its autoantibody in systemic lupus erythematosus and a proof-of-concept trial of metformin. Arthritis","volume":"hob. N.J.) 67","author":"Wang","year":"2015","journal-title":"Rheumatol"},{"key":"10.1016\/j.gene.2025.149660_b0215","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gene.2025.149660_b0220","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2025.149660_b0225","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201801451","article-title":"Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis","volume":"8","author":"Witherel","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.gene.2025.149660_b0230","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1038\/s41467-023-42634-3","article-title":"Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1\u03b1-mediated glycolytic reprogramming","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2025.149660_b0235","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.immuni.2014.01.006","article-title":"Transcriptome-based network analysis reveals a spectrum model of human macrophage activation","volume":"40","author":"Xue","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.gene.2025.149660_b0240","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/cge.13773","article-title":"A homozygous variant in NDUFA8 is associated with developmental delay, microcephaly, and epilepsy due to mitochondrial complex I deficiency","volume":"98","author":"Yatsuka","year":"2020","journal-title":"Clin. Genet."},{"key":"10.1016\/j.gene.2025.149660_b0245","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.gene.2025.149660_b0250","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.gene.2025.149660_b0255","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.192.7.1001","article-title":"Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes","volume":"192","author":"Zorov","year":"2000","journal-title":"J. Exp. Med."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925004494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925004494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:25:31Z","timestamp":1778505931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925004494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":51,"alternative-id":["S0378111925004494"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149660","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic and single-cell insights into mitochondrial genes NDUFA8, ECI2, and ACADM in acute myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"149660"}}