{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:02:14Z","timestamp":1786989734975,"version":"build-2736575974"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171258"],"award-info":[{"award-number":["32171258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870772"],"award-info":[{"award-number":["31870772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.gene.2025.149722","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T06:44:43Z","timestamp":1755067483000},"page":"149722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Neuroprotective mechanism of LincRNA in neurodegenerative diseases"],"prefix":"10.1016","volume":"967","author":[{"given":"Yizhou","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianye","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149722_b0005","doi-asserted-by":"crossref","unstructured":"Agnello, L., Ciaccio, M., 2022. Neurodegenerative diseases: from molecular basis to therapy. Int. J. Mol. Sci. 23(21), doi: 10.3390\/ijms232112854.","DOI":"10.3390\/ijms232112854"},{"issue":"2","key":"10.1016\/j.gene.2025.149722_b0010","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/labmed\/lmaa062","article-title":"Neurogranin as a novel biomarker in Alzheimer's disease","volume":"52","author":"Agnello","year":"2021","journal-title":"Lab. Med."},{"key":"10.1016\/j.gene.2025.149722_b0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13578-020-00445-9","article-title":"An update on long intergenic noncoding RNA p21: a regulatory molecule with various significant functions in cancer","volume":"10","author":"Amirinejad","year":"2020","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13045-018-0606-4","article-title":"MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches","volume":"11","author":"Amodio","year":"2018","journal-title":"J. Hematol. Oncol."},{"issue":"15","key":"10.1016\/j.gene.2025.149722_b0025","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.15252\/embj.201387576","article-title":"MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease","volume":"33","author":"Banzhaf-Strathmann","year":"2014","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2741\/S415","article-title":"Parkinson's disease: a review","volume":"6","author":"Beitz","year":"2014","journal-title":"Front. Biosci. (Schol. Ed.)"},{"issue":"18","key":"10.1016\/j.gene.2025.149722_b0035","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1038\/emboj.2010.199","article-title":"A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression","volume":"29","author":"Bernard","year":"2010","journal-title":"EMBO J."},{"issue":"Pt 6","key":"10.1016\/j.gene.2025.149722_b0040","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1042\/BST0371270","article-title":"Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease","volume":"37","author":"Bithell","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.gene.2025.149722_b0045","doi-asserted-by":"crossref","unstructured":"Burr\u00e9, J., Sharma, M., S\u00fcdhof, T.C., 2018. Cell Biology and pathophysiology of \u03b1-synuclein. Cold Spring Harbor Perspectives in Medicine 8(3). doi: 10.1101\/cshperspect.a024091.","DOI":"10.1101\/cshperspect.a024091"},{"key":"10.1016\/j.gene.2025.149722_b0050","article-title":"Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets","volume":"13","author":"Cai","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2025.149722_b0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuroscience.2018.07.019","article-title":"Long noncoding RNA SNHG1 promotes neuroinflammation in Parkinson's disease via regulating miR-7\/NLRP3 pathway","volume":"388","author":"Cao","year":"2018","journal-title":"Neuroscience"},{"issue":"8","key":"10.1016\/j.gene.2025.149722_b0060","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.18632\/aging.204025","article-title":"SNCA-AS1 in aging and Parkinson's disease","volume":"14","author":"Carelli","year":"2022","journal-title":"Aging"},{"issue":"4","key":"10.1016\/j.gene.2025.149722_b0065","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/cns.12841","article-title":"Huntington's disease: from basic science to therapeutics","volume":"24","author":"Cepeda","year":"2018","journal-title":"CNS Neurosci. Ther."},{"issue":"10","key":"10.1016\/j.gene.2025.149722_b0070","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1080\/15476286.2018.1534524","article-title":"Altered levels of long NcRNAs Meg3 and Neat1 in cell and animal models of Huntington's disease","volume":"15","author":"Chanda","year":"2018","journal-title":"RNA Biol."},{"issue":"5","key":"10.1016\/j.gene.2025.149722_b0075","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12032-017-0959-5","article-title":"LincRNa-p21: function and mechanism in cancer","volume":"34","author":"Chen","year":"2017","journal-title":"Med. Oncol. (Northwood, London, England)"},{"key":"10.1016\/j.gene.2025.149722_b0080","doi-asserted-by":"crossref","unstructured":"Chen, Y., Chen, H., Wang, Y., Liu, F., Fan, X., Shi, C., Su, X., Tan, M., Yang, Y., Lin, B., Lei, K., Qu, L., Yang, J., Zhu, Z., Yuan, Z., Xie, S., Sun, Q., Neculai, D., Liu, W., Yan, Q., Wang, X., Shao, J., Liu, J., Lin, A., 2024. LncRNA LINK-A remodels tissue inflammatory microenvironments to promote obesity. Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany) 11(10), e2303341. Doi: 10.1002\/advs.202303341.","DOI":"10.1002\/advs.202303341"},{"key":"10.1016\/j.gene.2025.149722_b0085","doi-asserted-by":"crossref","unstructured":"Cheng, Y.J., Lin, C.H., Lane, H.Y., 2021. From menopause to neurodegeneration-molecular basis and potential therapy. Int. J. Mol. Sci. 22(16), doi: 10.3390\/ijms22168654.","DOI":"10.3390\/ijms22168654"},{"key":"10.1016\/j.gene.2025.149722_b0090","doi-asserted-by":"crossref","unstructured":"Decourt, B., Sabbagh, M.N., 2011. BACE1 as a potential biomarker for Alzheimer's disease. Journal of Alzheimer's disease : JAD 24 Suppl 2(Suppl 2), 53-59. Doi: 10.3233\/jad-2011-110017.","DOI":"10.3233\/JAD-2011-110017"},{"issue":"5","key":"10.1016\/j.gene.2025.149722_b0095","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.molcel.2014.04.025","article-title":"LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1\/S checkpoint","volume":"54","author":"Dimitrova","year":"2014","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.gene.2025.149722_b0100","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1007\/s10528-023-10383-z","article-title":"Long non-coding RNA genes polymorphisms H19 (rs2251375) and MALAT1 (rs3200401) association with rheumatoid arthritis and their correlation with disease activity in a Cohort of Egyptian patients: a pilot study","volume":"61","author":"El-Sayed","year":"2023","journal-title":"Biochem. Genet."},{"issue":"5","key":"10.1016\/j.gene.2025.149722_b0105","article-title":"The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: a step toward ncRNA Precision. Non-coding","volume":"9","author":"Eldash","year":"2023","journal-title":"RNA"},{"key":"10.1016\/j.gene.2025.149722_b0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.lfs.2018.12.029","article-title":"Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies","volume":"218","author":"Elfawy","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2025.149722_b0115","doi-asserted-by":"crossref","unstructured":"Faghihi, M.A., Modarresi, F., Khalil, A.M., Wood, D.E., Sahagan, B.G., Morgan, T.E., Finch, C.E., St Laurent, G., 3rd, Kenny, P.J., Wahlestedt, C., 2008. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat. Med. 14(7), 723\u2013730. doi: 10.1038\/nm1784.","DOI":"10.1038\/nm1784"},{"key":"10.1016\/j.gene.2025.149722_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.598817","article-title":"Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers","volume":"10","author":"Gao","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2025.149722_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153556","article-title":"Long intergenic non-protein coding RNA 460: Review of its role in carcinogenesis","volume":"225","author":"Ghafouri-Fard","year":"2021","journal-title":"Pathol. Res. Pract."},{"issue":"5","key":"10.1016\/j.gene.2025.149722_b0130","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/cvr\/cvx013","article-title":"Increased BACE1-AS long noncoding RNA and \u03b2-amyloid levels in heart failure","volume":"113","author":"Greco","year":"2017","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.gene.2025.149722_b0135","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1080\/03007995.2024.2416985","article-title":"Advancements in current one-size-fits-all therapies compared to future treatment innovations for better improved chemotherapeutic outcomes: a step-toward personalized medicine","volume":"40","author":"Hamdy","year":"2024","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.gene.2025.149722_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122946","article-title":"Unraveling the ncRNA landscape that governs colorectal cancer: a roadmap to personalized therapeutics","volume":"354","author":"Hamdy","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2025.149722_b0145","doi-asserted-by":"crossref","unstructured":"Jimenez-Sanchez, M., Licitra, F., Underwood, B.R., Rubinsztein, D.C., 2017. Huntington's disease: mechanisms of pathogenesis and therapeutic strategies. Cold Spring Harbor perspectives in medicine 7(7). Doi: 10.1101\/cshperspect.a024240.","DOI":"10.1101\/cshperspect.a024240"},{"issue":"2","key":"10.1016\/j.gene.2025.149722_b0150","first-page":"2373","article-title":"MicroRNA\u2011125b regulates Alzheimer's disease through SphK1 regulation","volume":"18","author":"Jin","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.gene.2025.149722_b0155","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.nbd.2011.12.006","article-title":"Long non-coding RNAs in Huntington's disease neurodegeneration","volume":"46","author":"Johnson","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"28","key":"10.1016\/j.gene.2025.149722_b0160","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.0904715106","article-title":"Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression","volume":"106","author":"Khalil","year":"2009","journal-title":"PNAS"},{"issue":"11","key":"10.1016\/j.gene.2025.149722_b0165","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"6","key":"10.1016\/j.gene.2025.149722_b0170","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1161\/CIRCRESAHA.120.318577","article-title":"The SRSF4-GAS5-glucocorticoid receptor axis regulates ventricular hypertrophy","volume":"129","author":"Larrasa-Alonso","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.gene.2025.149722_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101878","article-title":"lncRNA NEAT1: key player in neurodegenerative diseases","volume":"86","author":"Li","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.gene.2025.149722_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104545","article-title":"Neuro-protective roles of long non-coding RNA MALAT1 in Alzheimer's disease with the involvement of the microRNA-30b\/CNR1 network and the following PI3K\/AKT activation","volume":"117","author":"Li","year":"2020","journal-title":"Exp. Mol. Pathol."},{"issue":"12","key":"10.1016\/j.gene.2025.149722_b0185","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1007\/s11064-021-03431-w","article-title":"Berberine attenuates MPP(+)-induced neuronal injury by regulating LINC00943\/miR-142-5p\/KPNA4\/NF-\u03baB pathway in SK-N-SH cells","volume":"46","author":"Li","year":"2021","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.gene.2025.149722_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112542","article-title":"A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma","volume":"42","author":"Li","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2025.149722_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111528","article-title":"MALAT1 downregulation is associated with polycystic ovary syndrome via binding with MDM2 and repressing P53 degradation","volume":"543","author":"Li","year":"2022","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.gene.2025.149722_b0200","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s13258-021-01084-1","article-title":"LINC00943 knockdown exerts neuroprotective effects in Parkinson's disease through regulates CXCL12 expression by sponging miR-7-5p","volume":"43","author":"Lian","year":"2021","journal-title":"Genes Genom."},{"issue":"6","key":"10.1016\/j.gene.2025.149722_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e16736","article-title":"LINC00943 regulates miR-1252-5p\/YWHAH axis to promote tumor proliferation and metastasis in lung adenocarcinoma","volume":"9","author":"Liu","year":"2023","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.gene.2025.149722_b0210","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.3892\/mmr.2014.2351","article-title":"Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1\u2011AS expression","volume":"10","author":"Liu","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.gene.2025.149722_b0215","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s12264-017-0183-5","article-title":"Biomarkers for Parkinson's disease: recent advancement","volume":"33","author":"Lotankar","year":"2017","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.gene.2025.149722_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112063","article-title":"An extensive overview of the role of lncRNAs generated from immune cells in the etiology of cancer","volume":"133","author":"Luo","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"7636","key":"10.1016\/j.gene.2025.149722_b0225","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature21034","article-title":"mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide","volume":"541","author":"Matsumoto","year":"2017","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.gene.2025.149722_b0230","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1021\/acs.biochem.5b01141","article-title":"Biochemical methods to investigate lncRNA and the influence of lncRNA:Protein complexes on chromatin","volume":"55","author":"McFadden","year":"2016","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.gene.2025.149722_b0235","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/01616412.2020.1834290","article-title":"LINC00943 knockdown attenuates MPP(+)-induced neuronal damage via miR-15b-5p\/RAB3IP axis in SK-N-SH cells","volume":"43","author":"Meng","year":"2021","journal-title":"Neurol. Res."},{"key":"10.1016\/j.gene.2025.149722_b0240","article-title":"Knockdown of BACE1-AS nonprotein-coding transcript modulates beta-amyloid-related hippocampal neurogenesis","volume":"2011","author":"Modarresi","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"issue":"16","key":"10.1016\/j.gene.2025.149722_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/cells11162517","article-title":"Signaling by LncRNAs: structure, cellular homeostasis, and disease pathology","volume":"11","author":"Nadhan","year":"2022","journal-title":"Cells"},{"issue":"20","key":"10.1016\/j.gene.2025.149722_b0250","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1038\/emboj.2012.251","article-title":"Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles","volume":"31","author":"Naganuma","year":"2012","journal-title":"EMBO J."},{"issue":"18","key":"10.1016\/j.gene.2025.149722_b0255","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1007\/s00018-012-0973-x","article-title":"Paraspeckle nuclear bodies\u2013useful uselessness?","volume":"69","author":"Nakagawa","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.gene.2025.149722_b0260","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2174\/0929866525666180809142326","article-title":"Insights into the noncoding RNA-encoded peptides","volume":"25","author":"Pan","year":"2018","journal-title":"Protein Pept. Lett."},{"issue":"33","key":"10.1016\/j.gene.2025.149722_b0265","doi-asserted-by":"crossref","first-page":"34658","DOI":"10.18632\/oncotarget.5778","article-title":"Wnt activated \u03b2-catenin and YAP proteins enhance the expression of non-coding RNA component of RNase MRP in colon cancer cells","volume":"6","author":"Park","year":"2015","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.gene.2025.149722_b0270","article-title":"NEAT1 and paraspeckles in cancer development and chemoresistance. non-coding","volume":"6","author":"Pisani","year":"2020","journal-title":"RNA"},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111614","article-title":"Downregulated lncRNA-SNHG1 enhances autophagy and prevents cell death through the miR-221\/222 \/p27\/mTOR pathway in Parkinson's disease","volume":"384","author":"Qian","year":"2019","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.gene.2025.149722_b0280","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2019.03.057","article-title":"Parkinson's disease: mechanisms, translational models and management strategies","volume":"226","author":"Raza","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2025.149722_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122850","article-title":"Revealing the role of serum exosomal novel long non-coding RNA NAMPT-AS as a promising diagnostic\/prognostic biomarker in colorectal cancer patients","volume":"352","author":"Rizk","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0290","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41467-022-28295-8","article-title":"A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis","volume":"13","author":"Robertson","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2025.149722_b0295","doi-asserted-by":"crossref","unstructured":"Rostagno, A.A., 2022. Pathogenesis of Alzheimer's disease. Int. J. Mol. Sci. 24(1). Doi: 10.3390\/ijms24010107.","DOI":"10.3390\/ijms24010107"},{"key":"10.1016\/j.gene.2025.149722_b0300","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.853180","article-title":"The emerging roles of the \u03b2-secretase BACE1 and the long non-coding RNA BACE1-AS in human diseases: a focus on neurodegenerative diseases and cancer","volume":"14","author":"Sayad","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.gene.2025.149722_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2022.102270","article-title":"Amyloid \u03b2, Tau, and \u03b1-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases","volume":"214","author":"Sengupta","year":"2022","journal-title":"Prog. Neurobiol."},{"issue":"8","key":"10.1016\/j.gene.2025.149722_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13081124","article-title":"Resveratrol promotes autophagy to improve neuronal injury in Parkinson's disease by regulating SNHG1\/miR-128-3p\/SNCA axis","volume":"13","author":"Shen","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.gene.2025.149722_b0315","article-title":"Upregulated Linc01836 in serum promisingly serving as a diagnostic and prognostic biomarker for colorectal cancer","volume":"13","author":"Shen","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"15","key":"10.1016\/j.gene.2025.149722_b0320","doi-asserted-by":"crossref","first-page":"8243","DOI":"10.1093\/nar\/gkaa630","article-title":"Transcriptional interference at tandem lncRNA and protein-coding genes: an emerging theme in regulation of cellular nutrient homeostasis","volume":"48","author":"Shuman","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0325","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/0113816128277350231219062154","article-title":"Differential signaling pathways in medulloblastoma: nano-biomedicine targeting non-coding epigenetics to improve current and future therapeutics","volume":"30","author":"Sokolov","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.gene.2025.149722_b0330","doi-asserted-by":"crossref","unstructured":"Spreafico, M., Grillo, B., Rusconi, F., Battaglioli, E., Venturin, M., 2018. Multiple layers of CDK5R1 regulation in alzheimer's disease implicate long non-coding RNAs. Int. J. Mol. Sci. 19(7). Doi: 10.3390\/ijms19072022.","DOI":"10.3390\/ijms19072022"},{"key":"10.1016\/j.gene.2025.149722_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147814","article-title":"LINC00943 acts as miR-338-3p sponge to promote MPP(+)-induced SK-N-SH cell injury by directly targeting SP1 in Parkinson's disease","volume":"1782","author":"Sun","year":"2022","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.gene.2025.149722_b0340","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.neuron.2019.01.039","article-title":"Huntingtin lowering strategies for disease modification in Huntington's disease","volume":"101","author":"Tabrizi","year":"2019","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.gene.2025.149722_b0345","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.molcel.2010.08.011","article-title":"The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation","volume":"39","author":"Tripathi","year":"2010","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.gene.2025.149722_b0350","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1210\/endrev\/bnz005","article-title":"The role of sex and sex hormones in neurodegenerative diseases","volume":"41","author":"Vegeto","year":"2020","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.gene.2025.149722_b0355","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10735-020-09931-3","article-title":"LncRNA SNHG1 promotes neuronal injury in Parkinson's disease cell model by miR-181a-5p\/CXCL12 axis","volume":"52","author":"Wang","year":"2021","journal-title":"J. Mol. Histol."},{"issue":"10","key":"10.1016\/j.gene.2025.149722_b0360","doi-asserted-by":"crossref","first-page":"851","DOI":"10.21037\/atm-21-1613","article-title":"Long non-coding RNA SNHG1 mediates neuronal damage in Parkinson's disease model cells by regulating miR-216a-3p\/Bcl-2-associated X protein","volume":"9","author":"Wang","year":"2021","journal-title":"Ann. Translat. Med."},{"key":"10.1016\/j.gene.2025.149722_b0365","article-title":"Long noncoding RNAs in the regulation of oxidative stress","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0370","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jcp.30556","article-title":"LncRNA NEAT1 induces autophagy through epigenetic regulation of autophagy-related geneexpression in neuroglial cells","volume":"237","author":"Wang","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0375","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40035-022-00330-0","article-title":"Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases","volume":"11","author":"Xia","year":"2022","journal-title":"Translat. Neurodegenerat."},{"key":"10.1016\/j.gene.2025.149722_b0380","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2147\/NDT.S286778","article-title":"Long noncoding RNA SNHG1 knockdown ameliorates apoptosis, oxidative stress and inflammation in models of Parkinson's disease by inhibiting the miR-125b-5p\/MAPK1 axis","volume":"17","author":"Xiao","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.gene.2025.149722_b0385","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8181374","article-title":"LincRNA-p21 inhibits cell viability and promotes cell apoptosis in Parkinson's disease through activating \u03b1-synuclein expression","volume":"2018","author":"Xu","year":"2018","journal-title":"Biomed Res. Int."},{"issue":"5","key":"10.1016\/j.gene.2025.149722_b0390","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.molcel.2010.03.021","article-title":"Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a","volume":"38","author":"Yap","year":"2010","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.gene.2025.149722_b0395","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41419-018-0821-5","article-title":"A lincRNA-p21\/miR-181 family feedback loop regulates microglial activation during systemic LPS- and MPTP- induced neuroinflammation","volume":"9","author":"Ye","year":"2018","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.gene.2025.149722_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2021.107704","article-title":"Crystal structure of human RPP20-RPP25 proteins in complex with the P3 domain of lncRNA RMRP","volume":"213","author":"Yin","year":"2021","journal-title":"J. Struct. Biol."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0405","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12935-023-03018-1","article-title":"LncRNA SNHG1: role in tumorigenesis of multiple human cancers","volume":"23","author":"Zeng","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.gene.2025.149722_b0410","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jchemneu.2019.04.001","article-title":"BACE1-AS prevents BACE1 mRNA degradation through the sequestration of BACE1-targeting miRNAs","volume":"98","author":"Zeng","year":"2019","journal-title":"J. Chem. Neuroanat."},{"issue":"16","key":"10.1016\/j.gene.2025.149722_b0415","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1080\/15384101.2018.1509622","article-title":"LncRNA DGCR5 suppresses neuronal apoptosis to improve acute spinal cord injury through targeting PRDM5","volume":"17","author":"Zhang","year":"2018","journal-title":"Cell Cycle (Georgetown Tex.)"},{"issue":"7","key":"10.1016\/j.gene.2025.149722_b0420","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1007\/s11011-022-01034-0","article-title":"A novel LINC00943\/miR-671-5p\/ELAVL1 ceRNA crosstalk regulates MPP(+) toxicity in SK-N-SH cells","volume":"37","author":"Zhang","year":"2022","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.gene.2025.149722_b0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40659-019-0267-y","article-title":"SNHG1 promotes MPP(+)-induced cytotoxicity by regulating PTEN\/AKT\/mTOR signaling pathway in SH-SY5Y cells via sponging miR-153-3p","volume":"53","author":"Zhao","year":"2020","journal-title":"Biol. Res."},{"issue":"22","key":"10.1016\/j.gene.2025.149722_b0430","first-page":"23233","article-title":"NEAT1 regulates microtubule stabilization via FZD3\/GSK3\u03b2\/P-tau pathway in SH-SY5Y cells and APP\/PS1 mice","volume":"12","author":"Zhao","year":"2020","journal-title":"Aging"},{"issue":"9","key":"10.1016\/j.gene.2025.149722_b0435","first-page":"5940","article-title":"Long noncoding RNA MALAT1 and its target microRNA-125b are potential biomarkers for Alzheimer's disease management via interactions with FOXQ1, PTGS2 and CDK5","volume":"12","author":"Zhuang","year":"2020","journal-title":"Am. J. Transl. Res."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:05:55Z","timestamp":1772805955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925005116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":87,"alternative-id":["S0378111925005116"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149722","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective mechanism of LincRNA in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149722"}}