{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:45:47Z","timestamp":1792021547703,"version":"4.4.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2024ZZTS0161"],"award-info":[{"award-number":["2024ZZTS0161"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002767","name":"China Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2023SK4018"],"award-info":[{"award-number":["2023SK4018"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ8235"],"award-info":[{"award-number":["2024JJ8235"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ8249"],"award-info":[{"award-number":["2024JJ8249"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873762"],"award-info":[{"award-number":["81873762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.gene.2025.149724","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:14:39Z","timestamp":1755098079000},"page":"149724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Exploring PTX3: a promising diagnostic marker and therapeutic target in neurology"],"prefix":"10.1016","volume":"969","author":[{"given":"Hong","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangxin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-1664","authenticated-orcid":false,"given":"Liqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149724_b0005","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3389\/fimmu.2019.00712","article-title":"The long pentraxin PTX3 as a link between innate immunity, tissue remodeling, and cancer","volume":"10","author":"Doni","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2025.149724_b0010","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cdd.2009.195","article-title":"Molecular mechanisms of late apoptotic\/necrotic cell clearance","volume":"17","author":"Poon","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2025.149724_b0015","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/physrev.00016.2017","article-title":"PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer","volume":"98","author":"Garlanda","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.gene.2025.149724_b0020","article-title":"Progress in the study of pentraxin-3(PTX-3) as a biomarker for sepsis","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.gene.2025.149724_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102163","article-title":"Pentraxin 3: a promising therapeutic target for cardiovascular diseases","volume":"93","author":"Ye","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.gene.2025.149724_b0030","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1007\/s10238-023-01137-7","article-title":"Role of long pentraxin PTX3 in cancer","volume":"23","author":"Li","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.gene.2025.149724_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1146017","article-title":"The crossroad between autoimmune disorder, tissue remodeling and cancer of the thyroid: the long pentraxin 3 (PTX3)","volume":"14","author":"Chiari","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.gene.2025.149724_b0040","doi-asserted-by":"crossref","first-page":"15302","DOI":"10.3390\/ijms232315302","article-title":"Insights into the relationship between pentraxin-3 and cancer","volume":"23","author":"Bogdan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2025.149724_b0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.12688\/amrcopenres.12875.1","article-title":"Pentraxin 3 regulates neutrophil infiltration to the brain during neuroinflammation","volume":"1","author":"Rajkovic","year":"2019","journal-title":"AMRC Open Res"},{"key":"10.1016\/j.gene.2025.149724_b0050","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neurobiolaging.2010.09.017","article-title":"CCAAT\/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells","volume":"33","author":"Ko","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.gene.2025.149724_b0055","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100408RR","article-title":"Pentraxin 3 secreted by human adipose-derived stem cells promotes dopaminergic neuron repair in Parkinson's disease via the inhibition of apoptosis","volume":"35","author":"Lian","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2025.149724_b0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/SHK.0b013e31817fd543","article-title":"Pentraxin 3 and C-reactive protein in severe meningococcal disease","volume":"31","author":"Sprong","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.gene.2025.149724_b0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jneuroim.2013.04.009","article-title":"The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas","volume":"260","author":"Locatelli","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.gene.2025.149724_b0070","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11060-016-2168-z","article-title":"Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo","volume":"129","author":"Tung","year":"2016","journal-title":"J. Neurooncol"},{"key":"10.1016\/j.gene.2025.149724_b0075","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/NEN.0b013e3182a776bf","article-title":"Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions","volume":"72","author":"Bsibsi","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.gene.2025.149724_b0080","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.4049\/jimmunol.150.5.1804","article-title":"TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins","volume":"150","author":"Lee","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.gene.2025.149724_b0085","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1074\/jbc.272.13.8172","article-title":"Characterization of the promoter for the human long pentraxin PTX3. Role of NF-kappaB in tumor necrosis factor-alpha and interleukin-1beta regulation","volume":"272","author":"Basile","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2025.149724_b0090","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/ATVBAHA.111.243998","article-title":"Long pentraxin 3\/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis","volume":"32","author":"Leali","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.gene.2025.149724_b0095","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2208144119","article-title":"PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation","volume":"119","author":"Noone","year":"2022","journal-title":"PNAS"},{"key":"10.1016\/j.gene.2025.149724_b0100","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899529","article-title":"Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and\u03b21-integrin","volume":"38","author":"Fossati","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2025.149724_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113946","article-title":"Pentraxin 3 promotes microglial M2 polarization and excitatory synapse formation in the hippocampus in depression","volume":"146","author":"Xu","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.gene.2025.149724_b0110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s12974-020-02022-w","article-title":"K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway","volume":"17","author":"Ham","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.gene.2025.149724_b0115","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.3390\/ijms25105550","article-title":"Inhibition of amyloid-\u03b2 (A\u03b2)-induced cognitive impairment and neuroinflammation in CHI3L1 knockout mice through downregulation of ERK-PTX3 pathway","volume":"25","author":"Ham","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2025.149724_b0120","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3390\/cancers11091277","article-title":"Long pentraxin-3 follows and modulates bladder cancer progression","volume":"11","author":"Matarazzo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gene.2025.149724_b0125","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.3390\/cancers14184438","article-title":"Pan-cancer analysis of pentraxin 3: a potential biomarker of COVID-19","volume":"14","author":"Zhou","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gene.2025.149724_b0130","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1016\/j.apsb.2022.09.012","article-title":"Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-\u03baB \/IL-6\/STAT3 and JNK\/PTX3 pathways","volume":"12","author":"Li","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.gene.2025.149724_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147752","article-title":"Enhanced expression of pentraxin-3 in glioblastoma cells correlates with increased invasion and IL8-VEGF signaling axis","volume":"1776","author":"Wesley","year":"2022","journal-title":"Brain Res."},{"key":"10.1016\/j.gene.2025.149724_b0140","first-page":"624","article-title":"SPOCD1 promotes the proliferation and metastasis of glioma cells by up-regulating PTX3","volume":"8","author":"Liu","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.gene.2025.149724_b0145","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1111\/cns.14213","article-title":"Upregulation of the ZNF148\/PTX3 axis promotes malignant transformation of dendritic cells in glioma stem-like cells microenvironment","volume":"29","author":"Cheng","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.gene.2025.149724_b0150","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1080\/15548627.2023.2165757","article-title":"PRMT1 driven PTX3 regulates ferritinophagy in glioma","volume":"19","author":"Lathoria","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.gene.2025.149724_b0155","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1084\/jem.20141268","article-title":"An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode","volume":"212","author":"Doni","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2025.149724_b0160","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3389\/fimmu.2018.00417","article-title":"The long pentraxin 3 plays a role in bone turnover and repair","volume":"9","author":"Gr\u010devi\u0107","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2025.149724_b0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40635-017-0126-5","article-title":"Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice","volume":"5","author":"Mauri","year":"2017","journal-title":"Intensive Care Med. Exp."},{"key":"10.1016\/j.gene.2025.149724_b0170","article-title":"Corrigendum to \u201cVascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation\u201d [Biochim. Biophys. Acta, 1862 (2016) 1182-1190]","volume":"262","author":"Bonacina","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis 1865"},{"key":"10.1016\/j.gene.2025.149724_b0175","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1007\/s12035-023-03207-z","article-title":"Astrocytic Cebpd regulates pentraxin 3 expression to promote fibrotic scar formation after spinal cord injury","volume":"60","author":"Wang","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.gene.2025.149724_b0180","doi-asserted-by":"crossref","DOI":"10.1007\/s11010-025-05259-2","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes inhibit inflammation and fibrotic scar formation after intracerebral hemorrhage","author":"Zhang","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.gene.2025.149724_b0185","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/jcbfm.2013.224","article-title":"The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury","volume":"34","author":"Rodriguez-Grande","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.gene.2025.149724_b0190","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/STROKEAHA.115.012133","article-title":"Astrocyte-derived pentraxin 3 supports blood-brain barrier integrity under acute phase of stroke","volume":"47","author":"Shindo","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.gene.2025.149724_b0195","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.atherosclerosis.2011.11.036","article-title":"Pentraxin 3: a novel and independent prognostic marker in ischemic stroke","volume":"220","author":"Ryu","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.gene.2025.149724_b0200","doi-asserted-by":"crossref","DOI":"10.1177\/17562864241243274","article-title":"Differential blood-based biomarkers of subcortical and deep brain small vessel disease","volume":"17","author":"Hervella","year":"2024","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.gene.2025.149724_b0205","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3389\/fneur.2019.01365","article-title":"Pentraxin 3, TNF-\u03b1, and LDL-C are associated with carotid artery stenosis in patients with ischemic stroke","volume":"10","author":"Yi","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.gene.2025.149724_b0210","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/jnr.23616","article-title":"Human umbilical cord blood-derived mesenchymal stem cells improve functional recovery through thrombospondin1, pantraxin3, and vascular endothelial growth factor in the ischemic rat brain","volume":"93","author":"Park","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.gene.2025.149724_b0215","article-title":"Synergic neuroprotection between ligusticum chuanxiong hort and borneol against ischemic stroke by neurogenesis via modulating reactive astrogliosis and maintaining the blood-brain barrier","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.gene.2025.149724_b0220","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3390\/v11100966","article-title":"Persistent infection with herpes simplex Virus 1 and Alzheimer's disease-a call to study how variability in both virus and host may impact disease","volume":"11","author":"Mangold","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.gene.2025.149724_b0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13024-024-00772-2","article-title":"Proteomic analysis of APOE\u03b54 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience","volume":"19","author":"Walker","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.gene.2025.149724_b0230","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jneuroim.2010.07.001","article-title":"Analysis of glial secretome: the long pentraxin PTX3 modulates phagocytic activity of microglia","volume":"229","author":"Jeon","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.gene.2025.149724_b0235","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.845542","article-title":"Proficiency of extracellular vesicles from hiPSC-derived neural stem cells in modulating proinflammatory human microglia: role of pentraxin-3 and miRNA-21-5p","volume":"15","author":"Upadhya","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.gene.2025.149724_b0240","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/jgs.14140","article-title":"Inflammatory biomarkers and cognitive decline: the ginkgo evaluation of memory study","volume":"64","author":"Sharma","year":"2016","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.gene.2025.149724_b0245","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/gerona\/glq030","article-title":"Plasma Pentraxin 3, but not high-sensitivity C-reactive protein, is a useful inflammatory biomarker for predicting cognitive impairment in elderly hypertensive patients","volume":"65","author":"Yano","year":"2010","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.gene.2025.149724_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110133","article-title":"Dopaminergic system and neurons: role in multiple neurological diseases","volume":"260","author":"Chen","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.gene.2025.149724_b0255","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1007\/s12035-023-03392-x","article-title":"Orally induced high serum level of trimethylamine N-oxide worsened glial reaction and neuroinflammation on MPTP-induced acute Parkinson's disease model mice","volume":"60","author":"Qiao","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.gene.2025.149724_b0260","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/mds.23871","article-title":"Increases of pentraxin 3 plasma levels in patients with Parkinson's disease","volume":"26","author":"Lee","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.gene.2025.149724_b0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0282004","article-title":"Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: a retrospective cohort study","volume":"18","author":"Thomsen","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2025.149724_b0270","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12887-024-05315-8","article-title":"Pentraxin 3: a novel biomarker in pediatric central nervous system infections","volume":"25","author":"El-Kady","year":"2025","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.gene.2025.149724_b0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120807","article-title":"Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant","volume":"10","author":"Bottazzi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2025.149724_b0280","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00430-023-00770-z","article-title":"Pentraxin 3, a serum biomarker in human T-cell lymphotropic virus type-1-associated myelopathy patients and asymptomatic carriers","volume":"212","author":"Manzarinejad","year":"2023","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.gene.2025.149724_b0285","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/glia.21136","article-title":"The brain tumor microenvironment","volume":"59","author":"Charles","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.gene.2025.149724_b0290","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/CJP.CJP_3_19","article-title":"Low expression of pentraxin 3 and nuclear factor-like 2 implying a relatively longer overall survival time in gliomas","volume":"62","author":"Ke","year":"2019","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.gene.2025.149724_b0295","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/jnen\/nlaa088","article-title":"Expression profiling of primary and recurrent glioblastomas reveals a reduced Level of Pentraxin 3 in recurrent glioblastomas","volume":"79","author":"Petterson","year":"2020","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.gene.2025.149724_b0300","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/eji.201545950","article-title":"Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease","volume":"46","author":"Ummenthum","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.gene.2025.149724_b0305","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1177\/1352458512457845","article-title":"Increased plasma levels of pentraxin 3 in patients with multiple sclerosis and neuromyelitis optica","volume":"19","author":"Wang","year":"2013","journal-title":"Mult. Scler."},{"key":"10.1016\/j.gene.2025.149724_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.105004","article-title":"A comparison of serum inflammatory parameters in progressive forms of multiple sclerosis","volume":"79","author":"Nowak-Kiczmer","year":"2023","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.gene.2025.149724_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577385","article-title":"12-months prospective Pentraxin-3 and metabolomic evaluation in multiple sclerosis patients treated with glatiramer acetate","volume":"348","author":"Signoriello","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.gene.2025.149724_b0320","doi-asserted-by":"crossref","first-page":"9616","DOI":"10.1038\/s41598-021-89032-7","article-title":"Long pentraxin PTX3 is upregulated systemically and centrally after experimental neurotrauma, but its depletion leaves unaltered sensorimotor deficits or histopathology","volume":"11","author":"Oggioni","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2025.149724_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113865","article-title":"Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice","volume":"346","author":"Pedragosa","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.gene.2025.149724_b0330","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00134-010-2075-2","article-title":"Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm","volume":"37","author":"Zanier","year":"2011","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.gene.2025.149724_b0335","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/brainsci12050648","article-title":"Pentraxin-3 in the spinal dorsal horn upregulates nectin-1 expression in neuropathic pain after spinal nerve damage in male mice","volume":"12","author":"Zhu","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.gene.2025.149724_b0340","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3390\/cells10081943","article-title":"Activation of neuroprotective microglia and astrocytes at the lesion site and in the adjacent segments is crucial for spontaneous locomotor recovery after spinal cord injury","volume":"10","author":"Kisuck\u00e1","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.gene.2025.149724_b0345","first-page":"134","article-title":"Inflammatory markers in recent onset psychosis and chronic schizophrenia","volume":"42","author":"Dickerson","year":"2016","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.gene.2025.149724_b0350","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/NMD.0000000000000285","article-title":"Predictors of the onset of schizophrenia in US military personnel","volume":"203","author":"Weber","year":"2015","journal-title":"J. Nerv. Ment. Dis."},{"key":"10.1016\/j.gene.2025.149724_b0355","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.npp.1300307","article-title":"Differential expression of pentraxin 3 in fibroblasts from patients with major depression","volume":"29","author":"Shelton","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.gene.2025.149724_b0360","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/bdi.12281","article-title":"Pentraxin 3 is reduced in bipolar disorder","volume":"17","author":"Dickerson","year":"2015","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.gene.2025.149724_b0365","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/acps.12451","article-title":"Immune alterations in acute bipolar depression","volume":"132","author":"Dickerson","year":"2015","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.gene.2025.149724_b0370","article-title":"Temporal lobe epilepsy semiology","volume":"2012","author":"Blair","year":"2012","journal-title":"Epilepsy Res Treat"},{"key":"10.1016\/j.gene.2025.149724_b0375","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0306-4522(01)00177-4","article-title":"Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration","volume":"105","author":"Ravizza","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.gene.2025.149724_b0380","first-page":"1133","article-title":"Effect of vagus nerve stimulation on blood inflammatory markers in children with drug-resistant epilepsy: a pilot study","volume":"9","author":"Baro","year":"2022","journal-title":"Children (Basel)"},{"key":"10.1016\/j.gene.2025.149724_b0385","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ejmech.2014.03.068","article-title":"Design, synthesis and evaluation of novel diaryl pyrrolopyrimidine and pyrrolothiazine derivatives as inhibitors of tumor necrosis factor stimulated gene-14 (TSG-14) production","volume":"78","author":"Hilmy","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.gene.2025.149724_b0390","doi-asserted-by":"crossref","first-page":"23987","DOI":"10.18632\/oncotarget.4364","article-title":"Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers","volume":"6","author":"Chi","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2025.149724_b0395","doi-asserted-by":"crossref","first-page":"e724","DOI":"10.1002\/ctm2.724","article-title":"Disruption of the pentraxin 3\/CD44 interaction as an efficient therapy for triple-negative breast cancers","volume":"12","author":"Hsiao","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.gene.2025.149724_b0400","first-page":"431","article-title":"Tunicamycin enhances the suppressive effects of cisplatin on lung cancer growth through PTX3 glycosylation via AKT\/NF-\u03baB signaling pathway","volume":"54","author":"Ahmmed","year":"2019","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.gene.2025.149724_b0405","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3892\/ijo.2023.5602","article-title":"The dual HDAC and PI3K inhibitor, CUDC\u2011907, inhibits tumor growth and stem\u2011like properties by suppressing PTX3 in neuroblastoma","volume":"64","author":"Li","year":"2024","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.gene.2025.149724_b0410","doi-asserted-by":"crossref","first-page":"16171","DOI":"10.3390\/ijms232416171","article-title":"PARP inhibitor inhibits the vasculogenic mimicry through a NF-\u03baB-PTX3 axis signaling in breast cancer cells","volume":"23","author":"Chivot","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2025.149724_b0415","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000496744","article-title":"Enhancement of tissue factor expression in monocyte-derived dendritic cells by pentraxin 3 and its modulation by C1 esterase inhibitor","volume":"179","author":"Kasuda","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.gene.2025.149724_b0420","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.vph.2014.11.008","article-title":"Atorvastatin reduces long pentraxin 3 expression in vascular cells by inhibiting protein geranylgeranylation","volume":"67\u201369","author":"Baetta","year":"2015","journal-title":"Vasc.Pharmacol."},{"key":"10.1016\/j.gene.2025.149724_b0425","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40256-016-0195-y","article-title":"Impact of adding eicosapentaenoic acid to statin therapy on plasma pentraxin 3 level in patients with stable coronary artery disease: a 6-month, randomized controlled study","volume":"17","author":"Tani","year":"2017","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1016\/j.gene.2025.149724_b0430","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/cns.13510","article-title":"Biphasic roles of pentraxin 3 in cerebrovascular function after white matter stroke","volume":"27","author":"Shindo","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.gene.2025.149724_b0435","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s12012-021-09671-0","article-title":"The protective role of the long pentraxin PTX3 in spontaneously hypertensive rats with heart failure","volume":"21","author":"Chen","year":"2021","journal-title":"Cardiovasc. Toxicol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192500513X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192500513X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:14:56Z","timestamp":1759007696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811192500513X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":87,"alternative-id":["S037811192500513X"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149724","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring PTX3: a promising diagnostic marker and therapeutic target in neurology","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149724"}}