{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:52:44Z","timestamp":1788580364636,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.gene.2025.149746","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T23:21:16Z","timestamp":1756768876000},"page":"149746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Progress and challenges in the use of Cofilin-1 as a prognostic and predictive biomarker for cancer management"],"prefix":"10.1016","volume":"968","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4822-4956","authenticated-orcid":false,"given":"Mariane Araujo","family":"Branco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Marquezin","family":"Kunst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brasil Silva","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Klamt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.gene.2025.149746_b0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3892\/ol.2022.13529","article-title":"Differentially expressed genes related to lymph node metastasis in advanced laryngeal squamous cell cancers","volume":"24","author":"Bay\u0131r","year":"2022","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.gene.2025.149746_b0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tcb.2010.01.001","article-title":"ADF\/cofilin: a functional node in cell biology","volume":"20","author":"Bernstein","year":"2010","journal-title":"Trends Cell Biol."},{"issue":"35","key":"10.1016\/j.gene.2025.149746_b0015","doi-asserted-by":"crossref","first-page":"24097","DOI":"10.18632\/oncotarget.25303","article-title":"Cofilin-1 levels and intracellular localization are associated with melanoma prognosis in a cohort of patients","volume":"9","author":"Bracalente","year":"2018","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.gene.2025.149746_b0020","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrm3609","article-title":"Functions of cofilin in cell locomotion and invasion","volume":"14","author":"Bravo-Cordero","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.gene.2025.149746_b0025","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.18632\/oncotarget.3102","article-title":"A three-protein signature and clinical outcome in esophageal squamous cell carcinoma","volume":"6","author":"Cao","year":"2015","journal-title":"Oncotarget"},{"issue":"15","key":"10.1016\/j.gene.2025.149746_b0030","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1002\/cncr.25125","article-title":"CFL1 expression levels as a prognostic and drug resistance marker in non-small cell lung cancer","volume":"116","author":"Castro","year":"2010","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.gene.2025.149746_b0035","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1002\/jcp.29562","article-title":"Overexpression of CFL1 in gastric cancer and the effects of its silencing by siRNA with a nanoparticle delivery system in the gastric cancer cell line","volume":"235","author":"Daryabari","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.gene.2025.149746_b0040","unstructured":"Estimate | 2023 \u2013 Cancer Incidence in Brazil. Rio de Janeiro: INCA, [Internet], 2022. Available from: http:\/\/www.inca.gov.br."},{"issue":"9","key":"10.1016\/j.gene.2025.149746_b0050","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1021\/pr8000404","article-title":"Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers","volume":"7","author":"Giusti","year":"2008","journal-title":"J. Proteome Res."},{"issue":"4","key":"10.1016\/j.gene.2025.149746_b0055","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1007\/s13277-014-2930-9","article-title":"MDA-9 and GRP78 as potential diagnostic biomarkers for early detection of melanoma metastasis","volume":"36","author":"Guan","year":"2015","journal-title":"Tumor Biol."},{"issue":"9","key":"10.1016\/j.gene.2025.149746_b0060","first-page":"1723","article-title":"Differential expression pattern of epithelial mesenchymal transition gens: AXL, GAS6, claudin-1, and cofilin-1, in different stages of epithelial ovarian cancer","volume":"48","author":"Hassani","year":"2019","journal-title":"Iran J. Public Health."},{"key":"10.1016\/j.gene.2025.149746_b0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.humpath.2016.06.020","article-title":"Association of epithelial\u2013-mesenchymal transition and nuclear cofilin with advanced urothelial cancer","volume":"57","author":"Hensley","year":"2016","journal-title":"Hum. Pathol."},{"issue":"12","key":"10.1016\/j.gene.2025.149746_b0070","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/dvdy.724","article-title":"Actin cytoskeletal regulation of ciliogenesis in development and disease","volume":"253","author":"Hufft-Martinez","year":"2024","journal-title":"Dev. Dyn."},{"issue":"10","key":"10.1016\/j.gene.2025.149746_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2019.152582","article-title":"Potential predictive value of cofilin-1 for metastasis occurrence in a small cohort of Argentinian patients with mid-low Breslow thickness melanoma","volume":"215","author":"Iba\u00f1ez","year":"2019","journal-title":"Pathol. Res. Pract."},{"issue":"2","key":"10.1016\/j.gene.2025.149746_b0080","first-page":"11","article-title":"The combination of positive anti WDR1 antibodies with negative anti CFL1 antibodies in serum is a poor prognostic factor for patients with esophageal carcinoma","volume":"3","author":"Ito","year":"2023","journal-title":"Med Int (lond)."},{"issue":"43","key":"10.1016\/j.gene.2025.149746_b0085","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000031309","article-title":"The phosphorylation level of Cofilin-1 is related to the pathological subtypes of gastric cancer","volume":"101","author":"Kang","year":"2022","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.gene.2025.149746_b0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4081\/aiua.2016.3.195","article-title":"In the search of novel urine biomarkers for the early diagnosis of prostate cancer. Intracellular or secreted proteins as the target group? where and how to search for possible biomarkers useful in the everyday clinical practice","volume":"88","author":"Katafigioti","year":"2016","journal-title":"Arch. Ital. Urol. Androl."},{"issue":"10","key":"10.1016\/j.gene.2025.149746_b0095","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/ncb1968","article-title":"Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin","volume":"11","author":"Klamt","year":"2009","journal-title":"Nat. Cell. Biol."},{"issue":"3","key":"10.1016\/j.gene.2025.149746_b0100","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10517-019-04534-9","article-title":"Adenylate cyclase-associated protein 1 and cofilin in progression of non-small cell lung cancer","volume":"167","author":"Kolegova","year":"2019","journal-title":"Bull. Exp. Biol. Med."},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0105","first-page":"465","article-title":"Phosphorylation of cofilin-1 enhances paclitaxel resistance of epithelial ovarian cancer cells by inhibiting apoptosis","volume":"34","author":"Li","year":"2021","journal-title":"Biomed. Environ. Sci."},{"issue":"19","key":"10.1016\/j.gene.2025.149746_b0110","article-title":"Remodeling serine synthesis and metabolism via nanoparticles (NPs)-mediated CFL1 silencing to enhance the sensitivity of hepatocellular carcinoma to sorafenib","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci. (Weinh)."},{"issue":"42","key":"10.1016\/j.gene.2025.149746_b0115","doi-asserted-by":"crossref","first-page":"68303","DOI":"10.18632\/oncotarget.11945","article-title":"CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0120","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.18632\/oncotarget.13434","article-title":"LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0125","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3892\/ol.2015.3133","article-title":"Overexpression of cofilin 1 in prostate cancer and the corresponding clinical implications","volume":"9","author":"Lu","year":"2015","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.gene.2025.149746_b0130","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbrc.2016.03.081","article-title":"Aurora kinase a induces papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity","volume":"473","author":"Maimaiti","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.gene.2025.149746_b0135","doi-asserted-by":"crossref","first-page":"791","DOI":"10.21037\/jgo.2018.05.17","article-title":"Study of cofilin 1 gene expression in colorectal cancer","volume":"9","author":"Mousavi","year":"2018","journal-title":"J Gastrointest Oncol."},{"issue":"9","key":"10.1016\/j.gene.2025.149746_b0140","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00432-011-1001-5","article-title":"Validation of cofilin-1 as a biomarker in non-small cell lung cancer: application of quantitative method in a retrospective cohort","volume":"137","author":"M\u00fcller","year":"2011","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.gene.2025.149746_b0145","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.3892\/or.2016.4567","article-title":"Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas","volume":"35","author":"Paricharttanakul","year":"2016","journal-title":"Oncol. Rep."},{"issue":"11","key":"10.1016\/j.gene.2025.149746_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027309","article-title":"Comparative proteomic approach identifies PKM2 and cofilin-1 as potential diagnostic, prognostic and therapeutic targets for pulmonary adenocarcinoma","volume":"6","author":"Peng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2025.149746_b0155","doi-asserted-by":"crossref","unstructured":"Rangel, M.P., Antonangelo, L., Acencio, M.M.P., Faria, C.S., de S\u00e1, V.K., Le\u00e3o, P.S., Farhat, C., Fabro, A.T., Longatto Filho, A., Reis, R.M., Takagaki, T., Capelozzi, V.L., 2018. Detection of sputum cofilin-1 as indicator of malignancy. Braz. J. Med. Biol. Res.; 51(8): e7138. doi: 10.1590\/1414-431x20187138. Epub 2018 May 28. PMID: 29846436; PMCID: PMC5999062.","DOI":"10.1590\/1414-431x20187138"},{"issue":"3","key":"10.1016\/j.gene.2025.149746_b0160","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41585-022-00676-0","article-title":"Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma","volume":"20","author":"Rosellini","year":"2023","journal-title":"Nat. Rev. Urol."},{"issue":"12","key":"10.1016\/j.gene.2025.149746_b0165","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1089\/thy.2018.0254","article-title":"Molecular classification of thyroid nodules with indeterminate cytology: development and validation of a highly sensitive and specific new miRNA-based classifier test using fine-needle aspiration smear slides","volume":"28","author":"Santos","year":"2018","journal-title":"Thyroid"},{"issue":"4","key":"10.1016\/j.gene.2025.149746_b0170","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/cas.13181","article-title":"Immune-complex level of cofilin-1 in sera is associated with cancer progression and poor prognosis in pancreatic cancer","volume":"108","author":"Satoh","year":"2017","journal-title":"Cancer Sci."},{"issue":"2","key":"10.1016\/j.gene.2025.149746_b0175","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12105-019-01040-2","article-title":"Proteomic investigation of malignant major salivary gland tumors","volume":"14","author":"Seccia","year":"2020","journal-title":"Head Neck Pathol."},{"issue":"4","key":"10.1016\/j.gene.2025.149746_b0180","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.200707009","article-title":"Cofilin determines the migration behavior and turning frequency of metastatic cancer cells","volume":"179","author":"Sidani","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gene.2025.149746_b0185","doi-asserted-by":"crossref","unstructured":"Siegel, R.L., Kratzer, T.B., Giaquinto, A.N., Sung, H., Jemal, A., 2025. Cancer statistics. CA Cancer J. Clin. 2025 Jan-Feb;75(1):10-45. doi: 10.3322\/caac.2187Epub 2025 Jan 16. PMID: 39817679; PMCID: PMC11745215.","DOI":"10.3322\/caac.21871"},{"issue":"8","key":"10.1016\/j.gene.2025.149746_b0190","article-title":"Primary cilia, ciliogenesis and the actin cytoskeleton: a little less resorption, a little more actin please","volume":"17","author":"Smith","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.gene.2025.149746_b0195","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12935-021-01770-w","article-title":"Cofilin-1, LIMK1 and SSH1 are differentially expressed in locally advanced colorectal cancer and according to consensus molecular subtypes","volume":"21","author":"Sousa-Squiavinato","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"12","key":"10.1016\/j.gene.2025.149746_b0200","article-title":"Immunopeptidomic profiling of HLA-A2-positive triple negative breast cancer identifies potential immunotherapy target antigens","volume":"18","author":"Ternette","year":"2018","journal-title":"Proteomics"},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0205","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrc2148","article-title":"The cofilin pathway in breast cancer invasion and metastasis","volume":"7","author":"Wang","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.gene.2025.149746_b0210","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41419-020-03316-w","article-title":"Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1\/Cofilin-1 signaling","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0215","first-page":"1595","article-title":"Differential expression of upregulated cofilin-1 and downregulated cofilin-2 characteristic of pancreatic cancer tissues","volume":"26","author":"Wang","year":"2011","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.gene.2025.149746_b0220","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.canlet.2015.02.015","article-title":"Cofilin-phosphatase slingshot-1 L1L (SSH1L) is overr-expressed in pancreatic cancer (PC) and contributes to tumor cell migration","volume":"360","author":"Wang","year":"2015","journal-title":"Cancer Lett."},{"issue":"24","key":"10.1016\/j.gene.2025.149746_b0225","doi-asserted-by":"crossref","first-page":"39131","DOI":"10.18632\/oncotarget.16608","article-title":"Cofilin 1 induces the epithelial\u2013-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0230","doi-asserted-by":"crossref","first-page":"537","DOI":"10.5301\/tj.5000569","article-title":"Study on the significance of Cofilin 1 overexpression in human bladder cancer","volume":"103","author":"Wang","year":"2017","journal-title":"Tumori"},{"issue":"19","key":"10.1016\/j.gene.2025.149746_b0235","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12935-019-0758-5","article-title":"miR-182-5p affects human bladder cancer cell proliferation, migration and invasion through regulating Cofilin 1","volume":"28","author":"Wang","year":"2019","journal-title":"Cancer Cell Int."},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0240","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1442-2050.2009.01035.x","article-title":"The expression of CFL1 and N-WASP in esophageal squamous cell carcinoma and its correlation with clinicopathological features","volume":"23","author":"Wang","year":"2010","journal-title":"Dis. Esophagus"},{"issue":"1\u20132","key":"10.1016\/j.gene.2025.149746_b0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11010-011-1008-x","article-title":"Comparative proteomic and radiobiological analyses in human lung adenocarcinoma cells","volume":"359","author":"Wei","year":"2012","journal-title":"Mol. Cell. Biochem."},{"issue":"10\u201311","key":"10.1016\/j.gene.2025.149746_b0250","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/prca.200800094","article-title":"MALDI-MS derived prognostic protein markers for resected non-small cell lung cancer","volume":"2","author":"Xu","year":"2008","journal-title":"Proteomics Clin. Appl."},{"issue":"9","key":"10.1016\/j.gene.2025.149746_b0255","article-title":"Cofilin: a promising protein implicated in cancer metastasis and apoptosis","volume":"4","author":"Xu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.gene.2025.149746_b0260","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1755-5949.2012.00353.x","article-title":"Over-expression of cofilin-1 and phosphoglycerate kinase 1 in astrocytomas involved in pathogenesis of radioresistance","volume":"18","author":"Yan","year":"2012","journal-title":"CNS Neurosci Ther."},{"issue":"2","key":"10.1016\/j.gene.2025.149746_b0265","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/07357907.2012.756113","article-title":"CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell\/adenosquamous carcinomas and adenocarcinomas of gallbladder","volume":"31","author":"Yang","year":"2013","journal-title":"Cancer Invest."},{"key":"10.1016\/j.gene.2025.149746_b0270","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.biopha.2018.09.110","article-title":"MicroRNA-384 inhibits the progression of esophageal squamous cell carcinoma through blockade of the LIMK1\/cofilin signaling pathway by binding to LIMK1","volume":"109","author":"Yu","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.gene.2025.149746_b0275","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00726-010-0733-x","article-title":"Influence of RET\/PTC1 and RET\/PTC3 oncoproteins in radiation-induced papillary thyroid carcinomas on amounts of cytoskeletal protein species","volume":"41","author":"Zeindl-Eberhart","year":"2011","journal-title":"Amino Acids"},{"issue":"9","key":"10.1016\/j.gene.2025.149746_b0280","article-title":"Nujiangexanthone a inhibits hepatocellular carcinoma metastasis via down regulation of cofilin 1","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"21","key":"10.1016\/j.gene.2025.149746_b0285","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.12659\/MSM.895242","article-title":"Expression of cofilin-1 and transgelin in esophageal squamous cell carcinoma","volume":"7","author":"Zhang","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.gene.2025.149746_b0290","doi-asserted-by":"crossref","DOI":"10.1177\/147323001003800331","article-title":"Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumor size","author":"Zhang","year":"2010","journal-title":"J. Int. Med. Res."},{"issue":"4","key":"10.1016\/j.gene.2025.149746_b0295","first-page":"53","article-title":"Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 regulates renal cancer cell migration via cofilin-1","volume":"20","author":"Zhang","year":"2020","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.gene.2025.149746_b0300","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/cr.2015.152","article-title":"NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1","volume":"26","author":"Zhang","year":"2016","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.gene.2025.149746_b0305","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3892\/ol.2012.897","article-title":"Expression of cofilin 1 is positively correlated with the differentiation of human epithelial ovarian cancer","volume":"4","author":"Zhou","year":"2012","journal-title":"Oncol. Lett."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T17:15:29Z","timestamp":1759857329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925005359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":60,"alternative-id":["S0378111925005359"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149746","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progress and challenges in the use of Cofilin-1 as a prognostic and predictive biomarker for cancer management","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149746"}}