{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:14:20Z","timestamp":1789470860692,"version":"build-2803163510"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.gene.2025.149758","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:51:51Z","timestamp":1757541111000},"page":"149758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Genetic susceptibility loci and predictive\/diagnostic model for gallstone disease risk"],"prefix":"10.1016","volume":"969","author":[{"given":"Lili","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3686-5404","authenticated-orcid":false,"given":"Shuang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149758_b0010","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1038\/s41467-021-24705-5","article-title":"Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia","volume":"12","author":"Ajiro","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2025.149758_b0015","first-page":"502","article-title":"Rapid identification of seven common ABO alleles by two-dimensional polymerase chain reaction technology","volume":"50","author":"Chen","year":"2023","journal-title":"Transfus. Med. Hemother."},{"key":"10.1016\/j.gene.2025.149758_b0020","first-page":"521","article-title":"Novel insights into causal effects of serum lipids and lipid-modifying targets on cholelithiasis","volume":"73","author":"Chen","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.gene.2025.149758_b0025","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/hep.32183","article-title":"Insights into modifiable risk factors of cholelithiasis: a Mendelian randomization study","volume":"75","author":"Chen","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.gene.2025.149758_b0035","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2018.12.015","article-title":"Predicting splicing from primary sequence with deep learning","volume":"176","author":"Jaganathan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.gene.2025.149758_b0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/j.gastro.2016.04.007","article-title":"Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies","volume":"151","author":"Joshi","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gene.2025.149758_b0045","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1016\/j.cell.2022.09.031","article-title":"En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH","volume":"185","author":"Kimura","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.gene.2025.149758_b0055","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.5009\/gnl230494","article-title":"Gallstone dissolution effects of combination therapy with n-3 polyunsaturated fatty acids and ursodeoxycholic acid: a randomized, prospective, preliminary clinical trial","volume":"18","author":"Lee","year":"2024","journal-title":"Gut Liver"},{"key":"10.1016\/j.gene.2025.149758_b0065","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41580-022-00545-z","article-title":"The physiology of alternative splicing","volume":"24","author":"Marasco","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2025.149758_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/genes16030256","article-title":"Genetics of gallstones","volume":"16","author":"Peczula","year":"2025","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.gene.2025.149758_b0075","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/ije\/dyad042","article-title":"Association of gallstone disease with risk of colorectal cancer: a systematic review and meta-analysis of observational studies","volume":"52","author":"Polychronidis","year":"2023","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.gene.2025.149758_b0080","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ejhg.2015.63","article-title":"Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array","volume":"24","author":"Rodriguez","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.gene.2025.149758_b0090","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41598-023-50928-1","article-title":"A novel method for detecting nine hotspot mutations of deafness genes in one tube","volume":"14","author":"Yu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2025.149758_b0095","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1021\/acs.analchem.9b02030","article-title":"High-throughput two-dimensional polymerase chain reaction technology","volume":"92","author":"Zhan","year":"2020","journal-title":"Anal. Chem."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:51:50Z","timestamp":1762303910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925005475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":14,"alternative-id":["S0378111925005475"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149758","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic susceptibility loci and predictive\/diagnostic model for gallstone disease risk","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149758"}}