{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:43:53Z","timestamp":1786553033796,"version":"build-2736575974"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006144","name":"Kerala State Council for Science, Technology and Environment","doi-asserted-by":"publisher","award":["516"],"award-info":[{"award-number":["516"]}],"id":[{"id":"10.13039\/501100006144","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.gene.2025.149806","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T01:21:33Z","timestamp":1759627293000},"page":"149806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Haplotype-based association of CYB5A gene polymorphisms (rs1790834 and rs1790858) with polycystic ovary syndrome in a south Indian cohort"],"prefix":"10.1016","volume":"971","author":[{"given":"Mary","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.P.","family":"Rema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetha","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareena","family":"Gilvaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijo","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Divya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Suresh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.gene.2025.149806_b0005","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3923\/pjbs.2024.526.536","article-title":"Association between NsiI and PmLI insulin receptors on the development of polycystic ovarian syndrome","volume":"27","author":"Abdul-Lateef","year":"2024","journal-title":"Pakistan Journal of Biological Sciences: PJBS."},{"issue":"11","key":"10.1016\/j.gene.2025.149806_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2024.103563","article-title":"Association of FokI, Tru91, and ApaI vitamin D receptor gene polymorphisms with the development of polycystic ovarian syndrome: a molecular genetic study","volume":"36","author":"Abdul-Lateef","year":"2024","journal-title":"Journal of King Saud University-Science."},{"issue":"6","key":"10.1016\/j.gene.2025.149806_b0015","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1074\/jbc.273.6.3158","article-title":"Cytochrome b 5 augments the 17, 20-lyase activity of human P450c17 without direct electron transfer","volume":"273","author":"Auchus","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.gene.2025.149806_b0020","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmu012","article-title":"Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"20","author":"Barry","year":"2014","journal-title":"Hum. Reprod. Update"},{"issue":"2","key":"10.1016\/j.gene.2025.149806_b0025","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/oby.23359","article-title":"Functional variants in cytochrome b5 type a (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity","volume":"30","author":"Day","year":"2022","journal-title":"Obesity"},{"issue":"1","key":"10.1016\/j.gene.2025.149806_b0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13104-025-07232-0","article-title":"Impact of a health coaching intervention on anthropometric indicators, physical activity, and life style of infertile women with polycystic ovary syndrome: a quasi-experimental study","volume":"18","author":"Delavar","year":"2025","journal-title":"BMC. Res. Notes"},{"issue":"13","key":"10.1016\/j.gene.2025.149806_b0035","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/1873-3468.13153","article-title":"Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP 17A1 oxy\u2010complex in the lyase step","volume":"592","author":"Duggal","year":"2018","journal-title":"FEBS Lett."},{"issue":"12","key":"10.1016\/j.gene.2025.149806_b0040","article-title":"Impact of increased oxidative stress on cardiovascular diseases in women with polycystic ovary syndrome","volume":"18","author":"Duic\u0103","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.gene.2025.149806_b0045","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11248-010-9426-1","article-title":"Cytochrome b 5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis","volume":"20","author":"Finn","year":"2011","journal-title":"Transgenic Res."},{"issue":"1","key":"10.1016\/j.gene.2025.149806_b0050","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/humupd\/dmz036","article-title":"Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis","volume":"26","author":"Gunning","year":"2020","journal-title":"Hum. Reprod. Update"},{"issue":"7","key":"10.1016\/j.gene.2025.149806_b0055","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41419-022-05053-8","article-title":"Cytochrome B5 type a alleviates HCC metastasis via regulating STOML2 related autophagy and promoting sensitivity to ruxolitinib","volume":"13","author":"Guo","year":"2022","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.gene.2025.149806_b0060","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2337\/dc18-1738","article-title":"The impact of obesity on the incidence of type 2 diabetes among women with polycystic ovary syndrome","volume":"42","author":"Kakoly","year":"2019","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.gene.2025.149806_b0065","article-title":"Cytogenetic screening of chromosomal abnormalities and genetic analysis of FSH receptor Ala307Thr and Ser680Asn genes in amenorrheic patients","volume":"26","author":"Kanaan","year":"2023","journal-title":"PeerJ"},{"issue":"8","key":"10.1016\/j.gene.2025.149806_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255920","article-title":"Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome","volume":"16","author":"Kargasheh","year":"2021","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.gene.2025.149806_b0075","article-title":"Cross-sectional study of chromosomal aberrations and immunologic factors in Iraqi couples with recurrent pregnancy loss","volume":"7","author":"Khamees","year":"2022","journal-title":"PeerJ"},{"issue":"8","key":"10.1016\/j.gene.2025.149806_b0080","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10815-017-0953-z","article-title":"FSH receptor gene p. Thr307Ala and p. Asn680Ser polymorphisms are associated with the risk of polycystic ovary syndrome","volume":"34","author":"Kim","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"issue":"11","key":"10.1016\/j.gene.2025.149806_b0085","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00228-021-03172-3","article-title":"Lack of association between CYB5A gene rs1790834 polymorphism and the response to leflunomide in women with rheumatoid arthritis","volume":"77","author":"\u0141\u0105czna","year":"2021","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.gene.2025.149806_b0090","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/humrep\/deaa371","article-title":"Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017","volume":"36","author":"Liu","year":"2021","journal-title":"Hum. Reprod."},{"issue":"15","key":"10.1016\/j.gene.2025.149806_b0095","doi-asserted-by":"crossref","first-page":"E1519","DOI":"10.1073\/pnas.1400574111","article-title":"Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype","volume":"111","author":"McAllister","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.gene.2025.149806_b0100","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/er.2010-0013","article-title":"The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders","volume":"32","author":"Miller","year":"2011","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.gene.2025.149806_b0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13075-015-0574-9","article-title":"CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women","volume":"17","author":"Stark","year":"2015","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.gene.2025.149806_b0110","doi-asserted-by":"crossref","DOI":"10.1093\/ejendo\/lvad096","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"189","author":"Teede","year":"2023","journal-title":"Eur. J. Endocrinol."},{"issue":"11","key":"10.1016\/j.gene.2025.149806_b0115","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3389\/fendo.2020.00274","article-title":"PCOS-GWAS susceptibility variants in THADA, INSR, TOX3, and DENND1A are associated with metabolic syndrome or insulin resistance in women with PCOS","volume":"30","author":"Tian","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.gene.2025.149806_b0120","first-page":"181","article-title":"Association between CYP17A1, CYB5A polymorphisms and efficacy of abiraterone acetate\/prednisone treatment in castration-resistant prostate cancer patients","volume":"4","author":"Wu","year":"2020","journal-title":"Pharmacogenomics Pers. Med."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925005955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:05:17Z","timestamp":1786550717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925005955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":24,"alternative-id":["S0378111925005955"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149806","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Haplotype-based association of CYB5A gene polymorphisms (rs1790834 and rs1790858) with polycystic ovary syndrome in a south Indian cohort","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149806"}}