{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:40:26Z","timestamp":1793212826948,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009009","name":"Heilongjiang University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023092203"],"award-info":[{"award-number":["2023092203"]}],"id":[{"id":"10.13039\/501100009009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["PL2024H224"],"award-info":[{"award-number":["PL2024H224"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["81973908"],"award-info":[{"award-number":["81973908"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.gene.2025.149853","type":"journal-article","created":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:47:17Z","timestamp":1761493637000},"page":"149853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Identification of ferroptosis-related genes in dry eye disease and their effects on inflammatory response and immune infiltration"],"prefix":"10.1016","volume":"974","author":[{"given":"Jiadi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-6245","authenticated-orcid":false,"given":"Zhirui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiting","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149853_b0005","doi-asserted-by":"crossref","unstructured":"Barrett T, Troup DB, Wilhite SE, et al. NCBI GEO: mining tens of millions of expression profiles--database and tools update.Nucleic Acids Res. 2007;35(Database issue):D760-D765. doi:10.1093\/nar\/gkl887.","DOI":"10.1093\/nar\/gkl887"},{"issue":"1","key":"10.1016\/j.gene.2025.149853_b0010","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","article-title":"Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade","volume":"18","author":"Charoentong","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2025.149853_b0015","doi-asserted-by":"crossref","unstructured":"Chen M, Rong R, Xia X. Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases.J Neuroinflammation. 2022;19(1):183. Published 2022 Jul 14. doi:10.1186\/s12974-022-02547-2.","DOI":"10.1186\/s12974-022-02547-2"},{"issue":"6","key":"10.1016\/j.gene.2025.149853_b0020","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J Exp Med."},{"key":"10.1016\/j.gene.2025.149853_b0025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling Tumor Infiltrating Immune Cells with CIBERSORT","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods Mol Biol."},{"issue":"D1","key":"10.1016\/j.gene.2025.149853_b0030","doi-asserted-by":"crossref","first-page":"D127","DOI":"10.1093\/nar\/gkz757","article-title":"miRDB: an online database for prediction of functional microRNA targets","volume":"48","author":"Chen","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"14","key":"10.1016\/j.gene.2025.149853_b0035","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","article-title":"GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor","volume":"23","author":"Davis","year":"2007","journal-title":"Bioinformatics."},{"issue":"9","key":"10.1016\/j.gene.2025.149853_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111307","article-title":"A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration","volume":"40","author":"Efraim","year":"2022","journal-title":"Cell Rep."},{"issue":"W1","key":"10.1016\/j.gene.2025.149853_b0045","doi-asserted-by":"crossref","first-page":"W60","DOI":"10.1093\/nar\/gky311","article-title":"GeneMANIA update 2018","volume":"46","author":"Franz","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.gene.2025.149853_b0050","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4274\/tjo.galenos.2019.45538","article-title":"Dry Eye Disease after Cataract Surgery: Study of its Determinants and Risk Factors","volume":"50","author":"Garg","year":"2020","journal-title":"Turk J Ophthalmol."},{"key":"10.1016\/j.gene.2025.149853_b0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics."},{"key":"10.1016\/j.gene.2025.149853_b0060","article-title":"Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases","author":"Huang","year":"2024","journal-title":"Sci Adv."},{"issue":"4","key":"10.1016\/j.gene.2025.149853_b0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"23","key":"10.1016\/j.gene.2025.149853_b0070","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.1002\/cam4.4341","article-title":"Identification of novel subtypes based on ssGSEA in immune-related prognostic signature for tongue squamous cell carcinoma","volume":"10","author":"Jin","year":"2021","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.gene.2025.149853_b0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2025.149853_b0080","doi-asserted-by":"crossref","unstructured":"Li JH, Liu S, Zhou H, et al. starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.Nucleic Acids Res. 2014;42(Database issue):D92-D97. doi:10.1093\/nar\/gkt1248.","DOI":"10.1093\/nar\/gkt1248"},{"issue":"12","key":"10.1016\/j.gene.2025.149853_b0085","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol Cell."},{"issue":"6","key":"10.1016\/j.gene.2025.149853_b0090","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.gene.2025.149853_b0095","doi-asserted-by":"crossref","unstructured":"Ma XH, Liu JH, Liu CY, et al. ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage.Signal Transduct Target Ther. 2022;7(1):288. Published 2022 Aug 15. doi:10.1038\/s41392-022-01090-z.","DOI":"10.1038\/s41392-022-01090-z"},{"issue":"5","key":"10.1016\/j.gene.2025.149853_b0100","first-page":"71","article-title":"The pathophysiology, diagnosis, and treatment of dry eye disease","volume":"112","author":"Messmer","year":"2015","journal-title":"Dtsch Arztebl Int."},{"key":"10.1016\/j.gene.2025.149853_b0105","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12(1):34","author":"Mou","year":"2019","journal-title":"J Hematol Oncol."},{"issue":"6","key":"10.1016\/j.gene.2025.149853_b0110","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/opo.12888","article-title":"The global prevalence of dry eye disease: A Bayesian view","volume":"41","author":"Papas","year":"2021","journal-title":"Ophthalmic Physiol Opt."},{"key":"10.1016\/j.gene.2025.149853_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108294","article-title":"Inflammatory basis for dry eye disease flares","volume":"201","author":"Perez","year":"2020","journal-title":"Exp Eye Res."},{"issue":"11S","key":"10.1016\/j.gene.2025.149853_b0120","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ophtha.2017.07.010","article-title":"The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research","volume":"124","author":"Pflugfelder","year":"2017","journal-title":"Ophthalmology."},{"key":"10.1016\/j.gene.2025.149853_b0125","doi-asserted-by":"crossref","unstructured":"Qian L, Wei W. Identified risk factors for dry eye syndrome: A systematic review and meta-analysis.PLoS One. 2022;17(8):e0271267. Published 2022 Aug 19. doi:10.1371\/journal.pone.0271267.","DOI":"10.1371\/journal.pone.0271267"},{"issue":"7","key":"10.1016\/j.gene.2025.149853_b0130","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2025.149853_b0135","doi-asserted-by":"crossref","unstructured":"Sakai O, Uchida T, Imai H, et al. Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells.FEBS Open Bio. 2016;6(12):1238-1247. Published 2016 Oct 24. doi:10.1002\/2211-5463.12141.","DOI":"10.1002\/2211-5463.12141"},{"issue":"11","key":"10.1016\/j.gene.2025.149853_b0140","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.gene.2025.149853_b0145","doi-asserted-by":"crossref","unstructured":"Shou Y, Yang L, Yang Y, et al. Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation.Cell Death Dis. 2021;12(11):1009. Published 2021 Oct 27. doi:10.1038\/s41419-021-04284-5.","DOI":"10.1038\/s41419-021-04284-5"},{"key":"10.1016\/j.gene.2025.149853_b0150","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.plipres.2018.11.001","article-title":"Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies","volume":"73","author":"Singh","year":"2019","journal-title":"Prog Lipid Res."},{"key":"10.1016\/j.gene.2025.149853_b0155","doi-asserted-by":"crossref","unstructured":"Stelzer G, Rosen N, Plaschkes I, et al. The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses.Curr Protoc Bioinformatics. 2016;54:1.30.1-1.30.33. Published 2016 Jun 20. doi:10.1002\/cpbi.5.","DOI":"10.1002\/cpbi.5"},{"issue":"43","key":"10.1016\/j.gene.2025.149853_b0160","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"D1","key":"10.1016\/j.gene.2025.149853_b0165","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.gene.2025.149853_b0170","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2025.149853_b0175","article-title":"Identification of Ferroptosis-Related Genes in Alzheimer's Disease Based on Bioinformatic Analysis","volume":"16","author":"Wang","year":"2022","journal-title":"Front Neurosci."},{"issue":"2","key":"10.1016\/j.gene.2025.149853_b0180","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system Xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2025.149853_b0185","article-title":"Identification of the prognostic value of ferroptosis-related gene signature in breast cancer patients","volume":"21(1):645","author":"Wang","year":"2021","journal-title":"BMC Cancer."},{"issue":"11","key":"10.1016\/j.gene.2025.149853_b0190","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00109-022-02263-7","article-title":"ATF3 in atherosclerosis: a controversial transcription factor","volume":"100","author":"Wang","year":"2022","journal-title":"J Mol Med (Berl)."},{"issue":"3","key":"10.1016\/j.gene.2025.149853_b0195","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II Diagnostic Methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf."},{"key":"10.1016\/j.gene.2025.149853_b0200","article-title":"TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models","volume":"13(1):676","author":"Wu","year":"2022","journal-title":"Nat Commun."},{"key":"10.1016\/j.gene.2025.149853_b0205","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-0716-0301-7_11","article-title":"Gene Ontology Semantic Similarity Analysis Using GOSemSim","volume":"2117","author":"Yu","year":"2020","journal-title":"Methods Mol Biol."},{"issue":"5","key":"10.1016\/j.gene.2025.149853_b0210","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS."},{"issue":"3","key":"10.1016\/j.gene.2025.149853_b0215","article-title":"Corneal Mucin-Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (Weinh)."},{"issue":"12","key":"10.1016\/j.gene.2025.149853_b0220","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.62.12.13","article-title":"Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease","volume":"62","author":"Zhang","year":"2021","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"10.1016\/j.gene.2025.149853_b0225","article-title":"FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations","volume":"2020: baaa021","author":"Zhou","year":"2020","journal-title":"Database (Oxford)"},{"issue":"10","key":"10.1016\/j.gene.2025.149853_b0230","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.63.10.3","article-title":"AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye","volume":"63","author":"Zuo","year":"2022","journal-title":"Invest Ophthalmol Vis Sci."},{"issue":"14","key":"10.1016\/j.gene.2025.149853_b0235","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.65.14.12","article-title":"Atg5-Mediated Lipophagy Induces Ferroptosis in Corneal Epithelial Cells in Dry Eye Disease","volume":"65","author":"Zuo","year":"2024","journal-title":"Invest Ophthalmol Vis Sci."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925006420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925006420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:29:56Z","timestamp":1777566596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925006420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":47,"alternative-id":["S0378111925006420"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149853","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of ferroptosis-related genes in dry eye disease and their effects on inflammatory response and immune infiltration","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149853","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149853"}}