{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:45:05Z","timestamp":1791999905903,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004920","name":"Royan Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.gene.2025.149945","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T17:08:22Z","timestamp":1766164102000},"page":"149945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A novel candidate missense variant in the catalytic domain of USP26 associated with asthenoteratozoospermia"],"prefix":"10.1016","volume":"982","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-2770","authenticated-orcid":false,"given":"Seyedeh Zahra","family":"Mousavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masomeh","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"McElreavey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Bashamboo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Rastari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab","family":"Rokhsattalab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram Mohammad","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Totonchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2025.149945_b0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"issue":"7","key":"10.1016\/j.gene.2025.149945_b0010","doi-asserted-by":"crossref","first-page":"e1258","DOI":"10.1002\/mgg3.1258","article-title":"Novel mutation in USP26 associated with azoospermia in a Sertoli cell\u2010only syndrome patient","volume":"8","author":"Arafat","year":"2020","journal-title":"Mol. Genet. Genomic Med."},{"key":"10.1016\/j.gene.2025.149945_b0015","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s10815-013-0027-9","article-title":"Ubiquitin-specific protease (USP26) gene alterations associated with male infertility and recurrent pregnancy loss (RPL) in iranian infertile patients","volume":"30","author":"Asadpor","year":"2013","journal-title":"J. Assist. Reprod. Genet."},{"issue":"D1","key":"10.1016\/j.gene.2025.149945_b0020","doi-asserted-by":"crossref","first-page":"D344","DOI":"10.1093\/nar\/gkaa977","article-title":"The InterPro protein families and domains database: 20 years on","volume":"49","author":"Blum","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"15","key":"10.1016\/j.gene.2025.149945_b0025","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.gene.2025.149945_b0030","first-page":"185","article-title":"Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia","volume":"22","author":"Boroujeni","year":"2018","journal-title":"JBRA Assisted Reproduction."},{"key":"10.1016\/j.gene.2025.149945_b0035","doi-asserted-by":"crossref","unstructured":"Bose R, Manku G, Culty M, Wing SS. Ubiquitin\u2013proteasome system in spermatogenesis. Posttranslational protein modifications in the reproductive system. 2014:181\u2013213.","DOI":"10.1007\/978-1-4939-0817-2_9"},{"issue":"5","key":"10.1016\/j.gene.2025.149945_b0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.gene.2025.149945_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1008543","article-title":"PremPS: predicting the impact of missense mutations on protein stability","volume":"16","author":"Chen","year":"2020","journal-title":"PLoS Comput. Biol."},{"issue":"4","key":"10.1016\/j.gene.2025.149945_b0050","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/prot.20810","article-title":"Prediction of protein stability changes for single\u2010site mutations using support vector machines","volume":"62","author":"Cheng","year":"2006","journal-title":"Proteins Struct. Funct. Bioinf."},{"issue":"3","key":"10.1016\/j.gene.2025.149945_b0055","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.fertnstert.2007.06.096","article-title":"Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls","volume":"90","author":"Christensen","year":"2008","journal-title":"Fertil. Steril."},{"issue":"9","key":"10.1016\/j.gene.2025.149945_b0060","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci."},{"issue":"W1","key":"10.1016\/j.gene.2025.149945_b0065","doi-asserted-by":"crossref","first-page":"W60","DOI":"10.1093\/nar\/gky311","article-title":"GeneMANIA update 2018","volume":"46","author":"Franz","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0070","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/bioinformatics\/11.6.681","article-title":"SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments","volume":"11","author":"Geourjon","year":"1995","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.10.026","article-title":"The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids","volume":"25","author":"Hermann","year":"2018","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/humupd\/dmab030","article-title":"A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene\u2013disease relationships","volume":"28","author":"Houston","year":"2022","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"suppl_2","key":"10.1016\/j.gene.2025.149945_b0090","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gkh468","article-title":"Protein structure prediction and analysis using the Robetta server","volume":"32","author":"Kim","year":"2004","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.gene.2025.149945_b0095","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrm2731","article-title":"Breaking the chains: structure and function of the deubiquitinases","volume":"10","author":"Komander","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.gene.2025.149945_b0100","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Cryst."},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0105","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1745-7262.2008.00439.x","article-title":"Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect","volume":"10","author":"Lee","year":"2008","journal-title":"Asian J. Androl."},{"issue":"14","key":"10.1016\/j.gene.2025.149945_b0110","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0115","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.1038\/srep08785","article-title":"Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.gene.2025.149945_b0120","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20191902","article-title":"A novel frameshift mutation in ubiquitin-specific protease 26 gene in a patient with severe oligozoospermia","volume":"40","author":"Li","year":"2020","journal-title":"Biosci. Rep."},{"issue":"4","key":"10.1016\/j.gene.2025.149945_b0125","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4103\/aja2021109","article-title":"The association between mutations in ubiquitin-specific protease 26 (USP26) and male infertility: a systematic review and meta-analysis","volume":"24","author":"Li","year":"2022","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.gene.2025.149945_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.634536","article-title":"Genes regulating spermatogenesis and sperm function associated with rare disorders","volume":"9","author":"Linn","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41380-021-01233-8","article-title":"Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases","volume":"27","author":"Liu","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.gene.2025.149945_b0140","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajhg.2021.01.002","article-title":"Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility","volume":"108","author":"Liu","year":"2021","journal-title":"Am. J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.gene.2025.149945_b0145","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3390\/cells10071594","article-title":"Novel mutations in X-linked, USP26-induced asthenoteratozoospermia and male infertility","volume":"10","author":"Liu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.gene.2025.149945_b0150","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.gene.2017.10.074","article-title":"The impacts of nineteen mutations on the enzymatic activity of USP26","volume":"641","author":"Liu","year":"2018","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.gene.2025.149945_b0155","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1177\/1933719116641758","article-title":"A novel missense mutation in USP26 gene is associated with nonobstructive azoospermia","volume":"23","author":"Ma","year":"2016","journal-title":"Reprod. Sci."},{"issue":"Suppl 9","key":"10.1016\/j.gene.2025.149945_b0160","first-page":"141","article-title":"Epidemiology and risk factors of pancreatic cancer","volume":"89","author":"Mario","year":"2018","journal-title":"Acta Bio Medica: Atenei Parmensis."},{"issue":"15","key":"10.1016\/j.gene.2025.149945_b0165","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1093\/bioinformatics\/bth254","article-title":"PerlPrimer: cross-platform, graphical primer design for standard, bisulphite and real-time PCR","volume":"20","author":"Marshall","year":"2004","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.gene.2025.149945_b0170","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.gene.2025.149945_b0175","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3390\/cells2040732","article-title":"Ubiquitination regulates the morphogenesis and function of sperm organelles","volume":"2","author":"Nakamura","year":"2013","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0180","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1472-6483(10)61119-4","article-title":"Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism","volume":"10","author":"Paduch","year":"2005","journal-title":"Reprod. Biomed. Online"},{"issue":"W1","key":"10.1016\/j.gene.2025.149945_b0185","doi-asserted-by":"crossref","first-page":"W229","DOI":"10.1093\/nar\/gkx439","article-title":"SDM: a server for predicting effects of mutations on protein stability","volume":"45","author":"Pandurangan","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.gene.2025.149945_b0190","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/molehr\/gal063","article-title":"Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26","volume":"12","author":"Ravel","year":"2006","journal-title":"Mol. Hum. Reprod."},{"issue":"5","key":"10.1016\/j.gene.2025.149945_b0195","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.gene.2025.149945_b0200","doi-asserted-by":"crossref","unstructured":"Richburg JH, Myers JL, Bratton SB, editors. The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis. Seminars in cell & developmental biology; 2014: Elsevier.","DOI":"10.1016\/j.semcdb.2014.03.001"},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0205","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.3390\/ijms23063281","article-title":"Insights in post-translational modifications: ubiquitin and SUMO","volume":"23","author":"Salas-Lloret","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0210","doi-asserted-by":"crossref","first-page":"19089","DOI":"10.1038\/s41598-021-98267-3","article-title":"Integration and gene co-expression network analysis of scRNA-seq transcriptomes reveal heterogeneity and key functional genes in human spermatogenesis","volume":"11","author":"Salehi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2025.149945_b0215","unstructured":"sanit\u00e0 Omd. WHO laboratory manual for the examination and processing of human semen: World Health Organization; 2010."},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0220","article-title":"The role of histone ubiquitination during spermatogenesis","volume":"2014","author":"Sheng","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"7\u20138","key":"10.1016\/j.gene.2025.149945_b0225","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cca.2010.12.005","article-title":"Association between ubiquitin-specific protease USP26 polymorphism and male infertility in Chinese men","volume":"412","author":"Shi","year":"2011","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0230","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high\u2010quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"issue":"3","key":"10.1016\/j.gene.2025.149945_b0235","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/sj.ejhg.5201335","article-title":"Possible role of USP26 in patients with severely impaired spermatogenesis","volume":"13","author":"Stouffs","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0240","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1365-2605.2006.00708.x","article-title":"Alterations of the USP26 gene in Caucasian men","volume":"29","author":"Stouffs","year":"2006","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.gene.2025.149945_b0245","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1007\/s00018-015-2030-z","article-title":"The role of deubiquitinating enzymes in spermatogenesis","volume":"72","author":"Suresh","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"D1","key":"10.1016\/j.gene.2025.149945_b0250","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein\u2013protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.gene.2025.149945_b0255","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsd\u00f3ttir","year":"2013","journal-title":"Brief. Bioinform."},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0260","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1472-6483(10)60531-7","article-title":"Gene polymorphisms and male infertility\u2013a meta-analysis and literature review","volume":"15","author":"T\u00fcttelmann","year":"2007","journal-title":"Reprod. Biomed. Online"},{"issue":"1","key":"10.1016\/j.gene.2025.149945_b0265","article-title":"From FastQ data to high\u2010confidence variant calls: the genome analysis toolkit best practices pipeline","volume":"43","author":"Van der Auwera","year":"2013","journal-title":"Curr. Protoc. Bioinformatics"},{"issue":"4","key":"10.1016\/j.gene.2025.149945_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2018.08.007","article-title":"Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098638","article-title":"Ubiquitin specific protease 26 (USP26) expression analysis in human testicular and extragonadal tissues indicates diverse action of USP26 in cell differentiation and tumorigenesis","volume":"9","author":"Wosnitzer","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.gene.2025.149945_b0280","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4103\/1008-682X.129134","article-title":"Association of 370-371insACA, 494T> C, and 1423C> T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis","volume":"16","author":"Xia","year":"2014","journal-title":"Asian J. Androl."},{"issue":"6","key":"10.1016\/j.gene.2025.149945_b0285","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3390\/cells11061058","article-title":"Ubiquitin-proteasome system\u2013regulated protein degradation in spermatogenesis","volume":"11","author":"Xiong","year":"2022","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.gene.2025.149945_b0290","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1039\/b907669g","article-title":"Dissection of USP catalytic domains reveals five common insertion points","volume":"5","author":"Ye","year":"2009","journal-title":"Mol. Biosyst."},{"issue":"2","key":"10.1016\/j.gene.2025.149945_b0295","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/andr.295","article-title":"Evidence from enzymatic and meta\u2010analyses does not support a direct association between USP26 gene variants and male infertility","volume":"3","author":"Zhang","year":"2015","journal-title":"Andrology"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925007358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111925007358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T23:35:32Z","timestamp":1768952132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111925007358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":59,"alternative-id":["S0378111925007358"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2025.149945","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel candidate missense variant in the catalytic domain of USP26 associated with asthenoteratozoospermia","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2025.149945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"149945"}}