{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:26:53Z","timestamp":1769045213829,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001867","name":"Xjenza Malta","doi-asserted-by":"publisher","award":["REP-2024\\u2013064"],"award-info":[{"award-number":["REP-2024\\u2013064"]}],"id":[{"id":"10.13039\/501100001867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.gene.2026.149999","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T16:46:43Z","timestamp":1767631603000},"page":"149999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Computational epitope discovery and in silico design of a bispecific antibody model (COMED hook) to block Plasmodium invasion into erythrocytes"],"prefix":"10.1016","volume":"984","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-4397","authenticated-orcid":false,"given":"Ahmet Efe","family":"K\u00f6seo\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadir","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011f\u00e7e","family":"Duran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cenk","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nezih","family":"Hekim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2026.149999_b0005","doi-asserted-by":"crossref","DOI":"10.1177\/11779322241306215","article-title":"Computational Development of Transmission-Blocking Vaccine Candidates based on Fused Antigens of Pre-and Post-fertilization Gametocytes against Plasmodium falciparum","volume":"19","author":"Adeleke","year":"2025","journal-title":"Bioinf. Biol. Insights"},{"key":"10.1016\/j.gene.2026.149999_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.810398","article-title":"Identification, mapping, and genetic diversity of novel conserved cross-species epitopes of RhopH2 in Plasmodium knowlesi with Plasmodium vivax","volume":"11","author":"Ahmed","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"24","key":"10.1016\/j.gene.2026.149999_b0015","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1093\/bioinformatics\/btab536","article-title":"Organism-specific training improves performance of linear B-cell epitope prediction","volume":"37","author":"Ashford","year":"2021","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.gene.2026.149999_b0020","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/mt.2015.22","article-title":"Intracellular delivery system for antibody\u2013peptide drug conjugates","volume":"23","author":"Berguig","year":"2015","journal-title":"Mol. Ther."},{"issue":"6","key":"10.1016\/j.gene.2026.149999_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021289","article-title":"Identification of a highly antigenic linear B cell epitope within Plasmodium vivax apical membrane antigen 1 (AMA-1)","volume":"6","author":"Bueno","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.gene.2026.149999_b0030","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1074\/mcp.M112.020800","article-title":"High-resolution mapping of linear antibody epitopes using ultrahigh-density peptide microarrays","volume":"11","author":"Buus","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"issue":"2","key":"10.1016\/j.gene.2026.149999_b0035","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00436-019-06561-x","article-title":"Contribution of introns to the species diversity associated with the apicomplexan parasite","volume":"119","author":"Calarco","year":"2020","journal-title":"Neospora Caninum. Parasitol. Res."},{"key":"10.1016\/j.gene.2026.149999_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.734263","article-title":"Studies on activities and chemical characterization of medicinal plants in search for new Antimalarials: a ten year review on Ethnopharmacology","volume":"12","author":"Ceravolo","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.gene.2026.149999_b0045","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s13721-012-0019-1","article-title":"Linear B cell epitope prediction for epitope vaccine design against meningococcal disease and their computational validations through physicochemical properties","volume":"1","author":"Chandra","year":"2012","journal-title":"Netw. Model. Anal. Health Informatics Bioinform."},{"key":"10.1016\/j.gene.2026.149999_b0050","series-title":"Molecular Medical Parasitology","first-page":"89","article-title":"Chapter 5: Antigenic variation in african trypanosomes and malaria","author":"Cross","year":"2003"},{"issue":"10","key":"10.1016\/j.gene.2026.149999_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2024.130674","article-title":"B cell epitope mapping: the journey to better vaccines and therapeutic antibodies","volume":"1868","author":"De Leon","year":"2024","journal-title":"Biochim. Biophys. Acta - Gen. Subj."},{"issue":"6","key":"10.1016\/j.gene.2026.149999_b0060","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1007\/s00894-014-2278-5","article-title":"AllerTOP vol 2 - a server for in silico prediction of allergens","volume":"20","author":"Dimitrov","year":"2014","journal-title":"J. Mol. Model."},{"issue":"39 Suppl 1","key":"10.1016\/j.gene.2026.149999_b0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/bioinformatics\/btad206","article-title":"PlasmoFAB: a benchmark to foster machine learning for Plasmodium falciparum protein antigen candidate prediction","volume":"39","author":"Ditz","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.gene.2026.149999_b0070","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinf."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0075","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41541-020-0196-3","article-title":"Malaria vaccines since 2000: progress, priorities, products","volume":"5","author":"Duffy","year":"2020","journal-title":"npj Vaccines"},{"issue":"2","key":"10.1016\/j.gene.2026.149999_b0080","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2958.2005.05007.x","article-title":"Antigenic variation by protozoan parasites: insights from Babesia bovis","volume":"59","author":"Dzikowski","year":"2006","journal-title":"Mol. Microbiol."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0085","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12936-022-04130-9","article-title":"Why Plasmodium vivax and Plasmodium falciparum are so different? a tale of two clades and their species diversities","volume":"21","author":"Escalante","year":"2022","journal-title":"Malar. J."},{"key":"10.1016\/j.gene.2026.149999_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.852239","article-title":"Shared mechanisms for mutually exclusive expression and antigenic variation by protozoan parasites","volume":"10","author":"Florini","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2026.149999_b0095","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/1471-2164-14-427","article-title":"Variant surface antigens of malaria parasites: functional and evolutionary insights from comparative gene family classification and analysis","volume":"14","author":"Frech","year":"2013","journal-title":"BMC Genomics"},{"issue":"4","key":"10.1016\/j.gene.2026.149999_b0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.30802\/AALAS-CM-24-000019","article-title":"Overview of Plasmodium spp. and animal models in malaria research","volume":"74","author":"Gozalo","year":"2024","journal-title":"Comp. Med."},{"key":"10.1016\/j.gene.2026.149999_b0105","doi-asserted-by":"crossref","unstructured":"Gupta, S., Kapoor, P., Chaudhary, K., Gautam, A., Kumar, R., Open Source Drug Discovery Consortium, et al., 2013. In silico approach for predicting toxicity of peptides and proteins. PloS One. 8 (9), e73957. https:\/\/doi.org\/10.1371\/journal.pone.0073957.","DOI":"10.1371\/journal.pone.0073957"},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0110","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1038\/s41467-022-30133-w","article-title":"Malaria in 2022: increasing challenges, cautious optimism","volume":"13","author":"Jagannathan","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0115","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","volume":"45","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.gene.2026.149999_b0120","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41577-019-0209-5","article-title":"Antibodies against Plasmodium falciparum malaria at the molecular level","volume":"19","author":"Julien","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.gene.2026.149999_b0125","doi-asserted-by":"crossref","DOI":"10.1002\/ece3.11103","article-title":"Population genomic evidence of structured and connected Plasmodium vivax populations under host selection in Latin America","volume":"14","author":"Kattenberg","year":"2024","journal-title":"Ecol. Evol."},{"issue":"2","key":"10.1016\/j.gene.2026.149999_b0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein\u2013protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0135","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41541-023-00786-9","article-title":"A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax","volume":"8","author":"Kunkeaw","year":"2023","journal-title":"npj Vaccines"},{"key":"10.1016\/j.gene.2026.149999_b0140","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41573-019-0028-1","article-title":"Bispecific antibodies: a mechanistic review of the pipeline","volume":"18","author":"Labrijn","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.gene.2026.149999_b0145","doi-asserted-by":"crossref","unstructured":"Luo, S., Su, Y., Peng, X., Wang, S., Peng, J., Ma, J., 2022. Antigen-Specific Antibody Design and Optimization with Diffusion-Based Generative Models for Protein Structures. bioRxiv [Preprint]. https:\/\/doi.org\/10.1101\/2022.07.10.499510.","DOI":"10.1101\/2022.07.10.499510"},{"issue":"7642","key":"10.1016\/j.gene.2026.149999_b0150","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature21060","article-title":"Sterile protection against human malaria by chemoattenuated PfSPZ vaccine","volume":"542","author":"Mordm\u00fcller","year":"2017","journal-title":"Nature"},{"issue":"28","key":"10.1016\/j.gene.2026.149999_b0155","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1074\/jbc.M116.773564","article-title":"The fibrinogen-like domain of FREP1 protein is a broad-spectrum malaria transmission-blocking vaccine antigen","volume":"292","author":"Niu","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0160","doi-asserted-by":"crossref","first-page":"e00027","DOI":"10.1128\/mSphereDirect.00027-19","article-title":"Antibody biomarkers associated with sterile protection induced by controlled human malaria infection under chloroquine prophylaxis","volume":"4","author":"Obiero","year":"2019","journal-title":"mSphere"},{"key":"10.1016\/j.gene.2026.149999_b0165","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/1475-2875-12-328","article-title":"Malarial parasite diversity in chimpanzees: the value of comparative approaches to ascertain the evolution of Plasmodium falciparum antigens","volume":"12","author":"Pacheco","year":"2013","journal-title":"Malar. J."},{"issue":"13","key":"10.1016\/j.gene.2026.149999_b0170","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"12","key":"10.1016\/j.gene.2026.149999_b0175","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.3390\/microorganisms12122575","article-title":"Animal trypanosomiasis: challenges and prospects for new vaccination strategies","volume":"12","author":"Pereira","year":"2024","journal-title":"Microorganisms"},{"issue":"4","key":"10.1016\/j.gene.2026.149999_b0180","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00436-010-2232-0","article-title":"Malaria vector control: from past to future","volume":"108","author":"Raghavendra","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.gene.2026.149999_b0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fimmu.2017.00077","article-title":"Plasmodium vivax cell-traversal protein for ookinetes and sporozoites: naturally acquired humoral immune response and B-cell epitope mapping in Brazilian amazon inhabitants","volume":"8","author":"Rodrigues-da-Silva","year":"2017","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.gene.2026.149999_b0190","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1473-3099(24)00141-5","article-title":"The emergence of artemisinin partial resistance in Africa: how do we respond?","volume":"24","author":"Rosenthal","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.gene.2026.149999_b0195","series-title":"International Conference on Artificial Immune Systems","first-page":"197","article-title":"BcePred: prediction of continuous B-cell epitopes in antigenic sequences using physico-chemical properties","author":"Saha","year":"2004"},{"key":"10.1016\/j.gene.2026.149999_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2025.105733","article-title":"In silico comparative analysis of genetic diversity and natural selection of Plasmodium knowlesi and Plasmodium vivax etramp11. 2 gene","volume":"129","author":"Saif","year":"2025","journal-title":"Infect. Genet. Evol."},{"issue":"17","key":"10.1016\/j.gene.2026.149999_b0205","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302152120","article-title":"The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching","volume":"120","author":"Schneider","year":"2023","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12936-025-05286-w","article-title":"Assessing fitness costs in malaria parasites: a comprehensive review and implications for drug resistance management","volume":"24","author":"Segovia","year":"2025","journal-title":"Malar. J."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12936-020-03548-3","article-title":"Isolation and light chain shuffling of a Plasmodium falciparum AMA1-specific human monoclonal antibody with growth inhibitory activity","volume":"20","author":"Seidel-Greven","year":"2021","journal-title":"Malar. J."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0220","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41564-018-0214-7","article-title":"Vector biology meets disease control: using basic research to fight vector-borne diseases","volume":"4","author":"Shaw","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.gene.2026.149999_b0225","article-title":"Clustal omega","volume":"48","author":"Sievers","year":"2014","journal-title":"Curr. Protoc. Bioinformatics"},{"issue":"4","key":"10.1016\/j.gene.2026.149999_b0230","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1021\/acs.bioconjchem.9b00025","article-title":"Antibody delivery for intracellular targets: emergent therapeutic potential","volume":"30","author":"Singh","year":"2019","journal-title":"Bioconjug. Chem."},{"issue":"10","key":"10.1016\/j.gene.2026.149999_b0235","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41573-023-00772-9","article-title":"Antimalarial drug discovery: progress and approaches","volume":"22","author":"Siqueira-Neto","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.gene.2026.149999_b0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molimm.2015.01.003","article-title":"Alternative molecular formats and therapeutic applications for bispecific antibodies","volume":"67","author":"Spiess","year":"2015","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.gene.2026.149999_b0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009269","article-title":"Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents","volume":"17","author":"Tonkin-Hill","year":"2021","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.gene.2026.149999_b0250","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13071-023-05755-8","article-title":"Malaria therapeutics: are we close enough?","volume":"16","author":"Tripathi","year":"2023","journal-title":"Parasit. Vectors"},{"issue":"4","key":"10.1016\/j.gene.2026.149999_b0255","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1017\/S0031182000085528","article-title":"Antigenic variation in parasites","volume":"88","author":"Turner","year":"1984","journal-title":"Parasitology"},{"issue":"7","key":"10.1016\/j.gene.2026.149999_b0260","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.3390\/pharmaceutics15071916","article-title":"Artificial intelligence in pharmaceutical technology and drug delivery design","volume":"15","author":"Vora","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.gene.2026.149999_b0265","unstructured":"WHO. World malaria report 2024. Geneva, World Health Organization, 2024. Available from: https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2024."},{"key":"10.1016\/j.gene.2026.149999_b0270","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s13071-015-0959-2","article-title":"Paratransgenesis: a promising new strategy for mosquito vector control","volume":"8","author":"Wilke","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.gene.2026.149999_b0275","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/nar\/gky1006","article-title":"The immune epitope database (IEDB): 2018 update","volume":"47","author":"Vita","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2026.149999_b0280","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1093\/nar\/gkv342","article-title":"I-TASSER server: new development for protein structure and function predictions","volume":"43","author":"Yang","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.gene.2026.149999_b0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062249","article-title":"Conformational B-cell epitope prediction on antigen protein structures: a review of current algorithms and comparison with common binding-site prediction methods","volume":"8","author":"Yao","year":"2013","journal-title":"PLoS One"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926000089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926000089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:41:59Z","timestamp":1768992119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926000089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":57,"alternative-id":["S0378111926000089"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.149999","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational epitope discovery and in silico design of a bispecific antibody model (COMED hook) to block Plasmodium invasion into erythrocytes","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.149999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"149999"}}