{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:43:06Z","timestamp":1791970986473,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400033"],"award-info":[{"award-number":["32400033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.gene.2026.150047","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:42:10Z","timestamp":1770943330000},"page":"150047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Kojic acid inhibits melanoma progression by targeting the MYC\u2013CCNA2\/KPNA2 axis"],"prefix":"10.1016","volume":"989","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-8869","authenticated-orcid":false,"given":"Yue","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2026.150047_b0005","article-title":"It's all about plant derived natural phytoconstituents and phytonanomedicine to control skin cancer","volume":"84","author":"Ashique","year":"2023","journal-title":"J. Drug Deliv. Sci. Tec."},{"key":"10.1016\/j.gene.2026.150047_b0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/cosmetics11010021","article-title":"Nanotechnology-enhanced cosmetic application of kojic acid dipalmitate, a kojic acid derivate with improved properties","volume":"11","author":"Ayuhastuti","year":"2024","journal-title":"Cosmetics"},{"key":"10.1016\/j.gene.2026.150047_b0015","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41392-023-01705-z","article-title":"Targeting the RAS\/RAF\/MAPK pathway for cancer therapy: from mechanism to clinical studies","volume":"8","author":"Bahar","year":"2023","journal-title":"Signal Transduct.. Target Ther."},{"key":"10.1016\/j.gene.2026.150047_b0020","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1039\/b603758p","article-title":"From miso, sake and shoyu to cosmetics: a century of science for kojic acid","volume":"23","author":"Bentley","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.gene.2026.150047_b0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1387-2656(07)13010-6","article-title":"Ganoderma lucidum and its pharmaceutically active compounds","volume":"13","author":"Boh","year":"2007","journal-title":"Biotechnol. Annu. Rev."},{"key":"10.1016\/j.gene.2026.150047_b0030","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.2042-7158.1994.tb03253.x","article-title":"Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase","volume":"46","author":"Cabanes","year":"1994","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.gene.2026.150047_b0035","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3390\/pharmaceutics16121571","article-title":"Advances in research of hydrogel microneedle-based delivery systems for disease treatment","volume":"16","author":"Cao","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.gene.2026.150047_b0040","doi-asserted-by":"crossref","unstructured":"Cardoso, R., Valente, R., Souza da Costa, C.H., da S Gon\u00e7alves Vianez, J.L., Jr, S.d.C., K., de Molfetta, F.A. and Nahum Alves, C., 2021. Analysis of kojic acid derivatives as competitive inhibitors of tyrosinase: A molecular modeling approach. Molecules 26, 2875.","DOI":"10.3390\/molecules26102875"},{"key":"10.1016\/j.gene.2026.150047_b0045","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3390\/jof9020259","article-title":"Kojic acid gene clusters and the transcriptional activation mechanism of Aspergillus flavus KojR on expression of clustered genes","volume":"9","author":"Chang","year":"2023","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.gene.2026.150047_b0050","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.3390\/ijms10062440","article-title":"An updated review of tyrosinase inhibitors","volume":"10","author":"Chang","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150047_b0055","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ijbiomac.2018.11.031","article-title":"Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish","volume":"123","author":"Chen","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.gene.2026.150047_b0060","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1248\/bpb.29.655","article-title":"Toxicogenomics of kojic acid on gene expression profiling of A375 human malignant melanoma cells","volume":"29","author":"Cheng","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.gene.2026.150047_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110592","article-title":"Lachnochromonin, a fungal metabolite from Lachnum virgineum, inhibits cell growth and promotes apoptosis in tumor cells through JAK\/STAT3 signaling","volume":"106","author":"Chu","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.gene.2026.150047_b0070","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF gene in human cancer","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150047_b0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","article-title":"The MYC oncogene - the grand orchestrator of cancer growth and immune evasion","volume":"19","author":"Dhanasekaran","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.gene.2026.150047_b0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s13659-024-00452-0","article-title":"Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012-2023)","volume":"14","author":"Evidente","year":"2024","journal-title":"Nat. Prod. Bioprospect."},{"key":"10.1016\/j.gene.2026.150047_b0085","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1039\/C3NP70078J","article-title":"Fungal metabolites with anticancer activity","volume":"31","author":"Evidente","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.gene.2026.150047_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbr.2023.100313","article-title":"Production of kojic acid by Aspergillus species: trends and applications","volume":"45","author":"Felipe","year":"2023","journal-title":"Fungal Biol. Rev."},{"key":"10.1016\/j.gene.2026.150047_b0095","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejso.2016.07.145","article-title":"Immunotherapy in melanoma: Recent advances and future directions","volume":"43","author":"Franklin","year":"2017","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.gene.2026.150047_b0100","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014241","article-title":"MYC activation is a hallmark of cancer initiation and maintenance","volume":"4","author":"Gabay","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.gene.2026.150047_b0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12860-022-00446-1","article-title":"CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression","volume":"23","author":"Geng","year":"2022","journal-title":"BMC Mol. Cell Biol."},{"key":"10.1016\/j.gene.2026.150047_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152115","article-title":"Construction and validation of a lipid metabolism-related genes prognostic signature for skin cutaneous melanoma","volume":"775","author":"Gui","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.gene.2026.150047_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156073","article-title":"A comprehensive and systematic review on Curcumin as a promising candidate for the inhibition of melanoma growth: From pre-clinical evidence to molecular mechanisms of action","volume":"135","author":"Guo","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.gene.2026.150047_b0120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150047_b0125","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.immunol.26.021607.090331","article-title":"PD-1 and its ligands in tolerance and immunity","volume":"26","author":"Keir","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.gene.2026.150047_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/952452","article-title":"Depigmenting effect of Kojic acid esters in hyperpigmented B16F1 melanoma cells","volume":"2012","author":"Lajis","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.gene.2026.150047_b0135","article-title":"Anti-cancer mechanisms of natural isoflavones against melanoma","volume":"10","author":"Liang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.gene.2026.150047_b0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.gene.2026.150047_b0145","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1073\/pnas.082005599","article-title":"Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes","volume":"99","author":"Menssen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.gene.2026.150047_b0150","article-title":"Preparation and evaluation of kojic acid dipalmitate solid lipid nanoparticles","volume":"61","author":"Mohammadi","year":"2021","journal-title":"J Drug Deliv Sci Tec"},{"key":"10.1016\/j.gene.2026.150047_b0155","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1021\/pr7008737","article-title":"Proteomics analysis of kojic acid treated A375 human malignant melanoma cells","volume":"7","author":"Nawarak","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.gene.2026.150047_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17050579","article-title":"Microneedles for melanoma therapy: exploring opportunities and challenges","volume":"17","author":"Nemakhavhani","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.gene.2026.150047_b0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fct.2003.08.008","article-title":"An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one]","volume":"42","author":"Nohynek","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.gene.2026.150047_b0170","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.gene.2026.150047_b0175","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/cosmetics9030064","article-title":"Review on the use of kojic acid-A skin-lightening ingredient","volume":"9","author":"Phasha","year":"2022","journal-title":"Cosmetics"},{"key":"10.1016\/j.gene.2026.150047_b0180","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMra1703481","article-title":"Immune-related adverse events associated with immune checkpoint blockade","volume":"378","author":"Postow","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2026.150047_b0185","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/modpathol.2012.75","article-title":"The role of 8q24 copy number gains and c-MYC expression in amelanotic cutaneous melanoma","volume":"25","author":"Pouryazdanparast","year":"2012","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.gene.2026.150047_b0190","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.biopha.2018.12.006","article-title":"Kojic acid applications in cosmetic and pharmaceutical preparations","volume":"110","author":"Saeedi","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.gene.2026.150047_b0195","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14165","article-title":"The role of topical imiquimod in melanoma cutaneous metastases: a critical review of the literature","volume":"33","author":"Scarf\u00ec","year":"2020","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.gene.2026.150047_b0200","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jare.2021.11.007","article-title":"Diverse host-associated fungal systems as a dynamic source of novel bioactive anthraquinones in drug discovery: current status and future perspectives","volume":"39","author":"Shakour","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.gene.2026.150047_b0205","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s11274-023-03587-3","article-title":"Challenges and advancements in bioprocess intensification of fungal secondary metabolite: kojic acid","volume":"39","author":"Sharma","year":"2023","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.gene.2026.150047_b0210","first-page":"3507","article-title":"Omomyc, a potential Myc dominant negative, enhances Myc-induced apoptosis","volume":"62","author":"Soucek","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2026.150047_b0215","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2026.150047_b0220","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s13555-023-00993-1","article-title":"Topical treatment of melanoma in situ, lentigo maligna, and lentigo maligna melanoma with limiquimod cream: A systematic review of the literature","volume":"13","author":"Vaienti","year":"2023","journal-title":"Dermatol. Ther (Heidelb)"},{"key":"10.1016\/j.gene.2026.150047_b0225","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202103090","article-title":"The long journey to bring a Myc inhibitor to the clinic","volume":"220","author":"Whitfield","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gene.2026.150047_b0230","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.phymed.2005.11.005","article-title":"Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL\/6 mice","volume":"14","author":"Wu","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.gene.2026.150047_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117611","article-title":"Karyopherin \u03b1 2 promotes proliferation, migration and invasion through activating NF-\u03baB\/p65 signaling pathways in melanoma cells","volume":"252","author":"Yang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2026.150047_b0240","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1101\/gad.350078.122","article-title":"Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma","volume":"37","author":"Zacar\u00edas-Fluck","year":"2023","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2026.150047_b0245","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s11864-022-01006-7","article-title":"BRAF inhibitor resistance in melanoma: Mechanisms and alternative therapeutic strategies","volume":"23","author":"Zhong","year":"2022","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.gene.2026.150047_b0250","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/exd.14662","article-title":"Biological activities and safety data of kojic acid and its derivatives: a review","volume":"31","author":"Zilles","year":"2022","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.gene.2026.150047_b0255","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s40257-021-00593-9","article-title":"Combining BRAF\/MEK inhibitors with immunotherapy in the treatment of metastatic melanoma","volume":"22","author":"Ziogas","year":"2021","journal-title":"Am. J. Clin. Dermatol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926000569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926000569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:30:13Z","timestamp":1777566613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926000569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":51,"alternative-id":["S0378111926000569"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150047","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kojic acid inhibits melanoma progression by targeting the MYC\u2013CCNA2\/KPNA2 axis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150047"}}