{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:46:22Z","timestamp":1776127582386,"version":"3.50.1"},"reference-count":147,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG2022"],"award-info":[{"award-number":["IG2022"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"AIRC Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.gene.2026.150142","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:00:57Z","timestamp":1775030457000},"page":"150142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Unmasking prostate cancer risk factors leveraging organoid technology"],"prefix":"10.1016","volume":"996","author":[{"given":"Marta","family":"Cantarelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Marmocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Lunardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens","family":"Begaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2026.150142_b0005","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1101\/gad.819500","article-title":"Molecular genetics of prostate cancer","volume":"14","author":"Abate-Shen","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2026.150142_b0010","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1073\/pnas.1902651116","article-title":"Genomic correlates of clinical outcome in advanced prostate cancer","volume":"116","author":"Abida","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0015","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/(SICI)1097-0045(19990501)39:2<135::AID-PROS9>3.0.CO;2-S","article-title":"Neuroendocrine differentiation in prostatic carcinoma","volume":"39","author":"Abrahamsson","year":"1999","journal-title":"Prostate"},{"key":"10.1016\/j.gene.2026.150142_b0020","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41586-019-1318-9","article-title":"FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes","volume":"571","author":"Adams","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physiol.00005.2019","article-title":"Brain organoids as tools for modeling human neurodevelopmental disorders","volume":"34","author":"Adams","year":"2019","journal-title":"Physiology"},{"key":"10.1016\/j.gene.2026.150142_b0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature11525","article-title":"Generation of functional thyroid from embryonic stem cells","volume":"491","author":"Antonica","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4939-6949-4_7","article-title":"Generation of functional thyroid tissue using 3D-based culture of embryonic stem cells","volume":"1597","author":"Antonica","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.gene.2026.150142_b0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13073-025-01432-w","article-title":"Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer","volume":"17","author":"Aparicio","year":"2025","journal-title":"Genome Med."},{"key":"10.1016\/j.gene.2026.150142_b0045","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1158\/1078-0432.CCR-19-2409","article-title":"A subset of colorectal cancers with cross-sensitivity to olaparib and oxaliplatin","volume":"26","author":"Arena","year":"2020","journal-title":"Clin Cancer Res off J Am Assoc Cancer Res"},{"key":"10.1016\/j.gene.2026.150142_b0050","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ccell.2020.08.003","article-title":"FOXA1 Mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer","volume":"38","author":"Arruabarrena-Aristorena","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.gene.2026.150142_b0055","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1053\/j.gastro.2007.06.066","article-title":"Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage","volume":"133","author":"Auclair","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gene.2026.150142_b0060","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0065","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/j.gastro.2014.09.042","article-title":"In Vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection","volume":"148","author":"Bartfeld","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gene.2026.150142_b0070","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/s41556-018-0143-y","article-title":"Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient","volume":"20","author":"Beumer","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.gene.2026.150142_b0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41580-020-0278-0","article-title":"Cell fate specification and differentiation in the adult mammalian intestine","volume":"22","author":"Beumer","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gene.2026.150142_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110438","article-title":"BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states","volume":"38","author":"Beumer","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0085","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019101654","article-title":"Xenograft and organoid model systems in cancerresearch","volume":"38","author":"Bleijs","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.gene.2026.150142_b0090","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.celrep.2013.06.039","article-title":"Functional Activation of ATM by the Prostate Cancer Suppressor NKX3.1","volume":"4","author":"Bowen","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0095","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4438","article-title":"Human primary liver cancer-derived organoid cultures for disease modeling and drug screening","volume":"23","author":"Broutier","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.gene.2026.150142_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222313097","article-title":"A review of prostate organogenesis and a role for iPSC-derived prostate organoids to study prostate development and disease","volume":"22","author":"Buskin","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0105","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202154049","article-title":"Intra\u2010epithelial non\u2010canonical Activin a signaling safeguards prostate progenitor quiescence","volume":"23","author":"Cambuli","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.gene.2026.150142_b0110","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1126\/science.abn0478","article-title":"Lineage plasticity in prostate cancer depends on JAK\/STAT inflammatory signaling","volume":"377","author":"Chan","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0115","doi-asserted-by":"crossref","first-page":"26338","DOI":"10.1038\/s41598-024-77863-z","article-title":"Prevalence and associated risk factors of prostate cancer among a large Chinese population","volume":"14","author":"Chen","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2026.150142_b0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ccr.2012.01.005","article-title":"Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation","volume":"21","author":"Choi","year":"2012","journal-title":"Cancer Cell"},{"issue":"951\u2013961","key":"10.1016\/j.gene.2026.150142_b0125","first-page":"1","article-title":"Single luminal epithelial progenitors can generate prostate organoids in culture","volume":"16","author":"Chua","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.gene.2026.150142_b0130","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s00018-025-05807-5","article-title":"Organoids as powerful models of endometrium epithelium in transcriptomic, cellular and functional mimicry","volume":"82","author":"Ciprietti","year":"2025","journal-title":"Cell Mol Life Sci CMLS"},{"key":"10.1016\/j.gene.2026.150142_b0135","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1038\/s41596-021-00607-0","article-title":"Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases","volume":"16","author":"Co","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2026.150142_b0140","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.celrep.2019.07.007","article-title":"Expansion of luminal progenitor cells in the aging mouse and human prostate","volume":"28","author":"Crowell","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0145","volume":"eLife 9","author":"Crowley","year":"2020","journal-title":"A Single-Cell Atlas of the Mouse and Human Prostate Reveals Heterogeneity and Conservation of Epithelial Progenitors."},{"key":"10.1016\/j.gene.2026.150142_b0150","first-page":"329","article-title":"Human urogenital sinus mesenchyme is an inducer of prostatic epithelial development","volume":"9","author":"Cunha","year":"2021","journal-title":"Am J Clin Exp Urol"},{"key":"10.1016\/j.gene.2026.150142_b0155","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s44319-024-00335-y","article-title":"Rar\u03b3-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer","volume":"26","author":"De Felice","year":"2025","journal-title":"EMBO Rep."},{"key":"10.1016\/j.gene.2026.150142_b0160","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1038\/s41596-020-00474-1","article-title":"Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids","volume":"16","author":"Dekkers","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2026.150142_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116352","article-title":"Single-cell analysis uncovers preserved prostate cancer lineages and universally altered pathways in Matrigel-free patient-derived organoids","volume":"44","author":"Dolgos","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0170","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.stem.2020.07.022","article-title":"Organoids model transcriptional hallmarks of oncogenic KRAS activation in lung epithelial progenitor cells","volume":"27","author":"Dost","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0175","doi-asserted-by":"crossref","unstructured":"Dotti I, Mora-Buch R, Ferrer-Pic\u00f3n E, Planell N, Jung P, Masamunt MC, Leal RF, Carpi JM de, Llach J, Ord\u00e1s I, et al (2017) Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis.","DOI":"10.1136\/gutjnl-2016-312609"},{"key":"10.1016\/j.gene.2026.150142_b0180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1126\/science.aao3130","article-title":"Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer","volume":"358","author":"Drost","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature14415","article-title":"Sequential cancer mutations in cultured human intestinal stem cells","volume":"521","author":"Drost","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0190","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1158\/1078-0432.CCR-22-0875","article-title":"Targeting the DNA damage Response Pathways and Replication stress in Colorectal Cancer","volume":"28","author":"Durinikova","year":"2022","journal-title":"Clin Cancer Res off J Am Assoc Cancer Res"},{"key":"10.1016\/j.gene.2026.150142_b0195","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/pros.2990150304","article-title":"Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration","volume":"15","author":"English","year":"1989","journal-title":"Prostate"},{"key":"10.1016\/j.gene.2026.150142_b0200","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/pros.2990110304","article-title":"Response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement","volume":"11","author":"English","year":"1987","journal-title":"Prostate"},{"key":"10.1016\/j.gene.2026.150142_b0205","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41419-024-07266-5","article-title":"Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance","volume":"15","author":"Esposito","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2026.150142_b0210","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/pros.2990110406","article-title":"Cell proliferation studies in the rat prostate: II. The effects of castration and androgen-induced regeneration upon basal and secretory cell proliferation","volume":"11","author":"Evans","year":"1987","journal-title":"Prostate"},{"key":"10.1016\/j.gene.2026.150142_b0215","doi-asserted-by":"crossref","DOI":"10.1126\/science.adv2367","article-title":"Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity","volume":"389","author":"Eyunni","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0220","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2012.08.031","article-title":"Redundant sources of Wnt regulate intestinal stem cells and promote formation of paneth cells","volume":"143","author":"Farin","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gene.2026.150142_b0225","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s41588-025-02289-w","article-title":"ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L","volume":"57","author":"Feng","year":"2025","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2026.150142_b0230","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.stem.2016.04.003","article-title":"A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis","volume":"18","author":"Fujii","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0235","doi-asserted-by":"crossref","first-page":"E2357","DOI":"10.1073\/pnas.1701219114","article-title":"Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids","volume":"114","author":"Fumagalli","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0240","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1038\/ncomms6548","article-title":"ERG induces taxane resistance in castration-resistant prostate cancer","volume":"5","author":"Galletti","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150142_b0245","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2014.08.016","article-title":"Organoid cultures derived from patients with advanced prostate cancer","volume":"159","author":"Gao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150142_b0250","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1158\/1078-0432.CCR-11-2449","article-title":"ERG rearrangement for predicting subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia and lymph node metastasis","volume":"18","author":"Gao","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.gene.2026.150142_b0255","first-page":"e754","article-title":"Benign prostatic hyperplasia collaborators (2022) the global, regional, and national burden of benign prostatic hyperplasia in 204 countries and territories from 2000 to 2019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"3","author":"Gbd","year":"2019","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.gene.2026.150142_b0260","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.1189992","article-title":"Identification of a cell of origin for human prostate cancer","volume":"329","author":"Goldstein","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0265","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.eururo.2022.09.004","article-title":"B7-H3 as a therapeutic target in advanced prostate cancer","volume":"83","author":"Guo","year":"2023","journal-title":"Eur. Urol."},{"key":"10.1016\/j.gene.2026.150142_b0270","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41588-020-0642-1","article-title":"Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips","volume":"52","author":"Guo","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2026.150142_b0275","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.1093587","article-title":"De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine","volume":"303","author":"Haramis","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0280","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.stem.2022.08.002","article-title":"Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation","volume":"29","author":"He","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0285","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1016\/j.celrep.2018.11.086","article-title":"A cellular anatomy of the normal adult human prostate and prostatic urethra","volume":"25","author":"Henry","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0290","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1158\/2159-8290.CD-18-0474","article-title":"Prediction of DNA repair inhibitor response in short-term patient-derived ovarian cancer organoids","volume":"8","author":"Hill","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.gene.2026.150142_b0295","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150142_b0300","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/cncr.32702","article-title":"Age dependence of modern clinical risk groups for localized prostate cancer \u2013 a population-based study","volume":"126","author":"Huynh-Le","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.gene.2026.150142_b0305","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.7150\/ijbs.113920","article-title":"Generation of human 3D airway assembloids for advanced modeling","volume":"21","author":"Iachini","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0310","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1158\/0008-5472.CAN-12-4213","article-title":"Animal models of human prostate cancer: the consensus report of the New York meeting of the mouse models of human cancers consortium prostate pathology committee","volume":"73","author":"Ittmann","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2026.150142_b0315","first-page":"101","volume":"genesis 54","author":"Janeckova","year":"2016","journal-title":"Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity."},{"key":"10.1016\/j.gene.2026.150142_b0320","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1158\/1541-7786.MCR-20-0913","article-title":"MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1","volume":"19","author":"Jillson","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.gene.2026.150142_b0325","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/pros.24020","article-title":"Urethral luminal epithelia are castration\u2010insensitive cells of the proximal prostate","volume":"80","author":"Joseph","year":"2020","journal-title":"Prostate"},{"key":"10.1016\/j.gene.2026.150142_b0330","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1242\/dev.104976","article-title":"Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts","volume":"141","author":"Kabiri","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.gene.2026.150142_b0335","first-page":"290","article-title":"Multi-layer stratified oncology platform utilizing transcriptomics, prostate cancer organoids, and modeling of drug response","volume":"44","author":"Kang","year":"2025","journal-title":"J Exp Clin Cancer Res CR"},{"key":"10.1016\/j.gene.2026.150142_b0340","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/s41467-021-21300-6","article-title":"Patient-derived xenografts and organoids model therapy response in prostate cancer","volume":"12","author":"Karkampouna","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150142_b0345","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1126\/science.aay0267","article-title":"Regenerative potential of prostate luminal cells revealed by single-cell analysis","volume":"368","author":"Karthaus","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0350","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cell.2014.08.017","article-title":"Identification of multipotent luminal progenitor cells in human prostate organoid cultures","volume":"159","author":"Karthaus","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150142_b0355","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3945\/ajcn.115.114306","article-title":"Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies123","volume":"102","author":"Key","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.gene.2026.150142_b0360","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/modpathol.2012.236","article-title":"Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions","volume":"26","author":"Kluth","year":"2013","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.gene.2026.150142_b0365","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/cells8050470","article-title":"Application of cancer organoid model for drug screening and personalized therapy","volume":"8","author":"Kondo","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.gene.2026.150142_b0370","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/1270","article-title":"Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4","volume":"19","author":"Korinek","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2026.150142_b0375","doi-asserted-by":"crossref","first-page":"15418","DOI":"10.1073\/pnas.0707210104","article-title":"Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors","volume":"104","author":"Kosinski","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0380","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.stem.2023.03.004","article-title":"Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche","volume":"30","author":"Kraiczy","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0385","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/cei\/uxad118","article-title":"Organoids as a tool to study homeostatic and pathological immune\u2013epithelial interactions in the gut","volume":"218","author":"Kromann","year":"2024","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.gene.2026.150142_b0390","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1073\/pnas.2536800100","article-title":"Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1","volume":"101","author":"Kuhnert","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2026.116950","article-title":"FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity","volume":"45","author":"Ladewig","year":"2026","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0400","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1073\/pnas.0609684104","article-title":"Isolation and functional characterization of murine prostate stem cells","volume":"104","author":"Lawson","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0405","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0913873107","article-title":"Basal epithelial stem cells are efficient targets for prostate cancer initiation","volume":"107","author":"Lawson","year":"2010","journal-title":"PNAS"},{"key":"10.1016\/j.gene.2026.150142_b0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011652","article-title":"Generation of prostate cancer assembloids modeling the patient-specific tumor microenvironment","volume":"21","author":"Lee","year":"2025","journal-title":"PLoS Genet."},{"key":"10.1016\/j.gene.2026.150142_b0415","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/JOE-11-0474","article-title":"Suppressor role of androgen receptor in proliferation of prostate basal epithelial and progenitor cells","volume":"213","author":"Lee","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.gene.2026.150142_b0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021650","article-title":"TMPRSS2\/ERG promotes epithelial to mesenchymal transition through the ZEB1\/ZEB2 axis in a prostate cancer model","volume":"6","author":"Leshem","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2026.150142_b0425","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41586-025-09727-z","article-title":"NSD2 targeting reverses plasticity and drug resistance in prostate cancer","volume":"649","author":"Li","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0430","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1210\/me.2011-1081","article-title":"Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate","volume":"25","author":"Liu","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.gene.2026.150142_b0435","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1158\/1078-0432.CCR-07-0300","article-title":"Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers","volume":"13","author":"Liu","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.gene.2026.150142_b0440","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.3390\/nu15122677","article-title":"Association between vitamin a and E forms and prostate cancer risk in the Singapore prostate cancer study","volume":"15","author":"Loh","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2026.150142_b0445","doi-asserted-by":"crossref","unstructured":"Lorenzoni M, De Felice D, Beccaceci G, Di Donato G, Foletto V, Genovesi S, Bertossi A, Cambuli F, Lorenzin F, Savino A, et al (2022) ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3\u03b2 dependent Nkx3.1 degradation. Cancer Lett 534: None.","DOI":"10.1016\/j.canlet.2022.215612"},{"key":"10.1016\/j.gene.2026.150142_b0450","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188746","article-title":"Current best practices in single\u2010cell RNA\u2010seq analysis: A tutorial","volume":"15","author":"Luecken","year":"2019","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.gene.2026.150142_b0455","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1158\/1535-7163.MCT-18-1386","article-title":"Aberrant expression of ERG promotes resistance to combined PI3K and AR pathway inhibition through maintenance of AR target genes","volume":"18","author":"Mao","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.gene.2026.150142_b0460","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nm.3802","article-title":"Modeling colorectal cancer using CRISPR-Cas9\u2013mediated engineering of human intestinal organoids","volume":"21","author":"Matano","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.gene.2026.150142_b0465","article-title":"Empowering clinical decision making in oligometastatic colorectal cancer: the potential role of drug screening of patient-derived organoids.","volume":"5","author":"Mauri","year":"2021","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.gene.2026.150142_b0470","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.stem.2020.01.008","article-title":"Distinct mesenchymal cell populations generate the essential intestinal BMP signaling gradient","volume":"26","author":"McCarthy","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0475","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/pros.2990020105","article-title":"The zonal anatomy of the prostate","volume":"2","author":"McNeal","year":"1981","journal-title":"Prostate"},{"key":"10.1016\/j.gene.2026.150142_b0480","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1038\/s41467-023-37696-2","article-title":"Bladder cancer organoids as a functional system to model different disease stages and therapy response","volume":"14","author":"Minoli","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150142_b0485","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1098-2353(2000)13:3<214::AID-CA10>3.0.CO;2-N","article-title":"Structure of the adult prostate from a clinician\u2019s standpoint","volume":"13","author":"Myers","year":"2000","journal-title":"Clin. Anat."},{"key":"10.1016\/j.gene.2026.150142_b0490","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.stem.2024.09.017","article-title":"Assembloid models of cell-cell interaction to study tissue and disease biology","volume":"31","author":"Onesto","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0495","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1073\/pnas.1603645113","article-title":"Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay","volume":"113","author":"Park","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0500","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1200\/JCO.2013.49.8386","article-title":"TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia","volume":"32","author":"Park","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.gene.2026.150142_b0505","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1101\/gad.267103","article-title":"Canonical Wnt signals are essential for homeostasis of the intestinal epithelium","volume":"17","author":"Pinto","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2026.150142_b0510","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1432-0436.2008.00277.x","article-title":"Molecular signaling pathways that regulate prostate gland development","volume":"76","author":"Prins","year":"2008","journal-title":"Differentiation"},{"key":"10.1016\/j.gene.2026.150142_b0515","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/s41596-021-00589-z","article-title":"Intestinal organoid cocultures with microbes","volume":"16","author":"Puschhof","year":"2021","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2026.150142_b0520","doi-asserted-by":"crossref","first-page":"13824","DOI":"10.1038\/ncomms13824","article-title":"BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes","volume":"8","author":"Qi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150142_b0525","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41586-024-07791-5","article-title":"Human organoids with an autologous tissue-resident immune compartment","volume":"633","author":"Recaldin","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0530","doi-asserted-by":"crossref","DOI":"10.1593\/neo.10866","article-title":"ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression","volume":"12","author":"Rickman","year":"2010","journal-title":"Neoplasia"},{"key":"10.1016\/j.gene.2026.150142_b0535","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41388-024-03230-x","article-title":"CRIPTO\u2019s multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient data","volume":"44","author":"Rodrigues Sousa","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2026.150142_b0540","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/s43018-024-00838-6","article-title":"The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1","volume":"5","author":"Romero","year":"2024","journal-title":"Nat Cancer"},{"key":"10.1016\/j.gene.2026.150142_b0545","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41576-018-0051-9","article-title":"Progress and potential in organoid research","volume":"19","author":"Rossi","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.gene.2026.150142_b0550","doi-asserted-by":"crossref","unstructured":"Sahu S & Sharan SK (2020) Translating Embryogenesis to Generate Organoids: Novel Approaches to Personalized Medicine. iScience 23.","DOI":"10.1016\/j.isci.2020.101485"},{"key":"10.1016\/j.gene.2026.150142_b0555","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of Epithelial Organoids from Human Colon, Adenoma, Adenocarcinoma, and Barrett\u2019s Epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gene.2026.150142_b0560","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0565","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/his.70046","article-title":"The Genitourinary Pathology Society and International Society of Urological Pathology Joint Expert Consultation Recommendations on intraductal carcinoma of the prostate","volume":"88","author":"Shah","year":"2026","journal-title":"Histopathology"},{"key":"10.1016\/j.gene.2026.150142_b0570","doi-asserted-by":"crossref","first-page":"14456","DOI":"10.18632\/oncotarget.24470","article-title":"Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2\/ERG fusion gene and decreased PTEN","volume":"9","author":"Shao","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.gene.2026.150142_b0575","article-title":"Patient-derived tumor organoid and fibroblast assembloid models for interrogation of the tumor microenvironment in esophageal adenocarcinoma. Cell Rep","volume":"4","author":"Sharpe","year":"2024","journal-title":"Methods"},{"key":"10.1016\/j.gene.2026.150142_b0580","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1101\/gad.1965810","article-title":"Molecular genetics of prostate cancer: new prospects for old challenges","volume":"24","author":"Shen","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.gene.2026.150142_b0585","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2007.09.042","article-title":"Anchorage-independent culture maintains prostate stem cells","volume":"312","author":"Shi","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gene.2026.150142_b0590","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0002-9440(10)64814-6","article-title":"p63 is a prostate basal cell marker and is required for prostate development","volume":"157","author":"Signoretti","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.gene.2026.150142_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112377","article-title":"Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells","volume":"42","author":"Steiner","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0600","doi-asserted-by":"crossref","first-page":"20111","DOI":"10.1073\/pnas.1320565110","article-title":"Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells","volume":"110","author":"Stoyanova","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0605","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.stem.2017.11.012","article-title":"Reconstruction of the human colon epithelium In Vivo","volume":"22","author":"Sugimoto","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0610","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150142_b0615","doi-asserted-by":"crossref","unstructured":"Tang F, Xu D, Wang S, Wong CK, Martinez-Fundichely A, Lee CJ, Cohen S, Park J, Hill CE, Eng K, et al (2022) Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. Science 376: eabe1505.","DOI":"10.1126\/science.abe1505"},{"key":"10.1016\/j.gene.2026.150142_b0620","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1432-0436.2006.00101.x","article-title":"Branching morphogenesis in the prostate gland and seminal vesicles","volume":"74","author":"Thomson","year":"2006","journal-title":"Differentiation"},{"key":"10.1016\/j.gene.2026.150142_b0625","article-title":"Spatiotemporal regulation of multipotency during prostate development","volume":"146","author":"Tika","year":"2019","journal-title":"Dev Camb Engl"},{"key":"10.1016\/j.gene.2026.150142_b0630","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.stemcr.2016.03.007","article-title":"Basal progenitors contribute to repair of the prostate epithelium following induced luminal anoikis","volume":"6","author":"Toivanen","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0635","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1242\/dev.148270","article-title":"Prostate organogenesis: tissue induction, hormonal regulation and cell type specification","volume":"144","author":"Toivanen","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.gene.2026.150142_b0640","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1593\/neo.07822","article-title":"Role of the TMPRSS2-ERG gene fusion in prostate cancer","volume":"10","author":"Tomlins","year":"2008","journal-title":"Neoplasia N Y N"},{"key":"10.1016\/j.gene.2026.150142_b0645","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1117679","article-title":"Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer","volume":"310","author":"Tomlins","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0650","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.stem.2018.08.008","article-title":"Esophageal Organoids from human pluripotent stem cells delineate Sox2 functions during esophageal specification","volume":"23","author":"Trisno","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.gene.2026.150142_b0655","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1126\/science.aaw6985","article-title":"Cancer modeling meets human organoid technology","volume":"364","author":"Tuveson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150142_b0660","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ajur.2019.10.003","article-title":"The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review","volume":"7","author":"Vickman","year":"2020","journal-title":"Asian J Urol"},{"key":"10.1016\/j.gene.2026.150142_b0665","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1158\/0008-5472.CAN-06-1966","article-title":"Expression of variant TMPRSS2\/ERG fusion messenger RNAs is associated with aggressive prostate cancer","volume":"66","author":"Wang","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2026.150142_b0670","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature08361","article-title":"A luminal epithelial stem cell that is a cell of origin for prostate cancer","volume":"461","author":"Wang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150142_b0675","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1432-0436.2001.680414.x","article-title":"Cell differentiation lineage in the prostate","volume":"68","author":"Wang","year":"2001","journal-title":"Differentiation"},{"key":"10.1016\/j.gene.2026.150142_b0680","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/ERC-17-0280","article-title":"Nuclear receptor profiling in prostatospheroids and castration-resistant prostate cancer","volume":"25","author":"Wang","year":"2018","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.gene.2026.150142_b0685","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.celrep.2014.08.002","article-title":"Luminal cells are favored as the cell of origin for prostate cancer","volume":"8","author":"Wang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0690","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(02)01014-0","article-title":"The \u03b2-Catenin\/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells","volume":"111","author":"Wetering","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150142_b0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107762","article-title":"Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses","volume":"31","author":"de Witte","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150142_b0700","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1158\/0008-5472.CAN-11-2724","article-title":"Suppression of Tak1 promotes prostate tumorigenesis","volume":"72","author":"Wu","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2026.150142_b0705","doi-asserted-by":"crossref","first-page":"14284","DOI":"10.1038\/ncomms14284","article-title":"Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing","volume":"8","author":"Xie","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150142_b0710","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1073\/pnas.0502320102","article-title":"The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis","volume":"102","author":"Xin","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.gene.2026.150142_b0715","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10559","article-title":"Flourishing tumor organoids: History, emerging technology, and application","volume":"8","author":"Yang","year":"2023","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.gene.2026.150142_b0720","article-title":"Organoids for tissue repair and regeneration","volume":"33","author":"Yu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.gene.2026.150142_b0725","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.trecan.2018.09.003","article-title":"Prostate luminal progenitor cells in development and cancer","volume":"4","author":"Zhang","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.gene.2026.150142_b0730","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/pros.23131","article-title":"Nkx3.1 controls the DNA repair response in the mouse prostate","volume":"76","author":"Zhang","year":"2016","journal-title":"Prostate"},{"key":"10.1016\/j.gene.2026.150142_b0735","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ccell.2020.06.005","article-title":"Tumor microenvironment-derived NRG1 Promotes antiandrogen resistance in prostate cancer","volume":"38","author":"Zhang","year":"2020","journal-title":"Cancer Cell"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926001526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926001526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:54:02Z","timestamp":1776124442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926001526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":147,"alternative-id":["S0378111926001526"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150142","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unmasking prostate cancer risk factors leveraging organoid technology","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150142"}}