{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:42:00Z","timestamp":1788093720356,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010891","name":"Guizhou Provincial Health Commission","doi-asserted-by":"publisher","award":["gzwkj2026-234"],"award-info":[{"award-number":["gzwkj2026-234"]}],"id":[{"id":"10.13039\/501100010891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.gene.2026.150143","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:09:02Z","timestamp":1775059742000},"page":"150143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Quercetin-driven M2 polarization of macrophages via ALOX5 inhibition in kupffer cells: A strategy for mouse liver fibrosis treatment"],"prefix":"10.1016","volume":"996","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengpeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuchan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2026.150143_b0005","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jcb.30296","article-title":"Quercetin ameliorates thioacetamide-induced hepatic fibrosis and oxidative stress by antagonizing the Hedgehog signaling pathway","volume":"123","author":"Aslam","year":"2022","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.gene.2026.150143_b0010","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1186\/s12890-024-03250-z","article-title":"Cepharanthine attenuates pulmonary fibrosis via modulating macrophage M2 polarization","volume":"24","author":"Bao","year":"2024","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.gene.2026.150143_b0015","doi-asserted-by":"crossref","first-page":"8995","DOI":"10.3390\/ijms25168995","article-title":"In vitro investigation of the anti-fibrotic effects of 1-phenyl-2-pentanol, identified from moringa oleifera lam., on hepatic stellate cells","volume":"25","author":"Buakaew","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150143_b0020","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adh1178","article-title":"ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis","volume":"17","author":"Cai","year":"2024","journal-title":"Sci. Signal."},{"key":"10.1016\/j.gene.2026.150143_b0025","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009492","article-title":"ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia\/macrophages","volume":"12","author":"Chen","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.gene.2026.150143_b0030","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.17305\/bb.2024.10530","article-title":"Quercetin alleviates liver fibrosis via regulating glycolysis of liver sinusoidal endothelial cells and neutrophil infiltration","volume":"24","author":"Chen","year":"2024","journal-title":"Biomol Biomed"},{"key":"10.1016\/j.gene.2026.150143_b0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3892\/etm.2022.11733","article-title":"Interference of ALOX5 alleviates inflammation and fibrosis in high glucose\u2011induced renal mesangial cells","volume":"25","author":"Chen","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.gene.2026.150143_b0040","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.3390\/molecules27082498","article-title":"Health benefits of quercetin in age-related diseases","volume":"27","author":"Deepika and Maurya","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.gene.2026.150143_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2024.101406","article-title":"Sphingosine kinase 1 aggravates liver fibrosis by mediating macrophage recruitment and polarization","volume":"18","author":"Ding","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.gene.2026.150143_b0050","first-page":"10","article-title":"Cyclooxygenase-2 inhibition attenuates hypoxic cancer cells induced m2-polarization of macrophages","volume":"60","author":"Dubey","year":"2014","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand)"},{"key":"10.1016\/j.gene.2026.150143_b0055","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.2337\/db16-0040","article-title":"ALOX5AP Overexpression in adipose tissue leads to LXA4 production and protection against diet-induced obesity and insulin resistance","volume":"65","author":"Elias","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.gene.2026.150143_b0060","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70641","article-title":"Downregulation of Alox5 inhibits ferroptosis to improve doxorubicin-induced cardiotoxicity via the P53\/SLC7A11 pathway","volume":"29","author":"Fang","year":"2025","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.gene.2026.150143_b0065","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.3390\/molecules28248141","article-title":"Quercetin: A potential polydynamic drug","volume":"28","author":"Georgiou","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.gene.2026.150143_b0070","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1007\/s12012-024-09901-1","article-title":"Quercetin alleviates LPS-stimulated myocardial injury through regulating ALOX5\/PI3K\/AKT pathway in sepsis","volume":"24","author":"Guan","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.gene.2026.150143_b0075","doi-asserted-by":"crossref","first-page":"19246","DOI":"10.1021\/acs.jafc.4c04994","article-title":"Integrating lipidomics, metabolomics, and network pharmacology to reveal the mechanism of cannabidiol against inflammation in high-fat, high-cholesterol diet-induced mice","volume":"72","author":"He","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.gene.2026.150143_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110505","article-title":"The ALOX5 inhibitor Zileuton regulates tumor-associated macrophage M2 polarization by JAK\/STAT and inhibits pancreatic cancer invasion and metastasis","volume":"121","author":"Hu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.gene.2026.150143_b0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1499-3872(16)60164-9","article-title":"Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats","volume":"16","author":"Kabirifar","year":"2017","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.gene.2026.150143_b0090","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4162\/nrp.2016.10.6.623","article-title":"Induction of heme oxygenase-1 with dietary quercetin reduces obesity-induced hepatic inflammation through macrophage phenotype switching","volume":"10","author":"Kim","year":"2016","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.gene.2026.150143_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1594757","article-title":"Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-\u03baB pathway in pulmonary fibrosis","volume":"16","author":"Lan","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.gene.2026.150143_b0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fphar.2018.00072","article-title":"The flavonoid quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.gene.2026.150143_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102452","article-title":"Chenodeoxycholic acid suppresses AML progression through promoting lipid peroxidation via ROS\/p38 MAPK\/DGAT1 pathway and inhibiting M2 macrophage polarization","volume":"56","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.gene.2026.150143_b0110","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bcp.2018.05.007","article-title":"Quercetin ameliorates kidney injury and fibrosis by modulating M1\/M2 macrophage polarization","volume":"154","author":"Lu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.gene.2026.150143_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120064","article-title":"The protective effect of quercetin on macrophage pyroptosis via TLR2\/Myd88\/NF-\u03baB and ROS\/AMPK pathway","volume":"291","author":"Luo","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.gene.2026.150143_b0120","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1053\/j.gastro.2023.05.053","article-title":"Prevalence of liver steatosis and fibrosis in the general population and various high-risk populations: A nationwide study with 5.7 million adults in China","volume":"165","author":"Man","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gene.2026.150143_b0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.14423\/SMJ.0000000000001769","article-title":"Liver fibrosis and cardiovascular events","volume":"118","author":"Nso","year":"2025","journal-title":"South. Med. J."},{"key":"10.1016\/j.gene.2026.150143_b0130","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1136\/gutjnl-2021-325150","article-title":"FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2","volume":"71","author":"Rao","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.gene.2026.150143_b0135","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41418-020-00650-6","article-title":"IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages","volume":"28","author":"Rao","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.gene.2026.150143_b0140","doi-asserted-by":"crossref","unstructured":"Remmerie, A., Martens, L., Thon\u00e9, T., Castoldi, A., Seurinck, R., Pavie, B., Roels, J., Vanneste, B., De Prijck, S., Vanhockerhout, M., Binte Abdul Latib, M., Devisscher, L., Hoorens, A., Bonnardel, J., Vandamme, N., Kremer, A., Borghgraef, P., Van Vlierberghe, H., Lippens, S., Pearce, E., Saeys, Y. and Scott, C.L., 2020. Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver. Immunity 53, 641-657.e14.","DOI":"10.1016\/j.immuni.2020.08.004"},{"key":"10.1016\/j.gene.2026.150143_b0145","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: Mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.gene.2026.150143_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175184","article-title":"Eucalyptol prevents bleomycin-induced pulmonary fibrosis and M2 macrophage polarization","volume":"931","author":"Rui","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.gene.2026.150143_b0155","doi-asserted-by":"crossref","DOI":"10.1002\/vms3.70183","article-title":"The M1\/M2 macrophage polarization and hepatoprotective activity of quercetin in cyclophosphamide-induced experimental liver toxicity","volume":"11","author":"Seker","year":"2025","journal-title":"Vet. Med. Sci."},{"key":"10.1016\/j.gene.2026.150143_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymgme.2025.109010","article-title":"Predicting liver fibrosis in Gaucher disease: Investigation of contributors and development of a clinically applicable Gaucher liver fibrosis score","volume":"144","author":"Starosta","year":"2025","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.gene.2026.150143_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1444198","article-title":"Targeting hepatic macrophages for non-alcoholic fatty liver disease therapy","volume":"12","author":"Tian","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2026.150143_b0170","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/nu14010067","article-title":"Regulatory effects of quercetin on M1\/M2 macrophage polarization and oxidative\/antioxidative balance","volume":"14","author":"Tsai","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.gene.2026.150143_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.803037","article-title":"Macrophage polarization and its role in liver disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2026.150143_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155016","article-title":"Corilagin alleviates liver fibrosis in zebrafish and mice by repressing IDO1-mediated M2 macrophage repolarization","volume":"119","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.gene.2026.150143_b0185","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130056","article-title":"Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis","volume":"4","author":"Wiley","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.gene.2026.150143_b0190","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-\u03b21\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2026.150143_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101634","article-title":"Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH","volume":"36","author":"Xu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.gene.2026.150143_b0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0309833","article-title":"Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-\u03b2\/Smad and p38MAPK signaling pathways","volume":"19","author":"Yin","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2026.150143_b0205","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.7150\/thno.109771","article-title":"Hepatic stellate cell-derived microfibrillar-associated protein 2 prevents liver fibrosis by regulating extracellular matrix and inflammation","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.gene.2026.150143_b0210","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3390\/ph17121724","article-title":"Pharmacotherapy of Liver Fibrosis and Hepatitis: recent advances","volume":"17","author":"Zhao","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.gene.2026.150143_b0215","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1186\/s12951-024-02824-7","article-title":"Apoptotic vesicles (apoVs) derived from fibroblast-converted hepatocyte-like cells effectively ameliorate liver fibrosis","volume":"22","author":"Zhong","year":"2024","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.gene.2026.150143_b0220","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/27694127.2022.2119513","article-title":"Macrophages produce PGE2 to promote hepatic stellate cell autophagy and liver fibrosis","volume":"1","author":"Zhu","year":"2022","journal-title":"Autophagy Rep."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926001538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926001538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:09:21Z","timestamp":1776182961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926001538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":44,"alternative-id":["S0378111926001538"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150143","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin-driven M2 polarization of macrophages via ALOX5 inhibition in kupffer cells: A strategy for mouse liver fibrosis treatment","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150143"}}