{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:51:13Z","timestamp":1785876673094,"version":"3.56.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["C43C22001330007"],"award-info":[{"award-number":["C43C22001330007"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.gene.2026.150276","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:07:59Z","timestamp":1781968079000},"page":"150276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Candidate genetic and multi-omics determinants potentially contributing to Macklin effect development in acute respiratory distress syndrome: A narrative review"],"prefix":"10.1016","volume":"1008","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-8313","authenticated-orcid":false,"given":"Rosa Paola","family":"Radice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Vignola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Montagnuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Belletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Paternoster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2026.150276_b0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s44231-023-00045-4","article-title":"Precision medicine using simultaneous monitoring and assessment with imaging and biomarkers to manage mechanical ventilation in ARDS","volume":"3","author":"Abbott","year":"2023","journal-title":"Intensive Care Res."},{"key":"10.1016\/j.gene.2026.150276_b0010","doi-asserted-by":"crossref","DOI":"10.1186\/s40635-025-00766-4","article-title":"Advancing omics technologies in acute respiratory distress syndrome: paving the way for personalized medicine","volume":"13","author":"Al-Husinat","year":"2025","journal-title":"Intensive Care Med. Exp."},{"key":"10.1016\/j.gene.2026.150276_b0015","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-025-05291-0","article-title":"A narrative review on the future of ARDS: evolving definitions, pathophysiology, and tailored management","volume":"29","author":"Al-Husinat","year":"2025","journal-title":"Crit. Care"},{"key":"10.1016\/j.gene.2026.150276_b0020","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1053\/j.jvca.2023.12.025","article-title":"Macklin effect: from pathophysiology to clinical implication","volume":"38","author":"Angelini","year":"2024","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.gene.2026.150276_b0025","doi-asserted-by":"crossref","DOI":"10.1186\/s12950-025-00448-8","article-title":"Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome","volume":"22","author":"Aoki","year":"2025","journal-title":"J. Inflamm. (Lond)"},{"key":"10.1016\/j.gene.2026.150276_b0030","doi-asserted-by":"crossref","first-page":"L38","DOI":"10.1152\/ajplung.00185.2022","article-title":"Biomarkers of alveolar epithelial injury and endothelial dysfunction are associated with scores of pulmonary edema in invasively ventilated patients","volume":"324","author":"Atmowihardjo","year":"2023","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.gene.2026.150276_b0035","doi-asserted-by":"crossref","unstructured":"Baizat, M., Iancu, M., Zaharie, G., H\u0103\u0219m\u0103\u0219anu, M., Matyas, M., Rotar, I.C., Lucaciu, R.L., Hangan, A.C., Bogdan, S.G., Procopciuc, L.M., 2026. Exploratory analysis of TLR2, TLR4, interleukin 6 and interleukin 10 gene polymorphisms in relation to clinical early-onset sepsis in preterm neonates: a single-center study. Life, 16, 103. Doi:10.3390\/life16010103.","DOI":"10.3390\/life16010103"},{"key":"10.1016\/j.gene.2026.150276_b0040","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-025-03782-y","article-title":"Effects of atorvastatin on inflammatory markers, lipid profile, liver enzymes, and pulmonary function in patients with lung diseases: a systematic review and meta-analysis of randomized controlled trials","volume":"31","author":"Baseri","year":"2026","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.gene.2026.150276_b0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/aor.14864","article-title":"Extracorporeal membrane oxygenation for prevention of barotrauma in patients with respiratory failure: a scoping review","volume":"49","author":"Belletti","year":"2025","journal-title":"Artif. Organs"},{"key":"10.1016\/j.gene.2026.150276_b0050","doi-asserted-by":"crossref","first-page":"10","DOI":"10.22514\/sv.2024.137","article-title":"The role of Macklin effect in management of ARDS: beyond spontaneous pneumomediastinum","volume":"20","author":"Belletti","year":"2024","journal-title":"Signa Vitae"},{"key":"10.1016\/j.gene.2026.150276_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/jcm15010159","article-title":"Spontaneous pneumomediastinum in COVID-19 and myasthenic-like symptom complications in two relatives: a coincidence or spike toxicity with thymic response in predisposed individuals? two clinical cases with a comprehensive literature review","volume":"15","author":"Brogna","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.gene.2026.150276_b0060","doi-asserted-by":"crossref","unstructured":"Brunetta, E., Folci, M., Bottazzi, B., Santis, M. De, Protti, A., Mapelli, S., Leone, R., My, I., Bacci, M., Zanon, V., Spata, G., Gianatti, A., Sironi, M., Angelini, C., Garlanda, C., Ciccarelli, M., Cecconi, M., Mantovani, A., 2020. Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19. medRxiv 2020.06.26.20139923. Doi:10.1101\/2020.06.26.20139923.","DOI":"10.1101\/2020.06.26.20139923"},{"key":"10.1016\/j.gene.2026.150276_b0065","article-title":"Circulating tissue inhibitor of metalloproteinases 1 (TIMP-1) at COVID-19 onset predicts severity status","volume":"9","author":"Brusa","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.gene.2026.150276_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1604243","article-title":"Serum calprotectin correlates with severity of severe fever with thrombocytopenia syndrome","volume":"16","author":"Cai","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.gene.2026.150276_b0075","doi-asserted-by":"crossref","unstructured":"Candelli, M., Sacco Fernandez, M., Rozzi, G., Sodero, G., Piccioni, A., Pignataro, G., Rigante, D., Franceschi, F., 2025. The interleukin network in sepsis: from cytokine storm to clinical applications. Diagnostics 2025, Vol. 15, 15. Doi:10.3390\/diagnostics15222927.","DOI":"10.3390\/diagnostics15222927"},{"key":"10.1016\/j.gene.2026.150276_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.114210","article-title":"Pediatric critical illness endotypes reveal distinct outcomes and immune pathways shared across cause of illness","volume":"28","author":"Carter","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.gene.2026.150276_b0085","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.19995","article-title":"A mini-review of the relationship between intestinal microecology and acute respiratory distress syndrome","volume":"13","author":"Chen","year":"2025","journal-title":"PeerJ"},{"key":"10.1016\/j.gene.2026.150276_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/jpm16020092","article-title":"Deep biological clocks in critical care medicine: a scoping review toward translational precision care","volume":"16","author":"Cheyne","year":"2026","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.gene.2026.150276_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25020962","article-title":"PAMPs and DAMPs in sepsis: a review of their molecular features and potential clinical implications","volume":"25","author":"Cicchinelli","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150276_b0100","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5005\/jp-journals-10071-25007","article-title":"The impact of inflammatory biomarker subphenotypes on acute respiratory distress syndrome prognosis: a systematic review and meta-analysis","volume":"29","author":"Das","year":"2025","journal-title":"Indian J. Crit. Care Med."},{"key":"10.1016\/j.gene.2026.150276_b0105","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/cvr\/cvae168","article-title":"Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature","volume":"120","author":"Del Gaudio","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.gene.2026.150276_b0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-89783-7","article-title":"Circulating extracellular vesicles as potential biomarkers and mediators of acute respiratory distress syndrome in sepsis","volume":"15","author":"do Nascimento","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2026.150276_b0115","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1074\/jbc.M112.404780","article-title":"Critical role of S1PR1 and integrin \u03b24 in HGF\/c-Met-mediated increases in vascular integrity","volume":"288","author":"Ephstein","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gene.2026.150276_b0120","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-09558-5","article-title":"Principles of airway management","volume":"1\u2013742","author":"Finucane","year":"2011","journal-title":"Principles of Airway Management"},{"key":"10.1016\/j.gene.2026.150276_b0125","doi-asserted-by":"crossref","unstructured":"Folci, M., Brunetta, E., Lanza, E., Bottazzi, B., Protti, A., Messana, G., Lisi, C., Leone, R., Sironi, M., Generali, E., Rodolfi, S., Sagasta, M., Voza, A., Ciccarelli, M., Garlanda, C., Balzarini, L., Mantovani, A., Cecconi, M., Force, H.C.-19 T., 2021. A PTX3\/LDH\/CRP signature correlates with lung injury CTs scan severity and disease progression in paucisymptomatic COVID-19. medRxiv 2021.09.29.21264061. Doi:10.1101\/2021.09.29.21264061.","DOI":"10.1101\/2021.09.29.21264061"},{"key":"10.1016\/j.gene.2026.150276_b0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144832","article-title":"TNF, IL6, and IL1B polymorphisms are associated with severe influenza a (H1N1) virus infection in the mexican population","volume":"10","author":"Garc\u00eda-Ram\u00edrez","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2026.150276_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1720862","article-title":"Molecular characterization of cell decay in inflammation and topological assignment of released cfDNA for integrative laboratory and radiological outcome assessment","volume":"15","author":"Gerhards","year":"2026","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.gene.2026.150276_b0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21873\/invivo.12672","article-title":"The impact of ACE and ACE2 gene polymorphisms in pulmonary diseases including COVID-19","volume":"36","author":"Gintoni","year":"2022","journal-title":"In Vivo"},{"key":"10.1016\/j.gene.2026.150276_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2024.e01956","article-title":"Secondary pneumomediastinum in COVID-19 patient: a case managed with VV-ECMO","volume":"36","author":"Golino","year":"2024","journal-title":"Idcases"},{"key":"10.1016\/j.gene.2026.150276_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26188859","article-title":"Assessing monoclonal and polyclonal antibodies in sepsis and septic shock: a systematic review of efficacy and safety","volume":"26","author":"Goulas","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150276_b0155","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202400606","article-title":"Native and engineered extracellular vesicles for the treatment of acute lung injury and acute respiratory distress syndrome","volume":"5","author":"Gu","year":"2025","journal-title":"Small Sci."},{"key":"10.1016\/j.gene.2026.150276_b0160","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1053\/j.jvca.2024.12.045","article-title":"Awake venovenous extracorporeal membrane oxygenation in the intensive care unit: challenges and emerging concepts","volume":"39","author":"Guarracino","year":"2025","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.gene.2026.150276_b0165","doi-asserted-by":"crossref","unstructured":"Hammond, T.C., Purbhoo, M.A., Kadel, S., Ritz, J., Nikiforow, S., Daley, H., Shaw, K., van Besien, K., Gomez-Arteaga, A., Stevens, D., Ortuzar, W., Michelet, X., Smith, R., Moskowitz, D., Masakayan, R., Yigit, B., Boi, S., Soh, K.T., Chamberland, J., Song, X., Qin, Y., Mishchenko, I., Kirby, M., Nasonenko, V., Buffa, A., Buell, J.S., Chand, D., van Dijk, M., Stebbing, J., Exley, M.A., 2024. A phase 1\/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome. Nat. Commun. 2024 15:1 15, 974-. Doi:10.1038\/s41467-024-44905-z.","DOI":"10.1038\/s41467-024-44905-z"},{"key":"10.1016\/j.gene.2026.150276_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/cells11121935","article-title":"Regulation and dysregulation of endothelial permeability during systemic inflammation","volume":"11","author":"Hellenthal","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.gene.2026.150276_b0175","doi-asserted-by":"crossref","unstructured":"Hong, X., Liang, T., Liu, X., 2025. The significance and role of the receptor and inflammatory factors in acute respiratory distress syndrome. Sci. Rep. 2025 15:1 15, 37949-. Doi:10.1038\/s41598-025-20041-6.","DOI":"10.1038\/s41598-025-20041-6"},{"key":"10.1016\/j.gene.2026.150276_b0180","article-title":"The association of cytokines IL-2, IL-6, TNF-\u03b1, IFN-\u03b3, and IL-10 with the disease severity of COVID-19: a study from Bangladesh","volume":"16","author":"Islam","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.gene.2026.150276_b0185","article-title":"Understanding and managing acute respiratory distress syndrome (ARDS): new pharmacological approaches reviewing recent developments in the pharmacological management of ARDS","volume":"5\u20139","author":"Jain, Dr.A.","year":"2024","journal-title":"Innovations in Pharmacy Planet"},{"key":"10.1016\/j.gene.2026.150276_b0190","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.2147\/JIR.S506693","article-title":"Exosome secretion regulation in mice with acute lung injury","volume":"18","author":"Jie","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.gene.2026.150276_b0195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1164\/rccm.201810-2033OC","article-title":"Plasma sRAGE acts as a genetically regulated causal intermediate in sepsis-associated acute respiratory distress syndrome","volume":"201","author":"Jones","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.gene.2026.150276_b0200","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/SHK.0000000000001833","article-title":"Elevated plasma levels of matrix metalloproteinase-3 and tissue-inhibitor of matrix metalloproteinases-1 associate with organ dysfunction and mortality in sepsis","volume":"57","author":"Jones","year":"2022","journal-title":"Shock"},{"key":"10.1016\/j.gene.2026.150276_b0205","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.31.1_supplement.995.12","article-title":"Monocytic sphingosine kinase 2 resolves LPS induced lung vascular injury","volume":"31","author":"Joshi","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2026.150276_b0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022596","article-title":"Early elevation of matrix metalloproteinase-8 and -9 in pediatric ARDS is associated with an increased risk of prolonged mechanical ventilation","volume":"6","author":"Kong","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2026.150276_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.00587","article-title":"C-C motif chemokine ligand 2 (CCL2) mediates acute lung injury induced by lethal influenza H7N9 virus","volume":"8","author":"Lai","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.gene.2026.150276_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.933960","article-title":"Long pentraxin 3 (PTX3) levels predict death, intubation and thrombotic events among hospitalized patients with COVID-19","volume":"13","author":"Lapadula","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2026.150276_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135160","article-title":"Targeted role for sphingosine-1-phosphate receptor 1 in cerebrovascular integrity and inflammation during acute ischemic stroke","volume":"735","author":"Li","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.gene.2026.150276_b0230","doi-asserted-by":"crossref","first-page":"e1457","DOI":"10.1097\/CCM.0000000000006719","article-title":"Plasma soluble intercellular adhesion molecule-1 has a central role in biomarker network analysis and is associated with poor outcomes in two distinct pediatric cohorts of acute respiratory distress syndrome and acute respiratory failure","volume":"53","author":"Lim","year":"2025","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.gene.2026.150276_b0235","article-title":"Circulating pulmonary-originated epithelial biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis","volume":"24","author":"Lin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150276_b0240","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clinbiochem.2019.02.009","article-title":"Explore potential plasma biomarkers of acute respiratory distress syndrome (ARDS) using GC\u2013MS metabolomics analysis","volume":"66","author":"Lin","year":"2019","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.gene.2026.150276_b0245","article-title":"Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients","volume":"19","author":"Liu","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2026.150276_b0250","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1089\/ars.2018.7701","article-title":"Genomic and genetic approaches to deciphering acute respiratory distress syndrome risk and mortality","volume":"31","author":"Lynn","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.gene.2026.150276_b0255","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pedneo.2024.03.011","article-title":"Plasma MiR-190 is a potential clinical biomarker for acute respiratory distress syndrome in children and its regulatory role in ARDS cell models by targeting KLF15","volume":"66","author":"Ma","year":"2025","journal-title":"Pediatr. Neonatol."},{"key":"10.1016\/j.gene.2026.150276_b0260","doi-asserted-by":"crossref","unstructured":"Ma, W., Tang, Songling, Yao, P., Zhou, T., Niu, Q., Liu, P., Tang, Shiyuan, Chen, Y., Gan, L., Cao, Y., 2025. Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies. Signal Transduction and Targeted Therapy 2025 10:1 10, 75-. Doi:10.1038\/s41392-025-02127-9.","DOI":"10.1038\/s41392-025-02127-9"},{"key":"10.1016\/j.gene.2026.150276_b0265","doi-asserted-by":"crossref","unstructured":"Nie, J., Zhou, L., Tian, W., Liu, X., Yang, L., Yang, X., Zhang, Y., Wei, S., Wang, D.W., Wei, J., 2025. Deep insight into cytokine storm: from pathogenesis to treatment. Signal Transduction and Targeted Therapy 2025 10:1 10, 112-. Doi:10.1038\/s41392-025-02178-y.","DOI":"10.1038\/s41392-025-02178-y"},{"key":"10.1016\/j.gene.2026.150276_b0270","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12987-025-00687-0","article-title":"Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1\u2013phosphate receptor 1","volume":"22","author":"Nosratabadi","year":"2025","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.gene.2026.150276_b0275","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1378\/chest.60.3.233","article-title":"The adult respiratory distress syndrome: clinical features, factors influencing prognosis and principles of management","volume":"60","author":"Petty","year":"1971","journal-title":"Chest"},{"key":"10.1016\/j.gene.2026.150276_b0280","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-024-01620-y","article-title":"Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications","volume":"22","author":"Qiao","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.gene.2026.150276_b0285","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.5005\/jp-journals-10071-25092","article-title":"Utility of extracellular nicotinamide phosphoribosyl transferase as a novel biomarker in predicting early severe organ dysfunction and mortality in acute respiratory distress syndrome: a prospective observational study","volume":"29","author":"Rao","year":"2025","journal-title":"Indian J. Crit. Care Med."},{"key":"10.1016\/j.gene.2026.150276_b0290","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s10875-020-00849-9","article-title":"Unraveling the immune response in severe COVID-19","volume":"40","author":"Rodriguez","year":"2020","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.gene.2026.150276_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22052566","article-title":"The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung","volume":"22","author":"Ruaro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150276_b0300","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202210579","article-title":"Engineered extracellular vesicles derived from dermal fibroblasts attenuate inflammation in a murine model of acute lung injury","volume":"35","author":"Salazar-Puerta","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.gene.2026.150276_b0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260450","article-title":"Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: a bioinformatics and experimental study","volume":"16","author":"Sen\u2019kova","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2026.150276_b0310","doi-asserted-by":"crossref","unstructured":"Serra-Llovich, A., Cullell, N., Maro\u00f1as, O., Jos\u00e9 Herrero, M., Cruz, R., Almoguera, B., Ayuso, C., L\u00f3pez-Rodr\u00edguez, R., Dom\u00ednguez-Garrido, E., Ortiz-Lopez, R., Barreda-S\u00e1nchez, M., Corton, M., Dalmau, D., Calbo, E., Boix-Palop, L., Dietl, B., Sangil, A., Gil-Rodriguez, A., Guill\u00e9n-Navarro, E., Mancebo, E., Lira-Albarr\u00e1n, S., Minguez, P., Paz-Artal, E., Olivera, G.G., Recarey-Rama, S., Sendra, L., Zucchet, E.G., L\u00f3pez de Heredia, M., Flores, C., Riancho, J.A., Rojas-Martinez, A., Lapunzina, P., Carracedo, \u00c1., Arranz, M.J., 2025. Pharmacogenomic study of SARS-CoV-2 treatments: identifying polymorphisms associated with treatment response in COVID-19 patients. Biomedicines 2025, Vol. 13, 13. Doi:10.3390\/biomedicines13030553.","DOI":"10.3390\/biomedicines13030553"},{"key":"10.1016\/j.gene.2026.150276_b0315","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1491175","article-title":"Revisiting surfactant protein D: an immune surveillance molecule bridging innate and adaptive immunity","volume":"15","author":"Shamim","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2026.150276_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154388","article-title":"Macrophage-epithelial cells crosstalk and the role of CCL2-CCR2 axis in single-walled carbon nanotubes-induced lung inflammation and fibrosis","volume":"521","author":"Shen","year":"2026","journal-title":"Toxicology"},{"key":"10.1016\/j.gene.2026.150276_b0325","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.bbagen.2019.04.001","article-title":"Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells","volume":"1863","author":"Shi","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.gene.2026.150276_b0330","unstructured":"Sinha, P., Meyer, N.J., Calfee, C.S., 2026. Biological phenotyping in sepsis and acute respiratory distress syndrome. Annual Review of Medicine Downloaded from www.annualreviews.org. Guest. Doi:10.1146\/annurev-med-043021."},{"key":"10.1016\/j.gene.2026.150276_b0335","doi-asserted-by":"crossref","DOI":"10.1113\/EP093296","article-title":"Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries","volume":"111","author":"Skovsted","year":"2026","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.gene.2026.150276_b0340","doi-asserted-by":"crossref","DOI":"10.1186\/s12950-018-0202-y","article-title":"Biomarkers for Acute respiratory distress syndrome and prospects for personalised medicine","volume":"16","author":"Spadaro","year":"2019","journal-title":"J. Inflamm. (Lond)"},{"key":"10.1016\/j.gene.2026.150276_b0345","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1097\/CCM.0000000000006458","article-title":"Pathophysiological markers of acute respiratory distress syndrome severity are correlated with ventilation-perfusion mismatch measured by electrical impedance tomography","volume":"53","author":"Spinelli","year":"2025","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.gene.2026.150276_b0350","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3390\/biom15111621","article-title":"Circulating microRNAs and plasma gelsolin as biomarkers of sepsis: molecular insights and prospects for precision medicine","volume":"15","author":"Stoian","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.gene.2026.150276_b0355","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1194495","article-title":"CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia","volume":"13","author":"Sun","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.gene.2026.150276_b0360","doi-asserted-by":"crossref","first-page":"L467","DOI":"10.1152\/ajplung.00010.2013","article-title":"Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome","volume":"305","author":"Sun","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.gene.2026.150276_b0365","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.5005\/jaypee-journals-10071-24933.15","article-title":"Biomarkers of sepsis: present and future perspectives","volume":"29","author":"Swain","year":"2025","journal-title":"Indian J. Crit. Care Med."},{"key":"10.1016\/j.gene.2026.150276_b0370","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1586949","article-title":"Lung microbiota: a new hope for treating acute respiratory distress syndrome?","volume":"16","author":"Tang","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.gene.2026.150276_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33679","article-title":"Pneumomediastinum and pneumothorax in coronavirus disease-2019: description of a case series and a matched cohort study","volume":"10","author":"Tekin","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.gene.2026.150276_b0380","doi-asserted-by":"crossref","DOI":"10.21037\/med-23-39","article-title":"Pneumomediastinum and pneumothorax in acute respiratory distress syndrome (ARDS) patients: a narrative review","volume":"8","author":"Teo","year":"2024","journal-title":"Mediastinum"},{"key":"10.1016\/j.gene.2026.150276_b0385","article-title":"The interplay between antibiotics and the host immune response in sepsis: from basic mechanisms to clinical considerations: a comprehensive narrative review","volume":"13","author":"Tosi","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.gene.2026.150276_b0390","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40203-025-00450-1","article-title":"Peripheral blood, lung and brain gene signatures in recovered and deceased patients with COVID-19","volume":"13","author":"Twum","year":"2025","journal-title":"In Silico Pharmacol."},{"key":"10.1016\/j.gene.2026.150276_b0395","doi-asserted-by":"crossref","first-page":"70","DOI":"10.31088\/CEM2024.13.3.70-78","article-title":"Evaluation of the expression of endothelial and some inflammation markers in an experimental acute respiratory distress syndrome model","volume":"13","author":"Ustenko","year":"2024","journal-title":"Clin. Exp. Morphol."},{"key":"10.1016\/j.gene.2026.150276_b0400","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20240806","article-title":"Targeting TNF\/TNFR superfamilies in immune-mediated inflammatory diseases","volume":"221","author":"Veerasubramanian","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.gene.2026.150276_b0405","article-title":"Regulatory role of S1P and its receptors in sepsis-induced liver injury","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2026.150276_b0410","doi-asserted-by":"crossref","unstructured":"Wang, F., Xie, C., Wang, X., 2025. Mesenchymal stem cell therapies for ARDS: translational promise and challenges. Stem Cell Res. & Therapy 2025 16:1 16, 504-. Doi:10.1186\/s13287-025-04614-w.","DOI":"10.1186\/s13287-025-04614-w"},{"key":"10.1016\/j.gene.2026.150276_b0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7717\/peerj.20317","article-title":"Serum growth differentiation factor 15 trajectory predicts 28-day mortality in critically ill patients: a multicenter cohort study","volume":"13","author":"Wang","year":"2025","journal-title":"PeerJ"},{"key":"10.1016\/j.gene.2026.150276_b0420","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1097\/JS9.0000000000000434","article-title":"Early plasma proteomic biomarkers and prediction model of acute respiratory distress syndrome after cardiopulmonary bypass: a prospective nested cohort study","volume":"109","author":"Wang","year":"2023","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.gene.2026.150276_b0425","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70812","article-title":"Genetic and multi-omics insights into monocyte pantothenate-mediated protection in acute respiratory distress syndrome","volume":"29","author":"Wang","year":"2025","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.gene.2026.150276_b0430","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076612","article-title":"Acute respiratory distress syndrome","volume":"387","author":"Wick","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.gene.2026.150276_b0435","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1662643","article-title":"Chemokines as potential biomarkers for predicting the course of COVID-19 \u2013 a review of the literature","volume":"16","author":"Wolszczak-Biedrzycka","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.gene.2026.150276_b0440","article-title":"Modified Dachengqi decoction ameliorates sepsis-induced lung injury via the gut microbiota-bile acid axis","volume":"16","author":"Wu","year":"2026","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.gene.2026.150276_b0445","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1551138","article-title":"Unraveling the deadly dance: endothelial cells and neutrophils in sepsis-induced acute lung injury\/acute respiratory distress syndrome","volume":"13","author":"Xu","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gene.2026.150276_b0450","article-title":"The association between toll-like receptor gene polymorphism and Helicobacter pylori infection risk: a systematic review and meta-analysis","volume":"105","author":"Xu","year":"2026","journal-title":"Medicine"},{"key":"10.1016\/j.gene.2026.150276_b0455","article-title":"Etiology and clinical significance of peripheral blood cytokines in geriatric patients with pulmonary infections","volume":"12","author":"Xue","year":"2025","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.gene.2026.150276_b0460","article-title":"The role of inflammasomes in human diseases and their potential as therapeutic targets","volume":"9","author":"Yao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.gene.2026.150276_b0465","doi-asserted-by":"crossref","DOI":"10.1172\/JCI177896","article-title":"Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome","volume":"134","author":"Yehya","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.gene.2026.150276_b0470","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ccm.2024.08.003","article-title":"Biomarkers of acute respiratory distress syndrome: current state and future prospects","volume":"45","author":"Zalucky","year":"2024","journal-title":"Clin. Chest Med."},{"key":"10.1016\/j.gene.2026.150276_b0475","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12964-025-02098-y","article-title":"Dysregulation of neutrophil in sepsis: recent insights and advances","volume":"23","author":"Zhang","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.gene.2026.150276_b0480","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2217\/bmm-2021-0749","article-title":"Novel biomarkers for acute respiratory distress syndrome: genetics, epigenetics and transcriptomics","volume":"16","author":"Zheng","year":"2022","journal-title":"Biomark. Med."},{"key":"10.1016\/j.gene.2026.150276_b0485","article-title":"Advancements in omics technologies: molecular mechanisms of acute lung injury and acute respiratory distress syndrome (review)","volume":"55","author":"Zheng","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.gene.2026.150276_b0490","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1563427","article-title":"Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases","volume":"13","author":"Zubair","year":"2025","journal-title":"Front. Cell Dev. Biol."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926002866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926002866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:30:12Z","timestamp":1785875412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926002866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":98,"alternative-id":["S0378111926002866"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150276","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Candidate genetic and multi-omics determinants potentially contributing to Macklin effect development in acute respiratory distress syndrome: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150276"}}