{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:01:25Z","timestamp":1785207685585,"version":"3.55.0"},"reference-count":127,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.gene.2026.150278","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:13:56Z","timestamp":1782231236000},"page":"150278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Whole exome sequencing uncovers key genetic variants in congenital tooth agenesis: an integrative omics approach"],"prefix":"10.1016","volume":"1008","author":[{"given":"Prashant","family":"Ranjan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Devi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay Kumar","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimjhim","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-4277","authenticated-orcid":false,"given":"Parimal","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0005","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/children10030596","article-title":"Permanent tooth agenesis and associated dental anomalies among Orthodontically treated children","volume":"10","author":"Schonberger","year":"2023","journal-title":"Children"},{"key":"10.1016\/j.gene.2026.150278_b0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jdsr.2023.07.001","article-title":"Tooth agenesis: an overview of diagnosis, aetiology and management","volume":"59","author":"Meade","year":"2023","journal-title":"Jpn. Dent. Sci. Rev."},{"issue":"7","key":"10.1016\/j.gene.2026.150278_b0015","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.archoralbio.2012.01.005","article-title":"Genetic basis of non-syndromic anomalies of human tooth number","volume":"57","author":"Galluccio","year":"2012","journal-title":"Arch. Oral Biol."},{"issue":"04","key":"10.1016\/j.gene.2026.150278_b0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1055\/s-0036-1592421","article-title":"Genetic basis of nonsyndromic and syndromic tooth agenesis","volume":"5","author":"Ye","year":"2016","journal-title":"J. Pediatr. Genet."},{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0025","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s40368-024-00901-x","article-title":"Non-syndromic tooth agenesis in Latvian adolescent dental patients: a retrospective study with relevant literature review","volume":"25","author":"Meistere","year":"2024","journal-title":"Eur. Arch. Paediatr. Dent."},{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0030","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/odi.12931","article-title":"Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis","volume":"25","author":"Yu","year":"2019","journal-title":"Oral Dis."},{"key":"10.1016\/j.gene.2026.150278_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2022.105465","article-title":"Role and mechanism of BMP4 in bone, craniofacial, and tooth development","volume":"140","author":"Ye","year":"2022","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.gene.2026.150278_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1168538","article-title":"The EDA\/EDAR\/NF-\u03baB pathway in non-syndromic tooth agenesis: a genetic perspective","volume":"14","author":"Gao","year":"2023","journal-title":"Front. Genet."},{"issue":"4","key":"10.1016\/j.gene.2026.150278_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115437","article-title":"Integrated multi-omics profiling characterizes the crucial role of human dental epithelium during tooth development","volume":"44","author":"Zhang","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.gene.2026.150278_b0050","first-page":"1","article-title":"Understanding the role of MicroRNAs in congenital tooth agenesis: a multi-omics integration","author":"Ranjan","year":"2025","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.gene.2026.150278_b0055","doi-asserted-by":"crossref","unstructured":"Ranjan, P., Devi, C., Srivastava, V.K., Chandel, M., Jain, G., Das, P., 2025. \u201cPan-Omics Fusion and Machine Learning Unveil Congenital Tooth Agenesis-Ecto-mesodermal Diseases Link and Biomarker Discovery,\u201d medRxiv, pp. 2003\u20132025. Doi:10.1101\/2025.03.09.25323497.","DOI":"10.1101\/2025.03.09.25323497"},{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0060","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41525-022-00295-z","article-title":"Best practices for the interpretation and reporting of clinical whole genome sequencing","volume":"7","author":"Austin-Tse","year":"2022","journal-title":"NPJ Genom. Med."},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0070","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/jmg-2023-109470","article-title":"Diagnostic genome sequencing improves diagnostic yield: a prospective single-centre study in 1000 patients with inherited eye diseases","volume":"61","author":"Weisschuh","year":"2024","journal-title":"J. Med. Genet."},{"issue":"8021","key":"10.1016\/j.gene.2026.150278_b0075","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-024-07556-0","article-title":"A deep catalogue of protein-coding variation in 983,578 individuals","volume":"631","author":"Sun","year":"2024","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.gene.2026.150278_b0080","first-page":"387","article-title":"The Human Protein Atlas\u2014a tool for pathology","volume":"216","author":"Pont\u00e9n","year":"2008","journal-title":"J. Pathol. A J. Pathol. Soc. Gt. Britain Irel."},{"key":"10.1016\/j.gene.2026.150278_b0085","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baq020","article-title":"GeneCards Version 3: the human gene integrator","volume":"2010","author":"Safran","year":"2010","journal-title":"Database"},{"issue":"9","key":"10.1016\/j.gene.2026.150278_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106811","article-title":"Whole genome sequencing reveals novel non-synonymous mutation in ectodysplasin a (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis","volume":"9","author":"Sarkar","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0095","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1021\/ci960402j","article-title":"GraphPad prism, data analysis, and scientific graphing","volume":"37","author":"Swift","year":"1997","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.gene.2026.150278_b0100","doi-asserted-by":"crossref","unstructured":"Oliveros, J.C., 2007. \u201cVENNY. An interactive tool for comparing lists with Venn Diagrams,\u201d http\/\/bioinfogp. cnb. csic. es\/tools\/venny\/index. html, Doi:10.32614\/cran.package.venny.","DOI":"10.32614\/CRAN.package.venny"},{"key":"10.1016\/j.gene.2026.150278_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-14-S18-S1","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"issue":"suppl_1","key":"10.1016\/j.gene.2026.150278_b0110","first-page":"D561","article-title":"The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored","volume":"39","author":"Szklarczyk","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0115","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: network analysis and visualization of proteomics data","volume":"18","author":"Doncheva","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.gene.2026.150278_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2015.123","article-title":"SIFT missense predictions for genomes","volume":"11","author":"Vaser","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.gene.2026.150278_b0130","doi-asserted-by":"crossref","unstructured":"Adzhubei, I., Jordan, D.M., \u201cSunyaev, predicting functional effect of human missense mutations using PolyPhen-2,\u201d Curr. Protoc. Hum. Genet. p. 7. Doi:10.1002\/0471142905.hg0720s76.","DOI":"10.1002\/0471142905.hg0720s76"},{"issue":"8","key":"10.1016\/j.gene.2026.150278_b0135","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nmeth0810-575","article-title":"MutationTaster evaluates disease-causing potential of sequence alterations","volume":"7","author":"Schwarz","year":"2010","journal-title":"Nat. Methods"},{"issue":"D1","key":"10.1016\/j.gene.2026.150278_b0140","doi-asserted-by":"crossref","first-page":"D886","DOI":"10.1093\/nar\/gky1016","article-title":"CADD: predicting the deleteriousness of variants throughout the human genome","volume":"47","author":"Rentzsch","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0145","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/bioinformatics\/btt691","article-title":"mCSM: predicting the effects of mutations in proteins using graph-based signatures","volume":"30","author":"Pires","year":"2014","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.gene.2026.150278_b0150","doi-asserted-by":"crossref","first-page":"W314","DOI":"10.1093\/nar\/gku411","article-title":"DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach","volume":"42","author":"Pires","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"suppl_2","key":"10.1016\/j.gene.2026.150278_b0155","doi-asserted-by":"crossref","first-page":"W215","DOI":"10.1093\/nar\/gkr363","article-title":"SDM\u2014a server for predicting effects of mutations on protein stability and malfunction","volume":"39","author":"Worth","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2026.150278_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-14-105","article-title":"SDM-Assist software to design site-directed mutagenesis primers introducing \u2018silent\u2019 restriction sites","volume":"14","author":"Karnik","year":"2013","journal-title":"BMC Bioinf."},{"issue":"suppl_2","key":"10.1016\/j.gene.2026.150278_b0165","doi-asserted-by":"crossref","first-page":"W306","DOI":"10.1093\/nar\/gki375","article-title":"I-Mutant2. 0: predicting stability changes upon mutation from the protein sequence or structure","volume":"33","author":"Capriotti","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"suppl_2","key":"10.1016\/j.gene.2026.150278_b0170","doi-asserted-by":"crossref","first-page":"W239","DOI":"10.1093\/nar\/gkl190","article-title":"CUPSAT: prediction of protein stability upon point mutations","volume":"34","author":"Parthiban","year":"2006","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/bioinformatics\/19.1.163","article-title":"ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information","volume":"19","author":"Glaser","year":"2003","journal-title":"Bioinformatics"},{"issue":"7873","key":"10.1016\/j.gene.2026.150278_b0180","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"suppl_1","key":"10.1016\/j.gene.2026.150278_b0185","doi-asserted-by":"crossref","first-page":"D387","DOI":"10.1093\/nar\/gkn750","article-title":"The SWISS-MODEL Repository and associated resources","volume":"37","author":"Kiefer","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"1\u20133","key":"10.1016\/j.gene.2026.150278_b0190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0010-4655(95)00042-E","article-title":"GROMACS: a message-passing parallel molecular dynamics implementation","volume":"91","author":"Berendsen","year":"1995","journal-title":"Comput. Phys. Commun."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0195","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/pro.3289","article-title":"PDBsum: Structural summaries of PDB entries","volume":"27","author":"Laskowski","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.gene.2026.150278_b0200","doi-asserted-by":"crossref","unstructured":"Devi, C., Ranjan, P., Raj, S., Das, P., 2024. \u201cComputational Exploration of Protein Structure Dynamics and RNA structural Consequences of PKD1 Missense Variants: Implications in ADPKD Pathogenesis,\u201d bioRxiv, pp. 2003\u20132024, 2024. Doi:10.1101\/2024.03.21.586139.","DOI":"10.1101\/2024.03.21.586139"},{"issue":"W1","key":"10.1016\/j.gene.2026.150278_b0205","doi-asserted-by":"crossref","first-page":"W471","DOI":"10.1093\/nar\/gkt290","article-title":"RNAstructure: web servers for RNA secondary structure prediction and analysis","volume":"41","author":"Bellaousov","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.gene.2026.150278_b0210","doi-asserted-by":"crossref","first-page":"W287","DOI":"10.1093\/nar\/gkaa331","article-title":"MutaRNA: analysis and visualization of mutation-induced changes in RNA structure","volume":"48","author":"Miladi","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2026.150278_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1748-7188-6-3","article-title":"RNA Accessibility in cubic time","volume":"6","author":"Bernhart","year":"2011","journal-title":"Algorithms Mol. Biol."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0220","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/nar\/gks1009","article-title":"Sensitive measurement of single-nucleotide polymorphism-induced changes of RNA conformation: application to disease studies","volume":"41","author":"Salari","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.gene.2026.150278_b0225","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1006\/jmbi.1999.3310","article-title":"Sequence and structure-based prediction of eukaryotic protein phosphorylation sites","volume":"294","author":"Blom","year":"1999","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0230","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2174\/0929866526666191002111404","article-title":"Nglyc: a random forest method for prediction of N-glycosylation sites in eukaryotic protein sequence","volume":"27","author":"Pugalenthi","year":"2020","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.gene.2026.150278_b0235","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1006960004440","article-title":"NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility","volume":"15","author":"Hansen","year":"1998","journal-title":"Glycoconj. J."},{"issue":"6","key":"10.1016\/j.gene.2026.150278_b0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011290","article-title":"GPS-SNO: computational prediction of protein S-nitrosylation sites with a modified GPS algorithm","volume":"5","author":"Xue","year":"2010","journal-title":"PLoS One"},{"issue":"W1","key":"10.1016\/j.gene.2026.150278_b0245","doi-asserted-by":"crossref","first-page":"W325","DOI":"10.1093\/nar\/gku383","article-title":"GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs","volume":"42","author":"Zhao","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.gene.2026.150278_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2005-6-6-r55","article-title":"Refinement and prediction of protein prenylation motifs","volume":"6","author":"Maurer-Stroh","year":"2005","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0255","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/prot.22555","article-title":"Identification, analysis, and prediction of protein ubiquitination sites","volume":"78","author":"Radivojac","year":"2010","journal-title":"Proteins Struct. Funct. Bioinforma."},{"key":"10.1016\/j.gene.2026.150278_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123375","article-title":"An inclusive study of deleterious missense PAX9 variants using user-friendly tools reveals structural, functional alterations, as well as potential therapeutic targets","volume":"233","author":"Ranjan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep39787","article-title":"GPS-PAIL: prediction of lysine acetyltransferase-specific modification sites from protein sequences","volume":"6","author":"Deng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2026.150278_b0270","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00249-011-0700-9","article-title":"Definition and testing of the GROMOS force-field versions 54A7 and 54B7","volume":"40","author":"Schmid","year":"2011","journal-title":"Eur. Biophys. J."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0275","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s43042-024-00593-4","article-title":"An integrative analysis of functional consequences of PKD2 missense variants on RNA and protein structures: a computational approach","volume":"25","author":"Devi","year":"2024","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"10.1016\/j.gene.2026.150278_b0280","unstructured":"Cowan, R., Grosdidier, G., 2000. \u201cVisualization tools for monitoring and evaluation of distributed computing systems,\u201d in: Proc. of the International Conference on Computing in High Energy and Nuclear Physics, Padova, Italy, 2000."},{"key":"10.1016\/j.gene.2026.150278_b0285","doi-asserted-by":"crossref","unstructured":"Berk, K.N., Carey, P., 1998. Data Analysis with Microsoft Excel. Duxbury Press Pacific Grove, CA, 1998. Doi:10.2307\/1271372.","DOI":"10.2307\/1271372"},{"key":"10.1016\/j.gene.2026.150278_b0290","series-title":"Machine Learning for Evolution Strategies","author":"Kramer","year":"2016"},{"key":"10.1016\/j.gene.2026.150278_b0295","doi-asserted-by":"crossref","unstructured":"Python, W., 2021. \u201cPython releases for windows,\u201d Python releases Wind., vol. 24, 2021. Doi:10.1016\/b978-0-12-819549-9.00035-x.","DOI":"10.1016\/B978-0-12-819549-9.00035-X"},{"key":"10.1016\/j.gene.2026.150278_b0300","doi-asserted-by":"crossref","unstructured":"Hunter, J., Dale, D., 2007. \u201cThe matplotlib user\u2019s guide,\u201d Matplotlib 0.90. 0 user\u2019s Guide Doi:10.1109\/mcse.2007.55.","DOI":"10.1109\/MCSE.2007.55"},{"issue":"W1","key":"10.1016\/j.gene.2026.150278_b0305","doi-asserted-by":"crossref","first-page":"W402","DOI":"10.1093\/nar\/gkz297","article-title":"The PSIPRED protein analysis workbench: 20 years on","volume":"47","author":"Buchan","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"suppl_2","key":"10.1016\/j.gene.2026.150278_b0310","doi-asserted-by":"crossref","first-page":"W47","DOI":"10.1093\/nar\/gkn285","article-title":"Superimpose: a 3D structural superposition server","volume":"36","author":"Bauer","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.gene.2026.150278_b0315","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.molp.2020.06.009","article-title":"TBtools: an integrative toolkit developed for interactive analyses of big biological data","volume":"13","author":"Chen","year":"2020","journal-title":"Mol. Plant"},{"issue":"W1","key":"10.1016\/j.gene.2026.150278_b0320","doi-asserted-by":"crossref","first-page":"W228","DOI":"10.1093\/nar\/gkac278","article-title":"DeepLoc 2.0: multi-label subcellular localization prediction using protein language models","volume":"50","author":"Thumuluri","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2026.150278_b0325","doi-asserted-by":"crossref","unstructured":"Syst\u00e8mes, D., 2016. \u201cBiovia, discovery studio modeling environment,\u201d Dassault Syst\u00e8mes Biovia San Diego, CA, USA. Doi:10.1016\/b978-0-443-26704-8.00002-2.","DOI":"10.1016\/B978-0-443-26704-8.00002-2"},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0330","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jcb.30186","article-title":"Understanding the impact of missense mutations on the structure and function of the EDA gene in X\u2010linked hypohidrotic ectodermal dysplasia: a bioinformatics approach","volume":"123","author":"Ranjan","year":"2022","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.gene.2026.150278_b0335","doi-asserted-by":"crossref","unstructured":"Ranjan Jr, P., Devi Jr, C., Verma Sr, N., Bansal Sr, R., Srivastava Sr, V.K., Das Sr, P., 2024. \u201cUnderstanding Tooth Agenesis: A Multi-omics Insight into MicroRNA Regulation,\u201d medRxiv, pp. 2009\u20132024. Doi:10.1101\/2024.09.02.24312916.","DOI":"10.1101\/2024.09.02.24312916"},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0340","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ajhg.2009.06.001","article-title":"WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes","volume":"85","author":"Bohring","year":"2009","journal-title":"Am. J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.gene.2026.150278_b0345","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/jmedgenet-2012-100750","article-title":"Mutations in WNT10A are present in more than half of isolated hypodontia cases","volume":"49","author":"van den Boogaard","year":"2012","journal-title":"J. Med. Genet."},{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0350","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/0022034520962728","article-title":"Functional effects of WNT10A rare variants associated with tooth agenesis","volume":"100","author":"Zeng","year":"2021","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.gene.2026.150278_b0355","first-page":"1161","article-title":"Hypohidrotic ectodermal dysplasia and its manifestations in the oral cavity","volume":"7","author":"Cardoso","year":"2021","journal-title":"J. Dent. Oral Disord."},{"key":"10.1016\/j.gene.2026.150278_b0360","doi-asserted-by":"crossref","unstructured":"Ranjan, P., Devi, C., Bansal, R., Srivastava, V., Srivastava, V.K., Das, P., 2025. \u201cNovel Ectodysplasin-A Variants: Structural and Functional Basis of Hypohidrotic Ectodermal Dysplasia,\u201d Doi:10.21203\/rs.3.rs-5743160\/v1.","DOI":"10.21203\/rs.3.rs-5743160\/v1"},{"key":"10.1016\/j.gene.2026.150278_b0365","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.2147\/CCID.S451125","article-title":"A novel ectodysplasin a gene mutation of X-linked hypohidrotic ectodermal dysplasia","author":"Zhuang","year":"2024","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"5","key":"10.1016\/j.gene.2026.150278_b0370","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/cge.12986","article-title":"PAX9 gene mutations and tooth agenesis: a review","volume":"92","author":"Bonczek","year":"2017","journal-title":"Clin. Genet."},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0375","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/0022034517729322","article-title":"Nine novel PAX9 mutations and a distinct tooth agenesis genotype-phenotype","volume":"97","author":"Wong","year":"2018","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.gene.2026.150278_b0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40101-018-0168-8","article-title":"Sequencing the exons of human glucocorticoid receptor (NR3C1) gene in Han Chinese with high-altitude pulmonary edema","volume":"37","author":"Du","year":"2018","journal-title":"J. Physiol. Anthropol."},{"issue":"10","key":"10.1016\/j.gene.2026.150278_b0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006369","article-title":"Mutations in TSPEAR, encoding a regulator of notch signaling, affect tooth and hair follicle morphogenesis","volume":"12","author":"Peled","year":"2016","journal-title":"PLoS Genet."},{"issue":"4","key":"10.1016\/j.gene.2026.150278_b0390","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ped4.12454","article-title":"Novel compound heterozygous variants in the TSPEAR gene causing autosomal recessive hearing loss in a Chinese family","volume":"8","author":"Shi","year":"2024","journal-title":"Pediatr. Investig."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0395","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yexcr.2013.08.002","article-title":"Signaling pathways regulating ectodermal cell fate choices","volume":"321","author":"Patthey","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.gene.2026.150278_b0400","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.csbj.2017.03.004","article-title":"Protein post-translational modifications: In silico prediction tools and molecular modeling","volume":"15","author":"Audagnotto","year":"2017","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"7","key":"10.1016\/j.gene.2026.150278_b0405","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/brain\/awy141","article-title":"Genetic study of multimodal imaging Alzheimer\u2019s disease progression score implicates novel loci","volume":"141","author":"Scelsi","year":"2018","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0410","doi-asserted-by":"crossref","first-page":"6372","DOI":"10.1038\/s41598-017-06766-z","article-title":"Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0415","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1038\/s41467-018-04193-w","article-title":"Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment","volume":"9","author":"Ashraf","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150278_b0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-018-0465-x","article-title":"AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells","volume":"25","author":"Cheng","year":"2018","journal-title":"J. Biomed. Sci."},{"issue":"5","key":"10.1016\/j.gene.2026.150278_b0425","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/gepi.21972","article-title":"Using whole exome sequencing to identify candidate genes with rare variants in nonsyndromic cleft lip and palate","volume":"40","author":"Aylward","year":"2016","journal-title":"Genet. Epidemiol."},{"issue":"20","key":"10.1016\/j.gene.2026.150278_b0430","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1093\/hmg\/ddq307","article-title":"A genome-wide scan for common alleles affecting risk for autism","volume":"19","author":"Anney","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2026.150278_b0435","article-title":"Pan-cancer investigation of C-to-U editing reveals its important role in cancer development and new targets for cancer treatment","volume":"13","author":"Guo","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2026.150278_b0440","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.912671","article-title":"Impaired neurodevelopmental genes in Slovenian autistic children elucidate the comorbidity of autism with other developmental disorders","volume":"15","author":"Krgovic","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.gene.2026.150278_b0445","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13040-014-0035-z","article-title":"Identifying genetic interactions associated with late-onset Alzheimer\u2019s disease","volume":"7","author":"Floudas","year":"2014","journal-title":"Biodata Min."},{"issue":"20","key":"10.1016\/j.gene.2026.150278_b0450","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1093\/hmg\/ddq315","article-title":"\u03b1-Cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects","volume":"19","author":"Granados-Riveron","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"24","key":"10.1016\/j.gene.2026.150278_b0455","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1093\/hmg\/dds386","article-title":"Kinetochore KMN network gene CASC5 mutated in primary microcephaly","volume":"21","author":"Genin","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gene.2026.150278_b0460","article-title":"KNL1 is a prognostic and diagnostic biomarker related to immune infiltration in patients with uterine corpus endometrial carcinoma","volume":"13","author":"He","year":"2023","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.gene.2026.150278_b0465","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/ejhg.2010.69","article-title":"Linkage and candidate gene studies of autism spectrum disorders in European populations","volume":"18","author":"Holt","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.gene.2026.150278_b0470","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1152\/physrev.00019.2022","article-title":"Mesenchymal condensation in tooth development and regeneration: a focus on translational aspects of organogenesis","volume":"103","author":"Sui","year":"2023","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.gene.2026.150278_b0475","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3390\/metabo13040520","article-title":"The role of cellular metabolism in maintaining the function of the dentine-pulp complex: a narrative review","volume":"13","author":"Nijakowski","year":"2023","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0480","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12887-023-04095-x","article-title":"Case\u2013control association study of congenital heart disease from a tertiary paediatric cardiac centre from North India","volume":"23","author":"Kukshal","year":"2023","journal-title":"BMC Pediatr."},{"issue":"16","key":"10.1016\/j.gene.2026.150278_b0485","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1158\/0008-5472.CAN-08-4818","article-title":"A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer","volume":"69","author":"Min","year":"2009","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.gene.2026.150278_b0490","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.3390\/ijms24119407","article-title":"The Lysyl oxidase G473A polymorphism exacerbates oral cancer development in humans and mice","volume":"24","author":"Peymanfar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.gene.2026.150278_b0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145815","article-title":"Association of common variants in LOX with keratoconus: a meta-analysis","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0500","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/diagnostics12010053","article-title":"Serum lysyl oxidase levels and lysyl oxidase gene polymorphism in ovarian cancer patients of eastern Indian population","volume":"12","author":"Kumari","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.gene.2026.150278_b0505","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijbiomac.2017.05.050","article-title":"Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers","volume":"103","author":"Pichu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.gene.2026.150278_b0510","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1089\/dna.2014.2490","article-title":"Lysyl oxidase genetic variants affect gene expression in cervical cancer","volume":"33","author":"Bu","year":"2014","journal-title":"DNA Cell Biol."},{"issue":"11","key":"10.1016\/j.gene.2026.150278_b0515","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1600-0463.2011.02802.x","article-title":"Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a south Korean population","volume":"119","author":"Yoon","year":"2011","journal-title":"APMIS"},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0520","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/humu.21384","article-title":"Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic\/anhidrotic ectodermal dysplasia cases","volume":"32","author":"Cluzeau","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.gene.2026.150278_b0525","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12894-017-0201-y","article-title":"Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer","volume":"17","author":"Fraga","year":"2017","journal-title":"BMC Urol."},{"issue":"7","key":"10.1016\/j.gene.2026.150278_b0530","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3390\/ijerph13070635","article-title":"Lysyl oxidase gene G473A polymorphism and cigarette smoking in association with a high risk of lung and colorectal cancers in a north Chinese population","volume":"13","author":"Wang","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"7","key":"10.1016\/j.gene.2026.150278_b0535","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041610","article-title":"Lysyl oxidase polymorphisms and susceptibility to osteosarcoma","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.gene.2026.150278_b0540","doi-asserted-by":"crossref","first-page":"11951","DOI":"10.3390\/ijms231911951","article-title":"Familial linkage and association of the NR3C1 gene with type 2 diabetes and depression comorbidity","volume":"23","author":"Amin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gene.2026.150278_b0545","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00439-018-1907-y","article-title":"Identification of likely pathogenic and known variants in TSPEAR, LAMB3, BCOR, and WNT10A in four Turkish families with tooth agenesis","volume":"137","author":"Du","year":"2018","journal-title":"Hum. Genet."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0550","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2217\/pgs-2017-0084","article-title":"NR3C1 gene polymorphisms are associated with steroid resistance in patients with primary nephrotic syndrome","volume":"19","author":"Liu","year":"2018","journal-title":"Pharmacogenomics"},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0555","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212097","article-title":"Reproducibility of pharmacogenetics findings for paclitaxel in a heterogeneous population of patients with lung cancer","volume":"14","author":"Sissung","year":"2019","journal-title":"PLoS One"},{"issue":"51","key":"10.1016\/j.gene.2026.150278_b0560","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000013829","article-title":"The association between IGF1 Gene 3\u2019-UTR polymorphisms and cancer risk: a Meta-analysis","volume":"97","author":"Xu","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0565","doi-asserted-by":"crossref","first-page":"39014","DOI":"10.1038\/srep39014","article-title":"Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population","volume":"6","author":"Cao","year":"2016","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.gene.2026.150278_b0570","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000024818","article-title":"Effect of TIMP2\/TIMP3 genes on the risk of osteosarcoma in Zhejiang population","volume":"100","author":"Wu","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"10.1016\/j.gene.2026.150278_b0575","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1136\/gutjnl-2015-309168","article-title":"Genetic variation and gastric cancer risk: a field synopsis and meta-analysis","volume":"64","author":"Mocellin","year":"2015","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.gene.2026.150278_b0580","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1158\/1078-0432.CCR-08-0177","article-title":"Functional variants in cell death pathway genes and risk of pancreatic cancer","volume":"14","author":"Yang","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.gene.2026.150278_b0585","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/ijc.24405","article-title":"Polymorphisms in tissue inhibitors of metalloproteinases\u20102 and\u20103 and breast cancer susceptibility and survival","volume":"125","author":"Peterson","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.gene.2026.150278_b0590","first-page":"37","article-title":"The rs1800471 polymorphism of TGFB1 gene, serum TGF-beta1 level and chronic kidney disease progression","author":"Kili\u015b-Pstrusi\u0144ska","year":"2015","journal-title":"Lung Cancer Autoimmune Disord."},{"key":"10.1016\/j.gene.2026.150278_b0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2350-13-39","article-title":"TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis","volume":"13","author":"Lu","year":"2012","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.gene.2026.150278_b0600","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00432-018-2585-9","article-title":"Transforming growth factor beta 1 (TGF\u03b21) polymorphisms and haplotype structures have dual roles in breast cancer pathogenesis","volume":"144","author":"Vitiello","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.gene.2026.150278_b0605","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.gde.2004.07.008","article-title":"TNF signalling in tooth development","volume":"14","author":"Ohazama","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"2","key":"10.1016\/j.gene.2026.150278_b0610","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/0022034511411302","article-title":"Tp63 in oral development, neoplasia, and autoimmunity","volume":"91","author":"Romano","year":"2012","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.gene.2026.150278_b0615","first-page":"1","article-title":"The association between runx signaling and craniofacial development and disease","author":"Yamashiro","year":"2022","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.gene.2026.150278_b0620","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00441-015-2248-y","article-title":"CXCR4\/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in the dental stem cell niche","volume":"362","author":"Yokohama-Tamaki","year":"2015","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.gene.2026.150278_b0625","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tig.2012.10.005","article-title":"Genetic pathways in disorders of epidermal differentiation","volume":"29","author":"Lopez-Pajares","year":"2013","journal-title":"Trends Genet."},{"key":"10.1016\/j.gene.2026.150278_b0630","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.740712","article-title":"Extracellular matrix derived from dental pulp stem cells promotes mineralization","volume":"9","author":"Nowwarote","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.gene.2026.150278_b0635","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70680","article-title":"Native proline-rich motifs exploit sequence context to target actin-remodeling Ena\/VASP protein ENAH","volume":"11","author":"Hwang","year":"2022","journal-title":"eLife"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192600288X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811192600288X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T12:08:46Z","timestamp":1784376526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811192600288X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":127,"alternative-id":["S037811192600288X"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150278","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole exome sequencing uncovers key genetic variants in congenital tooth agenesis: an integrative omics approach","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150278"}}