{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:49:46Z","timestamp":1786117786557,"version":"build-2736575974"},"reference-count":202,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.gene.2026.150311","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:12:38Z","timestamp":1783627958000},"page":"150311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genomic and chromosomal Instability: Hidden drivers of Glioblastoma aggressiveness"],"prefix":"10.1016","volume":"1009","author":[{"given":"Anlly","family":"Ni\u00f1o-Salgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3160-9316","authenticated-orcid":false,"given":"Milena","family":"Rond\u00f3n-Lagos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gene.2026.150311_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13099-025-00788-z","article-title":"Exploring the intricate link between gut microbiota dysbiosis and the aging process: implications for age-related diseases","volume":"18","author":"Abahussin","year":"2026","journal-title":"Gut Pathogens"},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2020.100884","article-title":"RNA-sequencing of IDH-wild-type glioblastoma with chromothripsis identifies novel gene fusions with potential oncogenic properties","volume":"14","author":"Ah-Pine","year":"2021","journal-title":"Transl. Oncol."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0015","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s40478-023-01605-x","article-title":"On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells","volume":"11","author":"Ah-Pine","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.gene.2026.150311_b0020","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/neuonc\/noad018","article-title":"Lysine-specific histone demethylase 1A (KDM1A\/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma","volume":"25","author":"Alejo","year":"2023","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2022.101913","article-title":"Chromosomal instability as a source of genomic plasticity","volume":"74","author":"Al-Rawi","year":"2022","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.gene.2026.150311_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.984329","article-title":"LncRNAs-associated to genomic instability: a barrier to cancer therapy effectiveness","volume":"13","author":"Andonegui-Elguera","year":"2022","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00280-019-03950-y","article-title":"Prexasertib, a checkpoint kinase inhibitor: from preclinical data to clinical development","volume":"85","author":"Angius","year":"2020","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/neuonc\/nox132","article-title":"Prognostic relevance of genetic alterations in diffuse lower-grade gliomas","volume":"20","author":"Aoki","year":"2018","journal-title":"Neuro Oncol."},{"issue":"6","key":"10.1016\/j.gene.2026.150311_b0045","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.cell.2018.08.027","article-title":"The multifaceted role of chromosomal instability in cancer and its microenvironment","volume":"174","author":"Bakhoum","year":"2018","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0050","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.trecan.2017.02.001","article-title":"Mitotic DNA damage response: at the crossroads of structural and numerical cancer chromosome instabilities","volume":"3","author":"Bakhoum","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.gene.2026.150311_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.810793","article-title":"Characterization of chromosomal instability in glioblastoma","volume":"12","author":"Balzano","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.gene.2026.150311_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2026.105206","article-title":"Mapping the molecular landscape of glioblastoma: Pathogenesis, therapeutic targets and bioactive interventions","volume":"221","author":"Banerjee","year":"2026","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.gene.2026.150311_b0065","doi-asserted-by":"crossref","unstructured":"Batist\u00e3o, H.K. de A., Oliveira-Silva, J.M., Oliveira, V.B., de Ara\u00fajo Batist\u00e3o, I.I., Castro-Gamero, A.M., 2026. Quantitative and qualitative methods for measuring chromosomal instability in tumor cells. Cancer Genet. 300\u2013301. Doi: 10.1016\/j.cancergen.2025.11.008.","DOI":"10.1016\/j.cancergen.2025.11.008"},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/epigenomes9010005","article-title":"Epigenomic echoes\u2014decoding genomic and epigenetic instability to distinguish lung cancer types and predict relapse","volume":"9","author":"Baumann","year":"2025","journal-title":"Epigenomes"},{"key":"10.1016\/j.gene.2026.150311_b0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2019.02.007","article-title":"Homologous recombination deficiency in triple negative breast cancer","volume":"45","author":"Belli","year":"2019","journal-title":"Breast"},{"issue":"15","key":"10.1016\/j.gene.2026.150311_b0080","doi-asserted-by":"crossref","first-page":"14429","DOI":"10.1007\/s00432-023-05244-6","article-title":"Microbiota as the unifying factor behind the hallmarks of cancer","volume":"149","author":"Bene\u0161ov\u00e1","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"28","key":"10.1016\/j.gene.2026.150311_b0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2111003119","article-title":"STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models","volume":"119","author":"Berger","year":"2022","journal-title":"PNAS"},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0090","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.ccell.2021.10.010","article-title":"Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer","volume":"39","author":"Berger","year":"2021","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0095","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1158\/0008-5472.CAN-10-3667","article-title":"Paradoxical relationship between chromosomal instability and survival outcome in cancer","volume":"71","author":"Birkbak","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2026.150311_b0100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fonc.2012.00176","article-title":"Repair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomide","volume":"2","author":"Bobola","year":"2012","journal-title":"Front. Oncol."},{"issue":"22","key":"10.1016\/j.gene.2026.150311_b0105","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1158\/0008-5472.CAN-20-1920","article-title":"Chromothripsis in human breast cancer","volume":"80","author":"Bolkestein","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.gene.2026.150311_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00073","article-title":"Landscape of microsatellite instability across 39 cancer types","volume":"2017","author":"Bonneville","year":"2017","journal-title":"JCO Precis. Oncol."},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00401-018-1913-0","article-title":"cIMPACT-NOW update 3: recommended diagnostic criteria for \u201cDiffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV\u201d","volume":"136","author":"Brat","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0120","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The somatic genomic landscape of glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150311_b0125","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3906\/sag-2010-166","article-title":"Investigation of the relationship between immune checkpoints and mismatch repair deficiency in recurrent and nonrecurrent glioblastoma","volume":"51","author":"\u00c7akir","year":"2021","journal-title":"Turk. J. Med. Sci."},{"issue":"4","key":"10.1016\/j.gene.2026.150311_b0130","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.mam.2012.06.007","article-title":"The good, the bad and the ugly: Epigenetic mechanisms in glioblastoma","volume":"34","author":"Car\u00e9n","year":"2013","journal-title":"Mol. Aspects Med."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/ijms24010245","article-title":"The adaptability of chromosomal instability in cancer therapy and resistance","volume":"24","author":"Carloni","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.gene.2026.150311_b0140","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/ng1861","article-title":"A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers","volume":"38","author":"Carter","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gene.2026.150311_b0145","first-page":"189","article-title":"Chromosomal instability as enabling feature and central hallmark of breast cancer","volume":"15","author":"Castellanos","year":"2023","journal-title":"Breast Cancer (dove Med Press)"},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0150","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.cell.2015.12.028","article-title":"Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma","volume":"164","author":"Ceccarelli","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0155","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41392-022-00975-3","article-title":"Targeting non-coding RNAs to overcome cancer therapy resistance","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.gene.2026.150311_b0160","article-title":"Development of a risk model to predict prognosis in breast cancer based on cGAS-STING-related genes","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Genet."},{"key":"10.1016\/j.gene.2026.150311_b0165","article-title":"Epigenetic underpinnings of inflammation: a key to unlock the tumor microenvironment in glioblastoma","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.gene.2026.150311_b0170","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.hbpd.2024.03.002","article-title":"Integrated chromosomal instability and tumor microbiome redefined prognosis-related subtypes of pancreatic cancer","volume":"23","author":"Chen","year":"2024","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.gene.2026.150311_b0175","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11060-014-1709-6","article-title":"HDAC4, a prognostic and chromosomal instability marker, refines the predictive value of MGMT promoter methylation","volume":"122","author":"Cheng","year":"2015","journal-title":"J. Neurooncol"},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0180","first-page":"1300","article-title":"Temozolomide-associated hypermutation in gliomas. Neuro","volume":"20","author":"Choi","year":"2018","journal-title":"Oncol"},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0185","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41588-019-0576-7","article-title":"Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing","volume":"52","author":"Cort\u00e9s-Ciriano, I., Lee, J.J., Xi, R., Jain, D., Jung, Y.L., Yang, L., Gordenin, D., Klimczak, L.J., Zhang, C.Z., Pellman, D.S., PCAWG Structural Variation Working Group, Park, P.J., PCAWG Consortium","year":"2020","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0190","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13375","article-title":"Systematic characterization and biological functions of non-coding RNAs in glioblastoma","volume":"56","author":"Dai","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.gene.2026.150311_b0195","doi-asserted-by":"crossref","DOI":"10.1177\/09636897221092778","article-title":"XPA enhances temozolomide resistance of glioblastoma cells by promoting nucleotide excision repair","volume":"31","author":"Dai","year":"2022","journal-title":"Cell Transplant."},{"issue":"8","key":"10.1016\/j.gene.2026.150311_b0200","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s11011-024-01414-8","article-title":"Genomic, epigenomic and transcriptomic landscape of glioblastoma","volume":"39","author":"Dakal","year":"2024","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0205","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1038\/s41467-023-36878-2","article-title":"Checkpoint kinase 1\/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade","volume":"14","author":"Dmello","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150311_b0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12885-021-07914-5","article-title":"Prognostic value of the micronucleus assay for clinical endpoints in neoadjuvant radiochemotherapy for rectal cancer","volume":"21","author":"Dr\u00f6ge","year":"2021","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0215","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ol.2016.5451","article-title":"Genetic alterations and epigenetic alterations of cancer-associated fibroblasts (Review)","volume":"13","author":"Du","year":"2017","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0220","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13048-024-01356-w","article-title":"Aneuploid serves as a prognostic marker and favors immunosuppressive microenvironment in ovarian cancer","volume":"17","author":"Du","year":"2024","journal-title":"J. Ovarian Res."},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0225","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1158\/1055-9965.EPI-14-0462","article-title":"The cytokinesis-blocked micronucleus assay as a strong predictor of lung cancer: Extension of a lung cancer risk prediction model","volume":"23","author":"El-Zein","year":"2014","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1083\/jcb.201312078","article-title":"DNA breaks and chromosomal aberrations arise when replication meets base excision repair","volume":"206","author":"Ensminger","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gene.2026.150311_b0235","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1344284","article-title":"Multi-omics-based investigation of Bifidobacterium\u2019s inhibitory effect on glioma: regulation of tumor and gut microbiota, and MEK\/ERK cascade","volume":"15","author":"Fan","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.gene.2026.150311_b0240","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mdr2.70001","article-title":"Systematic Investigation of Tumor Microenvironment and Antitumor Immunity with IOBR","volume":"1","author":"Fang","year":"2025","journal-title":"Med Research"},{"issue":"7","key":"10.1016\/j.gene.2026.150311_b0245","doi-asserted-by":"crossref","first-page":"618","DOI":"10.18632\/oncoscience.178","article-title":"Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma","volume":"2","author":"Furgason","year":"2015","journal-title":"Oncoscience"},{"key":"10.1016\/j.gene.2026.150311_b0250","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1158\/1078-0432.CCR-23-0493","article-title":"Functional Contribution and Clinical Implication of Cancer-Associated Fibroblasts in Glioblastoma","volume":"30","author":"Galbo","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.gene.2026.150311_b0255","doi-asserted-by":"crossref","unstructured":"Galbraith, K., Garcia, M., Wei, S., Chen, A., Schroff, C., Serrano, J., Pacione, D., Placantonakis, D.G., William, C.M., Faustin, A., Zagzag, D., Barbaro, M., Del Pilar Guillermo Prieto Eibl, M., Shirahata, M., Reuss, D., Tran, Q.T., Alom, Z., von Deimling, A., Orr, B.A., Sulman, E.P., Golfinos, J.G., Orringer, D.A., Jain, R., Lieberman, E., Feng, Y., Snuderl, M., 2024. Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A\/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas. Neuro. Oncol. 26 (6), 1042\u20131051. Doi: 10.1093\/neuonc\/noae009.","DOI":"10.1093\/neuonc\/noae009"},{"issue":"4","key":"10.1016\/j.gene.2026.150311_b0260","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3390\/cancers15041299","article-title":"Clinical utility of genomic tests evaluating homologous recombination repair deficiency (HRD) for treatment decisions in early and metastatic breast cancer","volume":"15","author":"Galland","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0265","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1038\/s41598-022-09614-x","article-title":"Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma","volume":"12","author":"Ganesa","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.gene.2026.150311_b0270","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41575-019-0126-x","article-title":"Immunotherapy in colorectal cancer: rationale, challenges and potential","volume":"16","author":"Ganesh","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.gene.2026.150311_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.medmic.2025.100131","article-title":"Gut brain axis and gut microbiome in glioblastoma: associations, treatment and outcomes","volume":"25","author":"Ganesh","year":"2025","journal-title":"Med. Microecol."},{"key":"10.1016\/j.gene.2026.150311_b0280","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/mdr2.70006","article-title":"Heterogeneity of Intratumoral Microbiota within the Tumor Microenvironment and Relationship to Tumor Development","volume":"1","author":"Gao","year":"2025","journal-title":"Med Research"},{"key":"10.1016\/j.gene.2026.150311_b0285","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1390300","article-title":"DNA damage response-related ncRNAs as regulators of therapy resistance in cancer","volume":"15","author":"Gao","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0290","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/neuonc\/noae164","article-title":"Contemporary prognostic signatures and refined risk stratification of gliomas: an analysis of 4400 tumors","volume":"27","author":"Ghosh","year":"2025","journal-title":"Neuro Oncol."},{"issue":"8","key":"10.1016\/j.gene.2026.150311_b0295","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3390\/biomedicines10082031","article-title":"The role of non-coding RNAs in glioma","volume":"10","author":"Goenka","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.gene.2026.150311_b0300","doi-asserted-by":"crossref","unstructured":"Gonzalez, E.A.P., Haider, K.H., 2024. Microbiota and its influence on stem cells, intrinsic and transplanted: With a special mention to bacteria-driven genetic damage. In: Handbook of Stem Cell Applications. Springer Nature Singapore, Singapore, pp. 1197\u20131232. Doi: 10.1007\/978-981-99-7119-0_50.","DOI":"10.1007\/978-981-99-7119-0_50"},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0305","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.3390\/biomedicines12112429","article-title":"Modulation of the immune environment in glioblastoma by the gut microbiota","volume":"12","author":"Green","year":"2024","journal-title":"Biomedicines"},{"issue":"22","key":"10.1016\/j.gene.2026.150311_b0310","doi-asserted-by":"crossref","DOI":"10.1172\/JCI164420","article-title":"STINGing the immune system: lessons learned through a model of G34-mutant pediatric high-grade glioma","volume":"132","author":"Hall","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0315","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.gene.2026.150311_b0320","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.7150\/jca.90535","article-title":"NCDN is a potential biomarker and therapeutic target for glioblastoma","volume":"15","author":"Huang","year":"2024","journal-title":"J. Cancer"},{"issue":"22","key":"10.1016\/j.gene.2026.150311_b0325","doi-asserted-by":"crossref","first-page":"16320","DOI":"10.3390\/ijms242216320","article-title":"The role of non-coding RNAs in epigenetic dysregulation in glioblastoma development","volume":"24","author":"Isachesku","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0330","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147087","article-title":"Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects","volume":"133","author":"Jain","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.gene.2026.150311_b0335","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/annonc\/mdv178","article-title":"Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial","volume":"26","author":"Jamal-Hanjani","year":"2015","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0340","first-page":"224","article-title":"Genome-wide DNA methylation regulation analysis of long non-coding RNAs in glioblastoma","volume":"46","author":"Ji","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.gene.2026.150311_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.106888","article-title":"Dysbiosis of the gut microbiota in glioblastoma patients and potential biomarkers for risk assessment","volume":"195","author":"Jiang","year":"2024","journal-title":"Microb. Pathog."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0350","article-title":"Emerging multi-omics biomarkers in glioblastoma: Integrative insights from genomics to metabolomics","volume":"1881","author":"Kakde","year":"2026","journal-title":"Biochim. Biophys. Acta"},{"issue":"21","key":"10.1016\/j.gene.2026.150311_b0355","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.3390\/cancers14215305","article-title":"The prognostic and therapeutic potential of DNA damage repair pathway alterations and homologous recombination deficiency in lung cancer","volume":"14","author":"Khaddour","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gene.2026.150311_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.mocell.2025.100186","article-title":"Cancer prognosis using base excision repair genes","volume":"48","author":"Kim","year":"2025","journal-title":"Mol. Cells"},{"key":"10.1016\/j.gene.2026.150311_b0365","doi-asserted-by":"crossref","unstructured":"Kloosterman, W.P., Hoogstraat, M., Paling, O., Tavakoli-Yaraki, M., Renkens, I., Vermaat, J.S., van Roosmalen, M.J., van Lieshout, S., Nijman, I.J., Roessingh, W., van \u2019t Slot, R., van de Belt, J., Guryev, V., Koudijs, M., Voest, E., Cuppen, E., 2011. Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol. 12 (10), R103. Doi: 10.1186\/gb-2011-12-10-r103.","DOI":"10.1186\/gb-2011-12-10-r103"},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0370","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00404-020-05677-1","article-title":"Overcoming PARP inhibitor resistance in ovarian cancer: what are the most promising strategies?","volume":"302","author":"Klotz","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0375","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41568-021-00377-7","article-title":"Mutational signatures: emerging concepts, caveats and clinical applications","volume":"21","author":"Koh","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0380","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00432-018-2600-1","article-title":"Treatment with 5-azacitidine delay growth of glioblastoma xenografts: a potential new treatment approach for glioblastomas","volume":"144","author":"Kratzsch","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0385","series-title":"Handbook of Cancer and Immunology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-032-00749-0_51","article-title":"The link between chromosomal instability and immunity in cancer","author":"Kumari","year":"2025"},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0390","doi-asserted-by":"crossref","first-page":"169","DOI":"10.37349\/ei.2024.00135","article-title":"Cancer stem cell, chromosomal instability, and cancer immunity","volume":"4","author":"Kumari","year":"2024","journal-title":"Explor. Immunol."},{"issue":"584","key":"10.1016\/j.gene.2026.150311_b0395","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb3945","article-title":"A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma","volume":"13","author":"Kumthekar","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0400","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/s12276-020-00529-z","article-title":"Small but mighty: the causes and consequences of micronucleus rupture","volume":"52","author":"Kwon","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.gene.2026.150311_b0405","doi-asserted-by":"crossref","unstructured":"Lavielle, S., Delrot, G., Haykal, M.M., Bomont, D., Derieppe, M.A., Martineau, J., Lillo, S., Gomes, P.A., Guichoux, E., Bur\u00e9, C., Pinson, B., Dugot-Senant, N., Klink, B., Nicot, N., Hoffmann, P., Frisan, T., Pateras, I.S., Nikolski, M., Daubon, T., Martin, O.C., 2026. Microbiota-gut-brain axis modulation drives glioblastoma progression and therapy resistance. bioRxiv 2026.05.14.724808. Doi: 10.64898\/2026.05.14.724808.","DOI":"10.64898\/2026.05.14.724808"},{"issue":"6349","key":"10.1016\/j.gene.2026.150311_b0410","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0415","doi-asserted-by":"crossref","first-page":"18577","DOI":"10.18632\/oncotarget.14612","article-title":"Advances in epigenetic glioblastoma therapy","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.066","article-title":"Molecular analysis of clinically defined subsets of high-grade serous ovarian cancer","volume":"31","author":"Lee","year":"2020","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0425","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101307R","article-title":"Circular RNA circBFAR promotes glioblastoma progression by regulating a miR-548b\/FoxM1 axis","volume":"36","author":"Li","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.gene.2026.150311_b0430","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.781741","article-title":"Current understanding of the human microbiome in glioma","volume":"12","author":"Liang","year":"2022","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.gene.2026.150311_b0435","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/ajcp\/aqaf011","article-title":"Revision of interpretation criteria to define microsatellite instability in mismatch repair-deficient neoplasms with subtle electropherogram changes","volume":"163","author":"Lin","year":"2025","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.gene.2026.150311_b0440","article-title":"Evolving insights into the biological function and clinical significance of long noncoding RNA in glioblastoma","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0445","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3892\/or.2025.8926","article-title":"Crosstalk between cancer-associated fibroblasts and inflammation in tumor microenvironment: a novel perspective in cancer therapy","volume":"54","author":"Liu","year":"2025","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0450","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40478-022-01339-2","article-title":"Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas","volume":"10","author":"Liu","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"issue":"12","key":"10.1016\/j.gene.2026.150311_b0455","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/s41423-024-01226-x","article-title":"Immunotherapy for glioblastoma: current state, challenges, and future perspectives","volume":"21","author":"Liu","year":"2024","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.gene.2026.150311_b0460","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/jso.26804","article-title":"Loss of STING expression is prognostic in non-small cell lung cancer","volume":"125","author":"Lohinai","year":"2022","journal-title":"J. Surg. Oncol."},{"issue":"6330","key":"10.1016\/j.gene.2026.150311_b0465","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.aam7344","article-title":"PARP inhibitors: Synthetic lethality in the clinic","volume":"355","author":"Lord","year":"2017","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.gene.2026.150311_b0470","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0475","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163452","article-title":"Understanding and therapeutically exploiting cGAS\/STING signaling in glioblastoma","volume":"134","author":"Low","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0480","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s13402-021-00613-0","article-title":"DNA damage repair in glioblastoma: current perspectives on its role in tumour progression, treatment resistance and PIKKing potential therapeutic targets","volume":"44","author":"Lozinski","year":"2021","journal-title":"Cell. Oncol."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0485","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.trecan.2021.09.002","article-title":"Chromosomal instability and aneuploidy as causes of cancer drug resistance","volume":"8","author":"Lukow","year":"2022","journal-title":"Trends in Cancer"},{"key":"10.1016\/j.gene.2026.150311_b0490","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.21037\/tcr-23-2077","article-title":"Prognostic signature detects homologous recombination deficient in glioblastoma","volume":"13","author":"Luo","year":"2024","journal-title":"Transl. Cancer Res."},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0495","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3390\/brainsci13050817","article-title":"From theory to practice: Implementing the WHO 2021 classification of adult diffuse gliomas in neuropathology diagnosis","volume":"13","author":"Martin","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.gene.2026.150311_b0500","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.cell.2023.12.013","article-title":"Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective","volume":"187","author":"Mathur","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.gene.2026.150311_b0505","unstructured":"Mayhead, N., 2020. Modulation of the base excision repair (BER) pathway in the treatment of glioblastoma with radiotherapy (Doctoral dissertation, University of Surrey). Doi: 10.15126\/thesis.00849272."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0510","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/s40001-024-02043-8","article-title":"Chromosomal instability: a key driver in glioma pathogenesis and progression","volume":"29","author":"Mazzoleni","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0515","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163450","article-title":"Impact of epigenetic reprogramming on antitumor immune responses in glioma","volume":"133","author":"McClellan","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0520","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40478-020-0892-2","article-title":"The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas","volume":"8","author":"McCord","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"issue":"12","key":"10.1016\/j.gene.2026.150311_b0525","doi-asserted-by":"crossref","first-page":"5634","DOI":"10.3390\/ijms26125634","article-title":"Epigenetic alterations in glioblastoma multiforme as novel therapeutic targets: a scoping review","volume":"26","author":"Meleiro","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.gene.2026.150311_b0530","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3390\/cancers17071222","article-title":"Chromosomal instability and clonal heterogeneity in breast cancer: from mechanisms to clinical applications","volume":"17","author":"Mel\u00e9ndez-Fl\u00f3rez","year":"2025","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0535","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/neuroglia5020011","article-title":"Prediction of glioma resistance to immune checkpoint inhibitors based on mutation profile","volume":"5","author":"Mestrallet","year":"2024","journal-title":"Neuroglia"},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0540","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1038\/s41467-025-60228-z","article-title":"Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma","volume":"16","author":"Mi","year":"2025","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.gene.2026.150311_b0545","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/ijms26072935","article-title":"The role of gut microbiome on glioblastoma oncogenesis and malignant evolution","volume":"26","author":"Mohamed","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0550","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1124\/jpet.122.001357","article-title":"The role of non-coding RNAs in chromosomal instability in cancer","volume":"384","author":"Mohapatra","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0555","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/jnci\/djab169","article-title":"Homologous recombination deficiency alterations in colorectal cancer: Clinical, molecular, and prognostic implications","volume":"114","author":"Moretto","year":"2022","journal-title":"JNCI: Journal of the National Cancer Institute"},{"issue":"24","key":"10.1016\/j.gene.2026.150311_b0560","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.1158\/0008-5472.CAN-18-2439","article-title":"Replication stress: an Achilles' heel of glioma cancer stem-like cells","volume":"78","author":"Morgan","year":"2018","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0565","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.gene.2026.150311_b0570","doi-asserted-by":"crossref","DOI":"10.1172\/JCI175033","article-title":"STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma","volume":"134","author":"Najem","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0575","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142750","article-title":"PCR-based simple subgrouping is validated for classification of gliomas and defines negative prognostic copy number aberrations in IDH mutant gliomas","volume":"10","author":"Nakae","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.gene.2026.150311_b0580","series-title":"Handbook of Oxidative Stress in Cancer: Mechanistic Aspects","article-title":"Genomic instability in carcinogenesis: the role of oxidative stress","author":"Nath","year":"2022"},{"issue":"6166","key":"10.1016\/j.gene.2026.150311_b0585","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.1241328","article-title":"Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA","volume":"343","author":"Nathanson","year":"2014","journal-title":"Science"},{"issue":"6494","key":"10.1016\/j.gene.2026.150311_b0590","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type-specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150311_b0595","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.683605","article-title":"Novel prognostic biomarkers in metastatic and locally advanced colorectal cancer: micronuclei frequency and telomerase activity in peripheral blood lymphocytes","volume":"11","author":"Nikolouzakis","year":"2021","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0600","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1158\/2159-8290.CD-24-1555","article-title":"Extrachromosomal DNA\u2013driven oncogene spatial heterogeneity and evolution in glioblastoma","volume":"15","author":"Noorani","year":"2025","journal-title":"Cancer Discov."},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0605","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41571-022-00679-1","article-title":"Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges","volume":"19","author":"Noorani","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0610","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/jnen\/nlad092","article-title":"Whole gain of chromosome 19, not co-gain of chromosomes 19 and 20, characterizes a class of glioblastomas with more favorable outcomes","volume":"83","author":"Nuechterlein","year":"2024","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0615","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/brainsci16010060","article-title":"Deciphering the clinical implications of concurrent chromosome 7 gain and chromosome 10 loss in glioblastoma: a scoping review","volume":"16","author":"Ord\u00f3\u00f1ez-Rubiano","year":"2025","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0620","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2407-14-121","article-title":"Impact of chromosomal instability on colorectal cancer progression and outcome","volume":"14","author":"Orsetti","year":"2014","journal-title":"BMC Cancer"},{"issue":"21","key":"10.1016\/j.gene.2026.150311_b0625","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.3390\/cancers13215352","article-title":"The role of circular RNAs in DNA damage response and repair","volume":"13","author":"Papaspyropoulos","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gene.2026.150311_b0630","doi-asserted-by":"crossref","unstructured":"Ortega, M.A., Fraile-Martinez, O., Boaru, D.L., De Le\u00f3n-Oliva, D., De Castro-Martinez, P., Garcia-Montero, C., Garc\u00eda-Gonz\u00e1lez, B., P\u00e9rez-Gonz\u00e1lez, I., Alhaddadin, M.N.M., Barrena-Bl\u00e1zquez, S., Lopez-Gonzalez, L., del Val Toledo-Lobo, M., Pekarek, L., Pedrero, R.D., Alvarez-Mon, M., Cobo-Prieto, D., Saez, M.A., 2026. From Classical to Emerging Biomarkers of Brain and Central Nervous System Tumors. An Evidence-Based Review with a Focus on Gliomas. Cell. Mol. Neurobiol.","DOI":"10.1007\/s10571-025-01642-1"},{"issue":"6190","key":"10.1016\/j.gene.2026.150311_b0635","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.gene.2026.150311_b0640","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.919391","article-title":"A risk model developed based on homologous recombination deficiency predicts overall survival in patients with lower grade glioma","volume":"13","author":"Peng","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.gene.2026.150311_b0645","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2026.101309","article-title":"Ataxia telangiectasia mutated (ATM) kinase as a predictive biomarker in clinical oncology: implications for a precision treatment approach","volume":"77","author":"Pham","year":"2026","journal-title":"Neoplasia"},{"key":"10.1016\/j.gene.2026.150311_b0650","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10555-013-9429-5","article-title":"The detection and implication of genome instability in cancer","volume":"32","author":"Pikor","year":"2013","journal-title":"Cancer Metastasis Rev."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0655","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41571-018-0114-z","article-title":"State-of-the-art strategies for targeting the DNA damage response in cancer","volume":"16","author":"Pili\u00e9","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0660","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1017\/erm.2023.10","article-title":"New perspective on DNA response pathway (DDR) in glioblastoma, focus on classic biomarkers and emerging roles of ncRNAs","volume":"25","author":"Pirlog","year":"2023","journal-title":"Expert Rev. Mol. Med."},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0665","first-page":"359","article-title":"Rad51 at the crossroads: bridging DNA repair, tumorigenesis, and immune regulation","volume":"1","author":"Qin","year":"2025","journal-title":"Medical Research"},{"key":"10.1016\/j.gene.2026.150311_b0670","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1462496","article-title":"Genomic instability as a driver and suppressor of anti-tumor immunity","volume":"15","author":"Requesens","year":"2024","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0675","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a004762","article-title":"Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study","volume":"6","author":"Restrepo","year":"2020","journal-title":"Molecular Case Studies"},{"key":"10.1016\/j.gene.2026.150311_b0680","first-page":"7","article-title":"Heterogeneity of DNA methylation profiles and copy number alterations in 10782 adult-type glioblastomas","volume":"5","author":"Reuss","year":"2024","journal-title":"IDH-Wildtype. Free Neuropathology"},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0685","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/jnen\/nlab023","article-title":"Molecular characterization of \u201ctrue\u201d low-grade IDH-wildtype astrocytomas","volume":"80","author":"Richardson","year":"2021","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"4","key":"10.1016\/j.gene.2026.150311_b0690","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/jnen\/nlab008","article-title":"Molecular signatures of chromosomal instability correlate with copy number variation patterns and patient outcome in IDH-mutant and IDH-wildtype astrocytomas","volume":"80","author":"Richardson","year":"2021","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.gene.2026.150311_b0695","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40478-022-01420-w","article-title":"Chromosomal instability in adult-type diffuse gliomas","volume":"10","author":"Richardson","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0700","article-title":"Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma","volume":"5","author":"Richardson","year":"2023","journal-title":"Neuro-Oncol. Adv."},{"issue":"9","key":"10.1016\/j.gene.2026.150311_b0705","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076401","article-title":"Integrated analysis of mismatch repair system in malignant astrocytomas","volume":"8","author":"Rodr\u00edguez-Hern\u00e1ndez","year":"2013","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.gene.2026.150311_b0710","first-page":"10263","article-title":"The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair","volume":"44","author":"Roos","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0715","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1158\/1055-9965.EPI-11-0343","article-title":"Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer","volume":"20","author":"Roylance","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0720","first-page":"e66","article-title":"The hidden architects of glioblastoma multiforme: glioma stem cells. MedComm \u2013","volume":"3","author":"Sahoo","year":"2024","journal-title":"Oncology"},{"key":"10.1016\/j.gene.2026.150311_b0725","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12964-021-00809-9","article-title":"Circular RNAs and glioblastoma multiforme: focus on molecular mechanisms","volume":"20","author":"Salami","year":"2022","journal-title":"Cell Commun. Signaling"},{"key":"10.1016\/j.gene.2026.150311_b0730","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fimmu.2016.00156","article-title":"Role of redox status in development of glioblastoma","volume":"7","author":"Salazar-Ramiro","year":"2016","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0735","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028373","article-title":"The role of aneuploidy in cancer evolution","volume":"7","author":"Sansregret","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0740","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00018-024-05469-9","article-title":"PARylation of GCN5 by PARP1 mediates its recruitment to DSBs and facilitates both HR and NHEJ repair","volume":"81","author":"Sarkar","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.gene.2026.150311_b0745","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.3390\/biomedicines13092172","article-title":"The gut\u2013brain axis in brain tumors: insights into tumor development, progression, and therapy","volume":"13","author":"Scuderi","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.gene.2026.150311_b0750","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10456-019-09691-z","article-title":"Vessel co-option in glioblastoma: emerging insights and opportunities","volume":"23","author":"Seano","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.gene.2026.150311_b0755","first-page":"12","article-title":"The epigenetic mechanisms involved in the treatment resistance of glioblastoma","volume":"8","author":"Shahani","year":"2025","journal-title":"Cancer Drug Resistance"},{"issue":"4","key":"10.1016\/j.gene.2026.150311_b0760","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006170","article-title":"Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer","volume":"11","author":"Shakfa","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.gene.2026.150311_b0765","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s11658-025-00806-7","article-title":"MicroRNA strand ratio disarray promotes temozolomide resistance in glioblastoma","volume":"30","author":"Shen","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0770","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1136\/gutjnl-2020-323426","article-title":"Lactobacillus rhamnosus GG induces cGAS\/STING-dependent type I interferon and improves response to immune checkpoint blockade","volume":"71","author":"Si","year":"2022","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0775","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3892\/mco.2024.2757","article-title":"Emerging applications of hypomethylating agents in the treatment of glioblastoma","volume":"21","author":"Silva-Hurtado","year":"2024","journal-title":"Molecular and Clinical Oncology"},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0780","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3892\/mco.2017.1123","article-title":"Chromothripsis and progression-free survival in metastatic colorectal cancer","volume":"6","author":"Skuja","year":"2017","journal-title":"Molecular and Clinical Oncology"},{"key":"10.1016\/j.gene.2026.150311_b0785","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39217","article-title":"Systematic identification of mutations and copy number alterations associated with cancer patient prognosis","volume":"7","author":"Smith","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.gene.2026.150311_b0790","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdz413.091","article-title":"Investigating the role of chromosomal instability in immune cell activation","volume":"30","author":"Sokac","year":"2019","journal-title":"Ann. Oncol."},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0795","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1073\/pnas.1219747110","article-title":"Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics","volume":"110","author":"Sottoriva","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.gene.2026.150311_b0800","article-title":"Chromothripsis is rare in IDH-mutant gliomas compared to IDH-wild-type glioblastomas whereas whole-genome duplication is equally frequent in both tumor types","volume":"6","author":"Sourty","year":"2024","journal-title":"Neuro-Oncol. Adv."},{"key":"10.1016\/j.gene.2026.150311_b0805","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1218297","article-title":"Investigating chromosomal instability in long-term survivors with glioblastoma and grade 4 astrocytoma","volume":"13","author":"Spoor","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0810","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s43018-022-00467-x","article-title":"Highly aneuploid non-small cell lung cancer shows enhanced responsiveness to concurrent radiation and immune checkpoint blockade","volume":"3","author":"Spurr","year":"2022","journal-title":"Nature Cancer"},{"key":"10.1016\/j.gene.2026.150311_b0815","doi-asserted-by":"crossref","first-page":"19375","DOI":"10.1038\/s41598-024-66062-5","article-title":"Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer","volume":"14","author":"Spurr","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.gene.2026.150311_b0820","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ccr.2010.10.034","article-title":"Loss of ATM\/Chk2\/p53 Pathway Components Accelerates Tumor Development and Contributes toRadiation Resistance in Gliomas","volume":"18","author":"Squatrito","year":"2010","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/j.gene.2026.150311_b0825","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.gene.2026.150311_b0830","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00401-020-02243-6","article-title":"Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis","volume":"141","author":"Suwala","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.gene.2026.150311_b0835","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1166207","article-title":"An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?","volume":"13","author":"Teraiya","year":"2023","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.gene.2026.150311_b0840","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/medsci6040085","article-title":"Genetic abnormalities, clonal evolution, and cancer stem cells of brain tumors","volume":"6","author":"Testa","year":"2018","journal-title":"Medical Sciences"},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0845","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3390\/cancers9110151","article-title":"Evolving therapeutic strategies to exploit chromosome instability in cancer","volume":"9","author":"Thompson","year":"2017","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gene.2026.150311_b0850","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13039-019-0429-1","article-title":"The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity","volume":"12","author":"Tijhuis","year":"2019","journal-title":"Mol. Cytogenet."},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0855","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijrobp.2024.11.004","article-title":"Recent mechanistic insight into the immunogenic properties of radiation-induced micronuclei","volume":"121","author":"Vanpouille-Box","year":"2025","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"8","key":"10.1016\/j.gene.2026.150311_b0860","doi-asserted-by":"crossref","first-page":"14475","DOI":"10.3390\/ijms150814475","article-title":"MicroRNAs, genomic instability and cancer","volume":"15","author":"Vincent","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.gene.2026.150311_b0865","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1136\/gut.2007.135004","article-title":"Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis","volume":"57","author":"Walther","year":"2008","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.gene.2026.150311_b0870","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tranon.2017.01.007","article-title":"ATM-deficient colorectal cancer cells are sensitive to the PARP inhibitor olaparib","volume":"10","author":"Wang","year":"2017","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0875","article-title":"Leveraging a chromosomal instability-based signature to predict the prognosis and immune landscape of breast cancer","volume":"101924","author":"Wang","year":"2025","journal-title":"Genes Dis."},{"key":"10.1016\/j.gene.2026.150311_b0880","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1704311","article-title":"Niche-specific epigenetic interventions in the spatially heterogeneous glioblastoma microenvironmental landscape: strategies for radiotherapy enhancement","volume":"12","author":"Wang","year":"2025","journal-title":"Front. Mol. Biosci."},{"issue":"12","key":"10.1016\/j.gene.2026.150311_b0885","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s43018-022-00475-x","article-title":"A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets","volume":"3","author":"Wang","year":"2022","journal-title":"Nature Cancer"},{"key":"10.1016\/j.gene.2026.150311_b0890","article-title":"Association between gut microbiota and glioblastoma: a Mendelian randomization study","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Genet."},{"issue":"47","key":"10.1016\/j.gene.2026.150311_b0895","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn4306","article-title":"Single-cell multi-omics sequencing uncovers region-specific plasticity of glioblastoma for complementary therapeutic targeting","volume":"10","author":"Wang","year":"2024","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0900","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/gutjnl-2014-307213","article-title":"Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect","volume":"64","author":"Wang","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.gene.2026.150311_b0905","article-title":"Genome instability-associated long non-coding RNAs reveal biomarkers for glioma immunotherapy and prognosis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.gene.2026.150311_b0910","doi-asserted-by":"crossref","DOI":"10.4172\/2157-2518.1000165","article-title":"Genomic instability and cancer","volume":"5","author":"Wei Dai","year":"2014","journal-title":"Journal of Carcinogenesis & Mutagenesis"},{"issue":"9","key":"10.1016\/j.gene.2026.150311_b0915","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00234-019-02219-8","article-title":"MR imaging phenotype correlates with extent of genome-wide copy number abundance in IDH mutant gliomas","volume":"61","author":"Wu","year":"2019","journal-title":"Neuroradiology"},{"issue":"11","key":"10.1016\/j.gene.2026.150311_b0920","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/life10110276","article-title":"Chromosomal instability may not be a predictor for immune checkpoint inhibitors from a comprehensive bioinformatics analysis","volume":"10","author":"Wu","year":"2020","journal-title":"Life"},{"issue":"6","key":"10.1016\/j.gene.2026.150311_b0925","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/neuonc\/noab003","article-title":"PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma","volume":"23","author":"Wu","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0930","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1038\/s41467-020-17279-1","article-title":"A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma","volume":"11","author":"Xie","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.gene.2026.150311_b0935","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.3390\/ijms26083743","article-title":"Targeting DNA damage repair to enhance antitumor immunity in radiotherapy: mechanisms and opportunities","volume":"26","author":"Yang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.gene.2026.150311_b0940","doi-asserted-by":"crossref","first-page":"607","DOI":"10.55730\/1300-0144.5828","article-title":"STING activation increases the efficiency of temozolomide in PTEN harbouring glioblastoma cells","volume":"54","author":"Yildirim","year":"2024","journal-title":"Turkish Journal of Medical Sciences"},{"key":"10.1016\/j.gene.2026.150311_b0945","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1186\/s12967-025-06360-2","article-title":"DNA methylation variations of DNA damage response in glioblastoma: NSUN5 modulates tumor-intrinsic cytosolic DNA-sensing and microglial behavior","volume":"23","author":"Yin","year":"2025","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.gene.2026.150311_b0950","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1158\/1541-7786.MCR-08-0270","article-title":"High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray","volume":"7","author":"Yin","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.gene.2026.150311_b0955","article-title":"ATRX mutation modifies the DNA damage response in glioblastoma multiforme tumor cells and enhances patient prognosis","volume":"104","author":"Yu","year":"2025","journal-title":"Medicine"},{"issue":"23","key":"10.1016\/j.gene.2026.150311_b0960","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.3390\/cancers14235805","article-title":"The Aurora kinase inhibitor TAK901 inhibits glioblastoma growth by blocking SREBP1-mediated lipid metabolism","volume":"14","author":"Zhan","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gene.2026.150311_b0965","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-024-01600-2","article-title":"Cancer-associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution","volume":"17","author":"Zhang","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0970","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.17305\/bb.2025.11898","article-title":"Glioblastoma induces CAF-like astrocyte activation via the AKT\/mTOR\u2013SERPINH1\/COL5A1 axis","volume":"25","author":"Zhang","year":"2025","journal-title":"Biomolecules and Biomedicine"},{"key":"10.1016\/j.gene.2026.150311_b0975","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41698-023-00453-1","article-title":"Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence","volume":"7","author":"Zhang","year":"2023","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b0980","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s40364-025-00788-w","article-title":"Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insights","volume":"13","author":"Zhang","year":"2025","journal-title":"Biomarker Res."},{"key":"10.1016\/j.gene.2026.150311_b0985","doi-asserted-by":"crossref","first-page":"23714","DOI":"10.1073\/pnas.1906346116","article-title":"Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma","volume":"116","author":"Zhang","year":"2019","journal-title":"PNAS"},{"issue":"23","key":"10.1016\/j.gene.2026.150311_b0990","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3390\/cells12232712","article-title":"Chromosomal instability-driven cancer progression: interplay with the tumour microenvironment and therapeutic strategies","volume":"12","author":"Zheng","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.gene.2026.150311_b0995","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1038\/s41467-023-39933-0","article-title":"Spatial cellular architecture predicts prognosis in glioblastoma","volume":"14","author":"Zheng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gene.2026.150311_b1005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13045-022-01283-7","article-title":"Homologous recombination deficiency (HRD) can predict the therapeutic outcomes of immuno-neoadjuvant therapy in NSCLC patients","volume":"15","author":"Zhou","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.gene.2026.150311_b1010","doi-asserted-by":"crossref","first-page":"e458","DOI":"10.1002\/mco2.458","article-title":"Identification of RP11-770J1.4 as immune-related lncRNA regulating the CTXN1\u2013cGAS\u2013STING axis in histologically lower-grade glioma","volume":"4","author":"Zhuang","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.gene.2026.150311_b1015","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41576-020-0263-7","article-title":"RNA: a double-edged sword in genome maintenance","volume":"21","author":"Zong","year":"2020","journal-title":"Nat. Rev. Genet."}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926003215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926003215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:30:18Z","timestamp":1786026618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926003215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":202,"alternative-id":["S0378111926003215"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150311","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic and chromosomal Instability: Hidden drivers of Glioblastoma aggressiveness","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150311"}}