{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:13:51Z","timestamp":1788614031087,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004761","name":"Hainan Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017960","name":"Hainan Province Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017960","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.gene.2026.150347","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:43:29Z","timestamp":1785944609000},"page":"150347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrative single\u2011cell and bulk transcriptomic profiling reveals MMP1 as a core effector and CTSB as a putative collaborator in ATBC\u2011aggravated pulmonary fibrosis"],"prefix":"10.1016","volume":"1011","author":[{"given":"Dajia","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-609X","authenticated-orcid":false,"given":"Chaochao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.gene.2026.150347_b0005","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s00018-020-03693-7","article-title":"Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis","volume":"78","author":"Phan","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.gene.2026.150347_b0010","doi-asserted-by":"crossref","unstructured":"Yang W, Yuan H, Sun H, et al. Co-Mn Complex Oxide Nanoparticles as Potential Reactive Oxygen Species Scavenging Agents for Pulmonary Fibrosis Treatment. Molecules. 2024;29(21):5106. Published 2024 Oct 29. doi:10.3390\/molecules29215106.","DOI":"10.3390\/molecules29215106"},{"issue":"1","key":"10.1016\/j.gene.2026.150347_b0015","article-title":"Microplastics, as a risk factor in the development of interstitial lung disease- a preliminary study","volume":"363","author":"\u00d6zgen Alpaydin","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.gene.2026.150347_b0020","doi-asserted-by":"crossref","unstructured":"Hayton C, Ahmed W, Terrington D, et al. Relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosis. Thorax. 2025;80(8):556-559. Published 2025 Jul 15. doi:10.1136\/thorax-2024-222321.","DOI":"10.1136\/thorax-2024-222321"},{"issue":"4","key":"10.1016\/j.gene.2026.150347_b0025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/jes.2015.33","article-title":"Assessment of phthalates\/phthalate alternatives in children's toys and childcare articles: Review of the report including conclusions and recommendation of the chronic hazard advisory panel of the consumer product safety commission","volume":"25","author":"Lioy","year":"2015","journal-title":"J. Eposure Sci. Environ. Epidemiol."},{"issue":"11","key":"10.1016\/j.gene.2026.150347_b0030","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1097\/JS9.0000000000002967","article-title":"The mechanisms of environmental pollutant acetyl tributyl citrate induced oral squamous cell carcinoma using network toxicology, molecular docking and molecular dynamics simulation","volume":"111","author":"Guo","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.gene.2026.150347_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108967","article-title":"Intergenerational metabolism-disrupting effects of maternal exposure to plasticizer acetyl tributyl citrate (ATBC)","volume":"191","author":"Zhang","year":"2024","journal-title":"Environ. Int."},{"issue":"20","key":"10.1016\/j.gene.2026.150347_b0040","doi-asserted-by":"crossref","first-page":"13961","DOI":"10.1021\/acs.est.1c04402","article-title":"Identifying citric acid esters, a class of phthalate substitute plasticizers, in indoor dust via an integrated target, suspect, and characteristic fragment-dependent screening strategy","volume":"55","author":"Zhang","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.gene.2026.150347_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108980","article-title":"Identification of candidate exposure biomarkers for acetyl tributyl citrate and acetyl triethyl citrate using suspect screening in human liver microsomes","volume":"192","author":"Choi","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.gene.2026.150347_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109062","article-title":"Suspect screening candidate exposure biomarkers of acetyl tributyl citrate and acetyl triethyl citrate after human oral administration","volume":"193","author":"Jo","year":"2024","journal-title":"Environ. Int."},{"key":"10.1016\/j.gene.2026.150347_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112920","article-title":"Gal-1-mediated cytochrome p450 activation promotes fibroblast into myofibroblast differentiation in pulmonary fibrosis","volume":"141","author":"Weng","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.gene.2026.150347_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.154009","article-title":"Efficient analysis of toxicity and mechanisms of Acetyl tributyl citrate on aging with network toxicology and molecular docking strategy","volume":"510","author":"Zheng","year":"2025","journal-title":"Toxicology"},{"issue":"W1","key":"10.1016\/j.gene.2026.150347_b0065","doi-asserted-by":"crossref","first-page":"W357","DOI":"10.1093\/nar\/gkz382","article-title":"Swisstargetprediction: updated data and new features for efficient prediction of protein targets of small molecules","volume":"47","author":"Daina","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gene.2026.150347_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2025.109324","article-title":"Exploring the mechanism of PPCPs on human metabolic diseases based on network toxicology and molecular docking","volume":"196","author":"Cheng","year":"2025","journal-title":"Environ. Int."},{"issue":"18","key":"10.1016\/j.gene.2026.150347_b0075","doi-asserted-by":"crossref","DOI":"10.1172\/JCI174598","article-title":"A fibroblast-dependent TGF-\u03b21\/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis","volume":"134","author":"Cohen","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.gene.2026.150347_b0080","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41401-022-01018-x","article-title":"Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression","volume":"44","author":"Lan","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.gene.2026.150347_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.115072","article-title":"Targeted metabolic reprogramming with lactate-scavenging CeO2@PLP nanoparticles attenuates pulmonary fibrosis via dual modulation of macrophage polarization and fibroblast activation","volume":"260","author":"Xu","year":"2025","journal-title":"Mater. Des."},{"key":"10.1016\/j.gene.2026.150347_b0090","doi-asserted-by":"crossref","unstructured":"Liu T, De Los Santos FG, Phan SH. The Bleomycin Model of Pulmonary Fibrosis. In: Ritti\u00e9 L, editor. Fibrosis: Methods and Protocols. Methods in Molecular Biology, vol 1627. New York, NY: Humana Press; 2017. p. 27-42. doi:10.1007\/978-1-4939-7113-8_2.","DOI":"10.1007\/978-1-4939-7113-8_2"},{"key":"10.1016\/j.gene.2026.150347_b0095","doi-asserted-by":"crossref","unstructured":"Wang J, Wang H, Fang F, et al. Danggui Buxue Tang Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing the TLR4\/NLRP3 Signaling Pathway in Rats. Evid Based Complement Alternat Med. 2021;2021:8030143. Published 2021 Jul 23. doi:10.1155\/2021\/8030143.","DOI":"10.1155\/2021\/8030143"},{"key":"10.1016\/j.gene.2026.150347_b0100","doi-asserted-by":"crossref","unstructured":"Wan H, Huang X, Cong P, et al. Identification of Hub Genes and Pathways Associated With Idiopathic Pulmonary Fibrosis via Bioinformatics Analysis. Front Mol Biosci. 2021;8:711239. Published 2021 Aug 12. doi:10.3389\/fmolb.2021.711239.","DOI":"10.3389\/fmolb.2021.711239"},{"key":"10.1016\/j.gene.2026.150347_b0105","doi-asserted-by":"crossref","unstructured":"Yeo HJ, Ha M, Shin DH, Lee HR, Kim YH, Cho WH. Development of a Novel Biomarker for the Progression of Idiopathic Pulmonary Fibrosis. Int J Mol Sci. 2024;25(1):599. Published 2024 Jan 2. doi:10.3390\/ijms25010599.","DOI":"10.3390\/ijms25010599"},{"key":"10.1016\/j.gene.2026.150347_b0110","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ecoenv.2018.07.076","article-title":"NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter","volume":"163","author":"Zheng","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.gene.2026.150347_b0115","article-title":"Association of phthalate exposure with pulmonary function in adults: NHANES 2007-2012","volume":"237","author":"Song","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.gene.2026.150347_b0120","doi-asserted-by":"crossref","unstructured":"Wu B, Shichino S, Ueha S, et al. Ex vivo lung-organoid model for aberrant basaloid cell induction and activation. Inflamm Regen. 2025;45(1):33. Published 2025 Oct 30. doi:10.1186\/s41232-025-00396-z.","DOI":"10.1186\/s41232-025-00396-z"},{"issue":"6646","key":"10.1016\/j.gene.2026.150347_b0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/37995","article-title":"Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1","volume":"389","author":"Gomis-R\u00fcth","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.gene.2026.150347_b0130","doi-asserted-by":"crossref","unstructured":"Lee KB, Nam DH, Nuhn JAM, Wang J, Schneider IC, Ge X. Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli. Microb Cell Fact. 2017;16(1):73. Published 2017 Apr 28. doi:10.1186\/s12934-017-0686-9.","DOI":"10.1186\/s12934-017-0686-9"},{"key":"10.1016\/j.gene.2026.150347_b0135","doi-asserted-by":"crossref","unstructured":"Modenbach JM, M\u00f6ller C, Asgarbeik S, et al. Biochemical analyses of cystatin-C dimers and cathepsin-B reveals a trypsin-driven feedback mechanism in acute pancreatitis. Nat Commun. 2025;16(1):1702. Published 2025 Feb 17. doi:10.1038\/s41467-025-56875-x.","DOI":"10.1038\/s41467-025-56875-x"},{"key":"10.1016\/j.gene.2026.150347_b0140","doi-asserted-by":"crossref","unstructured":"Okuno D, Sakamoto N, Akiyama Y, et al. Two Distinct Mechanisms Underlying \u03b3\u03b4 T Cell-Mediated Regulation of Collagen Type I in Lung Fibroblasts. Cells. 2022;11(18):2816. Published 2022 Sep 9. doi:10.3390\/cells11182816.","DOI":"10.3390\/cells11182816"},{"issue":"7","key":"10.1016\/j.gene.2026.150347_b0145","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.4049\/jimmunol.2300182","article-title":"End-stage idiopathic pulmonary fibrosis lung microenvironment promotes impaired NK activity","volume":"211","author":"Cruz","year":"2023","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2026.150347_b0150","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12940-021-00786-z","article-title":"Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis","volume":"20","author":"Tomos","year":"2021","journal-title":"Environ. Health"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926003574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926003574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:49:18Z","timestamp":1788612558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926003574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":30,"alternative-id":["S0378111926003574"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150347","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative single\u2011cell and bulk transcriptomic profiling reveals MMP1 as a core effector and CTSB as a putative collaborator in ATBC\u2011aggravated pulmonary fibrosis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150347"}}