{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:53:34Z","timestamp":1791089614995,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-ZDXM-47"],"award-info":[{"award-number":["2024JC-ZDXM-47"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004179","name":"Ningxia Medical University","doi-asserted-by":"publisher","award":["XY2025031"],"award-info":[{"award-number":["XY2025031"]}],"id":[{"id":"10.13039\/501100004179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005320","name":"Xidian University","doi-asserted-by":"publisher","award":["TZJH2024030"],"award-info":[{"award-number":["TZJH2024030"]}],"id":[{"id":"10.13039\/501100005320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005320","name":"Xidian University","doi-asserted-by":"publisher","award":["TZJH2024029"],"award-info":[{"award-number":["TZJH2024029"]}],"id":[{"id":"10.13039\/501100005320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.gene.2026.150399","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:31:09Z","timestamp":1789540269000},"page":"150399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ERO1A is a hypoxia-ER bridge in NSCLC: from pan-cancer identification to a dual-reporter visualization system"],"prefix":"10.1016","volume":"1014","author":[{"given":"Xiaoyu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyi","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuoye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-3441","authenticated-orcid":false,"given":"Yonghua","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-2366","authenticated-orcid":false,"given":"Wenhua","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2295-3246","authenticated-orcid":false,"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0005","first-page":"1","article-title":"The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment","volume":"21","author":"Asieh","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-020-01288-1","article-title":"Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments","volume":"20","author":"Wei","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.gene.2026.150399_b0015","first-page":"10","article-title":"Tumor hypoxia: impact on radiation therapy and molecular pathways","volume":"2020","author":"S\u00f8rensen","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gene.2026.150399_b0020","article-title":"Hypoxia as a driver of resistance to immunotherapy","volume":"59","author":"Joanna","year":"2021","journal-title":"Drug Resist. Updat."},{"issue":"5","key":"10.1016\/j.gene.2026.150399_b0025","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/cas.13990","article-title":"Hypoxia\/pseudohypoxia\u2010mediated activation of hypoxia\u2010inducible factor\u20101\u03b1 in cancer","volume":"110","author":"Yoshihiro","year":"2019","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-022-01292-6","article-title":"Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape","volume":"15","author":"Wu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.gene.2026.150399_b0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.canlet.2020.12.020","article-title":"Metabolic adaptation in hypoxia and cancer","volume":"502","author":"Paredes","year":"2021","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.gene.2026.150399_b0040","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3390\/cancers14051259","article-title":"Targeting HIF-2\u03b1 in the tumor microenvironment: redefining the role of HIF-2\u03b1 for solid cancer therapy","volume":"14","author":"Davis","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.trecan.2021.10.004","article-title":"Revisiting the HIF switch in the tumor and its immune microenvironment","volume":"8","author":"Cowman","year":"2022","journal-title":"Trends Cancer."},{"issue":"9","key":"10.1016\/j.gene.2026.150399_b0050","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3390\/cells14090673","article-title":"The distinct role of HIF-1\u03b1 and HIF-2\u03b1 in hypoxia and angiogenesis","volume":"14","author":"Bakleh","year":"2025","journal-title":"Cells."},{"issue":"6","key":"10.1016\/j.gene.2026.150399_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03985","article-title":"Glucose transporter 1 is important for the glycolytic metabolism of human endometrial stromal cells in hypoxic environment","volume":"6","author":"Kido","year":"2020","journal-title":"Heliyon."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0060","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1186\/s12864-021-07795-9","article-title":"A functional map of genomic HIF1\u03b1-DNA complexes in the eye lens revealed through multiomics analysis","volume":"22","author":"Disatham","year":"2021","journal-title":"BMC Genomics"},{"issue":"8","key":"10.1016\/j.gene.2026.150399_b0065","first-page":"577","article-title":"Targeting hypoxia and HIF1\u03b1 in triple-negative breast cancer: new insights from gene expression profiling and implications for therapy","volume":"13","author":"Han","year":"2024","journal-title":"Biology (Basel)."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0070","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1002\/ctm2.279","article-title":"Hypoxia-induced FOXO4\/LDHA axis modulates gastric cancer cell glycolysis and progression","volume":"11","author":"Wang","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"10.1016\/j.gene.2026.150399_b0075","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41419-023-05788-y","article-title":"CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR\/PI3K pathway","volume":"14","author":"Mao","year":"2023","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.gene.2026.150399_b0080","doi-asserted-by":"crossref","first-page":"759","DOI":"10.7150\/jca.33267","article-title":"MicroRNA-144-3p inhibits tumorigenesis of oral squamous cell carcinoma by downregulating ERO1L","volume":"11","author":"Li","year":"2020","journal-title":"J. Cancer"},{"issue":"4","key":"10.1016\/j.gene.2026.150399_b0085","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1080\/21655979.2022.2063537","article-title":"MicroRNA-218-5p affects lung adenocarcinoma progression through targeting endoplasmic reticulum oxidoreductase 1 alpha","volume":"13","author":"Chen","year":"2022","journal-title":"Bioengineered."},{"issue":"5","key":"10.1016\/j.gene.2026.150399_b0090","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3892\/ol.2021.13056","article-title":"circ-ACACA promotes proliferation, invasion, migration and glycolysis of cervical cancer cells by targeting the miR-582-5p\/ERO1A signaling axis","volume":"22","author":"Huang","year":"2021","journal-title":"Oncol. Lett."},{"issue":"9","key":"10.1016\/j.gene.2026.150399_b0095","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/s41388-021-01659-y","article-title":"The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions","volume":"40","author":"Varone","year":"2021","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.gene.2026.150399_b0100","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/sj.onc.1208325","article-title":"Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer","volume":"24","author":"May","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.gene.2026.150399_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.145498","article-title":"In vivo real-time monitoring of the development of hypoxia and angiogenesis in cervical cancer","volume":"473","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"23","key":"10.1016\/j.gene.2026.150399_b0110","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1158\/0008-5472.CAN-21-1337","article-title":"ALDH1A1 activity in tumor-initiating cells remodels myeloid-derived suppressor cells to promote breast cancer progression","volume":"81","author":"Liu","year":"2021","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.gene.2026.150399_b0115","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41419-024-06943-9","article-title":"ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.gene.2026.150399_b0120","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ncomms1829","article-title":"The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2","volume":"3","author":"L\u00f3pez-Dom\u00e9nech","year":"2012","journal-title":"Nat. Commun."},{"issue":"18","key":"10.1016\/j.gene.2026.150399_b0125","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148005","article-title":"A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes","volume":"131","author":"Segawa","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.gene.2026.150399_b0130","doi-asserted-by":"crossref","first-page":"465","DOI":"10.7150\/ijbs.72218","article-title":"BGN\/FAP\/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer","volume":"19","author":"Wu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"8","key":"10.1016\/j.gene.2026.150399_b0135","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s43018-023-00594-z","article-title":"The Akt\/mTOR and MNK\/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells","volume":"4","author":"Brina","year":"2023","journal-title":"Nat Cancer."},{"issue":"11","key":"10.1016\/j.gene.2026.150399_b0140","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/gim.2014.210","article-title":"The expanding phenotype of COL4A1 and COL4A2 mutations: clinical data on 13 newly identified families and a review of the literature","volume":"17","author":"Meuwissen","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.gene.2026.150399_b0145","article-title":"CTHRC1: a key player in colorectal cancer progression and immune evasion","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0150","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s12967-025-06236-5","article-title":"Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer","volume":"23","author":"Lu","year":"2025","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.gene.2026.150399_b0155","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/1873-3468.14523","article-title":"Structural biology of DOCK-family guanine nucleotide exchange factors","volume":"597","author":"Boland","year":"2023","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0160","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1186\/s12967-025-06754-2","article-title":"DSG3 promotes bladder cancer growth and metastasis via AKT\/GSK3\u03b2\/\u03b2-catenin pathway","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"14","key":"10.1016\/j.gene.2026.150399_b0165","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1038\/s44318-024-00126-0","article-title":"PARP14 and PARP9\/DTX3L regulate interferon-induced ADP-ribosylation","volume":"43","author":"Kar","year":"2024","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0170","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3892\/ijo.2014.2710","article-title":"Eps8 regulates cellular proliferation and migration of breast cancer","volume":"46","author":"Chen","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.gene.2026.150399_b0175","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3892\/or.2021.7927","article-title":"Effects and mechanisms of Eps8 on the biological behaviour of malignant tumours (Review)","volume":"45","author":"Luo","year":"2021","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41419-025-07426-1","article-title":"Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment","volume":"16","author":"Varone","year":"2025","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.gene.2026.150399_b0185","article-title":"Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity","volume":"4","author":"Liu","year":"2023","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0190","article-title":"Fingerprint of the oxido-reductase ERO1: a protein disulfide bond producer and supporter of cancer","volume":"1879","author":"Zito","year":"2024","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.gene.2026.150399_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101095","article-title":"FAT1 as a tumor mutation burden specific gene affects the immunotherapy effect in head and neck squamous cell cancer","volume":"76","author":"Cao","year":"2024","journal-title":"Drug Resist. Updat."},{"issue":"7842","key":"10.1016\/j.gene.2026.150399_b0200","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41586-020-03046-1","article-title":"Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis","volume":"589","author":"Pastushenko","year":"2024","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.gene.2026.150399_b0205","article-title":"Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via hedgehog signaling","volume":"11","author":"Zhang","year":"2024","journal-title":"Genes Dis."},{"issue":"7274","key":"10.1016\/j.gene.2026.150399_b0210","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nature08617","article-title":"Cancer-associated IDH1 mutations produce 2-hydroxyglutarate","volume":"462","author":"Dang","year":"2009","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.gene.2026.150399_b0215","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s43587-023-00464-4","article-title":"LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits","volume":"3","author":"Li","year":"2023","journal-title":"Nat. Aging"},{"issue":"8","key":"10.1016\/j.gene.2026.150399_b0220","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.7150\/ijbs.108618","article-title":"Integrative single-cell and spatial transcriptomics analysis reveals ECM-remodeling cancer-associated fibroblast-derived POSTN as a key mediator in pancreatic ductal adenocarcinoma progression","volume":"21","author":"Wu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"7","key":"10.1016\/j.gene.2026.150399_b0225","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008721","article-title":"POSTN+ cancer-associated fibroblasts determine the efficacy of immunotherapy in hepatocellular carcinoma","volume":"12","author":"Wang","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"12","key":"10.1016\/j.gene.2026.150399_b0230","doi-asserted-by":"crossref","first-page":"e1515","DOI":"10.1002\/ctm2.1515","article-title":"Single-cell and spatial transcriptomics reveal POSTN+ cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer","volume":"13","author":"Chen","year":"2024","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0235","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13046-024-03269-4","article-title":"Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression","volume":"44","author":"Ye","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0240","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12943-024-01985-1","article-title":"Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-\u03baB p65 nuclear translocation","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol. Cancer"},{"issue":"19","key":"10.1016\/j.gene.2026.150399_b0245","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202500136","article-title":"SERPINE1 facilitates metastasis in gastric cancer through anoikis resistance and tumor microenvironment remodeling","volume":"21","author":"Wang","year":"2025","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0250","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13046-024-03255-w","article-title":"SPP1+\u2009macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-\u03b1 and IL-1\u03b2","volume":"43","author":"Liu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"14","key":"10.1016\/j.gene.2026.150399_b0255","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.7150\/thno.61085","article-title":"Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics."},{"issue":"7","key":"10.1016\/j.gene.2026.150399_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e28445","article-title":"Association of TNFRSF19 with a TNF family-based prognostic model and subtypes in gliomas using machine learning","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon."},{"issue":"2","key":"10.1016\/j.gene.2026.150399_b0265","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jhep.2022.03.015","article-title":"Unique molecular characteristics of NAFLD-associated liver cancer accentuate \u03b2-catenin\/TNFRSF19-mediated immune evasion","volume":"77","author":"Wong","year":"2024","journal-title":"J. Hepatol."},{"issue":"18","key":"10.1016\/j.gene.2026.150399_b0270","doi-asserted-by":"crossref","first-page":"8400","DOI":"10.7150\/thno.45124","article-title":"Endoplasmic reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in pancreatic cancer","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics."},{"key":"10.1016\/j.gene.2026.150399_b0275","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ebiom.2019.01.053","article-title":"FoxO3a inhibiting expression of EPS8 to prevent progression of NSCLC: a new negative loop of EGFR signaling","volume":"40","author":"Wen","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.gene.2026.150399_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118586","article-title":"Taxus chinensis var. mairei (Lem\u00e9e et L\u00e9vl) Cheng et L.K. Fu overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer via suppression of ERK1\/2-related cholesterol biosynthesis","volume":"334","author":"Dai","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0285","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41698-024-00736-1","article-title":"ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer","volume":"8","author":"Voronkova","year":"2024","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.gene.2026.150399_b0290","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-025-02184-z","article-title":"ERO1A-positive tumor epithelial cells in colorectal cancer progression: a multi-omics perspective","author":"Hu","year":"2025","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0295","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1186\/s12967-025-07613-w","article-title":"ERO1A promotes the proliferation, migration and invasion of bladder cancer through ALOX5 mediated activation of JAK-STAT signaling pathway","volume":"23","author":"Huang","year":"2025","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.gene.2026.150399_b0300","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s41556-026-01980-2","article-title":"ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics","volume":"28","author":"Bassot","year":"2026","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.gene.2026.150399_b0305","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.redox.2018.09.021","article-title":"Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis","volume":"20","author":"Wu","year":"2019","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.gene.2026.150399_b0310","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/med.21477","article-title":"Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): a \u201cstructure-activity relationship\u201d perspective","volume":"38","author":"Bhattarai","year":"2018","journal-title":"Med. Res. Rev."},{"issue":"4","key":"10.1016\/j.gene.2026.150399_b0315","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bbrc.2008.03.147","article-title":"Rational design of minimal hypoxia-inducible enhancers","volume":"370","author":"Kaluz","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.gene.2026.150399_b0320","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12964-018-0241-2","article-title":"Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK\/HIF1\u03b1 axis","volume":"16","author":"Li","year":"2018","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.gene.2026.150399_b0325","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.3892\/or.2017.5728","article-title":"AAED1 modulates proliferation and glycolysis in gastric cancer","volume":"40","author":"Zhang","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.gene.2026.150399_b0330","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.canlet.2019.03.024","article-title":"UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer","volume":"452","author":"Hu","year":"2019","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.gene.2026.150399_b0335","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neo.2018.12.004","article-title":"Hypoxia patterns in primary and metastatic prostate cancer environments","volume":"21","author":"Bharti","year":"2019","journal-title":"Neoplasia"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926004099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378111926004099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:16:41Z","timestamp":1791087401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378111926004099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":67,"alternative-id":["S0378111926004099"],"URL":"https:\/\/doi.org\/10.1016\/j.gene.2026.150399","relation":{},"ISSN":["0378-1119"],"issn-type":[{"value":"0378-1119","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ERO1A is a hypoxia-ER bridge in NSCLC: from pan-cancer identification to a dual-reporter visualization system","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gene.2026.150399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"150399"}}