{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:12:26Z","timestamp":1791119546531,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["General Hospital Psychiatry"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.genhosppsych.2007.11.005","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T11:32:07Z","timestamp":1203507127000},"page":"155-161","source":"Crossref","is-referenced-by-count":137,"title":["Behavioural problems in Huntington's disease using the Problem Behaviours Assessment"],"prefix":"10.1016","volume":"30","author":[{"given":"Elisabeth M.","family":"Kingma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"van Duijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier","family":"Timman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose C.","family":"van der Mast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund A.C.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.genhosppsych.2007.11.005_bib1","series-title":"Huntington's disease","first-page":"29","author":"Bates","year":"2002"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib2","series-title":"Behavioural neurology of movement disorders","first-page":"1187","article-title":"Dementia and cognitive changes in Huntington's disease","author":"Morris","year":"1995"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/jnnp.74.1.120","article-title":"Behavioural abnormalities contribute to functional decline in Huntington's disease","volume":"74","author":"Hamilton","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1176\/appi.neuropsych.19.4.441","article-title":"Psychopathology in verified Huntington's disease gene carriers","volume":"19","author":"van Duijn","year":"2007","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0924-9338(01)00604-6","article-title":"Huntington's disease: a review of the literature on prevalence and treatment of neuropsychiatric phenomena","volume":"16","author":"Naarding","year":"2001","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1176\/appi.neuropsych.15.1.7","article-title":"Cognitive and motor functioning in gene carriers for Huntington's disease: a baseline study","volume":"15","author":"Witjes-An\u00e9","year":"2003","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib7","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/jnnp.69.6.773","article-title":"Subtle changes among presymptomatic carriers of the Huntington's disease gene","volume":"69","author":"Kirkwood","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/jmg.30.4.289","article-title":"Onset symptoms in 510 patients with Huntington's disease","volume":"30","author":"Di Maio","year":"1993","journal-title":"J Med Genet"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1017\/S0033291700047966","article-title":"The association of affective disorder with Huntington's disease in a case series and in families","volume":"13","author":"Folstein","year":"1983","journal-title":"Psychol Med"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S0033291700050054","article-title":"Conduct disorder and affective disorder among the offspring of patients with Huntington's disease","volume":"13","author":"Folstein","year":"1983","journal-title":"Psychol Med"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-0447.1991.tb05511.x","article-title":"The clinical manifestation of mental disorder in Huntington's disease: a retrospective case report study of disease progression","volume":"83","author":"Pflanz","year":"1991","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0447.1994.tb01587.x","article-title":"Psychopathology in Huntington's disease patients","volume":"90","author":"Shiwach","year":"1994","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1001\/archpsyc.1992.01820020068009","article-title":"Psychiatric, genetic, and positron emission tomographic evaluation of persons at risk from Huntington's disease","volume":"49","author":"Baxter","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1034\/j.1600-0447.2002.0o456.x","article-title":"Psychiatric symptoms in neurologically asymptomatic Huntington's disease gene carriers: a comparison with gene negative at risk subjects","volume":"105","author":"Berrios","year":"2002","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib15","first-page":"192","article-title":"Longitudinal personality changes among presymptomatic Huntington's disease gene carriers","volume":"15","author":"Kirkwood","year":"2002","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1192\/bjp.165.4.500","article-title":"A controlled study of individuals at risk for Huntington's disease","volume":"165","author":"Shiwach","year":"1994","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1017\/S109285290002201X","article-title":"Depression and Huntington's disease: prevalence, clinical manifestations, aetiology, and treatment","volume":"6","author":"Slaughter","year":"2001","journal-title":"CNS Spectr"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib18","first-page":"117","article-title":"Psychosoziale Probleme bei Huntingtonscher Chorea","volume":"23","author":"Jarka","year":"1996","journal-title":"Psychiatr Prax"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib19","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1176\/appi.ajp.159.8.1261","article-title":"Neuropsychiatry and the future of psychiatry and neurology","volume":"159","author":"Yudofsky","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/01.yco.0000069091.26384.24","article-title":"The neuropsychiatric manifestations of Huntington's disease","volume":"16","author":"Naarding","year":"2003","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib21","first-page":"219","article-title":"Behavioural changes in Huntington's disease","volume":"14","author":"Craufurd","year":"2001","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington\u2019s disease rating scale: reliability and consistency","volume":"11","year":"1996","journal-title":"Mov Disord"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib23","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1073\/pnas.94.8.3872","article-title":"Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease","volume":"94","author":"Rubinsztein","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.29.1.1","article-title":"Huntington disease: clinical care and evaluation","volume":"29","author":"Shoulson","year":"1979","journal-title":"Neurology"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u2018Mini-mental state\u2019. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib26","series-title":"Practical statistics for medical research","first-page":"403","author":"Altman","year":"1991"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib27","series-title":"Using multivariate statistics","first-page":"603","author":"Tabachnick","year":"1989"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib28","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00006842-199411000-00008","article-title":"Psychological effects of presymptomatic DNA testing for Huntington's disease in the Dutch program","volume":"56","author":"Tibben","year":"1994","journal-title":"Psychosom Med"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib29","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1176\/appi.ajp.158.12.1966","article-title":"Successful multimodality treatment of severe behavioral disturbance in a patient with advanced Huntington's disease","volume":"158","author":"Blass","year":"2001","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00005053-199001000-00004","article-title":"Clinical assessment of irritability, aggression, and apathy in Huntington and Alzheimer disease","volume":"178","author":"Burns","year":"1990","journal-title":"J Nerv Ment Dis"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib31","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1176\/ajp.140.6.728","article-title":"Psychiatric syndromes in Huntington's disease","volume":"140","author":"Caine","year":"1983","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archneur.58.2.273","article-title":"Progression of symptoms in the early and middle stages of Huntington's disease","volume":"58","author":"Kirkwood","year":"2001","journal-title":"Arch Neurol"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1176\/jnp.10.3.314","article-title":"Apathy is not depression","volume":"10","author":"Levey","year":"1998","journal-title":"J Neuropsychiatry"},{"key":"10.1016\/j.genhosppsych.2007.11.005_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1176\/appi.neuropsych.14.1.37","article-title":"Behavior in Huntington's disease: dissociating cognition-based and mood-based changes","volume":"14","author":"Thompson","year":"2002","journal-title":"J Neuropsychiatry Clin Neurosci"}],"container-title":["General Hospital Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163834307002265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163834307002265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T10:53:30Z","timestamp":1546253610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163834307002265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0163834307002265"],"URL":"https:\/\/doi.org\/10.1016\/j.genhosppsych.2007.11.005","relation":{},"ISSN":["0163-8343"],"issn-type":[{"value":"0163-8343","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}