{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:04:14Z","timestamp":1793271854972,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018736","name":"Kaken Pharmaceutical Co Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25 K19084"],"award-info":[{"award-number":["25 K19084"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["General Hospital Psychiatry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.genhosppsych.2025.09.009","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T17:19:22Z","timestamp":1758993562000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Falls and fractures associated with ramelteon use: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"97","author":[{"given":"Rintaro","family":"Sogawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Kotake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Monji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Shimanoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0005","first-page":"1527","article-title":"Prediction of pulmonary morbidity and mortality in patients with femur fracture","volume":"69","author":"Lefaivre","year":"2010","journal-title":"J Trauma"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2318-14-40","article-title":"Fall risk-increasing drugs and falls: a cross-sectional study among elderly patients in primary care","volume":"14","author":"Milos","year":"2014","journal-title":"BMC Geriatr"},{"issue":"371","key":"10.1016\/j.genhosppsych.2025.09.009_bb0015","first-page":"e1","article-title":"Fall-risk-increasing drugs: a systematic review and meta-analysis: I. Cardiovascular drugs","volume":"19","author":"de Vries","year":"2018","journal-title":"J Am Med Dir Assoc"},{"issue":"371","key":"10.1016\/j.genhosppsych.2025.09.009_bb0020","first-page":"e11","article-title":"Fall-risk-increasing drugs: a systematic review and meta-analysis: II","volume":"19","author":"Seppala","year":"2018","journal-title":"Psychotropics J Am Med Dir Assoc"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/pcn.13318","article-title":"Psychotropics use and occurrence of falls in hospitalized patients: a matched case-control study","volume":"76","author":"Morishita","year":"2022","journal-title":"Psychiatry Clin Neurosci"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0030","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/gerona\/62.10.1172","article-title":"Medication as a risk factor for falls: critical systematic review","volume":"62","author":"Hartikainen","year":"2007","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0035","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1001\/archinternmed.2009.357","article-title":"Meta-analysis of the impact of 9 medication classes on falls in elderly persons","volume":"169","author":"Woolcott","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0040","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.5665\/sleep.5742","article-title":"Nonbenzodiazepine sedative hypnotics and risk of fall-related injury","volume":"39","author":"Tom","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0045","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jpsychires.2024.06.029","article-title":"Association between the use of orexin receptor antagonists and falls or fractures: a meta-analysis","volume":"176","author":"Pan","year":"2024","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238723","article-title":"Non-GABA sleep medications, suvorexant as risk factors for falls: case-control and case-crossover study","volume":"15","author":"Ishibashi","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0055","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1248\/bpb.b19-00684","article-title":"Association of hypnotic drug use with fall incidents in hospitalized elderly patients: a case-crossover study","volume":"43","author":"Torii","year":"2020","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0060","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1248\/yakushi.20-00018","article-title":"Association suvorexant and ramelteon use with the risk of falling: a retrospective case-control study","volume":"140","author":"Ishigo","year":"2020","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0065","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/jcpt.13619","article-title":"Association of orexin receptor antagonists with falls during hospitalization","volume":"47","author":"Sogawa","year":"2022","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0070","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00228-023-03485-5","article-title":"Association between nocturnal falls and hypnotic drug use in older patients at acute care hospitals","volume":"79","author":"Oda","year":"2023","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0075","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5664\/jcsm.6470","article-title":"Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of sleep medicine clinical practice guideline","volume":"13","author":"Sateia","year":"2017","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0080","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamapsychiatry.2013.3320","article-title":"Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial","volume":"71","author":"Hatta","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0085","doi-asserted-by":"crossref","first-page":"19m12865","DOI":"10.4088\/JCP.19m12865","article-title":"Real-world effectiveness of ramelteon and suvorexant for delirium prevention in 948 patients with delirium risk factors","volume":"81","author":"Hatta","year":"2019","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0090","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0095","author":"Higgins"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2288-14-45","article-title":"Newcastle-Ottawa scale: comparing reviewers\u2019 to authors\u2019 assessments","volume":"14","author":"Lo","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0110","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5664\/jcsm.6470","article-title":"Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of sleep medicine clinical practice guideline","volume":"13","author":"Sateia","year":"2017","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.14035","article-title":"The European insomnia guideline: an update on the diagnosis and treatment of insomnia 2023","volume":"32","author":"Riemann","year":"2023","journal-title":"J Sleep Res"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0120","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.sleep.2021.02.041","article-title":"Asian accreditation of sleep medicine physicians and technologists: practice guidelines by the Asian society of sleep medicine","volume":"81","author":"BaHammam","year":"2021","journal-title":"Sleep Med"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0125","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2147\/IJGM.S452278","article-title":"The administration of Lemborexant at admission is not associated with inpatient falls: a multicenter retrospective observational study","volume":"17","author":"Hirata","year":"2024","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0130","author":"NCT00756002"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0135","doi-asserted-by":"crossref","first-page":"572","DOI":"10.5664\/jcsm.27991","article-title":"Effectiveness of ramelteon for insomnia symptoms in older adults with obstructive sleep apnea: a randomized placebo-controlled pilot study","volume":"6","author":"Gooneratne","year":"2010","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0140","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jad.2017.06.044","article-title":"Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: a phase 3, randomized controlled trial","volume":"221","author":"Mahableshwarkar","year":"2017","journal-title":"J Affect Disord"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jagp.2020.05.006","article-title":"Effects of ramelteon on the prevention of postoperative delirium in older patients undergoing orthopedic surgery: the RECOVER randomized controlled trial","volume":"29","author":"Oh","year":"2021","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","article-title":"MT1 and MT2 melatonin receptors: a therapeutic perspective","volume":"56","author":"Liu","year":"2016","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0155","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1001\/archpsyc.63.10.1149","article-title":"Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects","volume":"63","author":"Johnson","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0160","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5664\/jcsm.27390","article-title":"Effect of ramelteon on middle-of-the-night balance in older adults with chronic insomnia","volume":"5","author":"Zammit","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0165","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.psychres.2018.12.165","article-title":"Worldwide prevalence of falls in older adults with psychiatric disorders: a meta-analysis of observational studies","volume":"273","author":"Rao","year":"2019","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.genhosppsych.2025.09.009_bb0170","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/ageing\/afx167","article-title":"Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis","volume":"47","author":"Treves","year":"2018","journal-title":"Age Ageing"}],"container-title":["General Hospital Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163834325001884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163834325001884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:51:51Z","timestamp":1785862311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163834325001884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"alternative-id":["S0163834325001884"],"URL":"https:\/\/doi.org\/10.1016\/j.genhosppsych.2025.09.009","relation":{},"ISSN":["0163-8343"],"issn-type":[{"value":"0163-8343","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Falls and fractures associated with ramelteon use: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"General Hospital Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.genhosppsych.2025.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}