{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:06:52Z","timestamp":1789589212350,"version":"build-2803163510"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460226"],"award-info":[{"award-number":["82460226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFHA069156"],"award-info":[{"award-number":["2025GXNSFHA069156"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFBA069280"],"award-info":[{"award-number":["2025GXNSFBA069280"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023GXNSFAA026383"],"award-info":[{"award-number":["2023GXNSFAA026383"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["General Hospital Psychiatry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.genhosppsych.2026.09.004","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:01:46Z","timestamp":1788912106000},"page":"55-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Imaging marker-specific associations between cerebral small vessel disease and depression: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"103","author":[{"given":"Ziyuan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0005","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.4103\/NRR.NRR-D-24-01329","article-title":"Biomarker advancements in cerebral small vessel disease: an overview","volume":"21","author":"Luo","year":"2026","journal-title":"Neural Regen Res"},{"issue":"3","key":"10.1016\/j.genhosppsych.2026.09.004_bb0010","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/STROKEAHA.122.038265","article-title":"Cerebral small vessel disease\u2013related dementia: more questions than answers","volume":"54","author":"Elahi","year":"2023","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0015","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S1474-4422(23)00131-X","article-title":"Neuroimaging standards for research into small vessel disease\u2014advances since 2013","volume":"22","author":"Duering","year":"2023","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jad.2017.05.039","article-title":"Structural network connectivity impairment and depressive symptoms in cerebral small vessel disease","volume":"220","author":"Xie","year":"2017","journal-title":"J Affect Disord"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neurobiolaging.2025.07.013","article-title":"Neural network mechanisms of emotional dysregulation in cerebral small vessel disease","volume":"155","author":"Dobrushina","year":"2025","journal-title":"Neurobiol Aging"},{"issue":"9475","key":"10.1016\/j.genhosppsych.2026.09.004_bb0030","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0140-6736(05)66665-2","article-title":"Depression in the elderly","volume":"365","author":"Alexopoulos","year":"2005","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.genhosppsych.2026.09.004_bb0035","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/mp.2013.20","article-title":"The vascular depression hypothesis: mechanisms linking vascular disease with depression","volume":"18","author":"Taylor","year":"2013","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-66013-w","article-title":"Network localisation of white matter damage in cerebral small vessel disease","volume":"10","author":"Petersen","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.120089","article-title":"Multi-marker cerebral small vessel disease score and risk of incident depression: the Framingham heart study","volume":"392","author":"Araujo-Contreras","year":"2026","journal-title":"J Affect Disord"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0050","article-title":"Association between cerebral microbleeds and depression in the general elderly population: a meta-analysis","volume":"9","author":"Wang","year":"2018","journal-title":"Front Psychiatry"},{"issue":"15","key":"10.1016\/j.genhosppsych.2026.09.004_bb0055","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016512","article-title":"Cerebral small-vessel disease and risk of incidence of depression: a meta-analysis of longitudinal cohort studies","volume":"9","author":"Fang","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.genhosppsych.2026.09.004_bb0060","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/STROKEAHA.121.035488","article-title":"Cerebral small vessel disease and depression among intracerebral hemorrhage survivors","volume":"53","author":"Castello","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0065","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jad.2022.09.166","article-title":"White matter hyperintensities and post-stroke depression: a systematic review and meta-analysis","volume":"320","author":"Zhang","year":"2023","journal-title":"J Affect Disord"},{"issue":"9","key":"10.1016\/j.genhosppsych.2026.09.004_bb0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"issue":"19","key":"10.1016\/j.genhosppsych.2026.09.004_bb0075","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1001\/jama.280.19.1690","article-title":"What\u2019s the relative risk?","volume":"280","author":"Zhang","year":"1998","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.genhosppsych.2026.09.004_bb0080","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"7109","key":"10.1016\/j.genhosppsych.2026.09.004_bb0085","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.genhosppsych.2026.09.004_bb0090","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0095","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1017\/S1041610214000568","article-title":"Lacunar stroke, deep white matter disease and depression: a meta-analysis","volume":"26","author":"Egeto","year":"2014","journal-title":"Int Psychogeriatr"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1593402","article-title":"Reliability and validity of the total cerebral small vessel disease score: a systematic review and meta-analysis","volume":"16","author":"Silva","year":"2025","journal-title":"Front Neurol"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1335706","article-title":"White matter integrity and medication response to antidepressants in major depressive disorder: a review of the literature","volume":"14","author":"Videtta","year":"2024","journal-title":"Front Psychiatry"},{"issue":"4","key":"10.1016\/j.genhosppsych.2026.09.004_bb0110","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.biopsych.2015.03.004","article-title":"Voxel-based meta-analytical evidence of structural disconnectivity in major depression and bipolar disorder","volume":"79","author":"Wise","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2019.00347","article-title":"Nodal global efficiency in front-parietal lobe mediated periventricular white matter hyperintensity (PWMH)-related cognitive impairment","volume":"11","author":"Chen","year":"2019","journal-title":"Front Aging Neurosci"},{"issue":"S4","key":"10.1016\/j.genhosppsych.2026.09.004_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/alz.056596","article-title":"Disintegration of anterior thalamic radiation fibers in cerebrovascular disease subjects with periventricular white matter hyperintensities leads to lower executive function performance","volume":"17","author":"Haddad","year":"2021","journal-title":"Alzheimers Dement"},{"issue":"12","key":"10.1016\/j.genhosppsych.2026.09.004_bb0125","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1161\/STROKEAHA.110.593657","article-title":"Cerebral microbleeds in the elderly","volume":"41","author":"Fisher","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0130","doi-asserted-by":"crossref","first-page":"169","DOI":"10.25259\/JNRP_351_2023","article-title":"Cerebral microbleeds: causes, clinical relevance, and imaging approach \u2013 a narrative review","volume":"15","author":"Agarwal","year":"2024","journal-title":"J Neurosci Rural Pract"},{"issue":"3","key":"10.1016\/j.genhosppsych.2026.09.004_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/nu18030484","article-title":"The relationship between trace elements and depression","volume":"18","author":"Zhong","year":"2026","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-025-03486-1","article-title":"Glymphatic dysfunction associated with cortisol dysregulation in major depressive disorder","volume":"15","author":"Chen","year":"2025","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2026.121960","article-title":"A systematic review and meta-analysis on glymphatic flow dysfunction in depression evidence from the dti-alps index","volume":"410","author":"Zhang","year":"2026","journal-title":"J Affect Disord"},{"issue":"21","key":"10.1016\/j.genhosppsych.2026.09.004_bb0150","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1016\/j.neuron.2022.10.024","article-title":"Perivascular spaces and their role in neuroinflammation","volume":"110","author":"Ineichen","year":"2022","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.genhosppsych.2026.09.004_bb0155","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1212\/WNL.0000000000013077","article-title":"Physiology and clinical relevance of enlarged perivascular spaces in the aging brain","volume":"98","author":"Bown","year":"2022","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.genhosppsych.2026.09.004_bb0160","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.01.020","article-title":"Aortic pulsatility propagates intracranially and correlates with dilated perivascular spaces and small vessel compliance","volume":"28","author":"Thomas","year":"2019","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"5","key":"10.1016\/j.genhosppsych.2026.09.004_bb0165","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/ajh\/hpaa001","article-title":"Pathological continuum from the rise in pulse pressure to impaired neurovascular coupling and cognitive decline","volume":"33","author":"de Montgolfier","year":"2020","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1398009","article-title":"Amygdala and cognitive impairment in cerebral small vessel disease: structural, functional, and metabolic changes","volume":"15","author":"Cheng","year":"2024","journal-title":"Front Neurol"},{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0175","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jalz.2016.01.007","article-title":"Pathoconnectomics of cognitive impairment in small vessel disease: a systematic review","volume":"12","author":"Dey","year":"2016","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.1016\/j.genhosppsych.2026.09.004_bb0180","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/svn-2018-000209","article-title":"Neuroimaging studies on cognitive impairment due to cerebral small vessel disease","volume":"4","author":"Du","year":"2019","journal-title":"Stroke Vasc Neurol"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0185","article-title":"Impact of multimorbidity and cognitive impairment on depressive symptoms in community-dwelling older adults and their interaction effects","volume":"15","author":"Dong","year":"2025","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0190","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhad468","article-title":"Characteristic patterns of functional connectivity-mediated cerebral small vessel disease-related cognitive impairment and depression","volume":"34","author":"Xu","year":"2023","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijnurstu.2026.105574","article-title":"Determinants of social participation among community-dwelling older adults: a mixed-methods systematic review","volume":"181","author":"Yang","year":"2026","journal-title":"Int J Nurs Stud"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106946","article-title":"Vascular depression: a comprehensive exploration of the definition, mechanisms, and clinical challenges","volume":"211","author":"Wu","year":"2025","journal-title":"Neurobiol Dis"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0205","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12865-024-00653-9","article-title":"Convergence of endothelial dysfunction, inflammation and glucocorticoid resistance in depression-related cardiovascular diseases","volume":"25","author":"Hage","year":"2024","journal-title":"BMC Immunol"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jpsychires.2023.07.033","article-title":"Endocan: a novel biomarker of endothelial dysfunction in depression?","volume":"165","author":"\u015eahan","year":"2023","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0215","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jpsychires.2023.05.042","article-title":"Objectively assessed sleep and physical activity in depression subtypes and its mediating role in their association with cardiovascular risk factors","volume":"163","author":"Glaus","year":"2023","journal-title":"J Psychiatr Res"},{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0220","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/jamapsychiatry.2017.0984","article-title":"Association of microvascular dysfunction with late-life depression","volume":"74","author":"van Agtmaal","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"SA100","key":"10.1016\/j.genhosppsych.2026.09.004_bb0225","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/ijs.12270","article-title":"Race-ethnicity and cerebral small vessel disease \u2013 comparison between chinese and white populations","volume":"9","author":"Mok","year":"2014","journal-title":"Int J Stroke"},{"issue":"21","key":"10.1016\/j.genhosppsych.2026.09.004_bb0230","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010533","article-title":"Cardiovascular risk factors and white matter hyperintensities: difference in susceptibility in south asians compared with europeans","volume":"7","author":"Sudre","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0235","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1051\/e3sconf\/202021803040","article-title":"Study on the pathogenesis of poststroke depression","volume":"218","author":"Sui","year":"2020","journal-title":"E3S Web Confer"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113146","article-title":"The etiology of poststroke-depression: a hypothesis involving hpa axis","volume":"151","author":"Zhou","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"Pt A","key":"10.1016\/j.genhosppsych.2026.09.004_bb0245","doi-asserted-by":"crossref","first-page":"120542","DOI":"10.1016\/j.jad.2025.120542","article-title":"Selecting a depression measure for research: a critical examination of five common self-report scales","volume":"394","author":"Perez","year":"2026","journal-title":"J Affect Disord"},{"issue":"4","key":"10.1016\/j.genhosppsych.2026.09.004_bb0250","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S2215-0366(23)00438-8","article-title":"Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review","volume":"11","author":"Veal","year":"2024","journal-title":"Lancet Psychiatry"},{"issue":"4","key":"10.1016\/j.genhosppsych.2026.09.004_bb0255","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.12.018","article-title":"Lacunar infarcts, depression, and anxiety symptoms one year after stroke","volume":"25","author":"Arba","year":"2016","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0260","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/gps.5005","article-title":"Associations of white matter hyperintensities with poststroke depression: A 1-year longitudinal study","volume":"34","author":"Bae","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0265","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2377-10-125","article-title":"Mood after stroke: a case control study of biochemical, neuro-imaging and socio-economic risk factors for major depression in stroke survivors","volume":"10","author":"Chatterjee","year":"2010","journal-title":"BMC Neurol"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0270","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1177\/2396987319883445","article-title":"Imaging markers associated with the development of post-stroke depression and apathy: results of the cognition and affect after stroke \u2013 a prospective evaluation of risks study","volume":"5","author":"Douven","year":"2019","journal-title":"Eur Stroke J"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0275","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1192\/bjp.bp.111.098897","article-title":"Relationship between progression of brain white matter changes and late-life depression: 3-year results from the ladis study","volume":"201","author":"Firbank","year":"2012","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0280","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jad.2021.05.096","article-title":"The association of markers of cerebral small vessel disease and brain atrophy with incidence and course of depressive symptoms - the Maastricht study","volume":"292","author":"Geraets","year":"2021","journal-title":"J Affect Disord"},{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0285","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2007.09.006","article-title":"White matter lesions as a predictor of depression in the elderly: the 3c-Dijon study","volume":"63","author":"Godin","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0290","first-page":"1","article-title":"Whitematter lesionsandtemporal lobeatrophyrelatedtoincidence ofbothdementiaandmajordepressionin70-year-oldsfollowedover 10years","author":"Gudmundsson","year":"2015","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0295","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.792843","article-title":"Thyroid function affects the risk of post-stroke depression in patients with acute lacunar stroke","volume":"13","author":"Guo","year":"2022","journal-title":"Front Neurol"},{"issue":"5","key":"10.1016\/j.genhosppsych.2026.09.004_bb0300","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20209162","article-title":"Mir-22 and cerebral microbleeds in brainstem and deep area are associated with depression one month after ischemic stroke","volume":"53","author":"Hu","year":"2020","journal-title":"Braz J Med Biol Res"},{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0305","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/gps.4400","article-title":"Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct","volume":"31","author":"Kim","year":"2015","journal-title":"Int J Geriatr Psychiatry"},{"issue":"7","key":"10.1016\/j.genhosppsych.2026.09.004_bb0310","first-page":"2677","article-title":"The factors influencing the occurrence of post-ischemic stroke depression and its relationship with the burden score of cerebral small vessel disease","volume":"28","author":"Li","year":"2024","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0315","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jad.2017.11.080","article-title":"Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: a 3-month prospective study","volume":"228","author":"Liang","year":"2018","journal-title":"J Affect Disord"},{"issue":"3","key":"10.1016\/j.genhosppsych.2026.09.004_bb0320","doi-asserted-by":"crossref","DOI":"10.1212\/WN9.0000000000000029","article-title":"Association of MRI-visible perivascular spaces and incident depression in the Framingham heart study","volume":"1","author":"Medved","year":"2025","journal-title":"Neurol Open Access"},{"issue":"13","key":"10.1016\/j.genhosppsych.2026.09.004_bb0325","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1038\/npp.2010.176","article-title":"Temporal lobe atrophy and white matter lesions are related to major depression over 5 years in the elderly","volume":"35","author":"Olesen","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.genhosppsych.2026.09.004_bb0330","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/gps.4289","article-title":"Baseline characteristic of patients presenting with lacunar stroke and cerebral small vessel disease may predict future development of depression","volume":"31","author":"Pavlovic","year":"2015","journal-title":"Int J Geriatr Psychiatry"},{"issue":"2","key":"10.1016\/j.genhosppsych.2026.09.004_bb0335","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/gps.4469","article-title":"Effects of white matter integrity and brain volumes on late life depression in the Framingham heart study","volume":"32","author":"Qiu","year":"2016","journal-title":"Int J Geriatr Psychiatry"},{"issue":"6","key":"10.1016\/j.genhosppsych.2026.09.004_bb0340","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1176\/appi.ajp.2014.14050578","article-title":"Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly population: the ages-reykjavik study","volume":"172","author":"van Sloten","year":"2015","journal-title":"Am J Psychiatry"},{"issue":"9","key":"10.1016\/j.genhosppsych.2026.09.004_bb0345","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1161\/STROKEAHA.111.614586","article-title":"Cerebral microbleeds and depression in lacunar stroke","volume":"42","author":"Tang","year":"2011","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.genhosppsych.2026.09.004_bb0350","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/0891988714522699","article-title":"Pontine microbleeds and depression in stroke","volume":"27","author":"Tang","year":"2014","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"4","key":"10.1016\/j.genhosppsych.2026.09.004_bb0355","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1017\/S0033291709990857","article-title":"Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the ladis study","volume":"40","author":"Teodorczuk","year":"2010","journal-title":"Psychol Med"},{"issue":"4","key":"10.1016\/j.genhosppsych.2026.09.004_bb0360","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/gps.1477","article-title":"Progression of cerebral white matter lesions is not associated with development of depressive symptoms in elderly subjects at risk of cardiovascular disease. The prosper study","volume":"21","author":"Versluis","year":"2006","journal-title":"Int J Geriatr Psychiatry"},{"issue":"6","key":"10.1016\/j.genhosppsych.2026.09.004_bb0365","doi-asserted-by":"crossref","first-page":"587","DOI":"10.7150\/ijms.8025","article-title":"Late-onset depression in the absence of stroke: associated with silent brain infarctions, microbleeds and lesion locations","volume":"11","author":"Wu","year":"2014","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0370","first-page":"1","article-title":"Total magnetic resonance imaging burden of cerebral small-vessel disease is associated with post-stroke depression in patients with acute lacunar stroke","author":"Zhang","year":"2016","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.genhosppsych.2026.09.004_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.922530","article-title":"A new nomogram including total cerebral small vessel disease burden for individualized prediction of early-onset depression in patients with acute ischemic stroke","volume":"14","author":"Zhou","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"10.1016\/j.genhosppsych.2026.09.004_bb0380","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhae149","article-title":"Association between white matter hyperintensity and anxiety\/depression","volume":"34","author":"Zhou","year":"2024","journal-title":"Cereb Cortex"}],"container-title":["General Hospital Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163834326001891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163834326001891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:48:14Z","timestamp":1789588094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163834326001891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":76,"alternative-id":["S0163834326001891"],"URL":"https:\/\/doi.org\/10.1016\/j.genhosppsych.2026.09.004","relation":{},"ISSN":["0163-8343"],"issn-type":[{"value":"0163-8343","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging marker-specific associations between cerebral small vessel disease and depression: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"General Hospital Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.genhosppsych.2026.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}