{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:36:56Z","timestamp":1777441016822,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gender Medicine"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.genm.2009.03.003","type":"journal-article","created":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T05:19:03Z","timestamp":1241068743000},"page":"208-224","source":"Crossref","is-referenced-by-count":8,"special_numbering":"P2","title":["Sexual differentiation of rat reproductive versus opioid antinociceptive systems"],"prefix":"10.1016","volume":"6","author":[{"given":"Rebecca M.","family":"Craft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Ulibarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.genm.2009.03.003_bib1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.pain.2007.09.028","article-title":"Modulation of pain by estrogens","volume":"132","author":"Craft","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ejpain.2004.01.003","article-title":"Sex differences in pain and analgesia: the role of gonadal hormones","volume":"8","author":"Craft","year":"2004","journal-title":"Eur J Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1526-4610.2006.00708.x","article-title":"The influence of gender and sex steroids on craniofacial nociception","volume":"47","author":"Cairns","year":"2007","journal-title":"Headache"},{"key":"10.1016\/j.genm.2009.03.003_bib4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ejpain.2004.01.006","article-title":"Sex-based differences in gastrointestinal pain","volume":"8","author":"Mayer","year":"2004","journal-title":"Eur J Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib5","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1550-8579(05)80042-7","article-title":"Sex differences in pain perception","volume":"3","author":"Wiesenfeld-Hallin","year":"2005","journal-title":"Gend Med"},{"key":"10.1016\/j.genm.2009.03.003_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0304-3959(95)00214-6","article-title":"Gender variations in clinical pain experience","volume":"65","author":"Unruh","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib7","series-title":"Central Neural States Relating Sex and Pain","author":"Bodnar","year":"2002"},{"key":"10.1016\/j.genm.2009.03.003_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/endo-65-3-369","article-title":"Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig","volume":"65","author":"Phoenix","year":"1959","journal-title":"Endocrinology"},{"key":"10.1016\/j.genm.2009.03.003_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/frne.1998.0171","article-title":"Sexual differentiation of the vertebrate brain: Principles and mechanisms","volume":"19","author":"Cooke","year":"1998","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.genm.2009.03.003_bib10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ejpain.2007.07.014","article-title":"Doseand time-dependent estradiol modulation of morphine antinociception in adult female rats","volume":"12","author":"Craft","year":"2008","journal-title":"Eur J Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib11","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/s0304-3959(02)00457-8","article-title":"Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats","volume":"103","author":"Stoffel","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib12","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.lfs.2006.07.007","article-title":"Testosterone modulation of reproductive indices vs morphine antinociception in male rats","volume":"79","author":"Sumner","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.genm.2009.03.003_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1124\/jpet.300.2.695","article-title":"Role of steroids in sex differences in morphine-induced analgesia: Activational and organizational effects","volume":"300","author":"Cicero","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.genm.2009.03.003_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00213-002-1143-x","article-title":"Influence of gonadectomy on the antinociceptive effects of opioids in male and female rats","volume":"163","author":"Terner","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.genm.2009.03.003_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(01)03350-9","article-title":"Reversal of sex differences in morphine analgesia elicited from the ventrolateral periaqueductal gray in rats by neonatal hormone manipulations","volume":"929","author":"Krzanowska","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.genm.2009.03.003_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0031-9384(73)90124-8","article-title":"Neonatal androgen effects on open-field activity and sexual behavior in the female rat: The modifying influence of ovarian secretions during development","volume":"11","author":"Blizard","year":"1973","journal-title":"Physiol Behav"},{"key":"10.1016\/j.genm.2009.03.003_bib17","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1523\/JNEUROSCI.01-10-01142.1981","article-title":"The influence of gonadectomy, androgen exposure, or a gonadal graft in the neonatal rat on the volume of the sexually dimorphic nucleus of the preoptic area","volume":"1","author":"Jacobson","year":"1981","journal-title":"J Neurosci"},{"key":"10.1016\/j.genm.2009.03.003_bib18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1210\/en.133.2.433","article-title":"Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain","volume":"133","author":"McCarthy","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.genm.2009.03.003_bib19","series-title":"Sexual Differentiation of the Brain","author":"Goy","year":"1980"},{"key":"10.1016\/j.genm.2009.03.003_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2005.08.003","article-title":"Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats: effects of adult ovariectomy and estradiol replacement","volume":"1059","author":"Cataldo","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.genm.2009.03.003_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000121961","article-title":"Neonatal androgen effects on sexual and non-sexual behavior of adult rats tested under various hormone regimes","volume":"7","author":"Pfaff","year":"1971","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.genm.2009.03.003_bib22","series-title":"Core Curriculum for Professional Education in Pain","author":"Charlton","year":"2005"},{"key":"10.1016\/j.genm.2009.03.003_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0018-506X(77)90002-2","article-title":"The relationship between circulating testosterone levels and male sexual behavior in rats","volume":"8","author":"Damassa","year":"1977","journal-title":"Horm Behav"},{"key":"10.1016\/j.genm.2009.03.003_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0376-8716(00)00209-X","article-title":"Sex differences in opioid antinociception: kappa and mixed action agonists","volume":"63","author":"Craft","year":"2001","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.genm.2009.03.003_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0091-3057(89)90363-8","article-title":"Roles of gender, gonadectomy and estrous phase in the analgesic effects of intracerebroventricular morphine in rats","volume":"34","author":"Kepler","year":"1989","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.genm.2009.03.003_bib26","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1080\/00207450600910259","article-title":"Estrus phase differences in female rats in morphine antinociception elicited from the ventrolateral periaqueductal gray","volume":"117","author":"Shane","year":"2007","journal-title":"Int J Neurosci"},{"key":"10.1016\/j.genm.2009.03.003_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00002508-200305000-00005","article-title":"Sex differences in opioid analgesia: from mouse to man","volume":"19","author":"Craft","year":"2003","journal-title":"Clin J Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuroscience.2006.08.034","article-title":"Organizational and activational effects of testosterone on carrageenaninduced inflammatory pain and morphine analgesia","volume":"143","author":"Borzan","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.genm.2009.03.003_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0031-9384(77)90149-4","article-title":"Gonadectomy and sensitivity to electric shock in the rat","volume":"19","author":"Beatty","year":"1977","journal-title":"Physiol Behav"},{"key":"10.1016\/j.genm.2009.03.003_bib30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jpain.2004.07.002","article-title":"Nociception and antinociception during the first week of life in mice: Sex differences and test dependence","volume":"5","author":"Sternberg","year":"2004","journal-title":"J Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pain.2003.08.008","article-title":"Pharmacogenetic analysis of sex differences in opioid antinociception in rats","volume":"106","author":"Terner","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.genm.2009.03.003_bib32","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1159\/000127196","article-title":"Adaptation to prolonged or repeated stress-comparison between rat strains showing intrinsic differences in reactivity to acute stress","volume":"65","author":"Dhabhar","year":"1997","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.genm.2009.03.003_bib33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00213-006-0562-5","article-title":"Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague-Dawley rat strains","volume":"189","author":"Grakalic","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.genm.2009.03.003_bib34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1037\/h0088023","article-title":"Effects of early castration in male rats on adult sexual behavior","volume":"64","author":"Gerall","year":"1967","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.genm.2009.03.003_bib35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1037\/h0028197","article-title":"Influence of neonatally administered hormones and early gonadectomy on rats' sexual behavior","volume":"69","author":"Hendricks","year":"1969","journal-title":"J Comp Physiol Psychol"},{"key":"10.1016\/j.genm.2009.03.003_bib36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ar.1091570208","article-title":"Hormonal determinants of the development of masculine and feminine behavior in male and female rats","volume":"157","author":"Whalen","year":"1967","journal-title":"Anat Rec"}],"container-title":["Gender Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550857909000229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550857909000229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T15:19:04Z","timestamp":1558279144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550857909000229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":36,"alternative-id":["S1550857909000229"],"URL":"https:\/\/doi.org\/10.1016\/j.genm.2009.03.003","relation":{},"ISSN":["1550-8579"],"issn-type":[{"value":"1550-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}