{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:49:10Z","timestamp":1777517350275,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene Expression Patterns"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.gep.2018.03.004","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T10:57:54Z","timestamp":1521543474000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Age-dependent expression pattern in the mammalian brain of a novel, small peptide encoded in the 22q11.2 deletion syndrome region"],"prefix":"10.1016","volume":"28","author":[{"given":"Sabrina","family":"Kragness","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.A.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joby J.","family":"Westmoreland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Burstain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie R.","family":"Earls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.gep.2018.03.004_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0306-4522(89)90424-7","article-title":"The three-dimensional organization of the hippocampal formation: a review of anatomical data","volume":"31","author":"Amaral","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.gep.2018.03.004_bib2","series-title":"The hippocampus Book","first-page":"832","author":"Andersen","year":"2007"},{"issue":"2","key":"10.1016\/j.gep.2018.03.004_bib3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF00234087","article-title":"Lamellar organization of hippocampal pathways","volume":"13","author":"Andersen","year":"1971","journal-title":"Exp. Brain Res."},{"issue":"4","key":"10.1016\/j.gep.2018.03.004_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.01.009","article-title":"A micropeptide encoded by a putative long noncoding RNA regulates muscle performance","volume":"160","author":"Anderson","year":"2015","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.gep.2018.03.004_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrg3520","article-title":"Emerging evidence for functional peptides encoded by short open reading frames","volume":"15","author":"Andrews","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.gep.2018.03.004_bib6","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10803-013-1920-x","article-title":"Social impairments in chromosome 22q11.2 deletion syndrome (22q11.2DS): autism spectrum disorder or a different endophenotype?","volume":"44","author":"Angkustsiri","year":"2014","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.gep.2018.03.004_bib7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.psychres.2017.04.019","article-title":"Prevalence and treatment of psychiatric disorders other than psychosis in children and adolescents with 22q11DS: examining associations with social and role functioning","volume":"254","author":"Armando","year":"2017","journal-title":"Psychiatr. Res."},{"issue":"7","key":"10.1016\/j.gep.2018.03.004_bib8","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/npp.2012.5","article-title":"Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants","volume":"37","author":"Baj","year":"2012","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"10.1016\/j.gep.2018.03.004_bib9","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/embj.201488411","article-title":"Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation","volume":"33","author":"Bazzini","year":"2014","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.gep.2018.03.004_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10522-008-9197-8","article-title":"Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging","volume":"10","author":"Brink","year":"2009","journal-title":"Biogerontology"},{"issue":"10","key":"10.1016\/j.gep.2018.03.004_bib11","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/jmg.30.10.822","article-title":"Conotruncal anomaly face syndrome is associated with a deletion within chromosome 22q11","volume":"30","author":"Burn","year":"1993","journal-title":"J. Med. Genet."},{"issue":"6","key":"10.1016\/j.gep.2018.03.004_bib12","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.jpeds.2014.01.056","article-title":"Clinical features and follow-up in patients with 22q11.2 deletion syndrome","volume":"164","author":"Cancrini","year":"2014","journal-title":"J. Pediatr."},{"issue":"11","key":"10.1016\/j.gep.2018.03.004_bib13","doi-asserted-by":"crossref","first-page":"e0141853","DOI":"10.1371\/journal.pone.0141853","article-title":"With reference to reference genes: a systematic review of endogenous controls in gene expression studies","volume":"10","author":"Chapman","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.gep.2018.03.004_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nm.4240","article-title":"Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion","volume":"23","author":"Chun","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.gep.2018.03.004_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13229-017-0171-7","article-title":"Critical region within 22q11.2 linked to higher rate of autism spectrum disorder","volume":"8","author":"Clements","year":"2017","journal-title":"Mol. Autism."},{"key":"10.1016\/j.gep.2018.03.004_bib16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1186\/1471-2164-14-648","article-title":"Combining in silico prediction and ribosome profiling in a genome-wide search for novel putatively coding sORFs","volume":"14","author":"Crappe","year":"2013","journal-title":"BMC Genom."},{"key":"10.1016\/j.gep.2018.03.004_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1472-6750-7-32","article-title":"Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli","volume":"7","author":"de Marco","year":"2007","journal-title":"BMC Biotechnol."},{"issue":"9","key":"10.1016\/j.gep.2018.03.004_bib18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/mp.2016.75","article-title":"Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium","volume":"22","author":"Devaraju","year":"2016","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.gep.2018.03.004_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ijdevneu.2010.09.007","article-title":"The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders","volume":"29","author":"Drew","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"issue":"6","key":"10.1016\/j.gep.2018.03.004_bib20","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1192\/bjp.bp.111.097139","article-title":"Cognitive development in children with 22q11.2 deletion syndrome","volume":"200","author":"Duijff","year":"2012","journal-title":"Br. J. Psychiatry"},{"issue":"47","key":"10.1016\/j.gep.2018.03.004_bib21","doi-asserted-by":"crossref","first-page":"15843","DOI":"10.1523\/JNEUROSCI.1425-10.2010","article-title":"Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome","volume":"30","author":"Earls","year":"2010","journal-title":"J. Neurosci."},{"issue":"41","key":"10.1016\/j.gep.2018.03.004_bib22","doi-asserted-by":"crossref","first-page":"14132","DOI":"10.1523\/JNEUROSCI.1312-12.2012","article-title":"Age-dependent microRNA control of synaptic plasticity in 22q11 deletion syndrome and schizophrenia","volume":"32","author":"Earls","year":"2012","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.gep.2018.03.004_bib23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/CHI.0b013e31802f5490","article-title":"Autism in children with 22q11.2 deletion syndrome","volume":"46","author":"Eliez","year":"2007","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"7","key":"10.1016\/j.gep.2018.03.004_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00787-012-0273-x","article-title":"Depression and anxiety disorders in children and adolescents with velo-cardio-facial syndrome (VCFS)","volume":"21","author":"Fabbro","year":"2012","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"4","key":"10.1016\/j.gep.2018.03.004_bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.neuron.2013.06.016","article-title":"BLA to vHPC inputs modulate anxiety-related behaviors","volume":"79","author":"Felix-Ortiz","year":"2013","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.gep.2018.03.004_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10803-005-5036-9","article-title":"Autism spectrum disorders and symptoms in children with molecularly confirmed 22q11.2 deletion syndrome","volume":"35","author":"Fine","year":"2005","journal-title":"J. Autism Dev. Disord."},{"issue":"5","key":"10.1016\/j.gep.2018.03.004_bib27","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1371\/journal.pbio.0050106","article-title":"Peptides encoded by short ORFs control development and define a new eukaryotic gene family","volume":"5","author":"Galindo","year":"2007","journal-title":"PLoS Biol."},{"issue":"11","key":"10.1016\/j.gep.2018.03.004_bib28","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1097\/CHI.0b013e3181b76683","article-title":"Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome","volume":"48","author":"Green","year":"2009","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"issue":"3","key":"10.1016\/j.gep.2018.03.004_bib29","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0306-4522(00)00146-9","article-title":"The multifarious hippocampal mossy fiber pathway: a review","volume":"98","author":"Henze","year":"2000","journal-title":"Neuroscience"},{"issue":"7494","key":"10.1016\/j.gep.2018.03.004_bib30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature13028","article-title":"The hippocampal CA2 region is essential for social memory","volume":"508","author":"Hitti","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.gep.2018.03.004_bib31","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1038\/srep08388","article-title":"Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats","volume":"5","author":"Jin","year":"2015","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.gep.2018.03.004_bib32","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1101\/lm.688207","article-title":"Behavioral functions of the CA3 subregion of the hippocampus","volume":"14","author":"Kesner","year":"2007","journal-title":"Learn. Mem."},{"issue":"2","key":"10.1016\/j.gep.2018.03.004_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nn.3614","article-title":"Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits","volume":"17","author":"Kohara","year":"2014","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.gep.2018.03.004_bib34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/ncb1595","article-title":"Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA","volume":"9","author":"Kondo","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"39","key":"10.1016\/j.gep.2018.03.004_bib35","doi-asserted-by":"crossref","first-page":"16994","DOI":"10.1073\/pnas.1005362107","article-title":"RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory","volume":"107","author":"Lee","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7124","key":"10.1016\/j.gep.2018.03.004_bib36","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature05453","article-title":"Genome-wide atlas of gene expression in the adult mouse brain","volume":"445","author":"Lein","year":"2007","journal-title":"Nature"},{"issue":"6751","key":"10.1016\/j.gep.2018.03.004_bib37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/43900","article-title":"Congenital heart disease in mice deficient for the DiGeorge syndrome region","volume":"401","author":"Lindsay","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.gep.2018.03.004_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13059-015-0742-x","article-title":"Extensive identification and analysis of conserved small ORFs in animals","volume":"16","author":"Mackowiak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.gep.2018.03.004_bib39","doi-asserted-by":"crossref","first-page":"15071","DOI":"10.1038\/nrdp.2015.71","article-title":"22q11.2 deletion syndrome","volume":"1","author":"McDonald-McGinn","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.gep.2018.03.004_bib40","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jneumeth.2009.12.018","article-title":"Selection of reference genes for gene expression studies in rat oligodendrocytes using quantitative real time PCR","volume":"187","author":"Nelissen","year":"2010","journal-title":"J. Neurosci. Meth."},{"issue":"D1","key":"10.1016\/j.gep.2018.03.004_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1175","article-title":"sORFs.org: a repository of small ORFs identified by ribosome profiling","volume":"44","author":"Olexiouk","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.gep.2018.03.004_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051071","article-title":"Examining the overlap between autism spectrum disorder and 22q11.2 deletion syndrome","volume":"18","author":"Ousley","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.gep.2018.03.004_bib43","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.neuron.2016.01.011","article-title":"Direct ventral hippocampal-prefrontal input is required for anxiety-related neural activity and behavior","volume":"89","author":"Padilla-Coreano","year":"2016","journal-title":"Neuron"},{"issue":"23","key":"10.1016\/j.gep.2018.03.004_bib44","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/hmg\/10.23.2645","article-title":"Mice deleted for the DiGeorge\/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments","volume":"10","author":"Paylor","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.gep.2018.03.004_bib45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neuron.2015.11.036","article-title":"Age-dependent specific changes in area CA2 of the Hippocampus and social memory deficit in a mouse model of the 22q11.2 deletion syndrome","volume":"89","author":"Piskorowski","year":"2016","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.gep.2018.03.004_bib46","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1136\/jmg.34.10.798","article-title":"Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: a European collaborative study","volume":"34","author":"Ryan","year":"1997","journal-title":"J. Med. Genet."},{"issue":"16","key":"10.1016\/j.gep.2018.03.004_bib47","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1093\/hmg\/9.16.2421","article-title":"The 22q11 deletion syndromes","volume":"9","author":"Scambler","year":"2000","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.gep.2018.03.004_bib48","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1176\/appi.ajp.2013.13070864","article-title":"Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the international consortium on brain and behavior in 22q11.2 deletion syndrome","volume":"171","author":"Schneider","year":"2014","journal-title":"Am. J. Psychiatr."},{"issue":"47","key":"10.1016\/j.gep.2018.03.004_bib49","doi-asserted-by":"crossref","first-page":"15679","DOI":"10.1523\/JNEUROSCI.3234-13.2014","article-title":"Gap junctions in the ventral hippocampal-medial prefrontal pathway are involved in anxiety regulation","volume":"34","author":"Schoenfeld","year":"2014","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.gep.2018.03.004_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ddrr.2","article-title":"Velo-cardio-facial syndrome: 30 Years of study","volume":"14","author":"Shprintzen","year":"2008","journal-title":"Dev Disabil Res Rev"},{"issue":"2","key":"10.1016\/j.gep.2018.03.004_bib51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/ajmg.c.31435","article-title":"Developmental trajectories in 22q11.2 deletion","volume":"169","author":"Swillen","year":"2015","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"4","key":"10.1016\/j.gep.2018.03.004_bib52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1001\/jamapsychiatry.2014.2671","article-title":"Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome","volume":"72","author":"Vorstman","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.gep.2018.03.004_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13229-016-0090-z","article-title":"22q11.2 duplication syndrome: elevated rate of autism spectrum disorder and need for medical screening","volume":"7","author":"Wenger","year":"2016","journal-title":"Mol. Autism."}],"container-title":["Gene Expression Patterns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X17302144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X17302144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:07:20Z","timestamp":1534982840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567133X17302144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":53,"alternative-id":["S1567133X17302144"],"URL":"https:\/\/doi.org\/10.1016\/j.gep.2018.03.004","relation":{},"ISSN":["1567-133X"],"issn-type":[{"value":"1567-133X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-dependent expression pattern in the mammalian brain of a novel, small peptide encoded in the 22q11.2 deletion syndrome region","name":"articletitle","label":"Article Title"},{"value":"Gene Expression Patterns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gep.2018.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}