{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:46:50Z","timestamp":1772120810021,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene Expression Patterns"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.gep.2025.119392","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:46:37Z","timestamp":1741725997000},"page":"119392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Characterization of Hippo signaling components in the early dorsal pancreatic bud"],"prefix":"10.1016","volume":"55","author":[{"given":"Neha","family":"Ahuja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Maynard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Bierschenck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-6641","authenticated-orcid":false,"given":"Ondine","family":"Cleaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gep.2025.119392_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012401","article-title":"Deconstructing pancreas developmental biology","volume":"4","author":"Benitez","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.gep.2025.119392_bib2","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1242\/dev.128.24.5109","article-title":"Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis","volume":"128","author":"Bhushan","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119392_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fcell.2019.00049","article-title":"Role of Hippo pathway-YAP\/TAZ signaling in angiogenesis","volume":"7","author":"Boopathy","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.gep.2025.119392_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000382","article-title":"LATS1\/2 suppress NF\u03baB and aberrant EMT initiation to permit pancreatic progenitor differentiation","volume":"17","author":"Braitsch","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.gep.2025.119392_bib5","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nrm2523","article-title":"From cells to organs: building polarized tissue","volume":"9","author":"Bryant","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.gep.2025.119392_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.gep.2025.119392_bib7","doi-asserted-by":"crossref","first-page":"15810","DOI":"10.1073\/pnas.1004060107","article-title":"The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.gep.2025.119392_bib8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/cr.2015.101","article-title":"YAP activates the Hippo pathway in a negative feedback loop","volume":"25","author":"Dai","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.gep.2025.119392_bib9","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.celrep.2017.07.032","article-title":"The epithelial circumferential actin belt regulates YAP\/TAZ through nucleocytoplasmic shuttling of Merlin","volume":"20","author":"Furukawa","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.gep.2025.119392_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/BJ20110217","article-title":"The Hippo pathway and apico-basal cell polarity","volume":"436","author":"Genevet","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.gep.2025.119392_bib11","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1128\/MCB.01034-12","article-title":"Hippo signaling regulates pancreas development through inactivation of Yap","volume":"32","author":"George","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.gep.2025.119392_bib12","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.cub.2013.05.014","article-title":"Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos","volume":"23","author":"Hirate","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.gep.2025.119392_bib13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00018-022-04216-2","article-title":"TAZ promotes PDX1-mediated insulinogenesis","volume":"79","author":"Jeong","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.gep.2025.119392_bib14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1210\/er.2007-0016","article-title":"An illustrated review of early pancreas development in the mouse","volume":"28","author":"Jorgensen","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.gep.2025.119392_bib15","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.4161\/cc.10.12.16010","article-title":"Progenitor cell domains in the developing and adult pancreas","volume":"10","author":"Kopp","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.gep.2025.119392_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/jmcb\/mju046","article-title":"Hippo\/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung","volume":"7","author":"Lange","year":"2015","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.gep.2025.119392_bib17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-018-0762-2","article-title":"Mechanosignalling via integrins directs fate decisions of pancreatic progenitors","volume":"564","author":"Mamidi","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.gep.2025.119392_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00467-016-3326-4","article-title":"A holey pursuit: lumen formation in the developing kidney","volume":"32","author":"Marciano","year":"2017","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.gep.2025.119392_bib19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1369\/0022155415586441","article-title":"Progenitor epithelium: sorting out pancreatic lineages","volume":"63","author":"Marty-Santos","year":"2015","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.gep.2025.119392_bib20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.devcel.2009.02.003","article-title":"The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass","volume":"16","author":"Nishioka","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.gep.2025.119392_bib21","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1101\/gad.1536007","article-title":"Hippo signaling in organ size control","volume":"21","author":"Pan","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.gep.2025.119392_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12309","article-title":"A critical role for NF2 and the Hippo pathway in branching morphogenesis","volume":"7","author":"Reginensi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gep.2025.119392_bib23","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s41467-019-09404-6","article-title":"YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing beta cells","volume":"10","author":"Rosado-Olivieri","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.gep.2025.119392_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.gep.2025.119392_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4910280","article-title":"The HIPPO transducer YAP and its targets CTGF and Cyr61 drive a paracrine signalling in cold atmospheric plasma-mediated wound healing","volume":"2020","author":"Shome","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.gep.2025.119392_bib26","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nature05537","article-title":"Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver","volume":"445","author":"Stanger","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.gep.2025.119392_bib27","doi-asserted-by":"crossref","DOI":"10.1242\/dev.173716","article-title":"A transcriptomic roadmap to alpha- and beta-cell differentiation in the embryonic pancreas","volume":"146","author":"van Gurp","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119392_bib28","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1242\/dev.052993","article-title":"Epithelial dynamics of pancreatic branching morphogenesis","volume":"137","author":"Villasenor","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119392_bib29","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.celrep.2018.10.001","article-title":"Comprehensive molecular characterization of the Hippo signaling pathway in cancer","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.gep.2025.119392_bib30","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2013.08.025","article-title":"Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin\/NF2","volume":"154","author":"Yin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.gep.2025.119392_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1101\/gad.2000111","article-title":"Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein","volume":"25","author":"Zhao","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.gep.2025.119392_bib32","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.devcel.2019.06.003","article-title":"The Hippo signaling pathway in development and disease","volume":"50","author":"Zheng","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.gep.2025.119392_bib33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.devcel.2007.06.001","article-title":"A multipotent progenitor domain guides pancreatic organogenesis","volume":"13","author":"Zhou","year":"2007","journal-title":"Dev. Cell"}],"container-title":["Gene Expression Patterns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X25000043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X25000043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:07:57Z","timestamp":1749701277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567133X25000043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":33,"alternative-id":["S1567133X25000043"],"URL":"https:\/\/doi.org\/10.1016\/j.gep.2025.119392","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.26.619721","asserted-by":"object"}]},"ISSN":["1567-133X"],"issn-type":[{"value":"1567-133X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of Hippo signaling components in the early dorsal pancreatic bud","name":"articletitle","label":"Article Title"},{"value":"Gene Expression Patterns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gep.2025.119392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119392"}}