{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:45:06Z","timestamp":1776919506186,"version":"3.51.2"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03803"],"award-info":[{"award-number":["19H03803"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene Expression Patterns"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.gep.2025.119400","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T02:37:25Z","timestamp":1754447845000},"page":"119400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Spatiotemporal expression of CWC27 spliceosome-associated protein (CWC27) in the developing mouse inner ear"],"prefix":"10.1016","volume":"56","author":[{"given":"Li","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6868-8057","authenticated-orcid":false,"given":"Yosuke","family":"Tona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.gep.2025.119400_bib1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/hmg\/ddab319","article-title":"Cwc27, associated with retinal degeneration, functions as a splicing factor in vivo","volume":"31","author":"Bertrand","year":"2022","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"10.1016\/j.gep.2025.119400_bib2","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/s10038-019-0664-7","article-title":"Expanding the clinical and molecular spectrum of the CWC27-related spliceosomopathy","volume":"64","author":"Brea-Fern\u00e1ndez","year":"2019","journal-title":"J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.gep.2025.119400_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/biom10030370","article-title":"Hear, hear for notch: control of cell fates in the inner ear by notch signaling","volume":"10","author":"Brown","year":"2020","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.gep.2025.119400_bib4","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1093\/nar\/gkaa267","article-title":"Structural and functional insights into CWC27\/CWC22 heterodimer linking the exon junction complex to spliceosomes","volume":"48","author":"Busetto","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.gep.2025.119400_bib5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biocel.2013.11.001","article-title":"Usher protein functions in hair cells and photoreceptors","volume":"46","author":"Cosgrove","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.gep.2025.119400_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/jmedgenet-2015-103511","article-title":"Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt","volume":"53","author":"Di Donato","year":"2016","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.gep.2025.119400_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1112069","article-title":"Grainyhead-like 2 is required for morphological integrity of mouse embryonic stem cells and orderly formation of inner ear-like organoids","volume":"11","author":"Forrester-Gauntlett","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"18","key":"10.1016\/j.gep.2025.119400_bib8","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1007\/s00018-010-0403-x","article-title":"The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis","volume":"67","author":"Fritzsch","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"issue":"13","key":"10.1016\/j.gep.2025.119400_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136723","article-title":"Usher syndrome: genetics of a human ciliopathy","volume":"22","author":"Fuster-Garc\u00eda","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.gep.2025.119400_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2020.107932","article-title":"Disease mechanisms and gene therapy for Usher syndrome","volume":"394","author":"G\u00e9l\u00e9oc","year":"2020","journal-title":"Hear. Res."},{"issue":"14","key":"10.1016\/j.gep.2025.119400_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk0942","article-title":"Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction","volume":"8","author":"Giffen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.gep.2025.119400_bib12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.ph.37.030175.001021","article-title":"Vestibular mechanisms","volume":"37","author":"Goldberg","year":"1975","journal-title":"Annu. Rev. Physiol."},{"issue":"5","key":"10.1016\/j.gep.2025.119400_bib13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0896-6273(00)80385-2","article-title":"How hearing happens","volume":"19","author":"Hudspeth","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.gep.2025.119400_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/jmg.40.11.e118","article-title":"Clinical and immunohistochemical evidence for an X linked retinitis pigmentosa syndrome with recurrent infections and hearing loss in association with an RPGR mutation","volume":"40","author":"Iannaccone","year":"2003","journal-title":"J. Med. Genet."},{"issue":"11","key":"10.1016\/j.gep.2025.119400_bib15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nrn1987","article-title":"Regulation of cell fate in the sensory epithelia of the inner ear","volume":"7","author":"Kelley","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"7036","key":"10.1016\/j.gep.2025.119400_bib16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/nature03487","article-title":"Sox2 is required for sensory organ development in the Mammalian inner ear","volume":"434","author":"Kiernan","year":"2005","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.gep.2025.119400_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s101620010023","article-title":"Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice","volume":"1","author":"Lanford","year":"2000","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.gep.2025.119400_bib18","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3389\/fonc.2019.01082","article-title":"External replication of urinary bladder cancer prognostic polymorphisms in the UK biobank","volume":"9","author":"Lipunova","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.gep.2025.119400_bib19","series-title":"Springer Handbook of Auditory Research: Development of the Inner Ear","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/0-387-30678-1_3","author":"Mansour","year":"2005"},{"issue":"1","key":"10.1016\/j.gep.2025.119400_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004055","article-title":"The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs","volume":"10","author":"Moayedi","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.gep.2025.119400_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijporl.2017.03.008","article-title":"MYO15A splicing mutations in hearing loss: a review literature and report of a novel mutation","volume":"96","author":"Motavaf","year":"2017","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"issue":"10","key":"10.1016\/j.gep.2025.119400_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002966","article-title":"A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse","volume":"8","author":"Nakano","year":"2012","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.gep.2025.119400_bib23","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1261\/rna.033316.112","article-title":"Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS","volume":"18","author":"Ohrt","year":"2012","journal-title":"RNA"},{"issue":"16","key":"10.1016\/j.gep.2025.119400_bib24","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1523\/JNEUROSCI.20-16-06125.2000","article-title":"FGF\/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis","volume":"20","author":"Pirvola","year":"2000","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"issue":"1","key":"10.1016\/j.gep.2025.119400_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/dneu.22401","article-title":"Dual role for Sox2 in specification of sensory competence and regulation of Atoh1 function","volume":"77","author":"Puligilla","year":"2017","journal-title":"Dev. Neurobiol."},{"issue":"1","key":"10.1016\/j.gep.2025.119400_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2001.tb03730.x","article-title":"Development of the vertebrate inner ear","volume":"942","author":"Rinkwitz","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7","key":"10.1016\/j.gep.2025.119400_bib27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/neu.20244","article-title":"Retinoid signaling in inner ear development","volume":"66","author":"Romand","year":"2006","journal-title":"J. Neurobiol."},{"issue":"Suppl. 220","key":"10.1016\/j.gep.2025.119400_bib28","first-page":"1","article-title":"Development of the inner ear of the mouse: a radioautographic study of terminal mitoses","author":"Ruben","year":"1967","journal-title":"Acta Otolaryngol."},{"issue":"8","key":"10.1016\/j.gep.2025.119400_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183477","article-title":"A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells","volume":"12","author":"Seki","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.gep.2025.119400_bib30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00439-016-1648-8","article-title":"Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss","volume":"135","author":"Sloan-Heggen","year":"2016","journal-title":"Hum. Genet."},{"issue":"11","key":"10.1016\/j.gep.2025.119400_bib31","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1158\/0008-5472.CAN-15-2564","article-title":"Genome-wide association study of bladder cancer in a Chinese cohort reveals a new susceptibility locus at 5q12.3","volume":"76","author":"Wang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.gep.2025.119400_bib32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-biochem-091719-064225","article-title":"RNA splicing by the spliceosome","volume":"89","author":"Wilkinson","year":"2020","journal-title":"Annu. Rev. Biochem."},{"issue":"20","key":"10.1016\/j.gep.2025.119400_bib33","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1523\/JNEUROSCI.16-20-06454.1996","article-title":"Sensory organ generation in the chick inner ear","volume":"16","author":"Wu","year":"1996","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.gep.2025.119400_bib34","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ajhg.2017.02.008","article-title":"Mutations in the spliceosome component CWC27 cause retinal degeneration with or without additional developmental anomalies","volume":"100","author":"Xu","year":"2017","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.gep.2025.119400_bib35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ydbio.2011.03.016","article-title":"Rbpj regulates development of prosensory cells in the Mammalian inner ear","volume":"353","author":"Yamamoto","year":"2011","journal-title":"Dev. Biol."}],"container-title":["Gene Expression Patterns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X25000122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X25000122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:19:09Z","timestamp":1776917949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567133X25000122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":35,"alternative-id":["S1567133X25000122"],"URL":"https:\/\/doi.org\/10.1016\/j.gep.2025.119400","relation":{},"ISSN":["1567-133X"],"issn-type":[{"value":"1567-133X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal expression of CWC27 spliceosome-associated protein (CWC27) in the developing mouse inner ear","name":"articletitle","label":"Article Title"},{"value":"Gene Expression Patterns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gep.2025.119400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119400"}}