{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:44:59Z","timestamp":1776919499224,"version":"3.51.2"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"am","delay-in-days":322,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene Expression Patterns"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.gep.2025.119402","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:46:01Z","timestamp":1760543161000},"page":"119402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mapping Shroom3 expression across the adult mouse"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7526-181X","authenticated-orcid":false,"given":"Jennifer L.","family":"Carleton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewmini","family":"Dematagoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meg A.","family":"Schuurman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Willson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Timothy F.","family":"Plageman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Bridgewater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Drysdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gep.2025.119402_bib1","article-title":"Global analysis of cell behavior and protein localization dynamics reveals region-specific functions for Shroom3 and N-cadherin during neural tube closure","author":"Baldwin","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.gep.2025.119402_bib2","first-page":"1","article-title":"Tracing gene expression through detection of \u03b2-galactosidase activity in whole mouse embryos","author":"Blanco","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.gep.2025.119402_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-1-61779-851-1_21","article-title":"Chapter 21 detection of b -Galactosidase activity : X-gal staining. Kidney dev. Methods protoc","volume":"886","author":"Burn","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.gep.2025.119402_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-018-1664-7","article-title":"Genomic approaches in the search for molecular biomarkers in chronic kidney disease","volume":"16","author":"Ca\u00f1adas-Garre","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.gep.2025.119402_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0331583","article-title":"Understanding the role of Shroom3 in the developing mouse myocardium","volume":"20","author":"Carleton","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.gep.2025.119402_bib6","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1242\/dev.044610","article-title":"Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut","volume":"137","author":"Chung","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119402_bib7","article-title":"Loci associated with genomic damage levels in chronic kidney disease patients and controls","volume":"852","author":"Corredor","year":"2020","journal-title":"Mutant Res Gen Tox En"},{"key":"10.1016\/j.gep.2025.119402_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1095215","article-title":"Novel haplotype indicator for end-stage renal disease progression among Saudi patients","author":"Cyrus","year":"2019","journal-title":"Int. J. Nephrol"},{"key":"10.1016\/j.gep.2025.119402_bib9","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1242\/bio.20147450","article-title":"The interaction between Shroom3 and rho-kinase is required for neural tube morphogenesis in mice","volume":"3","author":"Das","year":"2014","journal-title":"Biol. Open"},{"key":"10.1016\/j.gep.2025.119402_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1083\/jcb.201307070","article-title":"Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension","volume":"204","author":"de Matos Sim\u00f5es","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.gep.2025.119402_bib11","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/dme.12211","article-title":"Investigation of known estimated glomerular filtration rate loci in patients with Type 2 diabetes","volume":"30","author":"Deshmukh","year":"2013","journal-title":"Diabet. Med."},{"key":"10.1016\/j.gep.2025.119402_bib12","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/ajmg.a.63336","article-title":"Rare variants found in multiplex families with orofacial clefts: does expanding the phenotype make a difference?","volume":"191","author":"Diaz Perez","year":"2023","journal-title":"Am. J. Med. Genet. Part A"},{"key":"10.1016\/j.gep.2025.119402_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/s12868-015-0171-5","article-title":"Targeted inhibition of the Shroom3-Rho kinase protein-protein interaction circumvents Nogo66 to promote axon outgrowth","volume":"16","author":"Dickson","year":"2015","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.gep.2025.119402_bib14","doi-asserted-by":"crossref","first-page":"13319","DOI":"10.1523\/JNEUROSCI.1324-10.2010","article-title":"POSH is an intracellular signal transducer for the axon outgrowth inhibitor Nogo66","volume":"30","author":"Dickson","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gep.2025.119402_bib15","doi-asserted-by":"crossref","first-page":"20542","DOI":"10.1074\/jbc.M512463200","article-title":"Differential actin-dependent localization modulates the evolutionarily conserved activity of shroom family proteins","volume":"281","author":"Dietz","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gep.2025.119402_bib16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ydbio.2020.05.013","article-title":"SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects","volume":"464","author":"Durbin","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gep.2025.119402_bib17","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1093\/hmg\/dds138","article-title":"Validated SNPs for eGFR and their associations with albuminuria","volume":"21","author":"Ellis","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.gep.2025.119402_bib18","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1101\/gad.5.9.1513","article-title":"Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice","volume":"5","author":"Friedrich","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.gep.2025.119402_bib19","article-title":"The twists and turns of left-right asymmetric gut morphogenesis","volume":"147","author":"Grzymkowski","year":"2020","journal-title":"Co. Biol"},{"key":"10.1016\/j.gep.2025.119402_bib20","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/ar.23623","article-title":"Muscular basis of whisker torsion in mice and rats","volume":"300","author":"Haidarliu","year":"2017","journal-title":"Anat. Rec."},{"key":"10.1016\/j.gep.2025.119402_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ar.25305","article-title":"Functional anatomy of mystacial active sensing in rats","volume":"307","author":"Haidarliu","year":"2023","journal-title":"Anat. Rec."},{"key":"10.1016\/j.gep.2025.119402_bib22","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.cub.2003.11.054","article-title":"Shroom induces apical constriction and is required for hingepoint formation during neural tube closure","volume":"13","author":"Haigo","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.gep.2025.119402_bib23","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/biolre\/ioab043","article-title":"Anatomical and cellular heterogeneity in the mouse oviduct - its potential roles in reproduction and preimplantation development","volume":"104","author":"Harwalkar","year":"2021","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.gep.2025.119402_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ydbio.2025.03.008","article-title":"Shroom3 facilitates optic fissure closure via tissue alignment and reestablishment of apical-basal polarity during epithelial fusion","volume":"522","author":"Herstine","year":"2025","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gep.2025.119402_bib25","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1242\/jcs.02626","article-title":"Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network","volume":"118","author":"Hildebrand","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.gep.2025.119402_bib26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0092-8674(00)81537-8","article-title":"Shroom, a PDZ domain\u2013containing actin-binding protein, is required for neural tube morphogenesis in mice","volume":"99","author":"Hildebrand","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.gep.2025.119402_bib27","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1681\/ASN.2015060621","article-title":"Developmental origins for kidney disease due to Shroom3 deficiency","volume":"27","author":"Khalili","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.gep.2025.119402_bib28","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease","volume":"41","author":"Kottgen","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.gep.2025.119402_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185476","article-title":"Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: a cross-sectional study in Japanese male workers","volume":"12","author":"Kubo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.gep.2025.119402_bib30","first-page":"3177","article-title":"p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis","volume":"141","author":"Lang","year":"2014","journal-title":"Co. Biol."},{"key":"10.1016\/j.gep.2025.119402_bib31","article-title":"Minimal kidney disease phenotype in Shroom3 heterozygous null mice","volume":"10","author":"Lawlor","year":"2023","journal-title":"Can. J. Kidney Heal. Dis"},{"key":"10.1016\/j.gep.2025.119402_bib32","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1242\/dev.02828","article-title":"Shroom family proteins regulate y-tubulin distribution and microtubule architecture during epithelial cell shape change","volume":"134","author":"Lee","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119402_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.34067\/KID.0003802021","article-title":"Shroom3, a gene associated with CKD, modulates epithelial recovery after AKI","volume":"3","author":"Li","year":"2022","journal-title":"Kidney360"},{"key":"10.1016\/j.gep.2025.119402_bib34","first-page":"130","article-title":"Thyroid bud morphogenesis requires CDC42-and SHROOM3-dependent apical constriction","volume":"5","author":"Loebel","year":"2016","journal-title":"Co. Biol"},{"key":"10.1016\/j.gep.2025.119402_bib35","first-page":"1","article-title":"SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure","volume":"10","author":"Matsuura","year":"2020","journal-title":"Nat. Sci. Reports"},{"key":"10.1016\/j.gep.2025.119402_bib36","first-page":"186","article-title":"Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure. Co","volume":"4","author":"McGreevy","year":"2015","journal-title":"Biol"},{"key":"10.1016\/j.gep.2025.119402_bib37","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1172\/JCI76902","article-title":"Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis","volume":"125","author":"Menon","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.gep.2025.119402_bib38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1369\/0022155416665337","article-title":"Comments on methods to suppress endogenous \u03b2-Galactosidase activity in mouse tissues expressing the LacZ reporter gene","volume":"64","author":"Merkwitz","year":"2016","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.gep.2025.119402_bib39","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1091\/mbc.e11-11-0937","article-title":"Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, rock binding, and apical constriction","volume":"23","author":"Mohan","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.gep.2025.119402_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ydbio.2016.02.016","article-title":"Lens placode planar cell polarity is dependent on Cdc42-mediated junctional contraction inhibition","volume":"412","author":"Muccioli","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gep.2025.119402_bib41","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1242\/dev.019646","article-title":"Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling","volume":"135","author":"Nishimura","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119402_bib42","article-title":"The good and the bad of SHROOM3 in kidney development and disease: a narrative review","volume":"10","author":"Paul","year":"2023","journal-title":"Can. J. Kidney Heal. Dis."},{"key":"10.1016\/j.gep.2025.119402_bib43","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1242\/dev.067868","article-title":"A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination","volume":"138","author":"Plageman","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119402_bib44","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1242\/dev.045369","article-title":"Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination","volume":"137","author":"Plageman","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.gep.2025.119402_bib45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ydbio.2011.06.027","article-title":"Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis","volume":"357","author":"Plageman","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.gep.2025.119402_bib46","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1681\/ASN.2017080856","article-title":"Characterization of coding\/noncoding variants for SHROOM3 in patients with CKD","volume":"29","author":"Prokop","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.gep.2025.119402_bib47","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1183\/09031936.00045507","article-title":"Shroom expression is attenuated in pulmonary arterial hypertension","volume":"32","author":"Sevilla-P\u00e9rez","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.gep.2025.119402_bib48","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1091\/mbc.e08-02-0231","article-title":"The scaffold protein POSH regulates axon outgrowth","volume":"19","author":"Taylor","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.gep.2025.119402_bib49","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1681\/ASN.2018060573","article-title":"SHROOM3-FYN interaction regulates nephrin phosphorylation and affects albuminuria in allografts","volume":"29","author":"Wei","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.gep.2025.119402_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/FPC.0000000000000251","article-title":"The influence of living donor SHROOM3 and ABCB1 genetic variants on renal function after kidney transplantation","volume":"27","author":"Yan","year":"2017","journal-title":"Pharmacogenet. Genomics"},{"key":"10.1016\/j.gep.2025.119402_bib51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1101\/gr.182881.114","article-title":"Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity","volume":"25","author":"Yeo","year":"2015","journal-title":"Genome Res."}],"container-title":["Gene Expression Patterns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X25000146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X25000146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:18:49Z","timestamp":1776917929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567133X25000146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":51,"alternative-id":["S1567133X25000146"],"URL":"https:\/\/doi.org\/10.1016\/j.gep.2025.119402","relation":{},"ISSN":["1567-133X"],"issn-type":[{"value":"1567-133X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping Shroom3 expression across the adult mouse","name":"articletitle","label":"Article Title"},{"value":"Gene Expression Patterns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gep.2025.119402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119402"}}