{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:43:40Z","timestamp":1792395820067,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"US Public Health Service Commissioned Corps","doi-asserted-by":"publisher","award":["HHSN-271-2013-00030"],"award-info":[{"award-number":["HHSN-271-2013-00030"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007086","name":"Pitt Hopkins Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene Expression Patterns"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.gep.2026.119416","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:18:48Z","timestamp":1791904728000},"page":"119416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["mGlu7 expression is upregulated by Tcf4 deficiency in a model of Pitt Hopkins syndrome"],"prefix":"10.1016","volume":"58","author":[{"given":"Geanne A.","family":"Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl Anne D.","family":"Vermudez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor C.","family":"Chopko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco G.","family":"Gogliotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen M.","family":"Niswender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gep.2026.119416_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2024.1332469","article-title":"MECP2-related disorders while gene-based therapies are on the horizon","volume":"15","author":"Allison","year":"2024","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.gep.2026.119416_bib2","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1086\/515582","article-title":"Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction","volume":"80","author":"Amiel","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome","volume":"21","author":"Asaka","year":"2006","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1471-4159.2006.04121.x","article-title":"MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels","volume":"99","author":"Bertaso","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.gep.2026.119416_bib5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fnmol.2016.00094","article-title":"Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7","volume":"9","author":"Chen","year":"2016","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.gep.2026.119416_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0306-4522(01)00591-7","article-title":"Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS","volume":"110","author":"Corti","year":"2002","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.gep.2026.119416_bib7","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1046\/j.1460-9568.1998.00371.x","article-title":"Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8","volume":"10","author":"Corti","year":"1998","journal-title":"Eur. J. Neurosci."},{"issue":"9","key":"10.1016\/j.gep.2026.119416_bib8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/cercor\/12.9.961","article-title":"Enrichment of mGluR7a in the presynaptic active zones of GABAergic and non-GABAergic terminals on interneurons in the rat somatosensory cortex","volume":"12","author":"Dalezios","year":"2002","journal-title":"Cereb Cortex"},{"issue":"19","key":"10.1016\/j.gep.2026.119416_bib9","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1523\/JNEUROSCI.20-19-07252.2000","article-title":"PICK1 interacts with and regulates PKC phosphorylation of mGLUR7","volume":"20","author":"Dev","year":"2000","journal-title":"J. Neurosci."},{"issue":"Pt 2","key":"10.1016\/j.gep.2026.119416_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1042\/bj20020481","article-title":"G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes","volume":"365","author":"El Far","year":"2002","journal-title":"Biochem. J."},{"issue":"45","key":"10.1016\/j.gep.2026.119416_bib11","doi-asserted-by":"crossref","first-page":"10520","DOI":"10.1523\/JNEUROSCI.2547-05.2005","article-title":"Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus","volume":"25","author":"Ferraguti","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gep.2026.119416_bib12","article-title":"Metabotropic glutamate receptor 7: a new therapeutic target in neurodevelopmental disorders","volume":"11","author":"Fisher","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"5","key":"10.1016\/j.gep.2026.119416_bib13","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/schbul\/sbx164","article-title":"The psychiatric risk gene transcription factor 4 (TCF4) regulates neurodevelopmental pathways associated with schizophrenia, autism, and intellectual disability","volume":"44","author":"Forrest","year":"2018","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.gep.2026.119416_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2023.173546","article-title":"GRM7 gene mutations and consequences for neurodevelopment","volume":"225","author":"Freitas","year":"2023","journal-title":"Pharmacol Biochem Behav"},{"issue":"11","key":"10.1016\/j.gep.2026.119416_bib15","doi-asserted-by":"crossref","first-page":"14015","DOI":"10.1007\/s12035-025-05183-y","article-title":"Overexpression of mGlu(7B) in mice: implications for neurodevelopmental disorders","volume":"62","author":"Freitas","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"16","key":"10.1016\/j.gep.2026.119416_bib16","doi-asserted-by":"crossref","first-page":"10975","DOI":"10.1074\/jbc.M113.542654","article-title":"Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior","volume":"289","author":"Gee","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.gep.2026.119416_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1124\/jpet.117.246991","article-title":"Total RNA sequencing of Rett syndrome autopsy samples identifies the M4 muscarinic receptor as a novel therapeutic target","volume":"365","author":"Gogliotti","year":"2018","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"403","key":"10.1016\/j.gep.2026.119416_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai7459","article-title":"mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome","volume":"9","author":"Gogliotti","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.gep.2026.119416_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000539267","article-title":"Preclinical milestones in MECP2 gene transfer for treating Rett syndrome","author":"Jagadeeswaran","year":"2024","journal-title":"Dev. Neurosci."},{"issue":"10","key":"10.1016\/j.gep.2026.119416_bib20","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1016\/j.celrep.2016.08.004","article-title":"Tcf4 regulates synaptic plasticity, DNA methylation, and memory function","volume":"16","author":"Kennedy","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.gep.2026.119416_bib21","doi-asserted-by":"crossref","first-page":"e72290","DOI":"10.7554\/eLife.72290","article-title":"Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression","volume":"11","author":"Kim","year":"2022","journal-title":"Elife."},{"issue":"3","key":"10.1016\/j.gep.2026.119416_bib22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2","article-title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study","volume":"393","author":"Kinoshita","year":"1998","journal-title":"J. Comp. Neurol."},{"issue":"19","key":"10.1016\/j.gep.2026.119416_bib23","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1523\/JNEUROSCI.4543-14.2015","article-title":"Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus","volume":"35","author":"Klar","year":"2015","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.gep.2026.119416_bib24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/(SICI)1096-9861(19991213)415:2<266::AID-CNE9>3.0.CO;2-7","article-title":"Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia","volume":"415","author":"Kosinski","year":"1999","journal-title":"J. Comp. Neurol."},{"issue":"7","key":"10.1016\/j.gep.2026.119416_bib25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/acn3.51003","article-title":"Biallelic GRM7 variants cause epilepsy, microcephaly, and cerebral atrophy","volume":"7","author":"Marafi","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"3","key":"10.1016\/j.gep.2026.119416_bib26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/s-0035-1564570","article-title":"Pitt-Hopkins syndrome and differential diagnosis: a molecular and clinical challenge","volume":"4","author":"Marangi","year":"2015","journal-title":"J. Pediatr. Genet."},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"Moretti","year":"2006","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/npp.2012.116","article-title":"The impact of MeCP2 loss- or gain-of-function on synaptic plasticity","volume":"38","author":"Na","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"16","key":"10.1016\/j.gep.2026.119416_bib29","doi-asserted-by":"crossref","first-page":"11868","DOI":"10.1016\/S0021-9258(19)50280-0","article-title":"Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate","volume":"268","author":"Nakajima","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gep.2026.119416_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic glutamate receptors: physiology, pharmacology, and disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.gep.2026.119416_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0092-8674(94)90151-1","article-title":"Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells","volume":"77","author":"Nomura","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.gep.2026.119416_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1172805","article-title":"Advanced genetic therapies for the treatment of Rett syndrome: state of the art and future perspectives","volume":"17","author":"Palmieri","year":"2023","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.gep.2026.119416_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/dmcn.15383","article-title":"State-of-the-art therapies for Rett syndrome","volume":"65","author":"Panayotis","year":"2023","journal-title":"Dev. Med. Child Neurol."},{"issue":"3","key":"10.1016\/j.gep.2026.119416_bib34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41593-019-0578-x","article-title":"A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder","volume":"23","author":"Phan","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinform"},{"issue":"6","key":"10.1016\/j.gep.2026.119416_bib35","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.gep.2026.119416_bib36","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/hmg\/dds112","article-title":"Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects","volume":"21","author":"Sepp","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"6582","key":"10.1016\/j.gep.2026.119416_bib37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/381523a0","article-title":"Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone","volume":"381","author":"Shigemoto","year":"1996","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2011.03.011","article-title":"MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation","volume":"43","author":"Singleton","year":"2011","journal-title":"Neurobiol. Dis."},{"issue":"12","key":"10.1016\/j.gep.2026.119416_bib39","doi-asserted-by":"crossref","DOI":"10.1046\/j.1460-9568.2003.02697.x","article-title":"High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus","volume":"17","author":"Somogyi","year":"2003","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.gep.2026.119416_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2009.01.042","article-title":"Regulation of translation initiation in eukaryotes: mechanisms and biological targets","volume":"136","author":"Sonenberg","year":"2009","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.gep.2026.119416_bib41","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.neuron.2008.03.028","article-title":"Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7","volume":"58","author":"Suh","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.gep.2026.119416_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.32","article-title":"Pitt-Hopkins syndrome: intellectual disability due to loss of TCF4-regulated gene transcription","volume":"45","author":"Sweatt","year":"2013","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.gep.2026.119416_bib43","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1523\/JNEUROSCI.1305-17.2017","article-title":"Common pathophysiology in multiple mouse models of pitt-hopkins syndrome","volume":"38","author":"Thaxton","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.gep.2026.119416_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2025.111310","article-title":"Fear conditioning: insights into learning, memory and extinction and its relevance to clinical disorders","volume":"138","author":"Trent","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.gep.2026.119416_bib45","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroscience.2026.01.040","article-title":"Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy","volume":"598","author":"Vermudez","year":"2026","journal-title":"Neuroscience"},{"issue":"52","key":"10.1016\/j.gep.2026.119416_bib46","doi-asserted-by":"crossref","first-page":"33100","DOI":"10.1074\/jbc.272.52.33100","article-title":"Functional coupling of a human retinal metabotropic glutamate receptor (hmGluR6) to bovine rod transducin and rat Go in an in vitro reconstitution system","volume":"272","author":"Weng","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.gep.2026.119416_bib47","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuroscience.2011.01.061","article-title":"Synaptic plasticity deficits in an experimental model of Rett syndrome: long-term potentiation saturation and its pharmacological reversal","volume":"180","author":"Weng","year":"2011","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib48","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/humu.21639","article-title":"Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum","volume":"33","author":"Whalen","year":"2012","journal-title":"Hum. Mutat."},{"issue":"10","key":"10.1016\/j.gep.2026.119416_bib49","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1167\/iovs.19-27689","article-title":"Gene expression and missplicing in the corneal endothelium of patients with a TCF4 trinucleotide repeat expansion without fuchs' endothelial corneal dystrophy","volume":"60","author":"Wieben","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"18","key":"10.1016\/j.gep.2026.119416_bib50","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1093\/hmg\/ddy222","article-title":"Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk","volume":"27","author":"Xia","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.gep.2026.119416_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-92119-0","article-title":"Comprehensive analysis of splicing variants in corneal endothelial cells of patients with Fuchs endothelial corneal dystrophy","volume":"15","author":"Yuasa","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.gep.2026.119416_bib52","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/cge.13506","article-title":"Diagnosis and management in Pitt-Hopkins syndrome: first international consensus statement","volume":"95","author":"Zollino","year":"2019","journal-title":"Clin. Genet."}],"container-title":["Gene Expression Patterns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X26000116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567133X26000116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:15:42Z","timestamp":1792394142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567133X26000116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":53,"alternative-id":["S1567133X26000116"],"URL":"https:\/\/doi.org\/10.1016\/j.gep.2026.119416","relation":{},"ISSN":["1567-133X"],"issn-type":[{"value":"1567-133X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mGlu7 expression is upregulated by Tcf4 deficiency in a model of Pitt Hopkins syndrome","name":"articletitle","label":"Article Title"},{"value":"Gene Expression Patterns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gep.2026.119416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119416"}}