{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:26:40Z","timestamp":1790976400066,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.ghir.2006.10.007","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T12:14:00Z","timestamp":1166012040000},"page":"54-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":152,"title":["Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report"],"prefix":"10.1016","volume":"17","author":[{"given":"O.","family":"Shevah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Laron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2006.10.007_bib1","first-page":"2803","article-title":"Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth","volume":"54","author":"Kappel","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.ghir.2006.10.007_bib2","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1172\/JCI114910","article-title":"Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor","volume":"86","author":"Yee","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ghir.2006.10.007_bib3","first-page":"4522","article-title":"Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis","volume":"56","author":"Singleton","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.ghir.2006.10.007_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/ajcp\/101.2.198","article-title":"Specific expression of insulin-like growth factor-II in rhabdomyosarcoma tumor cells","volume":"101","author":"Minniti","year":"1994","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ghir.2006.10.007_bib5","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1073\/pnas.90.12.5828","article-title":"Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product","volume":"90","author":"Werner","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ghir.2006.10.007_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1615\/CritRevOncog.v8.i1.40","article-title":"The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis","volume":"8","author":"Werner","year":"1997","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.ghir.2006.10.007_bib7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/mgme.2000.3130","article-title":"Genetic factors related to racial variation in plasma levels of insulin like growth factor-1: Implications for premenopausal breast cancer risk","volume":"72","author":"Jernstrom","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ghir.2006.10.007_bib8","series-title":"Biology of IGF-I: Its Interaction with Insulin in Health and Malignant States","first-page":"84","article-title":"Insulin-like growth factors and neoplasia","volume":"vol. 262","author":"Pollak","year":"2004"},{"key":"10.1016\/j.ghir.2006.10.007_bib9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.gastro.2005.05.051","article-title":"Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps","volume":"129","author":"Schoen","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ghir.2006.10.007_bib10","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/cncr.10945","article-title":"Overexpression of the insulin-like growth factor I receptor in human colon carcinomas","volume":"95","author":"Weber","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ghir.2006.10.007_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.bjc.6600728","article-title":"IGF-I genotype, mean plasma level and breast cancer risk in the Hawaii\/Los Angeles multiethnic cohort","volume":"88","author":"DeLellis","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ghir.2006.10.007_bib12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc1408","article-title":"Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms","volume":"4","author":"Calle","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ghir.2006.10.007_bib13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1210\/jc.2003-031033","article-title":"Laron syndrome (primary growth hormone resistance or insensitivity). The personal experience 1958\u20132003","volume":"89","author":"Laron","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.10.007_bib14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/edrv-15-3-369","article-title":"Growth hormone (GH) insensitivity due to primary GH receptor deficiency","volume":"15","author":"Rosenfeld","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2006.10.007_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S1043-2760(98)00070-8","article-title":"Lessons from the genetics of Laron syndrome","volume":"9","author":"Rosenbloom","year":"1998","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.10.007_bib16","first-page":"152","article-title":"Genetic pituitary dwarfism with high serum concentration of growth hormone. A new inborn error of metabolism?","volume":"2","author":"Laron","year":"1966","journal-title":"Isr. J. Med. Sci."},{"key":"10.1016\/j.ghir.2006.10.007_bib17","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1210\/en.2005-0607","article-title":"Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)\/T antigen mouse","volume":"146","author":"Wang","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2006.10.007_bib18","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1517\/13543784.13.12.1569","article-title":"The therapeutic potential of agents targeting the type I insulin-like growth factor receptor","volume":"13","author":"Zhang","year":"2004","journal-title":"Expert. Opin. Inv. Drug."},{"key":"10.1016\/j.ghir.2006.10.007_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2265.2005.02404.x","article-title":"Does growth hormone cause cancer?","volume":"64","author":"Jenkins","year":"2006","journal-title":"Clin. Endocrinol. (Oxf.)"}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637406001304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637406001304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:43:03Z","timestamp":1761086583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637406001304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1096637406001304"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2006.10.007","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2006.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}