{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:49:53Z","timestamp":1773308993263,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.ghir.2006.11.002","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T19:39:38Z","timestamp":1168976378000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Growth hormone (GH) replacement therapy in GH deficient adults: Predictors of one-year metabolic and clinical response"],"prefix":"10.1016","volume":"17","author":[{"given":"Johan","family":"Svensson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Finer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bouloux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bevan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders F.","family":"Mattsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Koltowska-H\u00e4ggstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Monson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2006.11.002_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1210\/er.16.1.63","article-title":"Clinical aspects of growth hormone deficiency in adults","volume":"16","author":"de Boer","year":"1995","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2006.11.002_bib2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/jcem.83.2.4594","article-title":"Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review","volume":"83","author":"Carroll","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1210\/edrv.22.4.0438","article-title":"Optimizing GH therapy in adults and children","volume":"22","author":"Drake","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2006.11.002_bib4","first-page":"3184","article-title":"Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficit","volume":"83","author":"Baum","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib5","first-page":"309","article-title":"Treatment of adults with growth hormone (GH) deficiency with recombinant human GH","volume":"76","author":"Bengtsson","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib6","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1210\/jcem.80.12.8530603","article-title":"Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial","volume":"80","author":"Burman","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib7","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1210\/jc.2003-030134","article-title":"Long-term improvement of quality of life during growth hormone (GH) replacement therapy in adults with GH deficiency, as measured by questions on life satisfaction-hypopituitarism (QLS-H)","volume":"89","author":"Rosilio","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib8","first-page":"550","article-title":"Growth hormone (GH)-deficient men are more responsive to GH replacement therapy than women","volume":"82","author":"Burman","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib9","first-page":"2002","article-title":"Gender differences in the effects of long term growth hormone (GH) treatment on bone in adults with GH deficiency","volume":"84","author":"Johansson","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1530\/eje.0.1400545","article-title":"Effects of 42 months of GH treatment on bone mineral density and bone turnover in GH-deficient adults","volume":"140","author":"V\u00e4lim\u00e4ki","year":"1999","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2006.11.002_bib11","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1210\/jcem.86.10.7887","article-title":"A prospective study of five years of growth hormone (GH) replacement therapy in GH deficient adults; sustained effects on body composition, bone mass, and metabolic indices","volume":"86","author":"G\u00f6therstr\u00f6m","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib12","first-page":"82","article-title":"Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment","volume":"82","author":"Attanasio","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib13","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1210\/jcem.86.10.7896","article-title":"Baseline characteristics and the effects of five years of growth hormone (GH) replacement therapy in adults with GH deficiency of childhood or adulthood onset; a comparative, prospective study","volume":"86","author":"Koranyi","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib14","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1365-2265.2004.02018.x","article-title":"Baseline characteristics and the effects of two years of growth hormone (GH) replacement therapy in adults with GH deficiency previously treated for Cushing\u00b4s disease","volume":"60","author":"Johannsson","year":"2004","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2006.11.002_bib15","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1210\/jcem.84.4.5634","article-title":"Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic GH deficiency","volume":"84","author":"Ranke","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib16","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1210\/jc.2003-030600","article-title":"On behalf of the Kabi International Growth Study of the Pfizer International Growth Database. The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose","volume":"88","author":"Ranke","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib17","first-page":"63","article-title":"Development of a questionnaire to assess the quality of life in adults with growth hormone deficiency","volume":"2","author":"Holmes","year":"1995","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib18","first-page":"420","article-title":"The development of the AGHDA: a measure to assess quality of life in adults with growth hormone deficiency","volume":"4","author":"Doward","year":"1995","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.ghir.2006.11.002_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1023\/A:1008987922774","article-title":"The QoL-AGHDA: an instrument for the assessment of quality of life in adults with growth hormone deficiency","volume":"8","author":"McKenna","year":"1999","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.ghir.2006.11.002_bib20","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/clinchem\/22.10.1627","article-title":"Cholesterol oxidase based determination by continuous-flow analysis of total and free cholesterol in serum","volume":"22","author":"Lie","year":"1976","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ghir.2006.11.002_bib21","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/clinchem\/23.5.882","article-title":"Cholesterol determination in high density lipoproteins separated by three different methods","volume":"23","author":"Lopez-Virella","year":"1977","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ghir.2006.11.002_bib22","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/clinchem\/28.10.2077","article-title":"Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide","volume":"28","author":"Fossati","year":"1982","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ghir.2006.11.002_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of low-density lipoprotein in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ghir.2006.11.002_bib24","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1365-2265.1997.1851001.x","article-title":"Insulin-like growth factor-I in growth hormone-deficient adults: relationship to population-based normal values, body composition and insulin tolerance test","volume":"46","author":"Svensson","year":"1997","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2006.11.002_bib25","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1210\/jcem.83.11.5223","article-title":"Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults","volume":"83","author":"Drake","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2006.11.002_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2265.2000.01104.x","article-title":"Growth hormone deficiency and replacement in elderly hypopituitary adults. KIMS Study Group and the KIMS International Board. Pharmacia and Upjohn International Metabolic Database","volume":"53","author":"Monson","year":"2000","journal-title":"Clin. Endocrinol."},{"issue":"Suppl A","key":"10.1016\/j.ghir.2006.11.002_bib27","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.ghir.2004.03.013","article-title":"Aspects of growth hormone deficiency and replacement in elderly hypopituitary adults","volume":"14","author":"Feldt-Rasmussen","year":"2004","journal-title":"Growth. Horm. IGF Res."}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637406001481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637406001481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:42:31Z","timestamp":1761086551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637406001481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1096637406001481"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2006.11.002","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth hormone (GH) replacement therapy in GH deficient adults: Predictors of one-year metabolic and clinical response","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2006.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}