{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:13:29Z","timestamp":1761167609215,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.ghir.2007.05.003","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T07:22:49Z","timestamp":1182496969000},"page":"500-505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genomic imprinting of insulin-like growth factor 2 (IGF-2) in chronic synovitis"],"prefix":"10.1016","volume":"17","author":[{"given":"B.","family":"M\u00f6ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kerschbaumer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Komor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Kerschbaumer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.G.","family":"Ottmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hoelzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.K.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2007.05.003_bib1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ng0593-98","article-title":"Parental genomic imprinting of the human IGF2 gene","volume":"4","author":"Giannoukakis","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ghir.2007.05.003_bib2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0002-9440(10)65309-6","article-title":"Genomic imprinting: implications for human disease","volume":"154","author":"Falls","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ghir.2007.05.003_bib3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S1521-6942(03)00040-8","article-title":"Genetics in rheumatoid arthritis","volume":"17","author":"Huizinga","year":"2003","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.ghir.2007.05.003_bib4","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ajmg.1320490405","article-title":"Excess functional copy of allele at chromosomal region 11p15 may cause Wiedemann-Beckwith (EMG) syndrome","volume":"49","author":"Kubota","year":"1994","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ghir.2007.05.003_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0027-5107(97)00180-2","article-title":"Role of imprinting in abnormal human development","volume":"396","author":"Mutter","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ghir.2007.05.003_bib6","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1182\/blood.V96.9.3023","article-title":"Imprinting of insulin-like growth factor 2 is modulated during hematopoiesis","volume":"96","author":"Morison","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ghir.2007.05.003_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0301-472X(01)00797-4","article-title":"Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells","volume":"30","author":"Hofmann","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.ghir.2007.05.003_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/dvg.1020170310","article-title":"Imprinting of IGF2, insulin-dependent diabetes, immune function, and apoptosis: a hypothesis","volume":"17","author":"Polychronakos","year":"1995","journal-title":"Dev. Genet."},{"key":"10.1016\/j.ghir.2007.05.003_bib9","first-page":"2560","article-title":"Developmental regulation of genomic imprinting of the IGF2 gene in human liver","volume":"54","author":"Davies","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.ghir.2007.05.003_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1073\/pnas.98.2.591","article-title":"Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer","volume":"98","author":"Nakagawa","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ghir.2007.05.003_bib11","doi-asserted-by":"crossref","first-page":"27983","DOI":"10.1074\/jbc.270.47.27983","article-title":"Concordant loss of imprinting of the human insulin-like growth factor II gene promoters in cancer","volume":"270","author":"Zhan","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ghir.2007.05.003_bib12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/362749a0","article-title":"Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms\u2019 tumour","volume":"362","author":"Ogawa","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ghir.2007.05.003_bib13","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1126\/science.1080902","article-title":"Loss of IGF2 imprinting: a potential marker of colorectal cancer risk","volume":"299","author":"Cui","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ghir.2007.05.003_bib14","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.4049\/jimmunol.176.8.4651","article-title":"Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice","volume":"176","author":"Hansenne","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ghir.2007.05.003_bib15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1210\/endo.141.3.7360","article-title":"Involvement of insulin-like growth factors in early T cell development: a study using fetal thymic organ cultures","volume":"141","author":"Kecha","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2007.05.003_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20050471","article-title":"Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels","volume":"202","author":"Derbinski","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ghir.2007.05.003_bib17","first-page":"1","article-title":"Revised criteria for the classification of rheumatoid arthritis","volume":"38","author":"Arnett","year":"1989","journal-title":"Bull. Rheum. Dis."},{"key":"10.1016\/j.ghir.2007.05.003_bib18","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/art.21675","article-title":"Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis","volume":"54","author":"Baecklund","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ghir.2007.05.003_bib19","first-page":"150","article-title":"Genetic epidemiology of rheumatoid arthritis","volume":"57","author":"Lynn","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ghir.2007.05.003_bib20","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.4049\/jimmunol.168.10.5333","article-title":"Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium","volume":"168","author":"Page","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.ghir.2007.05.003_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/clim.1998.4618","article-title":"Production of cytokines and metalloproteinases in rheumatoid synovitis is T cell dependent","volume":"90","author":"Klimiuk","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ghir.2007.05.003_bib22","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1196\/annals.1358.022","article-title":"Costimulatory pathways in rheumatoid synovitis and T-cell senescence","volume":"1062","author":"Goronzy","year":"2005","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ghir.2007.05.003_bib23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI119178","article-title":"Inhibition of T cell apoptosis in the rheumatoid synovium","volume":"99","author":"Salmon","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ghir.2007.05.003_bib24","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0002-9440(10)64272-1","article-title":"A question of transformation: the synovial fibroblast in rheumatoid arthritis","volume":"162","author":"Davis","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ghir.2007.05.003_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/03009740410006079","article-title":"The relationship between insulin-like growth factor-II gene Apa I polymorphism and rheumatoid arthritis","volume":"33","author":"Huang","year":"2004","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.ghir.2007.05.003_bib26","first-page":"275","article-title":"Detection of insulin-like growth factor I and II in synovial tissue specimens of patients with rheumatoid arthritis and osteoarthritis by in situ hybridization","volume":"22","author":"Keyszer","year":"1995","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ghir.2007.05.003_bib27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cca.2005.11.015","article-title":"Serum insulin-like growth factor-axis and matrix metalloproteinases in patients with rheumatic arthritis or rheumatic heart disease","volume":"367","author":"Lee","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ghir.2007.05.003_bib28","first-page":"29","article-title":"Association between insulin-like growth factor status and physical activity levels in rheumatoid arthritis","volume":"28","author":"Lemmey","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ghir.2007.05.003_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00019053-200422001-00002","article-title":"Epidemiology and burden of illness of rheumatoid arthritis","volume":"22","author":"Kvien","year":"2004","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.ghir.2007.05.003_bib30","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/1529-0131(200012)43:12<2634::AID-ANR3>3.0.CO;2-1","article-title":"Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression","volume":"43","author":"Neidhart","year":"2000","journal-title":"Arthritis Rheum."}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637407000706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637407000706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:43:46Z","timestamp":1761086626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637407000706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S1096637407000706"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2007.05.003","relation":{},"ISSN":["1096-6374"],"issn-type":[{"type":"print","value":"1096-6374"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic imprinting of insulin-like growth factor 2 (IGF-2) in chronic synovitis","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2007.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}