{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:25:48Z","timestamp":1778135148703,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.ghir.2007.11.005","type":"journal-article","created":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T12:07:54Z","timestamp":1203682074000},"page":"291-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Changes in total ghrelin within the somatotropic axis in severe burn patients: Comparison of those with inhalation injury and those without inhalation injury"],"prefix":"10.1016","volume":"18","author":[{"given":"B.W.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.H.","family":"Ihm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.C.","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.W.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2007.11.005_bib1","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2007.11.005_bib2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ghir.2007.11.005_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF03344083","article-title":"Ghrelin tissue distribution: comparison between gene and protein expression","volume":"29","author":"Ghelardoni","year":"2006","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.ghir.2007.11.005_bib4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1210\/er.2002-0029","article-title":"Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin","volume":"25","author":"Lely","year":"2004","journal-title":"Endocrine Rev."},{"key":"10.1016\/j.ghir.2007.11.005_bib5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1210\/en.2002-220852","article-title":"Interrelationship between the novel peptide ghrelin and somatostatin\/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion","volume":"144","author":"Tannenbaum","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2007.11.005_bib6","first-page":"1827","article-title":"Acute and prolonged critical illness as different neuroendocrine paradigms","volume":"83","author":"Van den Berghe","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2007.11.005_bib7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1096-6374(98)80298-0","article-title":"Thirty-day monitoring of insulin-like growth factors and their binding proteins in intensive care unit patients","volume":"8","author":"Baxter","year":"1998","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ghir.2007.11.005_bib8","first-page":"E565","article-title":"GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors","volume":"276","author":"Defalque","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ghir.2007.11.005_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/BF03343974","article-title":"Activity of GH\/IGF-1 axis in burn patients: comparison with normal subjects and patients with GH deficiency","volume":"25","author":"Gianotti","year":"2002","journal-title":"J. Endocrinol. Invest."},{"issue":"Suppl. 3","key":"10.1016\/j.ghir.2007.11.005_bib10","first-page":"21","article-title":"Growth hormone secretagogues in critical Illness","volume":"51","author":"Van den Berghe","year":"1999","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2007.11.005_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0196-0644(82)80096-6","article-title":"The abbreviated burn severity index","volume":"11","author":"Tobiasen","year":"1982","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.ghir.2007.11.005_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/BCR.0B013E31802C9E8F","article-title":"Which of the abbreviated burn severity index variables are having impact on the hospital length of stay?","volume":"28","author":"Andel","year":"2007","journal-title":"J. Burn Care. Res."},{"key":"10.1016\/j.ghir.2007.11.005_bib13","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ghir.2007.11.005_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00005373-199701000-00014","article-title":"Tracheobronchial cytology in inhalation injury","volume":"42","author":"Khoo","year":"1997","journal-title":"J. Trauma"},{"key":"10.1016\/j.ghir.2007.11.005_bib15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/014860717900300609","article-title":"Metabolic response to injury and illness: estimation of energy and protein needs from indirect calorimetry and nitrogen balance","volume":"3","author":"Long","year":"1979","journal-title":"J. Parenter. Enteral. Nutr."},{"key":"10.1016\/j.ghir.2007.11.005_bib16","first-page":"421","article-title":"Measurement of human growth hormone receptor messenger ribonucleic acid by a quantitative polymerase chain reaction-based assay: demonstration of reduced expression after elective surgery","volume":"82","author":"Hermansson","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2007.11.005_bib17","first-page":"211","article-title":"Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth hormone secretion in humans","volume":"67","author":"Kim","year":"2007","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2007.11.005_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2265.2006.02701.x","article-title":"Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion","volume":"66","author":"Huber","year":"2007","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2007.11.005_bib19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2265.2004.02121.x","article-title":"Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans","volume":"61","author":"Broglio","year":"2004","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2007.11.005_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1530\/eje.0.1510113","article-title":"Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans","volume":"151","author":"Otto","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2007.11.005_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2265.2004.02169.x","article-title":"Ghrelin and adiponectin in patients with Cushing\u2019s disease before and after successful transsphenoidal surgery","volume":"62","author":"Lib\u00e8","year":"2005","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2007.11.005_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1530\/eje.1.02003","article-title":"The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing\u2019s disease","volume":"153","author":"Giordano","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2007.11.005_bib23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1530\/eje.0.1510573","article-title":"Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus","volume":"151","author":"Katsuki","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2007.11.005_bib24","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.2337\/diabetes.52.10.2546","article-title":"Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes","volume":"52","author":"P\u00f6ykk\u00f6","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.ghir.2007.11.005_bib25","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.peptides.2006.02.005","article-title":"Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin","volume":"27","author":"Balasubramaniam","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ghir.2007.11.005_bib26","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1210\/en.2005-1357","article-title":"Acylated ghrelin and des-acyl ghrelin exert different effects on the gastrointestinal motility in conscious rats","volume":"147","author":"Toshinai","year":"2006","journal-title":"Endocrinology"}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637407001542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637407001542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:44:35Z","timestamp":1761086675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637407001542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S1096637407001542"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2007.11.005","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in total ghrelin within the somatotropic axis in severe burn patients: Comparison of those with inhalation injury and those without inhalation injury","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2007.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}