{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:15:04Z","timestamp":1761167704508,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.ghir.2013.08.003","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T13:02:08Z","timestamp":1376917328000},"page":"229-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of serum components of the GH-IGFs-IGFBPs system with GHR-exon 3 polymorphism in normal and idiopathic short stature children"],"prefix":"10.1016","volume":"23","author":[{"given":"Mar\u00eda Gabriela","family":"Ballerini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio Mario","family":"Domen\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Scaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Keselman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor Guillermo","family":"Jasper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Gabriela","family":"Ropelato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2013.08.003_bb0005","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1210\/er.2010-0023","article-title":"Evidence for a continuum of genetic, phenotypic, and biochemical abnormalities in children with growth hormone insensitivity","volume":"32","author":"David","year":"2011","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2013.08.003_bb0010","doi-asserted-by":"crossref","first-page":"18664","DOI":"10.1074\/jbc.M001615200","article-title":"Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution","volume":"275","author":"Pantel","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ghir.2013.08.003_bb0015","first-page":"33A","article-title":"Functional characterization of exon 3 deleted isoform of the growth hormone receptor","volume":"49","author":"Conte","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ghir.2013.08.003_bb0020","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1515\/JPEM.2001.14.4.355","article-title":"Growth hormone binding protein 2001","volume":"14","author":"Baumann","year":"2001","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ghir.2005.11.001","article-title":"Physiology and pathophysiology of growth hormone-binding protein: methodological and clinical aspects","volume":"16","author":"Fisker","year":"2006","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ghir.2013.08.003_bb0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1530\/eje.0.1480317","article-title":"Association between the GH receptor\/exon 3 genotype and the level of exon 3-positive GH-binding protein in human serum","volume":"148","author":"Seidel","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.003_bb0035","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1210\/jc.2008-0509","article-title":"Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop","volume":"93","author":"Cohen","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0040","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ghir.2007.11.004","article-title":"Idiopathic short stature: definition, epidemiology, and diagnostic evaluation","volume":"18","author":"Wit","year":"2008","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ghir.2013.08.003_bb0045","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJM199510263331701","article-title":"Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group","volume":"333","author":"Goddard","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2013.08.003_bb0050","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0022-3476(97)70012-X","article-title":"Partial growth-hormone insensitivity: the role of growth-hormone receptor mutations in idiopathic short stature","volume":"131","author":"Goddard","year":"1997","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ghir.2013.08.003_bb0055","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/S0022-3476(97)70013-1","article-title":"National Cooperative Growth Study substudy VI: the clinical utility of growth-hormone-binding protein, insulin-like growth factor I, and insulin-like growth factor-binding protein 3 measurements","volume":"131","author":"Attie","year":"1997","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ghir.2013.08.003_bb0060","first-page":"4079","article-title":"Growth hormone receptor mutations in children with idiopathic short stature","volume":"83","author":"Sanchez","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0065","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1210\/jcem.86.9.7850","article-title":"Study of GH sensitivity in Chilean patients with idiopathic short stature","volume":"86","author":"Sjoberg","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0070","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000330191","article-title":"Growth hormone\/IGF-I axis and growth hormone receptor mutations in idiopathic short stature","volume":"76","author":"El Kholy","year":"2011","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.ghir.2013.08.003_bb0075","first-page":"339","article-title":"Deficiency of the insulin-like growth factor-binding protein acid-labile subunit (ALS) of the circulating ternary complex in children with short stature","volume":"7","author":"Domen\u00e9","year":"2010","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.ghir.2013.08.003_bb0080","first-page":"209","article-title":"Referencias de peso y estatura desde el nacimiento hasta la madurez para ni\u00f1as y ni\u00f1os argentinos. Incorporaci\u00f3n de datos de la OMS de 0 a 2 a\u00f1os, rec\u00e1lculo de percentilos para obtenci\u00f3n de valores LMS","volume":"107","author":"Lejarraga","year":"2009","journal-title":"Arch. Argent. Pediatr."},{"key":"10.1016\/j.ghir.2013.08.003_bb0085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/adc.73.1.25","article-title":"Body mass index reference curves for the UK, 1990","volume":"73","author":"Cole","year":"1995","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2013.08.003_bb0090","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variation in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2013.08.003_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variation in pattern of pubertal changes in boys","volume":"45","author":"Marshall","year":"1970","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2013.08.003_bb0100","first-page":"4168","article-title":"Estrogen priming effect on growth hormone (GH) provocative test: a useful tool for the diagnosis of GH deficiency","volume":"85","author":"Mart\u00ednez","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0105","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2362.1996.2010558.x","article-title":"A simple, rapid immunometric assay for determination of functional and growth hormone-occupied growth hormone-binding protein in human serum","volume":"26","author":"Fisker","year":"1996","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.ghir.2013.08.003_bb0110","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1515\/JPEM.2004.17.5.749","article-title":"Differential impact of simple childhood obesity on the components of the growth hormone-insulin like growth factor (IGF), IGF binding protein axis","volume":"17","author":"Ballerini","year":"2004","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0115","first-page":"514","article-title":"The CTAB-DNA precipitation method: a common mini-scale preparation of template DNA from phagemids, phages or plasmids suitable for sequencing","volume":"7","author":"Del Sal","year":"1989","journal-title":"Biotechniques"},{"key":"10.1016\/j.ghir.2013.08.003_bb0120","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1210\/jc.2006-0828","article-title":"Exon 3-deleted\/full-length growth hormone receptor polymorphism genotype frequencies in Spanish short small-for-gestational-age (SGA) children and adolescents (n=247) and in an adult control population (n=289) show increased fl\/fl in short SGA","volume":"91","author":"Aud\u00ed","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0125","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/ng1379","article-title":"A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone","volume":"36","author":"Dos Santos","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ghir.2013.08.003_bb0130","first-page":"55","article-title":"Growth hormone receptor exon 3 isoforms and their implication in growth disorders and treatment","volume":"71","author":"Jorge","year":"2009","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2013.08.003_bb0135","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2265.2007.02915.x","article-title":"Exon 3-deleted genotype of growth hormone receptor (GHRd3) positively influences IGF-1 increase at generation test in children with idiopathic short stature","volume":"67","author":"Toyoshima","year":"2007","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.ghir.2013.08.003_bb0140","doi-asserted-by":"crossref","first-page":"E77","DOI":"10.1210\/jc.2012-2375","article-title":"Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA)","volume":"98","author":"Wan","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0145","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/humupd\/7.3.303","article-title":"The effects of oestrogens on linear bone growth","volume":"7","author":"Juul","year":"2001","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ghir.2013.08.003_bb0150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ghir.2009.09.004","article-title":"The current status of IGF-I assays \u2014 a 2009 update","volume":"20","author":"Frystyk","year":"2010","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ghir.2013.08.003_bb0155","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1210\/jcem.83.12.5311","article-title":"The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficiency","volume":"83","author":"Juul","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0160","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1515\/JPEM.2009.22.12.1127","article-title":"Serum IGF-I and IGFBP-3 reference values from a chemiluminescent assay in normal children and adolescents of Hispanic and Italian origin: presence of sexual dimorphism in IGF-I values","volume":"22","author":"Chaler","year":"2009","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0165","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1507\/endocrj.47.SupplMarch_S111","article-title":"Acid-labile subunit (ALS) measurements in children","volume":"47","author":"Nimura","year":"2011","journal-title":"Endocr. J."},{"key":"10.1016\/j.ghir.2013.08.003_bb0170","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ghir.2012.04.005","article-title":"Serum insulin-like growth factor-I (IGF-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients","volume":"22","author":"Bedogni","year":"2012","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ghir.2013.08.003_bb0175","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1373\/clinchem.2008.105726","article-title":"Within-subject variability and analytic imprecision of insulin like growth factor axis and collagen markers: implications for clinical diagnosis and doping tests","volume":"54","author":"Nguyen","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ghir.2013.08.003_bb0180","first-page":"452","article-title":"A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. I. Serum growth hormone-binding protein","volume":"77","author":"Martha","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.003_bb0185","first-page":"10","article-title":"The IGF-I response to growth hormone is related to body mass index in short children with normal weight","volume":"72","author":"Roman","year":"2009","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2013.08.003_bb0190","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1542\/peds.2004-1684","article-title":"Children with idiopathic short stature are poor eaters and have decreased body mass index","volume":"116","author":"Wudy","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.ghir.2013.08.003_bb0195","first-page":"13","article-title":"Growth hormone\/insulin-like growth factor-1 axis as related to body mass index in patients with idiopathic short stature","volume":"22","author":"Cengiz","year":"2013","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.003_bb0200","first-page":"1325","article-title":"Reduced concentration of serum growth hormone binding protein in children with idiopathic short stature. National Cooperative Growth Study","volume":"78","author":"Carlsson","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637413000725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637413000725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:47:29Z","timestamp":1761086849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637413000725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1096637413000725"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2013.08.003","relation":{},"ISSN":["1096-6374"],"issn-type":[{"type":"print","value":"1096-6374"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of serum components of the GH-IGFs-IGFBPs system with GHR-exon 3 polymorphism in normal and idiopathic short stature children","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2013.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}