{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:21:10Z","timestamp":1772792470691,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.ghir.2013.08.005","type":"journal-article","created":{"date-parts":[[2013,8,30]],"date-time":"2013-08-30T01:31:28Z","timestamp":1377826288000},"page":"243-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Growth hormone replacement normalizes impaired fibrinolysis: New insights into endothelial dysfunction in patients with hypopituitarism and growth hormone deficiency"],"prefix":"10.1016","volume":"23","author":[{"given":"D.","family":"Miljic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Miljic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Doknic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pekic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stojanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cvijovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Micic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Popovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2013.08.005_bb0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in hypopituitarism","volume":"336","author":"Rosen","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.ghir.2013.08.005_bb0010","first-page":"1169","article-title":"The effect of hypopituitarism on life expectancy","volume":"81","author":"Bates","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0015","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x","article-title":"Increased cerebrovascular mortality in patients with hypopituitarism","volume":"46","author":"Bulow","year":"1997","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism","volume":"357","author":"Tomilson","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ghir.2013.08.005_bb0025","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1530\/eje.0.1420254","article-title":"The effect of growth hormone replacement therapy on endothelial dysfunction and oxidative stress in adult growth hormone deficiency","volume":"142","author":"Evans","year":"2000","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1365-2265.1999.00671.x","article-title":"Endothelial dysfunction in hypopituitary adults with growth hormone deficiency","volume":"50","author":"Evans","year":"1999","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0035","first-page":"453","article-title":"Growth hormone(GH)treatment reverses early atherosclerotic changes in GH-deficient adults","volume":"84","author":"Pfeifer","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0040","first-page":"1329","article-title":"Decrease in carotid intima-media thickness after one year growth hormone (GH) treatment in adults with GH deficiency","volume":"84","author":"Berson-Chazot","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0045","first-page":"195","article-title":"Cardiovascular risk factors in growth hormone deficient adults","volume":"129","author":"Rosen","year":"1993","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2265.1999.00682.x","article-title":"Cardiovascular disease and risk factors in adults with hypopituitarism","volume":"50","author":"Beshyah","year":"1999","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0055","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1046\/j.1365-2265.2000.01002.x","article-title":"Increase of adhesion molecules, fibrinogen, type-1 plasminogen activator inhibitor and orosomucoid in growth hormone deficient adults and their modulation by recombinant human GH replacement","volume":"52","author":"Kvasnicka","year":"2000","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0060","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1055\/s-2000-8145","article-title":"Alterations of haemostatic and fibrinolytic markers in adult patients with growth hormone deficiency and with acromegaly","volume":"108","author":"Sartorio","year":"2000","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.ghir.2013.08.005_bb0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7326\/0003-4819-133-2-200007180-00010","article-title":"Effects of growth hormone administration on inflammation and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled, clinical trial","volume":"133","author":"Sesmilo","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ghir.2013.08.005_bb0070","first-page":"1518","article-title":"Effects of growth hormone(GH)administration on homocysteine levels in men with GH deficiency: a randomized controlled trial","volume":"86","author":"Sesmilo","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0075","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1055\/s-0038-1650594","article-title":"Long treatment with growth hormone decreases plasminogen activator inhibitor and tissue plasminogen activator in growth hormone deficient adults","volume":"76","author":"Johansson","year":"1996","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ghir.2013.08.005_bb0080","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.ATV.14.3.434","article-title":"High fibrinogen and plasminogen activator inhibitor activity in growth hormone deficient adults","volume":"14","author":"Johansson","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.ghir.2013.08.005_bb0085","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1210\/jc.2007-0609","article-title":"Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency","volume":"92","author":"Devin","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0090","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.thromres.2009.06.018","article-title":"Lack of change in insulin levels as a biological marker of PAI-1 lowering in GH-deficient adults on r-HGH replacement therapy","volume":"124","author":"Di Minno","year":"2009","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ghir.2013.08.005_bb0095","doi-asserted-by":"crossref","first-page":"187","DOI":"10.14310\/horm.2002.11183","article-title":"Changes in prothrombin and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone deficient adults","volume":"5","author":"Miljic","year":"2006","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.ghir.2013.08.005_bb0100","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1365-2265.2006.02518.x","article-title":"Peripheral fibrinolytic markers, soluble adhesion molecules, inflammatory cytokines and endothelial function inn hypopituitary adults with growth hormone deficiency","volume":"64","author":"Gomez","year":"2006","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0105","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jpeds.2004.07.037","article-title":"Peripheral inflammatory and fibrinolytic makers in adolescents with growth hormone deficiency: a relation to postprandial dyslipidemia","volume":"14","author":"Lanes","year":"2004","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ghir.2013.08.005_bb0110","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/EJE-12-0214","article-title":"Short-term effects of GH treatment on coagulation, fibrinolysis, inflammation biomarkers, and insulin resistance status in prepubertal children with GH deficiency","volume":"167","author":"Can\u1dc9ete","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0115","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1161\/01.ATV.17.12.3376","article-title":"Endothelium-dependent vasodilation and tissue-type plasminogen activator release in borderline hypertension","volume":"17","author":"Jern","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0120","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1074\/jbc.272.3.1976","article-title":"Tissue plasminogen activator (t-PA) is targeted to the regulated secretory pathway","volume":"272","author":"Parmer","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ghir.2013.08.005_bb0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1530\/EJE-07-0631","volume":"157","author":"Ho","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0130","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/jc.2011-0179","article-title":"Evaluation and treatment of adult growth hormone deficiency: an endocrine society clinical practice guideline","volume":"96","author":"Molitch","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0135","first-page":"260","article-title":"Effect of 12months of recombinant human growth hormone replacement therapy on insulin sensitivity in GH-deficient adults as determined by different methods","volume":"48","author":"Micic","year":"2002","journal-title":"J. Postgrad. Med."},{"key":"10.1016\/j.ghir.2013.08.005_bb0140","series-title":"Dacie and Lewis Practical Haematology","first-page":"441","article-title":"Investigation of thrombotic tendency","author":"Laffan","year":"2006"},{"key":"10.1016\/j.ghir.2013.08.005_bb0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0268-9499(93)90053-X","article-title":"Venous occlusion test: assessment of fibrinolytic capacity by D-dimer latex agglutination test","volume":"7","author":"Syrj\u00e4l\u00e4","year":"1993","journal-title":"Fibrinolysis"},{"key":"10.1016\/j.ghir.2013.08.005_bb0150","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.0954-6820.1987.tb01259.x","article-title":"On the usefulness of fibrinolytic variables in the characterization of a risk group for myocardial reinfarction","volume":"221","author":"Gram","year":"1987","journal-title":"Acta. Med. Scand."},{"key":"10.1016\/j.ghir.2013.08.005_bb0155","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198512193132501","article-title":"Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction","volume":"313","author":"Hamsten","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2013.08.005_bb0160","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/0140-6736(93)92062-X","article-title":"Fibrinolytic activity, clotting factors and long term incidence of ischemic heart disease in the Nothwick Park Heart Study","volume":"342","author":"Meade","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ghir.2013.08.005_bb0165","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1056\/NEJM199503093321003","article-title":"European Concentrated Action on Thrombosis and Disabilities Angina Pectoris Study Group. Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris","volume":"332","author":"Thompson","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2013.08.005_bb0170","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/01.ATV.21.4.611","article-title":"Prospective study of fibrinolytic factors and incident coronary disease: the Atherosclerosis Risk in Communities (ARIC) study","volume":"21","author":"Folson","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.ATV.18.1.1","article-title":"The adipocyte and hemostatic balance in obesity: studies of PAI-1","volume":"18","author":"Loskutoff","year":"1998","journal-title":"Atheroscl. Thromb. Vasc. Diab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0180","first-page":"370","article-title":"Plasminogen activator inhibitor-1: a common denominator in cardiovascular disease","volume":"46","author":"Vaughan","year":"1998","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.ghir.2013.08.005_bb0185","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1055\/s-0038-1649716","article-title":"The effects of insulin like growth factor-1 on plasminogen activator inhibitor-1 activity, synthesis and secretion: results from in vitro and in vivo studies","volume":"70","author":"Padayatty","year":"1993","journal-title":"Thromb. Hemost."},{"key":"10.1016\/j.ghir.2013.08.005_bb0190","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1172\/JCI119095","article-title":"Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study","volume":"98","author":"Boger","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ghir.2013.08.005_bb0195","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1530\/eje.0.1470523","article-title":"GH and IGF-1 regulate the expression of endothelial nitric oxide synthase (eNOS) in cardiovascular tissues of hypophysectomized female rats","volume":"147","author":"Wickman","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0200","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1210\/jc.2003-030144","article-title":"Acute effects of growth hormone on vascular function in human subjects in human subjects","volume":"88","author":"Napoli","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2013.08.005_bb0205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2265.1999.00805.x","article-title":"Growth hormone replacement therapy in adults with growth hormone deficiency improves vascular reactivity","volume":"51","author":"Christ","year":"1999","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/jmcc.1999.1053","article-title":"Angiotensin-converting enzyme inhibitor prevents plasminogen activator inhibitor-1 expression in a rat model with cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis","volume":"32","author":"Katoh","year":"2000","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0215","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.CIR.101.13.1539","article-title":"Role for insulin receptor, PI3-kinase and Akt in insulin signaling pathways related to production of nitric oxide in human vascular endothelial cells","volume":"101","author":"Zeng","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ghir.2013.08.005_bb0220","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0014-5793(03)01356-5","article-title":"Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line","volume":"555","author":"Thum","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ghir.2013.08.005_bb0225","first-page":"514","article-title":"Effects of growth hormone on fibrinolytic system in rat","volume":"36","author":"Buber","year":"1998","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0230","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0026-0495(84)90088-X","article-title":"Effects of growth hormone on the factor VIII complex in patients with growth hormone deficiency","volume":"12","author":"Borkenstain","year":"1984","journal-title":"Metabolism"},{"key":"10.1016\/j.ghir.2013.08.005_bb0235","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(84)90795-9","article-title":"A hypothalamic-pituitary system that stimulates the release of plasminogen activation in the rat","volume":"299","author":"Prowse","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.ghir.2013.08.005_bb0240","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2265.2011.04314.x","article-title":"Glucocorticoid replacement therapy and fibrinolysis in patients with hypopituitarism","volume":"77","author":"Peacey","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2013.08.005_bb0245","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1152\/ajpendo.00333.2002","article-title":"Influence of oral contraceptive use in endothelial t-PA release in healthy premenopausal women","volume":"284","author":"Hoetzer","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637413000919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637413000919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:47:45Z","timestamp":1761086865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637413000919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S1096637413000919"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2013.08.005","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth hormone replacement normalizes impaired fibrinolysis: New insights into endothelial dysfunction in patients with hypopituitarism and growth hormone deficiency","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2013.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}