{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:44:58Z","timestamp":1775706298165,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014382","name":"Ipsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.ghir.2015.01.002","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T10:30:35Z","timestamp":1422268235000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["A pilot study of growth hormone administration in boys with predicted adult short stature and near-ending growth"],"prefix":"10.1016","volume":"25","author":[{"given":"Anya","family":"Rothenbuhler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Ormi\u00e8res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Kalifa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bougn\u00e8res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2015.01.002_bb0005","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1542\/peds.102.S3.507","article-title":"Growth and normal puberty","volume":"102","author":"Abbassi","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.ghir.2015.01.002_bb0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jpeds.2011.07.008","article-title":"Growth hormone therapy needs to be tailored based on individual responsiveness in children with idiopathic short stature","volume":"159","author":"Albertsson-Wikland","year":"2011","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ghir.2015.01.002_bb0015","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1210\/jc.2008-0707","article-title":"Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency","volume":"93","author":"Albertsson-Wikland","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ghir.2009.09.005","article-title":"Measurement of human growth hormone by immunoassays: current status, unsolved problems and clinical consequences","volume":"20","author":"Bidlingmaier","year":"2010","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ghir.2015.01.002_bb0025","first-page":"CD004440","article-title":"Recombinant growth hormone for idiopathic short stature in children and adolescents","author":"Bryant","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"issue":"Suppl. 3","key":"10.1016\/j.ghir.2015.01.002_bb0030","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000330145","article-title":"Psychological criteria for treating children with idiopathic short stature","volume":"76","author":"Bullinger","year":"2011","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.ghir.2015.01.002_bb0035","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2265.2007.02901.x","article-title":"An evaluation of the relationship between adult height and health-related quality of life in the general UK population","volume":"67","author":"Christensen","year":"2007","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.ghir.2015.01.002_bb0040","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1210\/jc.2009-2139","article-title":"Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children","volume":"95","author":"Cohen","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0045","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1210\/jc.2008-0509","article-title":"Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop","volume":"93","author":"Cohen","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0050","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1210\/jc.2007-0204","article-title":"Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study","volume":"92","author":"Cohen","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0055","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/cen.12014","article-title":"Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels","volume":"78","author":"Cohen","year":"2013","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.ghir.2015.01.002_bb0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/cen.12408","article-title":"Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations","volume":"81","author":"Cohen","year":"2014","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.ghir.2015.01.002_bb0065","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1210\/jc.2010-1131","article-title":"Update in growth hormone therapy of children","volume":"96","author":"Collett-Solberg","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0070","doi-asserted-by":"crossref","first-page":"c7157","DOI":"10.1136\/bmj.c7157","article-title":"Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review","volume":"342","author":"Deodati","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.ghir.2015.01.002_bb0075","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archpedi.156.3.230","article-title":"Effect of growth hormone therapy on height in children with idiopathic short stature: a meta-analysis","volume":"156","author":"Finkelstein","year":"2002","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.ghir.2015.01.002_bb0080","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ajpa.1330190408","article-title":"Complete epiphyseal union of the hand","volume":"19","author":"Garn","year":"1961","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.ghir.2015.01.002_bb0085","first-page":"297","article-title":"A rational approach to the assessment of skeletal maturation","volume":"7","author":"Garn","year":"1964","journal-title":"Ann. Radiol. (Paris)"},{"key":"10.1016\/j.ghir.2015.01.002_bb0090","series-title":"Radiographic Atlas of Skeletal Development of Hand and Wrist","author":"Greulich","year":"1959"},{"key":"10.1016\/j.ghir.2015.01.002_bb0095","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1210\/jcem.86.2.7219","article-title":"Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging","volume":"86","author":"Harman","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0100","series-title":"Human Growth and Development","article-title":"Adolescent growth","author":"Hauspie","year":"2012"},{"key":"10.1016\/j.ghir.2015.01.002_bb0105","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1038\/sj.ejcn.1602474","article-title":"Growth curves of anthropometric indices in a general population of French children and comparison with reference data","volume":"60","author":"Heude","year":"2006","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.ghir.2015.01.002_bb0110","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2265.2011.04230.x","article-title":"Growth hormone regimens in Australia: analysis of the first 3years of treatment for idiopathic growth hormone deficiency and idiopathic short stature","volume":"77","author":"Hughes","year":"2012","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.ghir.2015.01.002_bb0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1687-9856-2012-22","volume":"2012","author":"Lee","year":"2012","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"10.1016\/j.ghir.2015.01.002_bb0120","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1210\/jc.2003-031457","article-title":"Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial","volume":"89","author":"Leschek","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0125","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1469-7580.2007.00847.x","article-title":"A method to establish the relationship between chronological age and stage of union from radiographic assessment of epiphyseal fusion at the knee: an Irish population study","volume":"212","author":"O'Connor","year":"2008","journal-title":"J. Anat."},{"key":"10.1016\/j.ghir.2015.01.002_bb0130","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2165\/00019053-200422080-00003","article-title":"Growth hormone therapy and quality of life in adults and children","volume":"22","author":"Radcliffe","year":"2004","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.ghir.2015.01.002_bb0135","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrendo.2013.71","article-title":"Treatment of children and adolescents with idiopathic short stature","volume":"9","author":"Ranke","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ghir.2015.01.002_bb0140","first-page":"53","article-title":"Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature","volume":"68","author":"Ranke","year":"2007","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2015.01.002_bb0145","doi-asserted-by":"crossref","unstructured":"A.F. Roche, Growth, Maturation and Body Composition. The Fels Longitudinal Study 1929\u20131991, in: C.U. Press (Ed.), 1992, pp. 104\u2013106 and 132\u2013138.","DOI":"10.1017\/CBO9780511661655"},{"key":"10.1016\/j.ghir.2015.01.002_bb0150","series-title":"The Knee Joint as a Biological Indicator","author":"Roche","year":"1975"},{"key":"10.1016\/j.ghir.2015.01.002_bb0155","first-page":"143","article-title":"History of the health notebook in France: a stake for mothers, doctors and state","volume":"23","author":"Rollet","year":"2003","journal-title":"Dynamis"},{"key":"10.1016\/j.ghir.2015.01.002_bb0160","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1210\/jc.2009-2531","article-title":"Near normalization of adult height and body proportions by growth hormone in pycnodysostosis","volume":"95","author":"Rothenbuhler","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0165","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1542\/peds.94.6.832","article-title":"Short stature: a psychosocial burden requiring growth hormone therapy?","volume":"94","author":"Sandberg","year":"1994","journal-title":"Pediatrics"},{"key":"10.1016\/j.ghir.2015.01.002_bb0170","doi-asserted-by":"crossref","first-page":"E213","DOI":"10.1210\/jc.2011-2882","article-title":"Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study","volume":"97","author":"Savendahl","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.01.002_bb0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1687-9856-2014-15","article-title":"Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit","volume":"2014","author":"Sotos","year":"2014","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"10.1016\/j.ghir.2015.01.002_bb0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/03014467600001231","article-title":"The adolescent growth spurt of boys and girls of the Harpenden growth study","volume":"3","author":"Tanner","year":"1976","journal-title":"Ann. Hum. Biol."},{"key":"10.1016\/j.ghir.2015.01.002_bb0185","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1530\/EJE-09-0880","article-title":"High-dose GH treatment limited to the prepubertal period in young children with idiopathic short stature does not increase adult height","volume":"162","author":"van Gool","year":"2010","journal-title":"Eur. J. Endocrinol."},{"issue":"Suppl. A","key":"10.1016\/j.ghir.2015.01.002_bb0190","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.ghir.2005.06.005","article-title":"A brief review of the use and utility of growth hormone stimulation testing in the NCGS: do we need to do provocative GH testing?","volume":"15","author":"Wilson","year":"2005","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.ghir.2015.01.002_bb0195","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpeds.2004.08.055","article-title":"Growth hormone (GH) treatment to final height in children with idiopathic short stature: evidence for a dose effect","volume":"146","author":"Wit","year":"2005","journal-title":"J. Pediatr."}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637415000040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637415000040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:48:57Z","timestamp":1761086937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637415000040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1096637415000040"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2015.01.002","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pilot study of growth hormone administration in boys with predicted adult short stature and near-ending growth","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2015.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}