{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:22:12Z","timestamp":1761513732031,"version":"build-2065373602"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1 RR025758"],"award-info":[{"award-number":["UL1 RR025758"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["M01-RR-01066","K23 DK094820"],"award-info":[{"award-number":["M01-RR-01066","K23 DK094820"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.ghir.2015.12.003","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T08:03:15Z","timestamp":1449216195000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effect of growth hormone treatment on diastolic function in patients who have developed growth hormone deficiency after definitive treatment of acromegaly"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-2927","authenticated-orcid":false,"given":"Pouneh K.","family":"Fazeli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G.","family":"Teoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor L.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu V.","family":"Gerweck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara L.","family":"Wexler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza P.","family":"Teo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronen","family":"Durst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McCarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory B.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Picard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Klibanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen K.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2015.12.003_bb0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2265.1994.tb03789.x","article-title":"Determinants of clinical outcome and survival in acromegaly","volume":"41","author":"Rajasoorya","year":"1994","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0010","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in hypopituitarism","volume":"336","author":"Rosen","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.ghir.2015.12.003_bb0015","first-page":"1047","article-title":"Cardiac involvement in acromegaly: specific myocardiopathy or consequence of systemic hypertension?","volume":"82","author":"Lopez-Velasco","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0020","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4158\/EP.13.4.363","article-title":"Increase of classic and nonclassic cardiovascular risk factors in patients with acromegaly","volume":"13","author":"Vilar","year":"2007","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.ghir.2015.12.003_bb0025","first-page":"E269","article-title":"Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action","volume":"250","author":"Hansen","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0030","first-page":"195","article-title":"Cardiovascular risk factors in adult patients with growth hormone deficiency","volume":"129","author":"Rosen","year":"1993","journal-title":"Acta Endocrinol. (Copenh)"},{"key":"10.1016\/j.ghir.2015.12.003_bb0035","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0026-0495(94)90245-3","article-title":"Serum lipid levels in growth hormone-deficient men","volume":"43","author":"de Boer","year":"1994","journal-title":"Metabolism"},{"key":"10.1016\/j.ghir.2015.12.003_bb0040","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/0026-0495(95)90004-7","article-title":"Growth hormone-deficient adults are insulin-resistant","volume":"44","author":"Johansson","year":"1995","journal-title":"Metabolism"},{"key":"10.1016\/j.ghir.2015.12.003_bb0045","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1210\/jc.2009-0941","article-title":"Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: a prospective study","volume":"94","author":"Colao","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0050","first-page":"1012","article-title":"Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy","volume":"74","author":"Moller","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0055","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1096-6374(02)00083-7","article-title":"Growth hormone receptor antagonist improves insulin resistance in acromegaly","volume":"12","author":"Rose","year":"2002","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2015.12.003_bb0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2265.2008.03181.x","article-title":"Amelioration of cardiovascular risk factors with partial biochemical control of acromegaly","volume":"69","author":"Delaroudis","year":"2008","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0065","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1210\/jcem.86.10.7887","article-title":"A prospective study of 5years of GH replacement therapy in GH-deficient adults: sustained effects on body composition, bone mass, and metabolic indices","volume":"86","author":"Gotherstrom","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0070","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1210\/jc.2007-2371","article-title":"Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study","volume":"93","author":"Beauregard","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.7326\/0003-4819-133-2-200007180-00010","article-title":"Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial","volume":"133","author":"Sesmilo","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ghir.2015.12.003_bb0080","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1210\/jcem.87.3.8336","article-title":"The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study","volume":"87","author":"Colao","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0085","first-page":"3419","article-title":"Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly","volume":"83","author":"Swearingen","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0090","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1210\/jc.2003-031199","article-title":"Factors influencing mortality in acromegaly","volume":"89","author":"Holdaway","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0095","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1210\/jc.2011-1215","article-title":"Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in adults","volume":"96","author":"van Bunderen","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0100","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1210\/jc.2014-1013","article-title":"Effects of long-term growth hormone replacement in adults with growth hormone deficiency following cure of acromegaly: a KIMS analysis","volume":"99","author":"Tritos","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0105","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1210\/jc.2007-2673","article-title":"Baseline characteristics and the effects of two years of growth hormone (GH) replacement therapy in adults with GH deficiency previously treated for acromegaly","volume":"93","author":"Norrman","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0110","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/01.CIR.99.11.1426","article-title":"Cell death in acromegalic cardiomyopathy","volume":"99","author":"Frustaci","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ghir.2015.12.003_bb0115","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1378\/chest.72.4.495","article-title":"Dysrhythmias and sudden death in acromegalic heart disease. A clinicopathologic study","volume":"72","author":"Rossi","year":"1977","journal-title":"Chest"},{"key":"10.1016\/j.ghir.2015.12.003_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11102-007-0062-6","article-title":"The long-term cardiovascular outcome of different GH-lowering treatments in acromegaly","volume":"11","author":"De Marinis","year":"2008","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2015.12.003_bb0125","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2265.1989.tb00266.x","article-title":"The cardiovascular effects of octreotide treatment in acromegaly: an echocardiographic study","volume":"30","author":"Thuesen","year":"1989","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0130","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/0002-9149(94)90865-6","article-title":"Effects of octreotide on left ventricular mass in acromegaly","volume":"74","author":"Tokgozoglu","year":"1994","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF03350250","article-title":"Acromegalic cardiopathy improves after treatment with increasing doses of octreotide","volume":"14","author":"Pereira","year":"1991","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.ghir.2015.12.003_bb0140","doi-asserted-by":"crossref","first-page":"719","DOI":"10.7326\/0003-4819-117-9-719","article-title":"Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion","volume":"117","author":"Lim","year":"1992","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ghir.2015.12.003_bb0145","first-page":"790","article-title":"Chronic treatment with the somatostatin analog octreotide improves cardiac abnormalities in acromegaly","volume":"77","author":"Merola","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0150","first-page":"1658","article-title":"Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency","volume":"77","author":"Merola","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2265.1998.00281.x","article-title":"Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency","volume":"48","author":"Longobardi","year":"1998","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0160","first-page":"1874","article-title":"Improved cardiovascular risk factors and cardiac performance after 12months of growth hormone (GH) replacement in young adult patients with GH deficiency","volume":"86","author":"Colao","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0165","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1210\/jc.2004-1042","article-title":"The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case\u2013control study","volume":"89","author":"Colao","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0170","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1210\/jcem.87.6.8542","article-title":"Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults","volume":"87","author":"Ezzat","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0175","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1161\/01.CIR.0000100720.01867.1D","article-title":"Cardiac effects of growth hormone in adults with growth hormone deficiency: a meta-analysis","volume":"108","author":"Maison","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ghir.2015.12.003_bb0180","first-page":"659","article-title":"Cardiac performance and mass in adults with hypopituitarism: effects of one year of growth hormone treatment","volume":"80","author":"Valcavi","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0185","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ghir.2010.05.003","article-title":"Growth hormone status predicts left ventricular mass in patients after cure of acromegaly","volume":"20","author":"Wexler","year":"2010","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2015.12.003_bb0190","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1210\/jc.2009-1611","article-title":"Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement","volume":"95","author":"Miller","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0195","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1210\/jcem.87.5.8509","article-title":"Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency","volume":"87","author":"Biller","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/jcem.87.2.8216","article-title":"Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency?","volume":"87","author":"Hartman","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ghir.2015.12.003_bb0210","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"Mosteller","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2015.12.003_bb0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"22","author":"Nagueh","year":"2009","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ghir.2015.12.003_bb0220","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1530\/EJE-09-0222","article-title":"Prevalence of GH deficiency in cured acromegalic patients: impact of different previous treatments","volume":"161","author":"Ronchi","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0225","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2265.2012.04361.x","article-title":"Effects of growth hormone deficiency on body composition and biomarkers of cardiovascular risk after definitive therapy for acromegaly","volume":"77","author":"Lin","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0230","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1210\/jc.2008-2671","article-title":"Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly","volume":"94","author":"Wexler","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0235","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/EJE-11-0558","article-title":"Body composition and quality of life in adults treated with GH therapy: a systematic review and meta-analysis","volume":"166","author":"Hazem","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0240","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ghir.2010.02.002","article-title":"The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency","volume":"20","author":"Deepak","year":"2010","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2015.12.003_bb0245","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4158\/EP11134.OR","article-title":"Effect of growth hormone replacement therapy on the quality of life in women with growth hormone deficiency who have a history of acromegaly versus other disorders","volume":"18","author":"Valassi","year":"2012","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.ghir.2015.12.003_bb0250","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11102-009-0186-y","article-title":"Limited effects of growth hormone replacement in patients with GH deficiency during long-term cure of acromegaly","volume":"12","author":"van der Klaauw","year":"2009","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2015.12.003_bb0255","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1210\/jc.2012-2477","article-title":"GH replacement improves quality of life and metabolic parameters in cured acromegalic patients with growth hormone deficiency","volume":"97","author":"Giavoli","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2015.12.003_bb0260","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1530\/eje.0.1460067","article-title":"Growth hormone deficiency and replacement in hypopituitary patients previously treated for acromegaly or Cushing's disease","volume":"146","author":"Feldt-Rasmussen","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2015.12.003_bb0265","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1530\/EJE-14-0515","article-title":"Effect of long-term GH replacement therapy on cardiovascular outcomes in GH-deficient patients previously treated for acromegaly: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults","volume":"171","author":"van Bunderen","year":"2014","journal-title":"Eur. J. Endocrinol."}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109663741530040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109663741530040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:49:12Z","timestamp":1761086952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109663741530040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":53,"alternative-id":["S109663741530040X"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2015.12.003","relation":{},"ISSN":["1096-6374"],"issn-type":[{"type":"print","value":"1096-6374"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of growth hormone treatment on diastolic function in patients who have developed growth hormone deficiency after definitive treatment of acromegaly","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2015.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}