{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:24:54Z","timestamp":1788866694805,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.ghir.2017.12.012","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T14:15:54Z","timestamp":1513779354000},"page":"44-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Insulin resistance depends on GH counter-regulation in two syndromes of short stature"],"prefix":"10.1016","volume":"38","author":[{"given":"Jaime","family":"Guevara-Aguirre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Bahamonde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2017.12.012_bb0005","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1073\/pnas.86.20.8083","article-title":"Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism","volume":"86","author":"Godowski","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ghir.2017.12.012_bb0010","first-page":"417","article-title":"Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations","volume":"76","author":"Guevara-Aguirre","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/humu.1380010105","article-title":"Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome","volume":"1","author":"Berg","year":"1992","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ghir.2017.12.012_bb0020","first-page":"4436","article-title":"Growth hormone receptor deficiency in Ecuador","volume":"84","author":"Rosenbloom","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0025","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJM199011153232002","article-title":"The little women of Loja\u2014growth hormone-receptor deficiency in an inbred population of southern Ecuador","volume":"323","author":"Rosenbloom","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2017.12.012_bb0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/edrv-15-3-369","article-title":"Growth hormone (GH) insensitivity due to primary GH receptor deficiency","volume":"15","author":"Rosenfeld","year":"1994","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2017.12.012_bb0035","doi-asserted-by":"crossref","first-page":"6983","DOI":"10.1073\/pnas.89.15.6983","article-title":"Importance of growth hormone for the induction of hepatic low density lipoprotein receptors","volume":"89","author":"Rudling","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ghir.2017.12.012_bb0040","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1210\/jc.2015-1678","article-title":"Associated with obesity and enhanced insulin sensitivity","volume":"100","author":"Guevara-Aguirre","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0045","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJM199610313351805","article-title":"Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene","volume":"335","author":"Woods","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2017.12.012_bb0050","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1056\/NEJM199610313351810","article-title":"Insulin-like growth factor I\u2014an important intrauterine growth factor","volume":"335","author":"Guevara-Aguirre","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2017.12.012_bb0055","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/adc.68.6.768","article-title":"Growth curves for Laron syndrome","volume":"68","author":"Laron","year":"1993","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2017.12.012_bb0060","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1210\/jcem-73-2-428","article-title":"Spontaneous growth hormone secretion increases during puberty in normal girls and boys","volume":"73","author":"Rose","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0065","first-page":"1393","article-title":"A randomized, double blind, placebo controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency","volume":"80","author":"Guevara-Aguirre","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0070","first-page":"248","article-title":"Effects of nutrient intake on growth, insulin-like growth factors, and their binding proteins in a Laron-type dwarf","volume":"76","author":"Crosnier","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0075","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1210\/jcem-59-1-34","article-title":"Phenotypic heterogeneity in familial isolated growth hormone deficiency type I-A","volume":"59","author":"Rivarola","year":"1984","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0080","first-page":"50","article-title":"Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP-1 gene","volume":"84","author":"Rosenbloom","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0085","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/jmg.31.8.635","article-title":"Facial morphometry in Ecuadorian patients with GHRD\/Laron syndrome","volume":"31","author":"Schaefer","year":"1994","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ghir.2017.12.012_bb0090","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1359\/jbmr.1998.13.3.415","article-title":"Bone mineral, histomorphometry, and body composition in adults with growth hormone receptor deficiency","volume":"13","author":"Bachrach","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ghir.2017.12.012_bb0095","article-title":"Osteopenia in Menstruating Women With Low IGF-I Levels Due to Growth Hormone Receptor Deficiency","author":"Guevara-Aguirre","year":"1991"},{"key":"10.1016\/j.ghir.2017.12.012_bb0100","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/1043-2760(94)P3205-L","article-title":"Growth in growth hormone insensitivity","volume":"5","author":"Rosenbloom","year":"1994","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0105","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI112884","article-title":"Glycemic thresholds for activation of glucose counterregulatory systems are higher than the threshold for symptoms","volume":"79","author":"Schwartz","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ghir.2017.12.012_bb0110","first-page":"273","article-title":"Hormonal and metabolic effects and pharmacokinetics of recombinant human insulin-like growth factor-I in growth hormone receptor deficiency\/Laron syndrome","volume":"77","author":"Vaccarello","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1651-2227.1993.tb12838.x","article-title":"Serum profiles of insulin-like growth factors and their binding proteins in adults with growth hormone receptor deficiency treated with insulin-like growth factor I","volume":"388","author":"Fielder","year":"1993","journal-title":"Acta Paediatr. Suppl."},{"key":"10.1016\/j.ghir.2017.12.012_bb0120","first-page":"1683","article-title":"The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3","volume":"77","author":"Gargosky","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0125","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1210\/jcem.86.11.8019","article-title":"The IGF-I generation test revisited: a marker of GH sensitivity","volume":"86","author":"Buckway","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0130","first-page":"762","article-title":"The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins","volume":"75","author":"Counts","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0135","doi-asserted-by":"crossref","first-page":"E405","DOI":"10.1152\/ajpendo.00423.2003","article-title":"Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice","volume":"287","author":"Liu","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0140","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1530\/EJE-11-0769","article-title":"Intrauterine and postnatal growth failure with normal GH\/IGF1 axis and insulin-resistant diabetes in a consanguineous kinship","volume":"166","author":"Guevara-Aguirre","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2017.12.012_bb0145","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.molmed.2014.09.001","article-title":"CDKN1C mutations: two sides of the same coin","volume":"20","author":"Eggermann","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ghir.2017.12.012_bb0150","doi-asserted-by":"crossref","first-page":"E2117","DOI":"10.1210\/jc.2014-1949","article-title":"A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood-onset diabetes","volume":"99","author":"Kerns","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2017.12.012_bb0155","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa010107","article-title":"IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation","volume":"349","author":"Abuzzahab","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2017.12.012_bb0160","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1210\/jc.2005-0158","article-title":"Hyperinsulinemic hypoglycemia in Beckwith-Wiedemann syndrome due to defects in the function of pancreatic \u03b2-cell adenosine triphosphate-sensitive potassium channels","volume":"90","author":"Hussain","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637417301211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637417301211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:51:33Z","timestamp":1761087093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637417301211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":32,"alternative-id":["S1096637417301211"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2017.12.012","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin resistance depends on GH counter-regulation in two syndromes of short stature","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2017.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}