{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:05:55Z","timestamp":1780409155143,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["SNF 320030_130331\/1"],"award-info":[{"award-number":["SNF 320030_130331\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ghir.2018.08.001","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T10:48:29Z","timestamp":1534502909000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Impaired repletion of intramyocellular lipids in patients with growth hormone deficiency after a bout of aerobic exercise"],"prefix":"10.1016","volume":"42-43","author":[{"given":"Hannah","family":"Loher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Jenni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Kr\u00fcsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-6875","authenticated-orcid":false,"given":"Roland","family":"Kreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Christ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2018.08.001_bb0005","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.2337\/diacare.15.11.1767","article-title":"Metabolic responses to exercise. Effects of endurance training and implications for diabetes","volume":"15","author":"Richter","year":"1992","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ghir.2018.08.001_bb0010","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.metabol.2012.11.004","article-title":"Insulin resistance: an adaptive mechanism becomes maladaptive in the current environment - an evolutionary perspective","volume":"62","author":"Tsatsoulis","year":"2013","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0015","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/er.2008-0027","article-title":"Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects","volume":"30","author":"Moller","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2018.08.001_bb0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/199913a0","article-title":"A metabolic regulating device based on the actions of human growth hormone and insulin, singly and together, on the human forearm","volume":"199","author":"Rabinowitz","year":"1963","journal-title":"Nature"},{"key":"10.1016\/j.ghir.2018.08.001_bb0025","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1210\/jc.2002-020540","article-title":"Effect of growth hormone (GH) on glycerol and free fatty acid metabolism during exhaustive exercise in GH-deficient adults","volume":"88","author":"Gibney","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0030","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.metabol.2010.08.004","article-title":"High fatty acid availability after exercise alters the regulation of muscle lipid metabolism","volume":"60","author":"Newsom","year":"2011","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0035","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.metabol.2011.01.003","article-title":"Moderate-intensity endurance exercise prevents short-term starvation-induced intramyocellular lipid accumulation but not insulin resistance","volume":"60","author":"Green","year":"2011","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.metabol.2009.07.009","article-title":"Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction","volume":"59","author":"Chow","year":"2010","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0045","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00125-014-3193-0","article-title":"The effect of a single 2 h bout of aerobic exercise on ectopic lipids in skeletal muscle, liver and the myocardium","volume":"57","author":"Bucher","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.ghir.2018.08.001_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070865","article-title":"The effect of aerobic exercise on intrahepatocellular and intramyocellular lipids in healthy subjects","volume":"8","author":"Egger","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2018.08.001_bb0055","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/mrm.24168","article-title":"Skeletal muscle (1)H MRSI before and after prolonged exercise. I. muscle specific depletion of intramyocellular lipids","volume":"68","author":"Vermathen","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.ghir.2018.08.001_bb0060","doi-asserted-by":"crossref","first-page":"E428","DOI":"10.1152\/ajpendo.00112.2007","article-title":"Evaluation of intramyocellular lipid breakdown during exercise by biochemical assay, NMR spectroscopy, and Oil Red O staining","volume":"293","author":"De Bock","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00421-006-0279-5","article-title":"Intramyocellular lipid stores increase markedly in athletes after 1.5 days lipid supplementation and are utilized during exercise in proportion to their content","volume":"98","author":"Zehnder","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0070","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1249\/01.mss.0000177478.14500.7c","article-title":"Gender-specific usage of intramyocellular lipids and glycogen during exercise","volume":"37","author":"Zehnder","year":"2005","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.ghir.2018.08.001_bb0075","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1152\/japplphysiol.00304.2003","article-title":"Intramyocellular lipid content is increased after exercise in nonexercising human skeletal muscle","volume":"95","author":"Schrauwen-Hinderling","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0080","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1210\/jc.2003-031006","article-title":"Intramyocellular lipid changes in men and women during aerobic exercise: a (1)H-magnetic resonance spectroscopy study","volume":"88","author":"White","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0085","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1152\/japplphysiol.00833.2002","article-title":"Intramyocellular triacylglycerol in prolonged cycling with high- and low-carbohydrate availability","volume":"94","author":"Johnson","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0090","doi-asserted-by":"crossref","first-page":"E95","DOI":"10.1152\/ajpendo.2002.282.1.E95","article-title":"Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study","volume":"282","author":"Larson-Meyer","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0095","first-page":"748","article-title":"Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study","volume":"85","author":"Krssak","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0100","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s11745-000-0647-2","article-title":"In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans","volume":"35","author":"Rico-Sanz","year":"2000","journal-title":"Lipids"},{"issue":"Pt 2","key":"10.1016\/j.ghir.2018.08.001_bb0105","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1469-7793.1998.615bk.x","article-title":"Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans","volume":"510","author":"Rico-Sanz","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0110","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00125-008-1045-5","article-title":"Fuel metabolism during exercise in euglycaemia and hyperglycaemia in patients with type 1 diabetes mellitus--a prospective single-blinded randomised crossover trial","volume":"51","author":"Jenni","year":"2008","journal-title":"Diabetologia"},{"issue":"19310","key":"10.1016\/j.ghir.2018.08.001_bb0115","article-title":"Effects of aerobic exercise on ectopic lipids in patients with growth hormone deficiency before and after growth hormone replacement therapy","volume":"6","author":"Christ","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ghir.2018.08.001_bb0120","doi-asserted-by":"crossref","first-page":"E1127","DOI":"10.1152\/ajpendo.00010.2008","article-title":"Effect of GH on human skeletal muscle lipid metabolism in GH deficiency","volume":"294","author":"Trepp","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091554","article-title":"The Flexibility of Ectopic Lipids","volume":"17","author":"Loher","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ghir.2018.08.001_bb0130","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.metabol.2012.09.007","article-title":"Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African-American versus Caucasian adolescents","volume":"62","author":"Lee","year":"2013","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0135","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.metabol.2007.10.013","article-title":"Short-term effects of dietary fat on intramyocellular lipid in sprinters and endurance runners","volume":"57","author":"Tamura","year":"2008","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0140","doi-asserted-by":"crossref","first-page":"E558","DOI":"10.1152\/ajpendo.00464.2003","article-title":"Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes","volume":"287","author":"van Loon","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0145","doi-asserted-by":"crossref","first-page":"E804","DOI":"10.1152\/ajpendo.00112.2003","article-title":"Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males","volume":"285","author":"van Loon","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0150","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0026-0495(86)90108-3","article-title":"Delayed effects of prolonged exercise on serum lipoproteins","volume":"35","author":"Dufaux","year":"1986","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0155","doi-asserted-by":"crossref","first-page":"E355","DOI":"10.1152\/ajpendo.00259.2005","article-title":"Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men","volume":"290","author":"Magkos","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0160","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.metabol.2007.03.012","article-title":"A single bout of brisk walking increases basal very low-density lipoprotein triacylglycerol clearance in young men","volume":"56","author":"Tsekouras","year":"2007","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ghir.2018.08.001_bb0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.atherosclerosis.2005.06.009","article-title":"Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men","volume":"185","author":"Gill","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ghir.2018.08.001_bb0170","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/BF00634304","article-title":"Acute and delayed effects of prolonged exercise on serum lipoproteins. II. Concentration and composition of low-density lipoprotein subfractions and very low-density lipoproteins","volume":"66","author":"Baumstark","year":"1993","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0175","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/eje.1.01967","article-title":"The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index","volume":"153","author":"Corneli","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0180","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1210\/jc.2005-2227","article-title":"Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline","volume":"91","author":"Molitch","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0185","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/jc.2011-0179","article-title":"Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Molitch","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0190","first-page":"R760","article-title":"Postexercise fat intake repletes intramyocellular lipids but no faster in trained than in sedentary subjects","volume":"281","author":"Decombaz","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0195","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/jmri.23707","article-title":"Magnetic resonance imaging based determination of body compartments with the versatile, interactive sparse sampling (VISS) method","volume":"36","author":"Buehler","year":"2012","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ghir.2018.08.001_bb0200","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.ghir.2018.08.001_bb0205","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.2337\/diab.39.10.1158","article-title":"Differences in lipoprotein subfraction composition and distribution between type I diabetic men and control subjects","volume":"39","author":"James","year":"1990","journal-title":"Diabetes"},{"key":"10.1016\/j.ghir.2018.08.001_bb0210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/EJE-10-0702","article-title":"The effect of GH replacement therapy on different fat compartments: a whole-body magnetic resonance imaging study","volume":"164","author":"Egger","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0215","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1530\/JME-13-0277","article-title":"Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease","volume":"52","author":"Nielsen","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ghir.2018.08.001_bb0220","first-page":"2010","article-title":"Abnormalities of very low density lipoprotein apolipoprotein B-100 metabolism contribute to the dyslipidaemia of adult growth hormone deficiency","volume":"82","author":"Cummings","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.08.001_bb0225","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/157340309788970306","article-title":"The GH\/IGF-1 axis and heart failure","volume":"5","author":"Castellano","year":"2009","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.ghir.2018.08.001_bb0230","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12020-014-0327-6","article-title":"GH and the cardiovascular system: an update on a topic at heart","volume":"48","author":"Isgaard","year":"2015","journal-title":"Endocrine"}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637418300650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637418300650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:51:08Z","timestamp":1761087068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637418300650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":46,"alternative-id":["S1096637418300650"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2018.08.001","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired repletion of intramyocellular lipids in patients with growth hormone deficiency after a bout of aerobic exercise","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2018.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}