{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:06:32Z","timestamp":1786989992892,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"JinLei Research Fund for Pediatric Endocrine Young Physician, China","award":["PEGRF201304006"],"award-info":[{"award-number":["PEGRF201304006"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ghir.2018.09.003","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T22:04:25Z","timestamp":1538431465000},"page":"80-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Efficacy and safety of recombinant human growth hormone in treating Chinese children with idiopathic short stature"],"prefix":"10.1016","volume":"42-43","author":[{"given":"Yan-Qin","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2018.09.003_bb0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000316130","article-title":"Current indications for growth hormone therapy for children and adolescents","volume":"18","author":"Richmond","year":"2010","journal-title":"Endocr. Dev."},{"key":"10.1016\/j.ghir.2018.09.003_bb0010","first-page":"eS16","article-title":"Indications for recombinant human growth hormone and evaluation of available recombinant human growth hormone devices: implications for managed care organizations","volume":"17","author":"Dunn","year":"2011","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.ghir.2018.09.003_bb0015","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/pmic.201200131","article-title":"Comparative proteomic analysis in children with idiopathic short stature (ISS) before and after short-term recombinant human growth hormone (rhGH) therapy","volume":"13","author":"Heo","year":"2013","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.ghir.2018.09.003_bb0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1687-9856-2014-15","article-title":"Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit","author":"Sotos","year":"2014","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"10.1016\/j.ghir.2018.09.003_bb0025","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1212\/WNL.0000000000000737","article-title":"Growth hormone treatment for childhood short stature and risk of stroke in early adulthood","volume":"83","author":"Poidvin","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.ghir.2018.09.003_bb0030","doi-asserted-by":"crossref","first-page":"E213","DOI":"10.1210\/jc.2011-2882","article-title":"Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, the Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study","volume":"97","author":"S\u00e4vendahl","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.09.003_bb0035","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/cen.13502","article-title":"Long-term safety of growth hormone-a combined registry analysis","volume":"88","author":"Stochholm","year":"2018","journal-title":"Endocrinol (Oxf)."},{"key":"10.1016\/j.ghir.2018.09.003_bb0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1440-1754.2012.02465.x","article-title":"Debate: idiopathic short stature should be treated with growth hormone","volume":"49","author":"Ambler","year":"2013","journal-title":"J. Paediatr. Child Health"},{"key":"10.1016\/j.ghir.2018.09.003_bb0045","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1210\/jc.2015-3951","article-title":"Mortality is not increased in recombinant human growth hormone-treated patients when adjusting for birth characteristics","volume":"101","author":"Albertsson-Wikland","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.09.003_bb0050","first-page":"426","article-title":"Recommendations for the clinical use of recombinant human growth hormone in children","volume":"51","author":"Subspecialty Group of Endocrinologic","year":"2013","journal-title":"Zhonghua Er Ke Za Zhi"},{"issue":"1","key":"10.1016\/j.ghir.2018.09.003_bb0055","first-page":"15","article-title":"Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit","author":"Juan","year":"2014","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"10.1016\/j.ghir.2018.09.003_bb0060","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000452150","article-title":"Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth Factor-I Deficiency","volume":"86","author":"Grimberg","year":"2016","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.ghir.2018.09.003_bb0065","first-page":"63","article-title":"Effect of recombinant human growth hormone therapy on idiopathic short stature patients: 12 months follow-up","volume":"7","author":"Wu","year":"2012","journal-title":"Chin. J. Evidence-based Pediatr."},{"key":"10.1016\/j.ghir.2018.09.003_bb0070","first-page":"1300","article-title":"The efficacy of rhGH treatment on 45 children with growth hormone deficiency and idiopathic short stature","volume":"31","author":"Zhao","year":"2016","journal-title":"Maternal Child Health Care China"},{"key":"10.1016\/j.ghir.2018.09.003_bb0075","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4103\/0971-6866.92102","article-title":"Growth response of Egyptian children with idiopathic short stature during four years of growth hormone therapy","volume":"17","author":"Ismail","year":"2011","journal-title":"Indian J. Hum. Genet."},{"key":"10.1016\/j.ghir.2018.09.003_bb0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1515\/jpem-2013-0210","article-title":"Expensive therapies in children: benefit versus cost of combined treatment of recombinant human growth hormone and gonadotropin-releasing hormone analogue in girls with poor height potential","volume":"27","author":"Toumba","year":"2014","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.09.003_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14420","article-title":"Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation","volume":"14","author":"Takeda","year":"2010","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.ghir.2018.09.003_bb0090","first-page":"1236","article-title":"Effects of rhGH replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature","volume":"16","author":"Zheng","year":"2014","journal-title":"Chin. J. Contemp. Pediatr."},{"key":"10.1016\/j.ghir.2018.09.003_bb0095","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ghir.2015.08.006","article-title":"Attaining genetic height potential: Analysis of height outcomes from the answer program in children treated with growth hormone over 5\u202fyears","volume":"25","author":"Ross","year":"2015","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2018.09.003_bb0100","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/adc.87.3.215","article-title":"High dose growth hormone treatment induces acceleration of skeletal maturation and an earlier onset of puberty in children with idiopathic short stature","volume":"87","author":"Kamp","year":"2002","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2018.09.003_bb0105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000330157","article-title":"Review of growth hormone randomized controlled trials in children with idiopathic short stature","volume":"76","author":"Deodati","year":"2011","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.ghir.2018.09.003_bb0110","first-page":"5","article-title":"Growth hormone responsiveness: peak stimulated growth hormone levels and other variables in idiopathic short stature (ISS): data from the National Cooperative Growth Study","volume":"6","author":"Moore","year":"2008","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.ghir.2018.09.003_bb0115","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1210\/jc.2014-1101","article-title":"IGF-1 and growth response to adult height in a randomized GH treatment trial in short non-GH-deficient children","volume":"99","author":"Kristr\u00f6m","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637418300716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637418300716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:51:51Z","timestamp":1761087111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637418300716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":23,"alternative-id":["S1096637418300716"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2018.09.003","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of recombinant human growth hormone in treating Chinese children with idiopathic short stature","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2018.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}