{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:08:57Z","timestamp":1786500537911,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.ghir.2018.10.004","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:09:57Z","timestamp":1540210197000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Long-term adherence to growth hormone therapy in a large health maintenance organization cohort"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-8836","authenticated-orcid":false,"given":"Alon","family":"Farfel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Shalitin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nira","family":"Morag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0599-533X","authenticated-orcid":false,"given":"Joseph","family":"Meyerovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2018.10.004_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000351800","article-title":"Growth hormone treatment adherence in prepubertal and pubertal children with different growth disorders","volume":"80","author":"Hartmann","year":"2013","journal-title":"Horm Res Paediatr."},{"key":"10.1016\/j.ghir.2018.10.004_bb0010","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000316130","article-title":"Current indications for growth hormone therapy for children and adolescents","volume":"18","author":"Richmond","year":"2010","journal-title":"Endocr. Dev."},{"key":"10.1016\/j.ghir.2018.10.004_bb0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ghir.2015.12.002","article-title":"Variability in adherence to rhGH treatment: Socioeconomic causes and effect on children's growth","volume":"26","author":"De Pedro","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2018.10.004_bb0020","first-page":"104","article-title":"Compliance with growth hormone treatment-is it a problem?","volume":"51","author":"Hindmarsh","year":"1999","journal-title":"Horm. Res."},{"key":"10.1016\/j.ghir.2018.10.004_bb0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/adc.68.1.91","article-title":"Compliance with growth hormone treatment-are they getting it?","volume":"68","author":"Smith","year":"1993","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2018.10.004_bb0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4158\/EP.14.2.143","article-title":"Compliance and persistence in pediatric and adult patients receiving growth hormone therapy","volume":"14","author":"Rosenfeld","year":"2008","journal-title":"Endocr. Pract."},{"issue":"42","key":"10.1016\/j.ghir.2018.10.004_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14420","article-title":"Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation","volume":"14","author":"Takeda","year":"2010","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.ghir.2018.10.004_bb0040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.clinthera.2008.02.017","article-title":"Observations of nonadherence to recombinant human growth hormone therapy in clinical practice","volume":"30","author":"Haverkamp","year":"2008","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ghir.2018.10.004_bb0045","series-title":"Adherence to Long-Term Therapies: Evidence for Action","first-page":"1","author":"Sabat\u00e9abat\u00e9","year":"2003"},{"key":"10.1016\/j.ghir.2018.10.004_bb0050","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1001\/jama.288.22.2880","article-title":"Helping patients follow prescribed treatment: clinical applications","volume":"288","author":"Haynes","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ghir.2018.10.004_bb0055","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0197-0070(84)80012-1","article-title":"Compliance with therapeutic regimens","volume":"5","author":"Jay","year":"1984","journal-title":"J. Adolesc. Health Care"},{"key":"10.1016\/j.ghir.2018.10.004_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016223","article-title":"Non-compliance with growth hormone treatment in children is common and impairs linear growth","volume":"6","author":"Cutfield","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2018.10.004_bb0065","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/adc.2006.114249","article-title":"Monitoring of concordance in growth hormone therapy","volume":"93","author":"Kapoor","year":"2008","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ghir.2018.10.004_bb0070","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000437305","article-title":"Low treatment adherence in pubertal children treated with thyroxin or growth hormone","volume":"84","author":"Lass","year":"2015","journal-title":"Hormone Research in Pediatrics"},{"key":"10.1016\/j.ghir.2018.10.004_bb0075","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4158\/EP13194.OR","article-title":"Adherence to growth hormone therapy: results of a multicenter study","volume":"20","author":"Aydin","year":"2014","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.ghir.2018.10.004_bb0080","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3111\/13696998.2011.590829","article-title":"A review of biopsychosocial strategies to prevent and overcome early-recognized poor adherence in growth hormone therapy of children","volume":"14","author":"Haverkamp","year":"2011","journal-title":"J. Med. Econ."},{"key":"10.1016\/j.ghir.2018.10.004_bb0085","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000350251","article-title":"Understanding the growth hormone therapy adherence paradigm: a systematic review","volume":"79","author":"Fisher","year":"2013","journal-title":"Horm Res in Paediatr."},{"key":"10.1016\/j.ghir.2018.10.004_bb0090","series-title":"Central Bureau of Statistics, Government of Israel website","article-title":"Local councils and municipalities by socio-economic index ranking in Israel (in Hebrew)","year":"2017"},{"key":"10.1016\/j.ghir.2018.10.004_bb0095","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/archinte.167.6.540","article-title":"Interventions to enhance medication adherence in chronic medical condition a systematic review","volume":"167","author":"Kripalani","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ghir.2018.10.004_bb0100","first-page":"327","article-title":"Patient outcomes in the GH Monitor: the effect of delivery device on compliance and growth","volume":"2","author":"Desrosiers","year":"2005","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.ghir.2018.10.004_bb0105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0738-3991(98)00107-4","article-title":"The Brief Medication Questionnaire: a tool for screening patient adherence and barriers to adherence","volume":"37","author":"Svarstad","year":"1999","journal-title":"Patient Educ. Couns."},{"key":"10.1016\/j.ghir.2018.10.004_bb0110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0895-4356(96)00268-5","article-title":"The assessment of refill compliance using pharmacy records: methods, validity, and applications","volume":"50","author":"Steiner","year":"1997","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.ghir.2018.10.004_bb0115","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ghir.2011.09.004","article-title":"The benefits of growth hormone therapy in patients with Turner syndrome, Noonan syndrome and children born small for gestational age","volume":"21","author":"Kappelgaard","year":"2011","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2018.10.004_bb0120","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1056\/NEJMra050100","article-title":"Adherence to medication","volume":"353","author":"Osterberg","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2018.10.004_bb0125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1651-2227.1998.tb01464.x","article-title":"Multicentre survey on compliance with growth hormone therapy: what can be improved?","volume":"87","author":"Oyarzabal","year":"1998","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.ghir.2018.10.004_bb0130","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4158\/EP171786.OR","article-title":"Prevalence and correlates of adherence in children and adolescents treated with growth hormone: a multicenter Italian study","volume":"23","author":"Bagnasco","year":"2017","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.ghir.2018.10.004_bb0135","first-page":"215","article-title":"The effect of socio-economic conditions on the time of diagnosis and compliance during treatment in growth hormone deficiency","volume":"31","author":"G\u00e1cs","year":"1991","journal-title":"Acta Paediatr Hung."},{"key":"10.1016\/j.ghir.2018.10.004_bb0140","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11102-011-0343-y","article-title":"How useful are serum IGF-1 measurements for managing GH replacement therapy in adults and children?","volume":"15","author":"Pawlikowska-Haddal","year":"2012","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2018.10.004_bb0145","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1210\/jc.2008-0509","article-title":"Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the growth hormone research society, the Lawson Wilkins paediatric endocrine society, and the European society for paediatric endocrinology workshop","volume":"98","author":"Cohen","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2018.10.004_bb0150","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0305-4179(03)00158-X","article-title":"Comparison of self-reported and monitored compliance of daily injection of human growth hormone in burned children","volume":"29","author":"Wilkins","year":"2003","journal-title":"Burns"},{"key":"10.1016\/j.ghir.2018.10.004_bb0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/0009922806289619","article-title":"Physicians' attitudes and practices regarding adherence to medical regimens by patients with chronic illness","volume":"45","author":"Patel","year":"2006","journal-title":"Clin. Pediatr. (Phila)"}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637418300753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637418300753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:50:40Z","timestamp":1761087040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637418300753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":31,"alternative-id":["S1096637418300753"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2018.10.004","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term adherence to growth hormone therapy in a large health maintenance organization cohort","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2018.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}