{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:15:57Z","timestamp":1780517757286,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ghir.2019.11.001","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T11:17:44Z","timestamp":1573298264000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1\/rhIGFBP-3 in extremely preterm infants"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-6502","authenticated-orcid":false,"given":"Susanna","family":"Klevebro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-7598","authenticated-orcid":false,"given":"Gunnel","family":"Hellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Hansen-Pupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Wackernagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubou","family":"Hallberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Borg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldina","family":"Pivodic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2019.11.001_bb0005","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/humrep\/13.5.1389","article-title":"Maternal and fetal insulin-like growth factors and their binding proteins in the second and third trimesters of human pregnancy","volume":"13","author":"Langford","year":"1998","journal-title":"Hum. Reprod. Oxf. Engl."},{"key":"10.1016\/j.ghir.2019.11.001_bb0010","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/apa.13350","article-title":"Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development","volume":"105","author":"Hellstr\u00f6m","year":"2016","journal-title":"Acta Paediatr. Oslo Nor."},{"key":"10.1016\/j.ghir.2019.11.001_bb0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0378-3782(86)90096-4","article-title":"Circulating insulin-like growth factor I levels in newborn premature and full-term infants followed longitudinally","volume":"13","author":"Lineham","year":"1986","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.ghir.2019.11.001_bb0020","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1203\/PDR.0b013e3182115000","article-title":"Influence of insulin-like growth factor I and nutrition during phases of postnatal growth in very preterm infants","volume":"69","author":"Hansen-Pupp","year":"2011","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ghir.2019.11.001_bb0025","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/j.1651-2227.2012.02826.x","article-title":"Low postnatal serum IGF-I levels are associated with bronchopulmonary dysplasia (BPD): Low IGF-I and BPD","volume":"101","author":"L\u00f6fqvist","year":"2012","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.ghir.2019.11.001_bb0030","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1542\/peds.112.5.1016","article-title":"Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth","volume":"112","author":"Hellstr\u00f6m","year":"2003","journal-title":"Pediatrics."},{"key":"10.1016\/j.ghir.2019.11.001_bb0035","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/pr.2013.135","article-title":"Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants","volume":"74","author":"Hansen-Pupp","year":"2013","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ghir.2019.11.001_bb0040","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1210\/jcem.87.5.8457","article-title":"IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants","volume":"87","author":"Kajantie","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2019.11.001_bb0045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/pr.2012.146","article-title":"Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: pharmacokinetics and short-term safety","volume":"73","author":"Ley","year":"2013","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ghir.2019.11.001_bb0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ghir.2017.08.004","article-title":"Continuous longitudinal infusion of rhIGF-1\/rhIGFBP-3 in extremely preterm infants: evaluation of feasibility in a phase II study","volume":"36","author":"Hansen-Pupp","year":"2017","journal-title":"Growth Horm. IGF Res. Off. J. Growth Horm. Res. Soc. Int. IGF Res. Soc."},{"key":"10.1016\/j.ghir.2019.11.001_bb0055","doi-asserted-by":"crossref","first-page":"5964","DOI":"10.2174\/1381612823666171002114545","article-title":"IGF-1 as a drug for preterm infants: a step-wise clinical development","volume":"23","author":"Hellstrom","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ghir.2019.11.001_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2018.10.033","article-title":"rhIGF-1\/rhIGFBP-3 in preterm infants: a phase 2 randomized controlled trial","volume":"206","author":"Ley","year":"2019","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ghir.2019.11.001_bb0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3181\/00379727-216-44182","article-title":"Insulin-like growth factor binding protein-1: recent findings and new directions","volume":"216","author":"Lee","year":"1997","journal-title":"Proc. Soc. Exp. Biol. Med. Soc. Exp. Biol. Med. N. Y. N."},{"key":"10.1016\/j.ghir.2019.11.001_bb0070","series-title":"Psychoneuroimmunology","first-page":"171","article-title":"Chapter 7 - crosstalk between insulin-like growth factors and pro-inflammatory cytokines","author":"McCusker","year":"2007"},{"key":"10.1016\/j.ghir.2019.11.001_bb0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ghir.2017.11.006","article-title":"Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity","volume":"39","author":"Hellgren","year":"2018","journal-title":"Growth Horm. IGF Res. Off. J. Growth Horm. Res. Soc. Int. IGF Res. Soc."},{"key":"10.1016\/j.ghir.2019.11.001_bb0080","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1651-2227.2007.00276.x","article-title":"Inflammation at birth and the insulin-like growth factor system in very preterm infants","volume":"96","author":"Hansen-Pupp","year":"2007","journal-title":"Acta Paediatr. Oslo Nor."},{"key":"10.1016\/j.ghir.2019.11.001_bb0085","first-page":"1011","article-title":"Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases (review)","volume":"18","author":"MacRae","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ghir.2019.11.001_bb0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1530\/eje.1.02251","article-title":"Changes in interleukin-6 and IGF system and their relationships in placenta and cord blood in newborns with fetal growth restriction compared with controls","volume":"155","author":"Street","year":"2006","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2019.11.001_bb0095","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1203\/PDR.0b013e31819d9e8c","article-title":"A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants","volume":"65","author":"L\u00f6fqvist","year":"2009","journal-title":"Pediatr. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.ghir.2019.11.001_bb0100","first-page":"11","article-title":"Radioimmunoassays for IGFs and IGFBPs","volume":"4","author":"Blum","year":"1994","journal-title":"Growth Regul."},{"key":"10.1016\/j.ghir.2019.11.001_bb0105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cellimm.2007.09.010","article-title":"Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology","volume":"252","author":"O\u2019Connor","year":"2008","journal-title":"Cell. Immunol."},{"issue":"172","key":"10.1016\/j.ghir.2019.11.001_bb0110","first-page":"7272","article-title":"IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells","volume":"1950","author":"Shen","year":"2004","journal-title":"J. Immunol. Baltim. Md."},{"key":"10.1016\/j.ghir.2019.11.001_bb0115","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.1074\/jbc.M310264200","article-title":"Tumor necrosis factor alpha inhibits cyclin a expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis","volume":"279","author":"Shen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ghir.2019.11.001_bb0120","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1006\/bbrc.1996.1705","article-title":"IL-6 stimulation of insulin-like growth factor binding protein (IGFBP)-1 production","volume":"228","author":"Samstein","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ghir.2019.11.001_bb0125","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1210\/endo.141.9.7641","article-title":"Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathway","volume":"141","author":"Frost","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2019.11.001_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2017.12.004","article-title":"MicroRNAs link chronic inflammation in childhood to growth impairment and insulin-resistance","volume":"39","author":"Cirillo","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ghir.2019.11.001_bb0135","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1172\/JCI119207","article-title":"Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation","volume":"99","author":"De Benedetti","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ghir.2019.11.001_bb0140","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1210\/endo.142.11.8511","article-title":"Effect of IL-6 on IGF binding protein-3: a study in IL-6 transgenic mice and in patients with systemic juvenile idiopathic arthritis","volume":"142","author":"De Benedetti","year":"2001","journal-title":"Endocrinology."},{"key":"10.1016\/j.ghir.2019.11.001_bb0145","first-page":"69","article-title":"Structural aspects of the IGFBP family","volume":"2","author":"Drop","year":"1992","journal-title":"Growth Regul."},{"key":"10.1016\/j.ghir.2019.11.001_bb0150","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/endo-129-4-2085","article-title":"Distribution of circulating insulin-like growth factor-I (IGF-I) into tissues","volume":"129","author":"Hodgkinson","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.ghir.2019.11.001_bb0155","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1097\/00004872-199715100-00014","article-title":"Is the tissue availability of circulating insulin-like growth factor I involved in organ damage and glucose regulation in hypertension?","volume":"15","author":"Laviades","year":"1997","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ghir.2019.11.001_bb0160","article-title":"ELGAN study investigators, early postnatal IGF-1 and IGFBP-1 blood levels in extremely preterm infants: relationships with indicators of placental insufficiency and with systemic inflammation","author":"Leviton","year":"2019","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.ghir.2019.11.001_bb0165","article-title":"Perinatal systemic inflammatory responses of growth-restricted preterm newborns","volume":"102","author":"McElrath","year":"2013","journal-title":"Acta Paediatr. Oslo Nor."},{"key":"10.1016\/j.ghir.2019.11.001_bb0170","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ghir.2013.03.005","article-title":"Insulin-like growth factor I and its binding protein 3 in sepsis","volume":"23","author":"Papastathi","year":"2013","journal-title":"Growth Horm. IGF Res. Off. J. Growth Horm. Res. Soc. Int. IGF Res. Soc."},{"key":"10.1016\/j.ghir.2019.11.001_bb0175","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1210\/jcem.87.7.8605","article-title":"Acute stress response in children with meningococcal sepsis: important differences in the growth hormone\/insulin-like growth factor I axis between nonsurvivors and survivors","volume":"87","author":"de Groof","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2019.11.001_bb0180","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2007.03.011","article-title":"The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis","volume":"21","author":"Steptoe","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ghir.2019.11.001_bb0185","first-page":"777","article-title":"Insulin-like growth factor binding protein-1 and interleukin-6 are markers of fetal stress during parturition at term gestation","volume":"18","author":"Marchini","year":"2005","journal-title":"J. Pediatr. Endocrinol. Metab. JPEM"},{"key":"10.1016\/j.ghir.2019.11.001_bb0190","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1210\/jc.2013-4018","article-title":"Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality","volume":"99","author":"Bartz","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2019.11.001_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086928","article-title":"Stunting is characterized by chronic inflammation in Zimbabwean infants","volume":"9","author":"Prendergast","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ghir.2019.11.001_bb0200","first-page":"4711","article-title":"Insulin-like growth factor I reduces the occurrence of necrotizing enterocolitis by reducing inflammatory response and protecting intestinal mucosal barrier in neonatal rats model","volume":"21","author":"Tian","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637419300541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637419300541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:51:20Z","timestamp":1761087080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637419300541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":40,"alternative-id":["S1096637419300541"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2019.11.001","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1\/rhIGFBP-3 in extremely preterm infants","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2019.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}