{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:16:45Z","timestamp":1761167805425,"version":"build-2065373602"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ghir.2020.101339","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T22:01:39Z","timestamp":1595887299000},"page":"101339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Assessing insulin sensitivity and resistance in syndromes of severe short stature"],"prefix":"10.1016","volume":"53-54","author":[{"given":"Jaime","family":"Guevara-Aguirre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Teran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Lescano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Guevara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Guevara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannette","family":"Saavedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricio","family":"Procel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive","family":"Wasserfall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio W.D.","family":"Gavilanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2020.101339_bb0005","unstructured":"Laron Z, Pertzelan A, Mannheimer S. Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism? Isr. J. Med. Sci. [Internet]. [cited 2019 Jul 7];2(2):152\u20135. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/5916640."},{"key":"10.1016\/j.ghir.2020.101339_bb0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ghir.2015.08.002","article-title":"Despite higher body fat content, Ecuadorian subjects with Laron syndrome have less insulin resistance and lower incidence of diabetes than their relatives","volume":"28","author":"Guevara-Aguirre","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2020.101339_bb0015","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1530\/EJE-11-0769","article-title":"Intrauterine and postnatal growth failure with normal GH\/IGF1 axis and insulin-resistant diabetes in a consanguineous kinship","volume":"166","author":"Guevara-Aguirre","year":"2012","journal-title":"Eur. J. Endocrinol."},{"issue":"10","key":"10.1016\/j.ghir.2020.101339_bb0020","doi-asserted-by":"crossref","first-page":"E2117","DOI":"10.1210\/jc.2014-1949","article-title":"A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood-onset diabetes","volume":"99","author":"Kerns","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101339_bb0025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ghir.2017.12.012","article-title":"Insulin resistance depends on GH counter-regulation in two syndromes of short stature","volume":"38","author":"Guevara-Aguirre","year":"2018","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2020.101339_bb0030","doi-asserted-by":"crossref","unstructured":"Rubio VY, Wasserfall C, Guevara-Aguirre J, Atkinson M, Rosenbloom A, Guevara A, Yost R, Garret T. Metabolomic characterization of Laron and Guevara-Rosenbloom syndrome using UHPLC-HRMS. Abstract # 2020, Annual Meeting of The American Diabetes Association, Chicago, Illinois.","DOI":"10.2337\/db20-195-LB"},{"key":"10.1016\/j.ghir.2020.101339_bb0035","unstructured":"Rubio VY, Waserfall C, Guevara-Aguirre J, Atkinson M, Rosenbloom A, Guevara A, Yost R, Garret T. Combined quantitation and profiling metabolomics to characterize Laron and Guevara-Rosenbloom syndromes. Abstract # 301772. ASMS Conference on Mass Spectrometry and Allied Topics. Houston Texas."},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/edrv-15-3-369","article-title":"Growth hormone (GH) insensitivity due to primary GH receptor deficiency","volume":"15","author":"RG Rosenfeld","year":"1994","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0045","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/humu.1380010105","article-title":"Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome","volume":"1","author":"Berg","year":"1992","journal-title":"Hum. Mutat."},{"issue":"Suppl. 5","key":"10.1016\/j.ghir.2020.101339_bb0050","first-page":"1453","article-title":"IGF generation in short stature","volume":"15","author":"Buckway","year":"2002","journal-title":"J. Pediatr. Endocrinol. Metab. [Internet]"},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000080757","article-title":"Insulin-like growth factor (IGF) parameters and tools for efficacy: The IGF-I generation test in children","volume":"62","author":"Rosenfeld","year":"2004","journal-title":"Horm. Res. Paediatr."},{"issue":"2","key":"10.1016\/j.ghir.2020.101339_bb0060","first-page":"417","article-title":"Growth hormone receptor deficiency in Ecuador: Clinical and biochemical phenotype in two populations","volume":"76","author":"Guevara-Aguirre","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.ghir.2020.101339_bb0065","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1210\/jc.2015-1678","article-title":"GH receptor deficiency in Ecuadorian adults is associated with obesity and enhanced insulin sensitivity","volume":"100","author":"Guevara-Aguirre","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.ghir.2020.101339_bb0070","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00125-003-1074-z","article-title":"Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex","volume":"46","author":"Cnop","year":"2003","journal-title":"Diabetologia."},{"issue":"8","key":"10.1016\/j.ghir.2020.101339_bb0075","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S2213-8587(18)30026-3","article-title":"The physiology of endocrine systems with ageing","volume":"6","author":"Van den Beld","year":"2018","journal-title":"Lancet Diab. Endocrinol."},{"issue":"6","key":"10.1016\/j.ghir.2020.101339_bb0080","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2337\/dc12-1235","article-title":"Ethnic differences in the relationship between insulin sensitivity and insulin response: A systematic review and meta-analysis","volume":"36","author":"Kodama","year":"2013","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.ghir.2020.101339_bb0085","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3390\/nu5062019","article-title":"Body fat distribution and insulin resistance","volume":"5","author":"Patel","year":"2013","journal-title":"Nutrients."},{"issue":"9","key":"10.1016\/j.ghir.2020.101339_bb0090","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S2213-8587(19)30076-2","article-title":"Understanding the mechanisms of reversal of type 2 diabetes","volume":"7","author":"Taylor","year":"2019","journal-title":"Lancet Diab. Endocrinol."},{"key":"10.1016\/j.ghir.2020.101339_bb0095","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/S0168-8227(11)70014-6","article-title":"Insulin effects in muscle and adipose tissue","volume":"93","author":"Dimitriadis","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9793","key":"10.1016\/j.ghir.2020.101339_bb0100","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(11)60814-3","article-title":"Health and economic burden of the projected obesity trends in the USA and the UK","volume":"378","author":"Wang","year":"2011","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.ghir.2020.101339_bb0105","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","article-title":"Cellular mechanisms of insulin resistance","volume":"106","author":"Shulman","year":"2000","journal-title":"J. Clin. Investig."},{"issue":"12","key":"10.1016\/j.ghir.2020.101339_bb0110","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Role of insulin resistance in human disease","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes."},{"key":"10.1016\/j.ghir.2020.101339_bb0115","series-title":"Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO\/IDF consultation","first-page":"17","author":"WHO","year":"2006"},{"issue":"7","key":"10.1016\/j.ghir.2020.101339_bb0120","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2337\/diab.45.7.947","article-title":"Insulin action and age: European Group for the Study of Insulin Resistance (EGIR)","volume":"45","author":"Ferrannini","year":"1996","journal-title":"Diabetes."},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0125","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2337\/diacare.19.3.278","article-title":"In praise of the hyperglycemic clamp: A method for assessment of beta-cell sensitivity and insulin resistance","volume":"19","author":"Elahi","year":"1996","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0130","doi-asserted-by":"crossref","first-page":"E214","DOI":"10.1152\/ajpendo.1979.237.3.E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0135","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1152\/ajpendo.00645.2007","article-title":"Current approaches for assessing insulin sensitivity and resistance in vivo: Advantages, limitations, and appropriate usage","volume":"294","author":"Muniyappa","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.ghir.2020.101339_bb0140","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.2337\/dc13-1120","article-title":"Quantitative estimation of insulin sensitivity in type 1 diabetic subjects wearing a sensor-augmented insulin pump","volume":"37","author":"Schiavon","year":"2014","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0145","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejim.2010.07.008","article-title":"The oral glucose tolerance test (OGTT) revisited","volume":"22","author":"Bartoli","year":"2011","journal-title":"Eur. J. Intern. Med."},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0150","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1464-5491.1994.tb00273.x","article-title":"Understanding oral glucose tolerance: Comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion","volume":"11","author":"Phillips","year":"1994","journal-title":"Diabet. Med."},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0155","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/2230-8210.146874","article-title":"Assessment of insulin sensitivity\/resistance","volume":"19","author":"Gutch","year":"2015","journal-title":"Ind. J. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.ghir.2020.101339_bb0160","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/oxfordjournals.aje.a116768","article-title":"How good a marker is insulin level for insulin resistance?","volume":"137","author":"Laakso","year":"1993","journal-title":"Am. J. Epidemiol."},{"issue":"8","key":"10.1016\/j.ghir.2020.101339_bb0165","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1210\/jc.2003-030219","article-title":"Glucose-to-insulin ratio rather than sex hormone-binding globulin and adiponectin levels is the best predictor of insulin resistance in nonobese women with polycystic ovary syndrome","volume":"88","author":"Ducluzeau","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.ghir.2020.101339_bb0170","first-page":"2694","article-title":"A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome1","volume":"83","author":"Legro","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0175","doi-asserted-by":"crossref","DOI":"10.1186\/1756-0500-7-98","article-title":"Limitations of fasting indices in the measurement of insulin sensitivity in Afro-Caribbean adults","volume":"7","author":"Thompson","year":"2014","journal-title":"BMC Res. Notes."},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000089314","article-title":"Simple fasting methods to assess insulin sensitivity in childhood","volume":"64","author":"Cutfield","year":"2005","journal-title":"Hormone Res. Paediatr."},{"issue":"7","key":"10.1016\/j.ghir.2020.101339_bb0185","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia."},{"issue":"7","key":"10.1016\/j.ghir.2020.101339_bb0190","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"14","key":"10.1016\/j.ghir.2020.101339_bb0195","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0025-7753(01)72168-9","article-title":"Cuantificaci\u00f3n de insulinorresistencia con los valores de insulina basal e \u00edndice HOMA en una poblaci\u00f3n no diab\u00e9tica","volume":"117","author":"Ascaso","year":"2001","journal-title":"Med. Clin."},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0200","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1210\/jc.87.1.144","article-title":"Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention","volume":"87","author":"H\u0159eb\u00ed\u010dek","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101339_bb0205","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ghir.2015.08.002","article-title":"Despite higher body fat content, Ecuadorian subjects with Laron syndrome have less insulin resistance and lower incidence of diabetes than their relatives","volume":"28","author":"Guevara-Aguirre","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"issue":"6","key":"10.1016\/j.ghir.2020.101339_bb0210","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1590\/0004-2730000003223","article-title":"Obesity, insulin resistance and comorbidities? Mechanisms of association","volume":"58","author":"Castro","year":"2014","journal-title":"Arq. Brasil. Endocrinol. Metabol."},{"key":"10.1016\/j.ghir.2020.101339_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2013.00037","article-title":"Beta cell dysfunction and insulin resistance","volume":"4","author":"Cerf","year":"2013","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0220","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000089313","article-title":"Clamp techniques in paediatrics: What have we learned?","volume":"64","author":"Arslanian","year":"2005","journal-title":"Hormone Res. Paediatr."},{"issue":"2","key":"10.1016\/j.ghir.2020.101339_bb0225","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/mgme.1997.2658","article-title":"Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels","volume":"63","author":"Belfiore","year":"1998","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ghir.2020.101339_bb0230","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/sj.ijo.0800864","article-title":"Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state","volume":"23","author":"Avignon","year":"1999","journal-title":"Int. J. Obes."},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0235","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0168-8227(99)00116-3","article-title":"Validation of the insulin sensitivity index (ISI0,120): Comparison with other measures","volume":"47","author":"Gutt","year":"2000","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"9","key":"10.1016\/j.ghir.2020.101339_bb0240","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0245","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2337\/diacare.23.3.295","article-title":"Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity","volume":"23","author":"Stumvoll","year":"2000","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0250","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2337\/diacare.24.3.460","article-title":"Diagnosing insulin resistance in the general population","volume":"24","author":"McAuley","year":"2001","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.ghir.2020.101339_bb0255","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: The link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.ghir.2020.101339_bb0260","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/oxfordjournals.aje.a010187","article-title":"Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies","volume":"151","author":"Hanson","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ghir.2020.101339_bb0265","first-page":"1","article-title":"Assessment of insulin resistance in subjects with normal glucose tolerance, hyperinsulinemia with normal blood glucose tolerance, impaired glucose tolerance, and newly diagnosed type 2 diabetes (prediabetes insulin resistance research)","volume":"2016","author":"Yang","year":"2016","journal-title":"J. Diab. Res."},{"issue":"9","key":"10.1016\/j.ghir.2020.101339_bb0270","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.2017-00828","article-title":"Pancreas fat and \u03b2 cell mass in humans with and without diabetes: An analysis in the Japanese population","volume":"102","author":"Murakami","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.ghir.2020.101339_bb0275","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S2213-8587(15)00482-9","article-title":"The incretin effect in healthy individuals and those with type 2 diabetes: Physiology, pathophysiology, and response to therapeutic interventions","volume":"4","author":"Nauck","year":"2016","journal-title":"Lancet Diab. Endocrinol."},{"issue":"suppl_2","key":"10.1016\/j.ghir.2020.101339_bb0280","doi-asserted-by":"crossref","first-page":"S362","DOI":"10.2337\/dc09-S340","article-title":"Adipocytokines and insulin resistance: The possible role of lipocalin-2, retinol binding protein-4, and adiponectin","volume":"32","author":"Estevez","year":"2009","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0285","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4239\/wjd.v5.i3.328","article-title":"Interrelationships between ghrelin, insulin and glucose homeostasis: Physiological relevance","volume":"5","author":"Chabot","year":"2014","journal-title":"World J. Diabetes"},{"issue":"9","key":"10.1016\/j.ghir.2020.101339_bb0290","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4103\/2230-8210.105571","article-title":"Leptin therapy, insulin sensitivity, and glucose homeostasis","volume":"16","author":"Paz-Filho","year":"2012","journal-title":"Ind. J. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.ghir.2020.101339_bb0295","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.molmet.2014.12.001","article-title":"Central insulin signalling modulates hypothalamus\u2013pituitary\u2013adrenal axis responsiveness","volume":"4","author":"Chong","year":"2015","journal-title":"Mol. Metab."},{"issue":"3","key":"10.1016\/j.ghir.2020.101339_bb0300","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00423.2003","article-title":"Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice","volume":"287","author":"Liu","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"year":"2013","series-title":"Pancreatic Surgery in Infants with Beckwith\u2013Wiedemann Syndrome and Hyperinsulinism","author":"Laje","key":"10.1016\/j.ghir.2020.101339_bb0305"}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637420300484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637420300484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:52:37Z","timestamp":1761087157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637420300484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":61,"alternative-id":["S1096637420300484"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2020.101339","relation":{},"ISSN":["1096-6374"],"issn-type":[{"type":"print","value":"1096-6374"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing insulin sensitivity and resistance in syndromes of severe short stature","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2020.101339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101339"}}