{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:58:54Z","timestamp":1793325534387,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone & IGF Research"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ghir.2020.101342","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T11:33:29Z","timestamp":1598528009000},"page":"101342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["A single-center observational study assessing the predictive factors associated with the prognosis of acromegaly"],"prefix":"10.1016","volume":"55","author":[{"given":"Halit","family":"Diri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"Ozaslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Kurtsoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahri","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2020.101342_bb0005","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/jc.2014-2700","article-title":"Acromegaly: an endocrine society clinical practice guideline","volume":"99","author":"Katznelson","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101342_bb0010","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2020.101342_bb0015","first-page":"168","article-title":"Pituitary tumor registry: a novel clinical resource","volume":"85","author":"Drange","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101342_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fendo.2015.00097","article-title":"Progress in the diagnosis and classification of pituitary adenomas","volume":"6","author":"Syro","year":"2015","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ghir.2020.101342_bb0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11102-016-0754-x","article-title":"Epidemiology of acromegaly: review of population studies","volume":"20","author":"Lavrentaki","year":"2017","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2020.101342_bb0030","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41574-018-0058-5","article-title":"A consensus statement on acromegaly therapeutic outcomes","volume":"14","author":"Melmed","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ghir.2020.101342_bb0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12902-017-0199-x","article-title":"Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center","volume":"17","author":"Carmichael","year":"2017","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.ghir.2020.101342_bb0040","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1210\/jc.2011-0554","article-title":"Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome","volume":"96","author":"Jane","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101342_bb0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11102-009-0191-1","article-title":"Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension","volume":"13","author":"Melmed","year":"2010","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2020.101342_bb0050","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM200004203421604","article-title":"Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant","volume":"342","author":"Trainer","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ghir.2020.101342_bb0055","doi-asserted-by":"crossref","first-page":"943","DOI":"10.4158\/EP14574.OR","article-title":"Radiotherapy versus radiosurgery in treating patients with acromegaly: a systematic review and meta-analysis","volume":"21","author":"Abu Dabrh","year":"2015","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.ghir.2020.101342_bb0060","first-page":"1","article-title":"Long-term outcomes of transsphenoidal surgery for management of growth hormone-secreting adenomas: single-center results","author":"Asha","year":"2019","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.ghir.2020.101342_bb0065","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1530\/eje.1.01968","article-title":"Predictors and rates of treatment-resistant tumor growth in acromegaly","volume":"153","author":"Besser","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2020.101342_bb0070","first-page":"679","article-title":"Prognostic factors obtained from long-term follow-up of pituitary adenomas and other sellar tumors","volume":"24","author":"Diri","year":"2014","journal-title":"Turk. Neurosurg."},{"key":"10.1016\/j.ghir.2020.101342_bb0075","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-0033-1354578","article-title":"Factors associated with biochemical remission after microscopic transsphenoidal surgery for acromegaly","volume":"75","author":"Sun","year":"2014","journal-title":"J. Neurol. Surg. B Skull Base"},{"key":"10.1016\/j.ghir.2020.101342_bb0080","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.wneu.2017.08.182","article-title":"Endoscopic transsphenoidal approach for acromegaly with remission rates in 401 patients: 2010 consensus criteria","volume":"108","author":"Anik","year":"2017","journal-title":"World Neurosurg."},{"key":"10.1016\/j.ghir.2020.101342_bb0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2265.2004.02082.x","article-title":"Cabergoline addition to depot somatostatin analogues in resistant acromegalic patients: efficacy and lack of predictive value of prolactin status","volume":"61","author":"Cozzi","year":"2004","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2020.101342_bb0090","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s11102-017-0813-y","article-title":"Acromegaly: surgical results in 548 patients","volume":"20","author":"Fernandez Mateos","year":"2017","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2020.101342_bb0095","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1530\/eje.1.01863","article-title":"The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical \u2018cure\u2019","volume":"152","author":"Nomikos","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2020.101342_bb0100","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/01616412.2017.1296653","article-title":"Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis","volume":"39","author":"Briceno","year":"2017","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ghir.2020.101342_bb0105","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.4158\/EP14587.OR","article-title":"Significant elevation of growth hormone level impacts surgical outcomes in acromegaly","volume":"21","author":"Anthony","year":"2015","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.ghir.2020.101342_bb0110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1055\/s-0043-107245","article-title":"3D volumetric measurements of GH secreting adenomas correlate with baseline pituitary function, initial surgery success rate, and disease control","volume":"49","author":"Tirosh","year":"2017","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.ghir.2020.101342_bb0115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11102-011-0347-7","article-title":"Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis","volume":"15","author":"Roelfsema","year":"2012","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2020.101342_bb0120","first-page":"401","article-title":"The predictive value of the IGF-1 level in acromegaly patients treated by surgery and a somatostatin analogue","volume":"62","author":"Baldys-Waligorska","year":"2011","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.ghir.2020.101342_bb0125","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1210\/jc.2018-01113","article-title":"Prevalence, clinical and biochemical spectrum, and treatment outcome of acromegaly with normal basal GH at diagnosis","volume":"103","author":"Espinosa de Los Monteros","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101342_bb0130","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1210\/jcem.83.10.5111","article-title":"Transsphenoidal microsurgery for growth hormone-secreting pituitary adenomas: initial outcome and long-term results","volume":"83","author":"Abosch","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101342_bb0135","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s12020-018-1590-8","article-title":"Predictors of surgical outcome and early criteria of remission in acromegaly","volume":"60","author":"Antunes","year":"2018","journal-title":"Endocrine"},{"key":"10.1016\/j.ghir.2020.101342_bb0140","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1210\/jcem.86.4.7398","article-title":"Predictors of the outcome of surgical treatment in acromegaly and the value of the mean growth hormone day curve in assessing postoperative disease activity","volume":"86","author":"Kaltsas","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101342_bb0145","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1210\/jc.2003-031316","article-title":"Significance of \u201cabnormal\u201d nadir growth hormone levels after oral glucose in postoperative patients with acromegaly in remission with normal insulin-like growth factor-I levels","volume":"89","author":"Freda","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2020.101342_bb0150","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s11102-018-0884-4","article-title":"How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review","volume":"21","author":"van Esdonk","year":"2018","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2020.101342_bb0155","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10143-015-0692-5","article-title":"Clinical features and natural course of acromegaly in patients with discordance in the nadir GH level on the oral glucose test and the IGF-1 value at 3 months after adenomectomy","volume":"39","author":"Kinoshita","year":"2016","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.ghir.2020.101342_bb0160","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ghir.2018.03.002","article-title":"Value of early postoperative random growth hormone levels and nadir growth hormone levels after oral glucose tolerance testing in acromegaly","volume":"41","author":"Rotermund","year":"2018","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2020.101342_bb0165","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s12020-011-9476-z","article-title":"Epidemiologic survey: reference ranges of serum insulin-like growth factor 1 levels in Caucasian adult population with immunoradiometric assay","volume":"40","author":"Bayram","year":"2011","journal-title":"Endocrine"},{"key":"10.1016\/j.ghir.2020.101342_bb0170","first-page":"610","article-title":"Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings","volume":"33","author":"Knosp","year":"1993","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ghir.2020.101342_bb0175","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/BF01105562","article-title":"Factors predicting pituitary adenoma invasiveness in acromegalic patients","volume":"20","author":"Rieger","year":"1997","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.ghir.2020.101342_bb0180","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1517\/14656566.2011.568478","article-title":"Therapy of aggressive pituitary tumors","volume":"12","author":"Colao","year":"2011","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.ghir.2020.101342_bb0185","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.3171\/2016.8.JNS161123","article-title":"Correlation between GH and IGF-1 during treatment for acromegaly","volume":"126","author":"Oldfield","year":"2017","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.ghir.2020.101342_bb0190","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1365-2265.1999.00760.x","article-title":"Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience","volume":"50","author":"Ahmed","year":"1999","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2020.101342_bb0195","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2265.1998.00581.x","article-title":"The outcome of surgery for acromegaly: the need for a specialist pituitary surgeon for all types of growth hormone (GH) secreting adenoma","volume":"49","author":"Lissett","year":"1998","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2020.101342_bb0200","article-title":"The acromegaly registry of ten different centers in Turkey","volume":"101322","author":"Keskin","year":"2020","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2020.101342_bb0205","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jocn.2010.10.003","article-title":"Treatment of persistent and recurrent acromegaly","volume":"18","author":"Del Porto","year":"2011","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.ghir.2020.101342_bb0210","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11102-016-0765-7","article-title":"The surgical treatment of acromegaly","volume":"20","author":"Buchfelder","year":"2017","journal-title":"Pituitary"},{"key":"10.1016\/j.ghir.2020.101342_bb0215","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s11102-017-0832-8","article-title":"Surgical debulking of pituitary adenomas improves responsiveness to octreotide Lar in the treatment of acromegaly","volume":"20","author":"Fahlbusch","year":"2017","journal-title":"Pituitary"}],"container-title":["Growth Hormone & IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637420300514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096637420300514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:52:17Z","timestamp":1761087137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096637420300514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":43,"alternative-id":["S1096637420300514"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2020.101342","relation":{},"ISSN":["1096-6374"],"issn-type":[{"value":"1096-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A single-center observational study assessing the predictive factors associated with the prognosis of acromegaly","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2020.101342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101342"}}