{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:33:14Z","timestamp":1765369994969,"version":"build-2065373602"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006928","name":"Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008076","name":"Ohio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Growth Hormone &amp; IGF Research"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ghir.2022.101460","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:31:39Z","timestamp":1650022299000},"page":"101460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Growth hormone modulates Trypanosoma cruzi infection in vitro"],"prefix":"10.1016","volume":"64","author":[{"given":"Patricia","family":"Mora-Criollo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reetobrata","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanrong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime A.","family":"Costales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Guevara-Aguirre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario J.","family":"Grijalva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Kopchick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ghir.2022.101460_bb0005","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.4269\/ajtmh.16-0761","article-title":"Experimental and clinical treatment of Chagas disease: a review","volume":"97","author":"Sales Junior","year":"2017","journal-title":"Am. J. Tropical Med. and Hygiene."},{"key":"10.1016\/j.ghir.2022.101460_bb0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fpubh.2019.00166","article-title":"Chagas disease: from discovery to a worldwide health problem","volume":"7","author":"Lidani","year":"2019","journal-title":"Front. Public Health"},{"author":"P AHO | Chagas disease","key":"10.1016\/j.ghir.2022.101460_bb0015"},{"key":"10.1016\/j.ghir.2022.101460_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/295394","article-title":"Review on Trypanosoma cruzi\u202f: host cell interaction","volume":"2010","author":"de Souza","year":"2010","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.ghir.2022.101460_bb0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pt.2019.10.002","article-title":"Trypanosoma cruzi","volume":"36","author":"Moretti","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ghir.2022.101460_bb0030","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.ygeno.2019.06.015","article-title":"Close encounters between Trypanosoma cruzi and the host mammalian cell: lessons from genome-wide expression studies","volume":"112","author":"Oliveira","year":"2020","journal-title":"Genomics."},{"key":"10.1016\/j.ghir.2022.101460_bb0035","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nrmicro1249","article-title":"The Trypanosoma cruzi\u2013host-cell interplay: location, invasion, retention","volume":"3","author":"Andrade","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0040","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0014-4894(73)90087-8","article-title":"Trypanosoma cruzi: interaction with vertebrate cells in vitro","volume":"34","author":"Dvorak","year":"1973","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ghir.2022.101460_bb0045","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1574-6976.2012.00333.x","article-title":"Host cell invasion by Trypanosoma cruzi\u202f: a unique strategy that promotes persistence","volume":"36","author":"Fernandes","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ghir.2022.101460_bb0050","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1053\/j.semdp.2019.04.008","article-title":"Chagas disease as example of a reemerging parasite","volume":"36","author":"Guarner","year":"2019","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.ghir.2022.101460_bb0055","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ejmech.2018.06.040","article-title":"Current advances in drug discovery for Chagas disease","volume":"155","author":"Scarim","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ghir.2022.101460_bb0060","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41579-019-0238-x","article-title":"Protozoan persister-like cells and drug treatment failure","volume":"17","author":"Barrett","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0065","unstructured":"WHO | Chagas disease (American trypanosomiasis), WHO. http:\/\/www.who.int\/chagas\/en\/ (accessed December 11, 2018)."},{"key":"10.1016\/j.ghir.2022.101460_bb0070","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fendo.2018.00334","article-title":"Role of hormonal circuitry upon T cell development in Chagas disease: possible implications on T cell dysfunctions","volume":"9","author":"P\u00e9rez","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ghir.2022.101460_bb0075","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijcard.2015.09.052","article-title":"Could Carlos Chagas\u2019 assumption on the relationship between goiter and chronic Chagas heart disease be correct? A historical reappraisal","volume":"202","author":"Bestetti","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0080","doi-asserted-by":"crossref","first-page":"152024","DOI":"10.1016\/j.imbio.2020.152024","article-title":"Hypothyroidism impairs the host immune response during the acute phase of Chagas disease","volume":"225","author":"Sampaio","year":"2020","journal-title":"Immunobiology"},{"key":"10.1016\/j.ghir.2022.101460_bb0085","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000180264","article-title":"The impact of infectious diseases upon neuroendocrine circuits","volume":"16","author":"P\u00e9rez","year":"2009","journal-title":"Neuroimmunomodulation."},{"key":"10.1016\/j.ghir.2022.101460_bb0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/vim.2005.18.41","article-title":"Immune modulation of the hypothalamic-pituitary-adrenal (HPA) Axis during viral infection","volume":"18","author":"Silverman","year":"2005","journal-title":"Viral Immunol."},{"key":"10.1016\/j.ghir.2022.101460_bb0095","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1196\/annals.1366.005","article-title":"Immunoneuroendocrine interactions in Chagas disease","volume":"1088","author":"Correa-De-Santana","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ghir.2022.101460_bb0100","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000205513","article-title":"Modulation of growth hormone and prolactin secretion in Trypanosoma cruzi-infected Mammosomatotrophic cells","volume":"16","author":"Corr\u00eaa-de-Santana","year":"2009","journal-title":"Neuroimmunomodulation."},{"key":"10.1016\/j.ghir.2022.101460_bb0105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jneuroim.2005.08.015","article-title":"Hypothalamus\u2013pituitary\u2013adrenal axis during Trypanosoma cruzi acute infection in mice","volume":"173","author":"Corr\u00eaa-de-Santana","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ghir.2022.101460_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002470","article-title":"Trypanosoma cruzi disrupts Thymic homeostasis by altering Intrathymic and systemic stress-related endocrine circuitries","volume":"7","author":"Lepletier","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ghir.2022.101460_bb0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fimmu.2020.01838","article-title":"The Thymus in Chagas disease: molecular interactions involved in abnormal T-cell migration and differentiation","volume":"11","author":"P\u00e9rez","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ghir.2022.101460_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.00704","article-title":"Evasion and Immuno-endocrine regulation in parasite infection: two sides of the same coin in Chagas disease?","volume":"7","author":"Morrot","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/nyas.13946","article-title":"Glucocorticoids and sympathetic neurotransmitters modulate the acute immune response to Trypanosoma cruzi: T. cruzi and neuroendocrine immunoregulation","volume":"1437","author":"Roggero","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ghir.2022.101460_bb0130","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.rvsc.2009.10.001","article-title":"Growth hormones therapy in immune response against Trypanosoma cruzi","volume":"88","author":"Frare","year":"2010","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.ghir.2022.101460_bb0135","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.vetpar.2011.04.008","article-title":"Prolactin: does it exert an up-modulation of the immune response in Trypanosoma cruzi-infected rats?","volume":"181","author":"Filipin","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ghir.2022.101460_bb0140","doi-asserted-by":"crossref","first-page":"154736","DOI":"10.1016\/j.cyto.2019.154736","article-title":"M. Paula Alonso Toldo, F. Rossetto de Morais, J.C. do Prado J\u00fanior, Does Prolactin treatment trigger imunoendocrine alterations during experimental T. cruzi infection?","volume":"121","author":"Del Vecchio Filipin","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.ghir.2022.101460_bb0145","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/gut.21.9.772","article-title":"Response of plasma pancreatic and gastrointestinal hormones and growth hormone to oral and intravenous glucose and insulin hypoglycaemia in Chagas\u2019s disease","volume":"21","author":"Long","year":"1980","journal-title":"Gut."},{"key":"10.1016\/j.ghir.2022.101460_bb0150","doi-asserted-by":"crossref","first-page":"18885","DOI":"10.1038\/s41598-019-55363-9","article-title":"Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice","volume":"9","author":"Lucchetti","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ghir.2022.101460_bb0155","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1210\/er.2018-00216","article-title":"Growth hormone deficiency: health and longevity","volume":"40","author":"Aguiar-Oliveira","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2022.101460_bb0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-019-0036-y","article-title":"Targeting growth hormone function: strategies and therapeutic applications","volume":"4","author":"Lu","year":"2019","journal-title":"Sig Transduct Target Ther."},{"key":"10.1016\/j.ghir.2022.101460_bb0165","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","article-title":"Acromegaly","volume":"5","author":"Colao","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ghir.2022.101460_bb0170","article-title":"Laron syndrome \u2013 a historical perspective","author":"Laron","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.ghir.2022.101460_bb0175","doi-asserted-by":"crossref","first-page":"70ra13","DOI":"10.1126\/scitranslmed.3001845","article-title":"Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, Cancer and diabetes in humans","volume":"3","author":"Guevara-Aguirre","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ghir.2022.101460_bb0180","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/jmg.31.8.635","article-title":"Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency\/Laron syndrome","volume":"31","author":"Schaefer","year":"1994","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ghir.2022.101460_bb0185","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ghir.2015.08.001","article-title":"A half-century of studies of growth hormone insensitivity\/Laron syndrome: a historical perspective","volume":"28","author":"Rosenbloom","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2022.101460_bb0190","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S1043-2760(98)00070-8","article-title":"Lessons from the genetics of Laron syndrome","volume":"9","author":"Rosenbloom","year":"1998","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ghir.2022.101460_bb0195","first-page":"123","article-title":"IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome, mutation research\/reviews in mutation","volume":"772","author":"Laron","year":"2017","journal-title":"Research."},{"key":"10.1016\/j.ghir.2022.101460_bb0200","article-title":"Insights from the clinical phenotype of subjects with Laron syndrome in Ecuador","author":"Guevara-Aguirre","year":"2020","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.ghir.2022.101460_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.111044","article-title":"IGF-I deficiency and enhanced insulin sensitivity due to a mutated growth hormone receptor gene in humans","volume":"519","author":"Guevara-Aguirre","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ghir.2022.101460_bb0210","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ghir.2015.08.002","article-title":"Despite higher body fat content, Ecuadorian subjects with Laron syndrome have less insulin resistance and lower incidence of diabetes than their relatives","volume":"28","author":"Guevara-Aguirre","year":"2016","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ghir.2022.101460_bb0215","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1523\/JNEUROSCI.1929-16.2016","article-title":"Brain structure and function associated with younger adults in growth hormone receptor-deficient humans","volume":"37","author":"Nashiro","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ghir.2022.101460_bb0220","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1073\/pnas.91.4.1391","article-title":"Growth hormone (GH) induces tyrosine-phosphorylated proteins in mouse L cells that express recombinant GH receptors","volume":"91","author":"Wang","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ghir.2022.101460_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006747","article-title":"Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes","volume":"13","author":"Shah-Simpson","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ghir.2022.101460_bb0230","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00673-18","article-title":"Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular Trypanosoma cruzi Amastigotes","volume":"9","author":"Dumoulin","year":"2018","journal-title":"MBio"},{"key":"10.1016\/j.ghir.2022.101460_bb0235","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41598-018-36718-0","article-title":"Overexpression of Trypanosoma cruzi high mobility group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity","volume":"9","author":"Tavernelli","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ghir.2022.101460_bb0240","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1462-5822.2004.00405.x","article-title":"Host cell actin polymerization is required for cellular retention of Trypanosoma cruzi and early association with endosomal\/lysosomal compartments: actin remodelling facilitates trypanosome invasion","volume":"6","author":"Woolsey","year":"2004","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0245","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1369-5274(98)80066-0","article-title":"Signaling and host cell invasion by Trypanosoma cruzi","volume":"1","author":"Burleigh","year":"1998","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0250","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/excr.2000.5123","article-title":"Trypanosoma cruzi: phosphatidylinositol 3-kinase and protein kinase B activation is associated with parasite invasion","volume":"264","author":"Wilkowsky","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ghir.2022.101460_bb0255","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinformatics."},{"key":"10.1016\/j.ghir.2022.101460_bb0260","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/apa.1991.80.s377.96","article-title":"Growth hormone receptor deficiency (Laron syndrome): clinical and genetic characteristics","volume":"80","author":"Guevara-Aguirre","year":"1991","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.ghir.2022.101460_bb0265","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2265.2009.03626.x","article-title":"Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains under-recognized and under-diagnosed","volume":"72","author":"Reid","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ghir.2022.101460_bb0270","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11102-016-0772-8","article-title":"Acromegaly: clinical features at diagnosis","volume":"20","author":"Vilar","year":"2017","journal-title":"Pituitary."},{"key":"10.1016\/j.ghir.2022.101460_bb0275","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/en.2008-1199","article-title":"Age-related changes in body composition of bovine growth hormone transgenic mice","volume":"150","author":"Palmer","year":"2009","journal-title":"Endocrinology."},{"key":"10.1016\/j.ghir.2022.101460_bb0280","doi-asserted-by":"crossref","first-page":"13215","DOI":"10.1073\/pnas.94.24.13215","article-title":"A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor\/binding protein gene (the Laron mouse)","volume":"94","author":"Zhou","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ghir.2022.101460_bb0285","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1550-7408.2002.tb00216.x","article-title":"Epidermal growth factor binds to a receptor on Trypanosoma cruziAmastigotes inducing signal transduction events and cell proliferation","volume":"49","author":"Ghansah","year":"2002","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0290","series-title":"The Somatotrophic Axis in Brain Function","first-page":"39","article-title":"Chapter 3 - mechanisms of signal transduction utilized by growth hormone","author":"Shafiei","year":"2006"},{"key":"10.1016\/j.ghir.2022.101460_bb0295","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi0301s42","article-title":"An introduction to sequence similarity (\u201chomology\u201d) searching","volume":"42","author":"Pearson","year":"2013","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.ghir.2022.101460_bb0300","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/er.2001-0022","article-title":"Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly","volume":"23","author":"Kopchick","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ghir.2022.101460_bb0305","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1530\/eje.0.148s021","article-title":"Discovery and mechanism of action of pegvisomant","volume":"148","author":"Kopchick","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ghir.2022.101460_bb0310","doi-asserted-by":"crossref","unstructured":"F.B. Gonz\u00e1lez, S.R. Villar, M.F. Pacini, O.A. Bottasso, A.R. P\u00e9rez, Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: new clues for understanding Chagas disease pathology, Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. 1866 (2020) 165642. doi:https:\/\/doi.org\/10.1016\/j.bbadis.2019.165642.","DOI":"10.1016\/j.bbadis.2019.165642"},{"key":"10.1016\/j.ghir.2022.101460_bb0315","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/dbio.2000.9975","article-title":"Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth","volume":"229","author":"Lupu","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ghir.2022.101460_bb0320","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1177\/000456329002700604","article-title":"Prolactin and growth hormone: molecular heterogeneity and measurement in serum","volume":"27","author":"Smith","year":"1990","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.ghir.2022.101460_bb0325","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/me.2012-1297","article-title":"The role of prolactin receptor in GH signaling in breast Cancer cells","volume":"27","author":"Xu","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ghir.2022.101460_bb0330","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1172\/JCI113804","article-title":"Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice","volume":"82","author":"Jansson","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ghir.2022.101460_bb0335","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.actatropica.2017.09.017","article-title":"Trypanosoma cruzi genetic diversity: something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity","volume":"184","author":"Zingales","year":"2018","journal-title":"Acta Trop."},{"key":"10.1016\/j.ghir.2022.101460_bb0340","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pt.2014.01.008","article-title":"Chagas disease: the challenge of polyparasitism?","volume":"30","author":"Perez","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ghir.2022.101460_bb0345","doi-asserted-by":"crossref","DOI":"10.1080\/21623996.2015.1012964","article-title":"Trypanosoma cruzi parasites fight for control of the JAK-STAT pathway by disarming their host","volume":"3","author":"Stahl","year":"2014","journal-title":"JAK-STAT."},{"key":"10.1016\/j.ghir.2022.101460_bb0350","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.00183","article-title":"The mitogen-activated protein kinase (MAPK) pathway: role in immune evasion by Trypanosomatids","volume":"7","author":"Soares-Silva","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ghir.2022.101460_bb0355","first-page":"21","article-title":"Alterations triggered by steroid gonadal hormones in triglycerides and the cellular immune response of Calomys callosus infected with the Y strain of Trypanosoma cruzi","author":"D\u2019ambrosio","year":"2008","journal-title":"Vet. Parasitol. 152"},{"key":"10.1016\/j.ghir.2022.101460_bb0360","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.vetpar.2006.08.038","article-title":"Haematological and histopathological findings after ovariectomy in Trypanosoma cruzi infected mice","author":"Dominguez Santos","year":"2007","journal-title":"Vet. Parasitol. 143"}],"container-title":["Growth Hormone &amp; IGF Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109663742200017X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S109663742200017X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:52:16Z","timestamp":1761087136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S109663742200017X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":72,"alternative-id":["S109663742200017X"],"URL":"https:\/\/doi.org\/10.1016\/j.ghir.2022.101460","relation":{},"ISSN":["1096-6374"],"issn-type":[{"type":"print","value":"1096-6374"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth hormone modulates Trypanosoma cruzi infection in vitro","name":"articletitle","label":"Article Title"},{"value":"Growth Hormone & IGF Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ghir.2022.101460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101460"}}